ROBERT BRITTON

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    2007 - 2013NSF CAREER Award
    2010College of Natural Science Teacher Scholar Award, Michigan State University

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    Areas of Interest

    The role of intestinal bacteria in health and disease
    Recombineering in lactic acid bacteria
    GTPase control of ribosome assembly

    Research Summary

    1. The role of intestinal bacteria in health and disease.

    Recent work into the role of intestinal bacteria in a variety of disease states including inflammatory bowel disease, obesity, and diabetes has established a clear link between these bacteria and our health. The Britton laboratory is focused on two areas of research in this area: the role of probiotic bacteria in treating disease and the role of the intestinal microbiota in preventing pathogen invasion.

    Probiotic Lactobacillus reuteri

    Much of our work focuses on characterizing how different strains of Lactobacillus reuteri impact various aspects of the host response including inflammation, bone health, pathogen invasion and intestinal function. We use a variety of in vitro and animal models to explore how L. reuteri impacts health. Our overall goals are to identify novel probiotic strains that can be used to prevent or ameliorate disease and to develop a platform for the delivery of biotherapeutics.

    Microbiota and prevention of pathogen invasion.

    We are interested in understanding how the intestinal microbiota provides a barrier to incoming pathogens and how perturbations of the microbiota result in an established infection. We have focused most of our attention on the pathogen Clostridium difficile, which is the most common cause of antibiotic associated diarrhea and is quickly becoming the most common cause of nosocomial infections. We have developed mini-bioreactors and mice colonized with a human intestinal microbiota to address which members of the community are responsible for inhibiting C. difficile invasion. Our ultimate goal is to develop a probiotic cocktail derived from the human intestinal microbiota that will suppress C. difficile invasion.

    This project is funded by the NIH Enteric Research Investigative Network (ERIN). The Michigan State University ERIN is directed by Linda Mansfield with myself and Shannon Manning as project leaders.

    Collaborators: Much of the work we do is interdisciplinary and thus we engage in a number of collaborative projects. Our collaborators include Laura McCabe (Michigan State University), Nara Parameswaran (Michigan State University), Vincent Young (University of Michigan), James Versalovic (Baylor College of Medicine), Stefan Roos (Swedish University of Agricultural Sciences), Eamonn Connolly (Biogaia AB), Linda Mansfield (Michigan State University), Shannon Manning (Michigan State University), Kathryn Eaton (University of Michigan).


    2. Recombineering in lactic acid bacteria.

    Recombineering technology allows for the precise genetic manipulation of bacterial chromosomes. Using single-stranded DNA (ssDNA) recombineering technology point mutations, small deletions, and small insertions can be recovered without the need for selection. Previous to our recent work, non-selected ssDNA recombineering could only be performed in Escherichia coli. We have now established non-selected recombineering in two lactic acid bacteria strains, Lactobacillus reuteri and Lactococcus lactis. We also have shown that recombineering can function in other Gram-positive bacteria as well. We can achieve average recombineering efficiencies of ~15% in L. lactis, which will now enable directed evolution of multiple chromosomal sites to be achieved simultaneously. Finally, we have also developed an efficient method for inserting genes stably into the chromosome of L. reuteri, which will enable the use of this human-derived organism to be used in the intestinal delivery of biotherapeutics and vaccines.L. reuteri.

    Collaborators: James Ferrara (Mt. Sinai School of Medicine), Jeff Tabor (Rice University), Jan Peter van Pijkeren (University of Wisconsin-Madison).


    3. GTPase control of ribosome assembly. GTPases play an important role in the assembly of ribosomes in all three kingdoms of life. The molecular mechanisms by which they function are largely unknown. We are studying the ribosome assembly GTPase RbgA in Bacillus subtilis in an attempt to understand how these proteins act in the maturation of the large ribosomal subunit using a combination of biochemical, structural and genetic approaches. Interestingly, mutation or depletion of RbgA results in the accumulation of a ribosome assembly intermediate that is arrested at a very late stage of development. Work on eukaryotic homologs of RbgA suggests that these proteins are involved in a late assembly step of the large ribosomal subunit. The results from this bacterial work will have important implications for the formation of cytoplasmic, mitochondrial, and chloroplast ribosomes.

    Collaborators: Joaquin Ortega (McMaster University), James Williamson (Scripps Institute).

    Funding

    We are grateful to the following funding agencies for current and past support of our research: NIH, NSF, DARPA, Michigan State University Foundation, Gerber Foundation, Michigan State University Vice President for Research Office, Biogaia AB, Christian Hansen, Novozymes, Procter and Gamble, Michigan State University Department of Microbiology and Molecular Genetics.

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    F32GM019302     (BRITTON, ROBERT A)Jan 1, 1998
    NIH/NIGMS
    CHROMOSOME PARTITIONING IN BACILLUS SUBTILUS
    Role: Principal Investigator

    R21AT005472     (MCCABE, LAURA R)Jul 1, 2010 - Jun 30, 2012
    NIH/NCCIH
    Probiotics and Bone Health - Role of Gender and Intestinal Health
    Role: Co-Principal Investigator

    R01AT007695     (MCCABE, LAURA R)Sep 1, 2013 - May 31, 2018
    NIH/NCCIH
    Mechanistic basis of probiotic prevention of osteoporosis
    Role: Co-Principal Investigator

    R01GM110248     (BRITTON, ROBERT A)Mar 1, 2015 - Feb 28, 2019
    NIH/NIGMS
    GTPase control of large ribosome subunit biogenesis
    Role: Principal Investigator

    R21AI121522     (BRITTON, ROBERT A)Dec 1, 2015 - Nov 30, 2017
    NIH/NIAID
    Defined microbial communities for the treatment of recurrent C. difficile infection
    Role: Principal Investigator

    R33AI121522     (BRITTON, ROBERT A)Dec 1, 2015 - Nov 30, 2020
    NIH/NIAID
    Defined microbial communities for the treatment of recurrent C. difficile infection
    Role: Principal Investigator

    U01AI124290     (SAVIDGE, TOR)Aug 20, 2016 - Jul 31, 2021
    NIH/NIAID
    Decoding Antibiotic-induced Susceptibility to Clostridium difficile Infection
    Role: Co-Principal Investigator

    R01AI123278     (BRITTON, ROBERT A)Nov 17, 2017 - Oct 31, 2022
    NIH/NIAID
    Diet driven evolution of epidemic ribotypes of Clostridium difficile
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Engevik MA, Danhof HA, Shrestha R, Chang-Graham AL, Hyser JM, Haag AM, Mohammad MA, Britton RA, Versalovic J, Sorg JA, Spinler JK. Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation. Gut Microbes. 2020 Nov 09; 12(1):1788898. PMID: 32804011.
      Citations:    Fields:    
    2. Engevik MA, Luck B, Visuthranukul C, Ihekweazu FD, Engevik AC, Shi Z, Danhof HA, Chang-Graham AL, Hall A, Endres BT, Haidacher SJ, Horvath TD, Haag AM, Devaraj S, Garey KW, Britton RA, Hyser JM, Shroyer NF, Versalovic J. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis. Cell Mol Gastroenterol Hepatol. 2020 Aug 12; 11(1):221-248. PMID: 32795610.
      Citations:    Fields:    
    3. Auchtung JM, Preisner EC, Collins J, Lerma AI, Britton RA. Identification of Simplified Microbial Communities That Inhibit Clostridioides difficile Infection through Dilution/Extinction. mSphere. 2020 07 29; 5(4). PMID: 32727857.
      Citations: 1     Fields:    
    4. Ruan W, Engevik MA, Chang-Graham AL, Danhof HA, Goodwin A, Engevik KA, Shi Z, Hall A, Rienzi SCD, Venable S, Britton RA, Hyser J, Versalovic J. Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli. J Physiol. 2020 Aug; 598(15):3085-3105. PMID: 32428244.
      Citations:    Fields:    
    5. Khoruts A, Hoffmann DE, Britton RA. Probiotics: Promise, Evidence, and Hope. Gastroenterology. 2020 Aug; 159(2):409-413. PMID: 32531290.
      Citations:    Fields:    
    6. Ortiz-Velez L, Goodwin A, Schaefer L, Britton RA. Challenges and Pitfalls in the Engineering of Human Interleukin 22 (hIL-22) Secreting Lactobacillus reuteri. Front Bioeng Biotechnol. 2020; 8:543. PMID: 32582668.
      Citations:    
    7. Mahnic A, Auchtung JM, Poklar Ulrih N, Britton RA, Rupnik M. Microbiota in vitro modulated with polyphenols shows decreased colonization resistance against Clostridioides difficile but can neutralize cytotoxicity. Sci Rep. 2020 05 20; 10(1):8358. PMID: 32433519.
      Citations:    Fields:    
    8. Di Rienzi SC, Britton RA. Adaptation of the Gut Microbiota to Modern Dietary Sugars and Sweeteners. Adv Nutr. 2020 05 01; 11(3):616-629. PMID: 31696209.
      Citations: 4     Fields:    
    9. Call L, Molina T, Stoll B, Guthrie G, Chacko S, Plat J, Robinson J, Lin S, Vonderohe C, Mohammad M, Kunichoff D, Cruz S, Lau P, Premkumar M, Nielsen J, Fang Z, Olutoye O, Thymann T, Britton R, Sangild P, Burrin D. Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs. J Lipid Res. 2020 Jul; 61(7):1038-1051. PMID: 32350078.
      Citations:    Fields:    
    10. Engevik MA, Danhof HA, Chang-Graham AL, Spinler JK, Engevik KA, Herrmann B, Endres BT, Garey KW, Hyser JM, Britton RA, Versalovic J. Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis. Am J Physiol Gastrointest Liver Physiol. 2020 05 01; 318(5):G870-G888. PMID: 32223302.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Tomaro-Duchesneau C, LeValley SL, Roeth D, Sun L, Horrigan FT, Kalkum M, Hyser JM, Britton RA. Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease. Sci Rep. 2020 03 18; 10(1):4922. PMID: 32188864.
      Citations:    Fields:    
    12. Rios-Arce ND, Schepper JD, Dagenais A, Schaefer L, Daly-Seiler CS, Gardinier JD, Britton RA, McCabe LR, Parameswaran N. Post-antibiotic gut dysbiosis-induced trabecular bone loss is dependent on lymphocytes. Bone. 2020 May; 134:115269. PMID: 32061677.
      Citations: 1     Fields:    
    13. LeValley SL, Tomaro-Duchesneau C, Britton RA. Degradation of the Incretin Hormone Glucagon-Like Peptide-1 (GLP-1) by Enterococcus faecalis Metalloprotease GelE. mSphere. 2020 02 12; 5(1). PMID: 32051237.
      Citations: 2     Fields:    
    14. Schepper JD, Collins F, Rios-Arce ND, Kang HJ, Schaefer L, Gardinier JD, Raghuvanshi R, Quinn RA, Britton R, Parameswaran N, McCabe LR. Involvement of the Gut Microbiota and Barrier Function in Glucocorticoid-Induced Osteoporosis. J Bone Miner Res. 2020 Apr; 35(4):801-820. PMID: 31886921.
      Citations: 3     Fields:    
    15. Seffouh A, Jain N, Jahagirdar D, Basu K, Razi A, Ni X, Guarné A, Britton RA, Ortega J. Structural consequences of the interaction of RbgA with a 50S ribosomal subunit assembly intermediate. Nucleic Acids Res. 2019 11 04; 47(19):10414-10425. PMID: 31665744.
      Citations: 1     Fields:    Translation:Cells
    16. Quach D, Parameswaran N, McCabe L, Britton RA. Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation. Bone Rep. 2019 Dec; 11:100227. PMID: 31763377.
      Citations:    
    17. Trujillo-Vargas CM, Schaefer L, Alam J, Pflugfelder SC, Britton RA, de Paiva CS. The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome. Ocul Surf. 2020 04; 18(2):335-344. PMID: 31644955.
      Citations:    Fields:    
    18. Robinson CD, Bohannan BJ, Britton RA. Scales of persistence: transmission and the microbiome. Curr Opin Microbiol. 2019 08; 50:42-49. PMID: 31629296.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Collins FL, Rios-Arce ND, Schepper JD, Jones AD, Schaefer L, Britton RA, McCabe LR, Parameswaran N. Beneficial effects of Lactobacillus reuteri 6475 on bone density in male mice is dependent on lymphocytes. Sci Rep. 2019 10 11; 9(1):14708. PMID: 31605025.
      Citations: 3     Fields:    
    20. Wang C, Schaefer L, Bian F, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4224-4233. PMID: 31618426.
      Citations:    Fields:    Translation:Animals
    21. Razi A, Davis JH, Hao Y, Jahagirdar D, Thurlow B, Basu K, Jain N, Gomez-Blanco J, Britton RA, Vargas J, Guarné A, Woodson SA, Williamson JR, Ortega J. Role of Era in assembly and homeostasis of the ribosomal small subunit. Nucleic Acids Res. 2019 09 05; 47(15):8301-8317. PMID: 31265110.
      Citations: 3     Fields:    Translation:Cells
    22. Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019; 8(2):209-229. PMID: 31029854.
      Citations: 10     Fields:    Translation:HumansCells
    23. Danielson ND, Collins J, Stothard AI, Dong QQ, Kalera K, Woodruff PJ, DeBosch BJ, Britton RA, Swarts BM. Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile. Chem Commun (Camb). 2019 Apr 23; 55(34):5009-5012. PMID: 30968891.
      Citations: 3     Fields:    Translation:AnimalsCells
    24. Schepper JD, Collins FL, Rios-Arce ND, Raehtz S, Schaefer L, Gardinier JD, Britton RA, Parameswaran N, McCabe LR. Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption. J Bone Miner Res. 2019 04; 34(4):681-698. PMID: 30690795.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Sgritta M, Dooling SW, Buffington SA, Momin EN, Francis MB, Britton RA, Costa-Mattioli M. Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron. 2019 01 16; 101(2):246-259.e6. PMID: 30522820.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    26. Ortiz-Velez L, Ortiz-Villalobos J, Schulman A, Oh JH, van Pijkeren JP, Britton RA. Genome alterations associated with improved transformation efficiency in Lactobacillus reuteri. Microb Cell Fact. 2018 Sep 03; 17(1):138. PMID: 30176942.
      Citations:    Fields:    Translation:Cells
    27. Collins J, Danhof H, Britton RA. The role of trehalose in the global spread of epidemic Clostridium difficile. Gut Microbes. 2019; 10(2):204-209. PMID: 30118389.
      Citations: 9     Fields:    Translation:HumansCells
    28. Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2). PMID: 29438346.
      Citations: 8     Fields:    Translation:AnimalsCells
    29. Quach D, Collins F, Parameswaran N, McCabe L, Britton RA. Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice. mSphere. 2018 Jan-Feb; 3(1). PMID: 29299532.
      Citations: 4     Fields:    
    30. Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Ross CL, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC. Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis. Infect Immun. 2017 10; 85(10). PMID: 28760934.
      Citations: 11     Fields:    Translation:HumansCells
    31. Ortiz-Velez L, Britton R. Genetic Tools for the Enhancement of Probiotic Properties. Microbiol Spectr. 2017 09; 5(5). PMID: 28936946.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    32. Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ. Structural and functional insight into human O-GlcNAcase. Nat Chem Biol. 2017 06; 13(6):610-612. PMID: 28346405.
      Citations: 11     Fields:    Translation:HumansCells
    33. Razi A, Britton RA, Ortega J. The impact of recent improvements in cryo-electron microscopy technology on the understanding of bacterial ribosome assembly. Nucleic Acids Res. 2017 02 17; 45(3):1027-1040. PMID: 28180306.
      Citations: 4     Fields:    Translation:Cells
    34. Quach D, Britton RA. Gut Microbiota and Bone Health. Adv Exp Med Biol. 2017; 1033:47-58. PMID: 29101651.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    35. Velly H, Britton RA, Preidis GA. Mechanisms of cross-talk between the diet, the intestinal microbiome, and the undernourished host. Gut Microbes. 2017 03 04; 8(2):98-112. PMID: 27918230.
      Citations: 6     Fields:    Translation:HumansAnimals
    36. Ni X, Davis JH, Jain N, Razi A, Benlekbir S, McArthur AG, Rubinstein JL, Britton RA, Williamson JR, Ortega J. YphC and YsxC GTPases assist the maturation of the central protuberance, GTPase associated region and functional core of the 50S ribosomal subunit. Nucleic Acids Res. 2016 09 30; 44(17):8442-55. PMID: 27484475.
      Citations: 7     Fields:    Translation:Cells
    37. Collins FL, Irwin R, Bierhalter H, Schepper J, Britton RA, Parameswaran N, McCabe LR. Lactobacillus reuteri 6475 Increases Bone Density in Intact Females Only under an Inflammatory Setting. PLoS One. 2016; 11(4):e0153180. PMID: 27058036.
      Citations: 18     Fields:    Translation:AnimalsCells
    38. Auchtung JM, Robinson CD, Farrell K, Britton RA. MiniBioReactor Arrays (MBRAs) as a Tool for Studying C. difficile Physiology in the Presence of a Complex Community. Methods Mol Biol. 2016; 1476:235-58. PMID: 27507346.
      Citations: 6     Fields:    Translation:HumansCells
    39. McCabe L, Britton RA, Parameswaran N. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome. Curr Osteoporos Rep. 2015 Dec; 13(6):363-71. PMID: 26419466.
      Citations: 37     Fields:    Translation:HumansAnimals
    40. Auchtung JM, Robinson CD, Britton RA. Cultivation of stable, reproducible microbial communities from different fecal donors using minibioreactor arrays (MBRAs). Microbiome. 2015 Sep 30; 3:42. PMID: 26419531.
      Citations: 26     Fields:    Translation:HumansAnimals
    41. Singh P, Teal TK, Marsh TL, Tiedje JM, Mosci R, Jernigan K, Zell A, Newton DW, Salimnia H, Lephart P, Sundin D, Khalife W, Britton RA, Rudrik JT, Manning SD. Intestinal microbial communities associated with acute enteric infections and disease recovery. Microbiome. 2015 Sep 22; 3:45. PMID: 26395244.
      Citations: 44     Fields:    Translation:HumansCellsPHPublic Health
    42. Collins J, Auchtung JM, Schaefer L, Eaton KA, Britton RA. Humanized microbiota mice as a model of recurrent Clostridium difficile disease. Microbiome. 2015 Aug 20; 3:35. PMID: 26289776.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    43. Zhang J, Motyl KJ, Irwin R, MacDougald OA, Britton RA, McCabe LR. Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the Probiotic Lactobacillus reuteri. Endocrinology. 2015 Sep; 156(9):3169-82. PMID: 26135835.
      Citations: 27     Fields:    Translation:AnimalsCells
    44. Britton RA, Irwin R, Quach D, Schaefer L, Zhang J, Lee T, Parameswaran N, McCabe LR. Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol. 2014 Nov; 229(11):1822-30. PMID: 24677054.
      Citations: 74     Fields:    Translation:AnimalsCells
    45. Gulati M, Jain N, Davis JH, Williamson JR, Britton RA. Functional interaction between ribosomal protein L6 and RbgA during ribosome assembly. PLoS Genet. 2014 Oct; 10(10):e1004694. PMID: 25330043.
      Citations: 15     Fields:    Translation:Cells
    46. van Pijkeren JP, Britton RA. Precision genome engineering in lactic acid bacteria. Microb Cell Fact. 2014 Aug 29; 13 Suppl 1:S10. PMID: 25185700.
      Citations: 17     Fields:    Translation:Cells
    47. Dishisha T, Pereyra LP, Pyo SH, Britton RA, Hatti-Kaul R. Flux analysis of the Lactobacillus reuteri propanediol-utilization pathway for production of 3-hydroxypropionaldehyde, 3-hydroxypropionic acid and 1,3-propanediol from glycerol. Microb Cell Fact. 2014 May 27; 13:76. PMID: 24886501.
      Citations: 13     Fields:    Translation:Cells
    48. Robinson CD, Auchtung JM, Collins J, Britton RA. Epidemic Clostridium difficile strains demonstrate increased competitive fitness compared to nonepidemic isolates. Infect Immun. 2014 Jul; 82(7):2815-25. PMID: 24733099.
      Citations: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Britton RA, Young VB. Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology. 2014 May; 146(6):1547-53. PMID: 24503131.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    50. Jensen H, Roos S, Jonsson H, Rud I, Grimmer S, van Pijkeren JP, Britton RA, Axelsson L. Role of Lactobacillus reuteri cell and mucus-binding protein A (CmbA) in adhesion to intestinal epithelial cells and mucus in vitro. Microbiology (Reading). 2014 Apr; 160(Pt 4):671-681. PMID: 24473252.
      Citations:    
    51. Jomaa A, Jain N, Davis JH, Williamson JR, Britton RA, Ortega J. Functional domains of the 50S subunit mature late in the assembly process. Nucleic Acids Res. 2014 Mar; 42(5):3419-35. PMID: 24335279.
      Citations: 26     Fields:    Translation:Cells
    52. McCabe LR, Irwin R, Schaefer L, Britton RA. Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol. 2013 Aug; 228(8):1793-8. PMID: 23389860.
      Citations: 55     Fields:    Translation:AnimalsCells
    53. Sharma D, Malik A, Lee E, Britton RA, Parameswaran N. Gene dosage-dependent negative regulatory role of ß-arrestin-2 in polymicrobial infection-induced inflammation. Infect Immun. 2013 Aug; 81(8):3035-44. PMID: 23753627.
      Citations: 10     Fields:    Translation:AnimalsCells
    54. Gulati M, Jain N, Anand B, Prakash B, Britton RA. Mutational analysis of the ribosome assembly GTPase RbgA provides insight into ribosome interaction and ribosome-stimulated GTPase activation. Nucleic Acids Res. 2013 Mar 01; 41(5):3217-27. PMID: 23325847.
      Citations: 10     Fields:    Translation:Cells
    55. Stockdale SR, Mahony J, Courtin P, Chapot-Chartier MP, van Pijkeren JP, Britton RA, Neve H, Heller KJ, Aideh B, Vogensen FK, van Sinderen D. The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization. J Biol Chem. 2013 Feb 22; 288(8):5581-90. PMID: 23300085.
      Citations: 41     Fields:    Translation:Cells
    56. Van Pijkeren JP, Neoh KM, Sirias D, Findley AS, Britton RA. Exploring optimization parameters to increase ssDNA recombineering in Lactococcus lactis and Lactobacillus reuteri. Bioengineered. 2012 Jul-Aug; 3(4):209-17. PMID: 22750793.
      Citations: 24     Fields:    Translation:Cells
    57. De Weirdt R, Crabbé A, Roos S, Vollenweider S, Lacroix C, van Pijkeren JP, Britton RA, Sarker S, Van de Wiele T, Nickerson CA. Glycerol supplementation enhances L. reuteri's protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium. PLoS One. 2012; 7(5):e37116. PMID: 22693569.
      Citations: 11     Fields:    Translation:HumansCells
    58. Britton RA, Young VB. Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol. 2012 Jul; 20(7):313-9. PMID: 22595318.
      Citations: 94     Fields:    Translation:HumansCells
    59. Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, Britton RA, Kalkum M, Versalovic J. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One. 2012; 7(2):e31951. PMID: 22384111.
      Citations: 112     Fields:    Translation:HumansCells
    60. van Pijkeren JP, Britton RA. High efficiency recombineering in lactic acid bacteria. Nucleic Acids Res. 2012 May; 40(10):e76. PMID: 22328729.
      Citations: 59     Fields:    Translation:Cells
    61. Achila D, Gulati M, Jain N, Britton RA. Biochemical characterization of ribosome assembly GTPase RbgA in Bacillus subtilis. J Biol Chem. 2012 Mar 09; 287(11):8417-23. PMID: 22267738.
      Citations: 18     Fields:    Translation:Cells
    62. Jones SE, Whitehead K, Saulnier D, Thomas CM, Versalovic J, Britton RA. Cyclopropane fatty acid synthase mutants of probiotic human-derived Lactobacillus reuteri are defective in TNF inhibition. Gut Microbes. 2011 Mar-Apr; 2(2):69-79. PMID: 21637024.
      Citations: 11     Fields:    Translation:HumansCells
    63. Eaton KA, Honkala A, Auchtung TA, Britton RA. Probiotic Lactobacillus reuteri ameliorates disease due to enterohemorrhagic Escherichia coli in germfree mice. Infect Immun. 2011 Jan; 79(1):185-91. PMID: 20974822.
      Citations: 26     Fields:    Translation:AnimalsCells
    64. Walter J, Britton RA, Roos S. Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm. Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1:4645-52. PMID: 20615995.
      Citations: 85     Fields:    Translation:AnimalsCells
    65. Schaefer L, Auchtung TA, Hermans KE, Whitehead D, Borhan B, Britton RA. The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. Microbiology (Reading). 2010 Jun; 156(Pt 6):1589-1599. PMID: 20150236.
      Citations:    
    66. Young VB, Britton RA, Schmidt TM. The human microbiome and infectious diseases: beyond koch. Interdiscip Perspect Infect Dis. 2008; 2008:296873. PMID: 19343181.
      Citations:    
    67. Britton RA, Versalovic J. Probiotics and gastrointestinal infections. Interdiscip Perspect Infect Dis. 2008; 2008:290769. PMID: 19277100.
      Citations:    
    68. Britton RA. Role of GTPases in bacterial ribosome assembly. Annu Rev Microbiol. 2009; 63:155-76. PMID: 19575570.
      Citations: 65     Fields:    Translation:Cells
    69. Hüfner E, Britton RA, Roos S, Jonsson H, Hertel C. Global transcriptional response of Lactobacillus reuteri to the sourdough environment. Syst Appl Microbiol. 2008 Oct; 31(5):323-38. PMID: 18762399.
      Citations: 13     Fields:    Translation:Cells
    70. Cadieux P, Wind A, Sommer P, Schaefer L, Crowley K, Britton RA, Reid G. Evaluation of reuterin production in urogenital probiotic Lactobacillus reuteri RC-14. Appl Environ Microbiol. 2008 Aug; 74(15):4645-9. PMID: 18539802.
      Citations: 9     Fields:    Translation:HumansCells
    71. Whitehead K, Versalovic J, Roos S, Britton RA. Genomic and genetic characterization of the bile stress response of probiotic Lactobacillus reuteri ATCC 55730. Appl Environ Microbiol. 2008 Mar; 74(6):1812-9. PMID: 18245259.
      Citations: 39     Fields:    Translation:Cells
    72. Wicker-Planquart C, Foucher AE, Louwagie M, Britton RA, Jault JM. Interactions of an essential Bacillus subtilis GTPase, YsxC, with ribosomes. J Bacteriol. 2008 Jan; 190(2):681-90. PMID: 17981968.
      Citations: 12     Fields:    Translation:Cells
    73. Wall T, Båth K, Britton RA, Jonsson H, Versalovic J, Roos S. The early response to acid shock in Lactobacillus reuteri involves the ClpL chaperone and a putative cell wall-altering esterase. Appl Environ Microbiol. 2007 Jun; 73(12):3924-35. PMID: 17449683.
      Citations: 35     Fields:    Translation:Cells
    74. Uicker WC, Schaefer L, Koenigsknecht M, Britton RA. The essential GTPase YqeH is required for proper ribosome assembly in Bacillus subtilis. J Bacteriol. 2007 Apr; 189(7):2926-9. PMID: 17237168.
      Citations: 27     Fields:    Translation:Cells
    75. Britton RA, Wen T, Schaefer L, Pellegrini O, Uicker WC, Mathy N, Tobin C, Daou R, Szyk J, Condon C. Maturation of the 5' end of Bacillus subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1. Mol Microbiol. 2007 Jan; 63(1):127-38. PMID: 17229210.
      Citations: 70     Fields:    Translation:Cells
    76. Schaefer L, Uicker WC, Wicker-Planquart C, Foucher AE, Jault JM, Britton RA. Multiple GTPases participate in the assembly of the large ribosomal subunit in Bacillus subtilis. J Bacteriol. 2006 Dec; 188(23):8252-8. PMID: 16997968.
      Citations: 36     Fields:    Translation:Cells
    77. Uicker WC, Schaefer L, Britton RA. The essential GTPase RbgA (YlqF) is required for 50S ribosome assembly in Bacillus subtilis. Mol Microbiol. 2006 Jan; 59(2):528-40. PMID: 16390447.
      Citations: 48     Fields:    Translation:Cells
    78. Jiang X, Zhao B, Britton R, Lim LY, Leong D, Sanghera JS, Zhou BB, Piers E, Andersen RJ, Roberge M. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. . 2004 Oct; 3(10):1221-7. PMID: 15486189.
      Citations:    
    79. Britton RA. DNA microarrays and bacterial gene expression. Methods Enzymol. 2003; 370:264-78. PMID: 14712651.
      Citations: 1     Fields:    Translation:Cells
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