"Bicuculline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
| Descriptor ID |
D001640
|
| MeSH Number(s) |
D03.132.098.077 D03.633.100.531.085.077
|
| Concept/Terms |
Bicuculline- Bicuculline
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
|
Below are MeSH descriptors whose meaning is more general than "Bicuculline".
Below are MeSH descriptors whose meaning is more specific than "Bicuculline".
This graph shows the total number of publications written about "Bicuculline" by people in this website by year, and whether "Bicuculline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 1 | 3 | 4 |
| 2004 | 1 | 4 | 5 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 4 | 4 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bicuculline" by people in Profiles.
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Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. J Neurochem. 2016 Apr; 137(2):226-39.
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Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates Pro-Opiomelanocortin Neurons in the Arcuate Nucleus. Neuroendocrinology. 2016; 103(5):476-488.
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Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. Pain. 2011 Apr; 152(4):844-852.
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Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats. Regul Pept. 2011 Jan 17; 166(1-3):112-20.
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Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J Neurochem. 2010 Apr; 113(2):530-42.
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Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala. J Neurochem. 2008 Jul; 106(2):889-99.
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Effects of chronic network hyperexcitability on the growth of hippocampal dendrites. Neurobiol Dis. 2008 Feb; 29(2):267-77.
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The impact of chronic network hyperexcitability on developing glutamatergic synapses. Eur J Neurosci. 2007 Aug; 26(4):975-91.
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Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons. J Neurophysiol. 2007 May; 97(5):3279-87.
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Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons in rats with diabetic neuropathy. J Physiol. 2007 Mar 15; 579(Pt 3):849-61.