Inhibitory Concentration 50
"Inhibitory Concentration 50" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
| Descriptor ID |
D020128
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| MeSH Number(s) |
E05.940.350 G07.690.936.563
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Inhibitory Concentration 50".
Below are MeSH descriptors whose meaning is more specific than "Inhibitory Concentration 50".
This graph shows the total number of publications written about "Inhibitory Concentration 50" by people in this website by year, and whether "Inhibitory Concentration 50" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 3 | 3 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 4 | 4 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 5 | 5 |
| 2015 | 0 | 5 | 5 |
| 2016 | 0 | 5 | 5 |
| 2017 | 0 | 5 | 5 |
| 2018 | 0 | 4 | 4 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 3 | 3 |
| 2021 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inhibitory Concentration 50" by people in Profiles.
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Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium. Mol Biochem Parasitol. 2024 12; 260:111637.
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Two new isoquinoline alkaloids from Cryptocarya wrayi and their biological activities. Fitoterapia. 2022 Jan; 156:105086.
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Optimized culture of retinal ganglion cells and amacrine cells from adult mice. PLoS One. 2020; 15(12):e0242426.
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1,2,3-Triazole-linked 5-benzylidene (thio)barbiturates as novel tyrosinase inhibitors and free-radical scavengers. Arch Pharm (Weinheim). 2020 Oct; 353(10):e2000058.
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An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors. Int J Cancer. 2020 11 01; 147(9):2621-2633.
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Veratric acid derivatives containing benzylidene-hydrazine moieties as promising tyrosinase inhibitors and free radical scavengers. Bioorg Med Chem. 2019 06 15; 27(12):2644-2651.
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GSK3? regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res. 2019 03 07; 21(1):37.
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Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects. Pharm Biol. 2018 Dec; 56(1):235-244.
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An Organoid-Based Preclinical Model of Human Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2019; 7(1):161-184.
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Converting a weaker ATP-binding site inhibitor into a potent hetero-bivalent ligand by tethering to a unique peptide sequence derived from the same kinase. Org Biomol Chem. 2018 09 11; 16(35):6443-6449.