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KEVIN ROARTY

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    K22CA207463     (ROARTY, KEVIN P.)Jun 6, 2017 - May 31, 2021
    NIH
    Wnt pathway dynamics in breast cancer metastasis
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Roarty K. Taking shape: Intercalation within the mammary terminal end bud. Dev Cell. 2023 07 10; 58(13):1123-1125. PMID: 37433279.
      Citations:    Fields:    Translation:Cells
    2. Si H, Esquivel M, Mendoza Mendoza E, Roarty K. The covert symphony: cellular and molecular accomplices in breast cancer metastasis. Front Cell Dev Biol. 2023; 11:1221784. PMID: 37440925; PMCID: PMC10333702.
      Citations:    
    3. Roarty K. Unlocking the secrets of cancer stem cells: Immune checkpoint inhibitors face their formidable foes. Cell Stem Cell. 2023 06 01; 30(6):743-744. PMID: 37267909.
      Citations:    Fields:    Translation:Cells
    4. Si H, Zhao N, Pedroza A, Zaske AM, Rosen JM, Creighton CJ, Roarty K. Noncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer. Mol Biol Cell. 2022 09 15; 33(11):ar103. PMID: 36001375; PMCID: PMC9582800.
      Citations:    
    5. Zhao N, Powell RT, Yuan X, Bae G, Roarty KP, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition. Nat Commun. 2021 07 12; 12(1):4262. PMID: 34253738; PMCID: PMC8275587.
      Citations: 4     Fields:    Translation:Animals
    6. Roarty K, Echeverria GV. Laboratory Models for Investigating Breast Cancer Therapy Resistance and Metastasis. Front Oncol. 2021; 11:645698. PMID: 33777805; PMCID: PMC7988094.
      Citations: 3     
    7. Nguyen TM, Kabotyanski EB, Dou Y, Reineke LC, Zhang P, Zhang XH, Malovannaya A, Jung SY, Mo Q, Roarty KP, Chen Y, Zhang B, Neilson JR, Lloyd RE, Perou CM, Ellis MJ, Rosen JM. FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res. 2018 08 01; 78(15):4229-4240. PMID: 29844125; PMCID: PMC6072612.
      Citations: 9     Fields:    Translation:AnimalsCells
    8. Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JM. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017 11 20; 43(4):436-448.e6. PMID: 29103953; PMCID: PMC5698144.
      Citations: 17     Fields:    Translation:AnimalsCells
    9. Roarty K, Pfefferle AD, Creighton CJ, Perou CM, Rosen JM. Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 2017 10 26; 36(43):5958-5968. PMID: 28650466; PMCID: PMC5658260.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    10. Sreekumar A, Roarty K, Rosen JM. The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer. 2015 Dec; 22(6):T161-76. PMID: 26206777; PMCID: PMC4618079.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    11. Roarty K, Shore AN, Creighton CJ, Rosen JM. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015 Feb 02; 208(3):351-66. PMID: 25624393; PMCID: PMC4315251.
      Citations: 23     Fields:    Translation:AnimalsCells
    12. Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells. 2014 Oct; 32(10):2571-82. PMID: 24891218.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    13. Rosen JM, Roarty K. Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Res. 2014 Jan 29; 16(1):202. PMID: 24476463; PMCID: PMC3978850.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Roarty K, Rosen JM. Pygopus 2: tilting the Wnt-Notch balance in mammary epithelial lineage determination. Breast Cancer Res. 2013 Dec 23; 15(6):322. PMID: 24365076; PMCID: PMC3979041.
      Citations:    Fields:    Translation:AnimalsCells
    15. Pond AC, Bin X, Batts T, Roarty K, Hilsenbeck S, Rosen JM. Fibroblast growth factor receptor signaling is essential for normal mammary gland development and stem cell function. Stem Cells. 2013 Jan; 31(1):178-89. PMID: 23097355; PMCID: PMC3690809.
      Citations: 49     Fields:    Translation:AnimalsCells
    16. Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. PLoS Genet. 2012; 8(7):e1002840. PMID: 22911650; PMCID: PMC3406180.
      Citations: 28     Fields:    Translation:Animals
    17. Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3665-70. PMID: 21307310; PMCID: PMC3048138.
      Citations: 356     Fields:    Translation:HumansAnimalsCells
    18. Roarty K, Rosen JM. Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol. 2010 Dec; 10(6):643-9. PMID: 20810315; PMCID: PMC2981611.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    19. Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, Benveniste EN, Cong Y. TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol. 2009 Jul 01; 183(1):97-105. PMID: 19535626; PMCID: PMC2851540.
      Citations: 103     Fields:    Translation:AnimalsCells
    20. Roarty K, Baxley SE, Crowley MR, Frost AR, Serra R. Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res. 2009; 11(2):R19. PMID: 19344510; PMCID: PMC2688948.
      Citations: 42     Fields:    Translation:AnimalsCells
    21. Johnson ET, Nicola T, Roarty K, Yoder BK, Haycraft CJ, Serra R. Role for primary cilia in the regulation of mouse ovarian function. Dev Dyn. 2008 Aug; 237(8):2053-60. PMID: 18629867.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Brantley EC, Nabors LB, Gillespie GY, Choi YH, Palmer CA, Harrison K, Roarty K, Benveniste EN. Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression. Clin Cancer Res. 2008 Aug 01; 14(15):4694-704. PMID: 18676737; PMCID: PMC3886729.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    23. Roarty K, Serra R. Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development. 2007 Nov; 134(21):3929-39. PMID: 17898001.
      Citations: 92     Fields:    Translation:AnimalsCells
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