TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
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    R01DK121970     (LI, FENG)Jan 1, 2020 - Dec 31, 2023
    Mechanisms of Liver Toxicity of Anit-Depressant Duloxetine
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li F, J?ger V. Synthesis of proteasome inhibitor 6-deoxy-omuralide and its enantiomer using stereoselective alkylation of substituted proline ester. Org Biomol Chem. 2020 May 29. PMID: 32469026.
      Citations:    Fields:    
    2. Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, Fan D, Yin L, Zhang Y. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020 01 08; 28(1):202-216. PMID: 31604677; PMCID: PMC6952168.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    3. Feng D, Lu Y, Kong X, Li F. Immunotherapy of Liver Diseases. J Immunol Res. 2019; 2019:9343505. PMID: 31531375; PMCID: PMC6720676.
      Citations:    Fields:    Translation:Humans
    4. Chen K, Baluya D, Tosun M, Li F, Maletic-Savatic M. Imaging Mass Spectrometry: A New Tool to Assess Molecular Underpinnings of Neurodegeneration. Metabolites. 2019 Jul 10; 9(7). PMID: 31295847; PMCID: PMC6681116.
      Citations: 7     
    5. Lu Y, Zhao X-M, Hu Z, Wang L, LI F . LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury. Curr Pharmacol Rep. 2019; 5(1):56-67.
    6. Zhu J, Wang P, Li F, Lu J, Shehu AI, Xie W, McMahon D, Ma X. CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor. Biochem Pharmacol. 2018 12; 158:174-184. PMID: 30342022; PMCID: PMC6263788.
      Citations: 4     Fields:    Translation:HumansAnimals
    7. Duan YH, Zeng LM, Li FN, Kong XF, Xu K, Guo QP, Wang WL, Zhang LY. ?-hydroxy-?-methyl butyrate promotes leucine metabolism and improves muscle fibre composition in growing pigs. J Anim Physiol Anim Nutr (Berl). 2018 Oct; 102(5):1328-1339. PMID: 30009416.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD. Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 06 01; 159(6):2435-2446. PMID: 29718219; PMCID: PMC7263843.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Li F, Zhang N, Gorantla S, Gilbertson SR, Pati D. The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes. Front Pharmacol. 2018; 9:313. PMID: 29867452; PMCID: PMC5949348.
      Citations: 4     
    10. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299. PMID: 29480818; PMCID: PMC5873887.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    11. Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017 11 14; 8(1):1493. PMID: 29138395; PMCID: PMC5686208.
      Citations: 44     Fields:    Translation:Animals
    12. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 10 17; 8(1):984. PMID: 29042563; PMCID: PMC5645338.
      Citations: 1     Fields:    
    13. York B, Li F, Lin F, Marcelo KL, Mao J, Dean A, Gonzales N, Gooden D, Maity S, Coarfa C, Putluri N, Means AR. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017 09 18; 7(1):11793. PMID: 28924233; PMCID: PMC5603587.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    14. Shi X, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 11; 6(11):1350-1359. PMID: 29107283; PMCID: PMC5681239.
      Citations: 14     Fields:    Translation:AnimalsCells
    15. Kim ER, Fan S, Akhmedov D, Sun K, Lim H, O'Brien W, Xu Y, Mangieri LR, Zhu Y, Lee CC, Chung Y, Xia Y, Xu Y, Li F, Sun K, Berdeaux R, Tong Q. Red blood cell ?-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724789; PMCID: PMC5518553.
      Citations: 3     Fields:    
    16. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087. PMID: 28703127; PMCID: PMC5511354.
      Citations: 47     Fields:    Translation:HumansCells
    17. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39. PMID: 28659616; PMCID: PMC5489481.
      Citations: 14     Fields:    Translation:HumansAnimals
    18. Li F, He Z, Ye Y. Isocartormin, a novel quinochalcone C-glycoside from Carthamus tinctorius. Acta Pharm Sin B. 2017 Jul; 7(4):527-531. PMID: 28752041; PMCID: PMC5518645.
      Citations: 1     
    19. Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem. 2017 Jan 06; 292(1):146-160. PMID: 27881673; PMCID: PMC5217674.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Cai M, He J, Xiong J, Tay LW, Wang Z, Rog C, Wang J, Xie Y, Wang G, Banno Y, Li F, Zhu M, Du G. Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells. Cell Death Dis. 2016 11 03; 7(11):e2448. PMID: 27809301; PMCID: PMC5260880.
      Citations: 12     Fields:    Translation:HumansCells
    21. Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477. PMID: 27571217.
      Citations: 9     Fields:    Translation:Animals
    22. Li F, Wang P, Liu K, Tarrago MG, Lu J, Chini EN, Ma X. A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver. Drug Metab Dispos. 2016 11; 44(11):1742-1751. PMID: 27531952; PMCID: PMC5074471.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Sachar M, Li F, Liu K, Wang P, Lu J, Ma X. Chronic Treatment with Isoniazid Causes Protoporphyrin IX Accumulation in Mouse Liver. Chem Res Toxicol. 2016 08 15; 29(8):1293-7. PMID: 27438535; PMCID: PMC5316289.
      Citations: 11     Fields:    Translation:Animals
    24. Donepudi AC, Boehme S, Li F, Chiang JY. G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Hepatology. 2017 03; 65(3):813-827. PMID: 27351453; PMCID: PMC5195921.
      Citations: 50     Fields:    Translation:AnimalsCells
    25. Ferrell JM, Boehme S, Li F, Chiang JY. Cholesterol 7a-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016 07; 57(7):1144-54. PMID: 27146480; PMCID: PMC4918844.
      Citations: 37     Fields:    Translation:HumansAnimals
    26. Liu X, Lu YF, Guan X, Zhao M, Wang J, Li F. Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016 06 01; 109:70-82. PMID: 27021842.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011. PMID: 26431029; PMCID: PMC4592245.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    28. Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li F. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 01; 97(1):111-21. PMID: 26212543.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Woolbright BL, Dorko K, Antoine DJ, Clarke JI, Gholami P, Li F, Kumer SC, Schmitt TM, Forster J, Fan F, Jenkins RE, Park BK, Hagenbuch B, Olyaee M, Jaeschke H. Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. Toxicol Appl Pharmacol. 2015 Mar 15; 283(3):168-77. PMID: 25636263; PMCID: PMC4361327.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    30. Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P. Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver. J Biol Chem. 2015 Mar 20; 290(12):7871-86. PMID: 25623066; PMCID: PMC4367286.
      Citations: 5     Fields:    Translation:AnimalsCells
    31. Woolbright BL, Li F, Xie Y, Farhood A, Fickert P, Trauner M, Jaeschke H. Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice. Toxicol Lett. 2014 Jul 03; 228(1):56-66. PMID: 24742700; PMCID: PMC4057375.
      Citations: 30     Fields:    Translation:AnimalsCells
    32. Liu K, Li F, Lu J, Liu S, Dorko K, Xie W, Ma X. Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May; 42(5):863-6. PMID: 24513655; PMCID: PMC3989786.
      Citations: 13     Fields:    Translation:HumansCells
    33. Li F, Lu J, Ma X. CPY3A4-mediated a-hydroxyaldehyde formation in saquinavir metabolism. Drug Metab Dispos. 2014 Feb; 42(2):213-20. PMID: 24212380; PMCID: PMC3912542.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    34. Bhushan B, Borude P, Edwards G, Walesky C, Cleveland J, Li F, Ma X, Apte U. Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol. 2013 Nov; 183(5):1518-1526. PMID: 24007882; PMCID: PMC3814573.
      Citations: 34     Fields:    Translation:Animals
    35. McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol. 2014 Feb; 88(2):391-401. PMID: 23979652; PMCID: PMC3946727.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    36. Li F, Lu J, Cheng J, Wang L, Matsubara T, Klaassen CD, Gonzalez FJ, Ma X, Csanaky IL. Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med. 2013 Apr; 19(4):418-20. PMID: 23475203; PMCID: PMC3618537.
      Citations: 56     Fields:    Translation:HumansAnimals
    37. Borude P, Edwards G, Walesky C, Li F, Ma X, Kong B, Guo GL, Apte U. Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology. 2012 Dec; 56(6):2344-52. PMID: 22730081; PMCID: PMC3469721.
      Citations: 43     Fields:    Translation:AnimalsCells
    38. Li F, Lu J, Ma X. Metabolomic screening and identification of the bioactivation pathways of ritonavir. Chem Res Toxicol. 2011 Dec 19; 24(12):2109-14. PMID: 22040299; PMCID: PMC3243766.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    39. Li F, Lu J, Ma X. CYP3A4-mediated lopinavir bioactivation and its inhibition by ritonavir. Drug Metab Dispos. 2012 Jan; 40(1):18-24. PMID: 21953914; PMCID: PMC3250054.
      Citations: 11     Fields:    Translation:HumansCells
    40. Li F, Miao Y, Zhang L, Neuenswander SA, Douglas JT, Ma X. Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine. Drug Metab Pharmacokinet. 2011; 26(6):569-76. PMID: 21844656.
      Citations: 17     Fields:    Translation:HumansCells
    41. Li F, Lu J, Ma X. Profiling the reactive metabolites of xenobiotics using metabolomic technologies. Chem Res Toxicol. 2011 May 16; 24(5):744-51. PMID: 21469730; PMCID: PMC3100669.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    42. Li F, Lu J, Wang L, Ma X. CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. Drug Metab Dispos. 2011 Mar; 39(3):394-401. PMID: 21148252; PMCID: PMC3061559.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    43. Wang L, Li F, Lu J, Li G, Li D, Zhong XB, Guo GL, Ma X. The Chinese herbal medicine Sophora flavescens activates pregnane X receptor. Drug Metab Dispos. 2010 Dec; 38(12):2226-31. PMID: 20736322; PMCID: PMC2993459.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    44. Niu S, Li F, Tan DX, Zhang L, Idle JR, Gonzalez FJ, Ma X. Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice. J Pineal Res. 2010 Sep; 49(2):106-14. PMID: 20545825; PMCID: PMC4699585.
      Citations: 5     Fields:    Translation:HumansAnimals
    45. Li F, Wang L, Guo GL, Ma X. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May; 38(5):871-8. PMID: 20103582; PMCID: PMC2872945.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
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