"Bestrophins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
| Descriptor ID |
D000075002
|
| MeSH Number(s) |
D12.776.157.530.400.175.063 D12.776.306.228 D12.776.543.550.450.175.063 D12.776.543.585.400.175.063
|
| Concept/Terms |
Bestrophins- Bestrophins
- Bestrophin Proteins
- Bestrophin Family
Bestrophin-1- Bestrophin-1
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
Bestrophin-2- Bestrophin-2
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Bestrophins".
Below are MeSH descriptors whose meaning is more specific than "Bestrophins".
This graph shows the total number of publications written about "Bestrophins" by people in this website by year, and whether "Bestrophins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bestrophins" by people in Profiles.
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Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. Commun Biol. 2023 08 16; 6(1):852.
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Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus. Biol Psychiatry. 2022 04 15; 91(8):740-752.
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Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus. Neuron. 2020 11 25; 108(4):691-706.e10.
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The molecular mechanism of synaptic activity-induced astrocytic volume transient. J Physiol. 2020 10; 598(20):4555-4572.
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Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi. Glia. 2020 05; 68(5):1065-1080.
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Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide. Pharmacogenet Genomics. 2018 11; 28(11):251-255.
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Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):5004-5009.
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Direct interaction with 14-3-3? promotes surface expression of Best1 channel in astrocyte. Mol Brain. 2017 Nov 09; 10(1):51.
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Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain. 2015 Feb 03; 8:7.
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High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte. Mol Brain. 2013 Dec 09; 6:54.