TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lahiri SK, Lu J, Aguilar-Sanchez Y, Li H, Moreira LM, Hulsurkar MM, Mendoza A, Turkieltaub Paredes MR, Navarro-Garcia JA, Munivez E, Horist B, Moore OM, Weninger G, Brandenburg S, Lenz C, Lehnart SE, Sayeed R, Krasopoulos G, Srivastava V, Zhang L, Karch JM, Reilly S, Wehrens XHT. Targeting Calpain-2-mediated Junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Jul 01. PMID: 38960317.
    2. Mendoza A, Patel P, Robichaux D, Ramirez D, Karch J. Inhibition of the mPTP and Lipid Peroxidation Is Additively Protective Against I/R Injury. Circ Res. 2024 May 10; 134(10):1292-1305. PMID: 38618716; PMCID: PMC11081482.
      Citations:    Fields:    Translation:AnimalsCells
    3. Song J, Wu J, Robichaux DJ, Li T, Wang S, Arredondo Sancristobal MJ, Dong B, Dobrev D, Karch J, Thomas SS, Li N. A High-Protein Diet Promotes Atrial Arrhythmogenesis via Absent-in-Melanoma 2 Inflammasome. Cells. 2024 01 05; 13(2). PMID: 38247800; PMCID: PMC10814244.
      Citations:    Fields:    Translation:AnimalsCells
    4. Bround MJ, Havens JR, York AJ, Sargent MA, Karch J, Molkentin JD. ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Sci Adv. 2023 08 25; 9(34):eadi2767. PMID: 37624892; PMCID: PMC10456852.
      Citations: 4     Fields:    Translation:Animals
    5. Bernardi P, Gerle C, Halestrap AP, Jonas EA, Karch J, Mnatsakanyan N, Pavlov E, Sheu SS, Soukas AA. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions. Cell Death Differ. 2023 08; 30(8):1869-1885. PMID: 37460667; PMCID: PMC10406888.
      Citations: 20     Fields:    Translation:Cells
    6. Robichaux DJ, Harata M, Murphy E, Karch J. Mitochondrial permeability transition pore-dependent necrosis. J Mol Cell Cardiol. 2023 01; 174:47-55. PMID: 36410526; PMCID: PMC9868081.
      Citations: 7     Fields:    Translation:HumansCells
    7. Mendoza A, Karch J. Keeping the beat against time: Mitochondrial fitness in the aging heart. Front Aging. 2022; 3:951417. PMID: 35958271; PMCID: PMC9360554.
    8. Hulsurkar MM, Lahiri SK, Karch J, Wang MC, Wehrens XHT. Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases. Expert Opin Ther Targets. 2022 04; 26(4):303-317. PMID: 35426759; PMCID: PMC9081256.
      Citations:    Fields:    Translation:HumansCells
    9. Mendoza AM, Karch J. Simultaneous Acquisition of Mitochondrial Calcium Retention Capacity and Swelling to Measure Permeability Transition Sensitivity. Methods Mol Biol. 2022; 2497:129-140. PMID: 35771440; PMCID: PMC10263276.
      Citations:    Fields:    Translation:Cells
    10. Patel P, Mendoza A, Robichaux DJ, Wang MC, Wehrens XHT, Karch J. Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak. Front Cell Dev Biol. 2021; 9:765973. PMID: 34926454; PMCID: PMC8672142.
      Citations: 2     
    11. Martens MD, Seshadri N, Nguyen L, Chapman D, Henson ES, Xiang B, Falk L, Mendoza A, Rattan S, Field JT, Kawalec P, Gibson SB, Keijzer R, Saleem A, Hatch GM, Doucette CA, Karch JM, Dolinsky VW, Dixon IM, West AR, Rampitsch C, Gordon JW. Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3. Cell Death Dis. 2021 11 26; 12(12):1105. PMID: 34824192; PMCID: PMC8617186.
      Citations:    Fields:    Translation:HumansAnimals
    12. Wang Y, Liu H, Sun N, Li J, Peng X, Jia Y, Karch J, Yu B, Wehrens XHT, Tian J. Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy. Oxid Med Cell Longev. 2021; 2021:5391706. PMID: 34745418; PMCID: PMC8570861.
      Citations:    Fields:    Translation:HumansAnimals
    13. Martens MD, Karch J, Gordon JW. The molecular mosaic of regulated cell death in the cardiovascular system. Biochim Biophys Acta Mol Basis Dis. 2022 01 01; 1868(1):166297. PMID: 34718119.
      Citations:    Fields:    Translation:HumansCells
    14. Chiang DY, Lahiri S, Wang G, Karch J, Wang MC, Jung SY, Heck AJR, Scholten A, Wehrens XHT. Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart. Proteomes. 2021 Jun 07; 9(2). PMID: 34200203; PMCID: PMC8293434.
      Citations: 2     
    15. Patel P, Karch J. Regulation of cell death in the cardiovascular system. Int Rev Cell Mol Biol. 2020; 353:153-209. PMID: 32381175.
      Citations: 12     Fields:    Translation:HumansAnimals
    16. Karch J, Bround MJ, Khalil H, Sargent MA, Latchman N, Terada N, Peixoto PM, Molkentin JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Sci Adv. 2019 08; 5(8):eaaw4597. PMID: 31489369; PMCID: PMC6713508.
      Citations: 59     Fields:    Translation:AnimalsCells
    17. Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nat Commun. 2019 01 08; 10(1):76. PMID: 30622267; PMCID: PMC6325143.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. Maliken BD, Kanisicak O, Karch J, Khalil H, Fu X, Boyer JG, Prasad V, Zheng Y, Molkentin JD. Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018 09 04; 138(10):1012-1024. PMID: 29666070; PMCID: PMC6125755.
      Citations: 19     Fields:    Translation:AnimalsCells
    19. van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SJ, Middleton RC, Molkentin JD, Marb?n E. van Berlo et al. reply. Nature. 2018 03 21; 555(7697):E18. PMID: 29565361.
      Citations: 4     Fields:    
    20. Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, Molkentin JD. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. Elife. 2017 11 17; 6. PMID: 29148970; PMCID: PMC5697932.
      Citations: 26     Fields:    Translation:AnimalsCells
    21. Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, Vagnozzi RJ, Liu R, Huynh T, Lee SJ, Karch J, Molkentin JD. Fibroblast-specific TGF-?-Smad2/3 signaling underlies cardiac fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3770-3783. PMID: 28891814; PMCID: PMC5617658.
      Citations: 247     Fields:    Translation:AnimalsCells
    22. Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ, Tallquist MD, Molkentin JD. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun. 2016 07 22; 7:12260. PMID: 27447449; PMCID: PMC5512625.
      Citations: 306     Fields:    Translation:AnimalsCells
    23. Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V, Molkentin JD. Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Mol Cell Biol. 2016 Jan 01; 36(1):2-12. PMID: 26459760; PMCID: PMC4702604.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS One. 2015; 10(6):e0130520. PMID: 26061004; PMCID: PMC4465034.
      Citations: 37     Fields:    Translation:AnimalsCells
    25. Karch J, Molkentin JD. Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circ Res. 2015 May 22; 116(11):1800-9. PMID: 25999420; PMCID: PMC4443748.
      Citations: 42     Fields:    Translation:HumansCells
    26. Karch J, Molkentin JD. Identifying the components of the elusive mitochondrial permeability transition pore. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10396-7. PMID: 25002521; PMCID: PMC4115577.
      Citations: 57     Fields:    Translation:HumansAnimals
    27. Wissing ER, Boyer JG, Kwong JQ, Sargent MA, Karch J, McNally EM, Otsu K, Molkentin JD. P38a MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Hum Mol Genet. 2014 Oct 15; 23(20):5452-63. PMID: 24876160; PMCID: PMC4184390.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    28. van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Molkentin JD, Marb?n E. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15; 509(7500):337-41. PMID: 24805242; PMCID: PMC4127035.
      Citations: 369     Fields:    Translation:AnimalsCells
    29. Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife. 2013 Aug 27; 2:e00772. PMID: 23991283; PMCID: PMC3755340.
      Citations: 122     Fields:    Translation:Animals
    30. Karch J, Molkentin JD. Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis? Circ Res. 2012 Oct 26; 111(10):1258-60. PMID: 23104876.
      Citations: 20     Fields:    
    31. Comstock CES, Augello MA, Schiewer MJ, Karch J, Burd CJ, Ertel A, Knudsen ES, Jessen WJ, Aronow BJ, Knudsen KE. Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function. J Biol Chem. 2011 Mar 11; 286(10):8117-8127. PMID: 21212260; PMCID: PMC3048698.
      Citations: 21     Fields:    Translation:HumansCells
    32. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. PMID: 20890047; PMCID: PMC2947235.
      Citations: 180     Fields:    Translation:AnimalsCells
    33. Comstock CE, Augello MA, Benito RP, Karch J, Tran TH, Utama FE, Tindall EA, Wang Y, Burd CJ, Groh EM, Hoang HN, Giles GG, Severi G, Hayes VM, Henderson BE, Le Marchand L, Kolonel LN, Haiman CA, Baffa R, Gomella LG, Knudsen ES, Rui H, Henshall SM, Sutherland RL, Knudsen KE. Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer. Clin Cancer Res. 2009 Sep 01; 15(17):5338-49. PMID: 19706803; PMCID: PMC2849314.
      Citations: 54     Fields:    Translation:HumansCells
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