Inhibitory Concentration 50
"Inhibitory Concentration 50" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
| Descriptor ID |
D020128
|
| MeSH Number(s) |
E05.940.350 G07.690.936.563
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Inhibitory Concentration 50".
Below are MeSH descriptors whose meaning is more specific than "Inhibitory Concentration 50".
This graph shows the total number of publications written about "Inhibitory Concentration 50" by people in this website by year, and whether "Inhibitory Concentration 50" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 8 | 8 |
| 2004 | 0 | 10 | 10 |
| 2005 | 0 | 14 | 14 |
| 2006 | 0 | 5 | 5 |
| 2007 | 0 | 8 | 8 |
| 2008 | 0 | 8 | 8 |
| 2009 | 0 | 8 | 8 |
| 2010 | 0 | 10 | 10 |
| 2011 | 0 | 11 | 11 |
| 2012 | 0 | 9 | 9 |
| 2013 | 0 | 11 | 11 |
| 2014 | 0 | 5 | 5 |
| 2015 | 0 | 9 | 9 |
| 2016 | 0 | 4 | 4 |
| 2017 | 0 | 8 | 8 |
| 2018 | 0 | 4 | 4 |
| 2019 | 0 | 4 | 4 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Inhibitory Concentration 50" by people in Profiles.
-
Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium. Mol Biochem Parasitol. 2024 12; 260:111637.
-
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature. 2022 02; 602(7898):676-681.
-
Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner. J Biol Chem. 2021 07; 297(1):100775.
-
GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals. Cells. 2021 04 06; 10(4).
-
Optimized culture of retinal ganglion cells and amacrine cells from adult mice. PLoS One. 2020; 15(12):e0242426.
-
Heparin-mediated dimerization of follistatin. Exp Biol Med (Maywood). 2021 02; 246(4):467-482.
-
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem. 2020 11 12; 63(21):12957-12977.
-
Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 01; 207:112761.
-
An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors. Int J Cancer. 2020 11 01; 147(9):2621-2633.
-
Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy. Clin Cancer Res. 2020 07 15; 26(14):3740-3750.