"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
| Descriptor ID |
D000073940
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| MeSH Number(s) |
D12.776.260.108.092.937 D12.776.930.125.500.937
|
| Concept/Terms |
Transcription Factor 4- Transcription Factor 4
- TCF4 Transcription Factor
- Transcription Factor, TCF4
- TCF-4 Transcription Factor
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- TCF-4 Protein
- TCF 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor 4".
This graph shows the total number of publications written about "Transcription Factor 4" by people in this website by year, and whether "Transcription Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transcription Factor 4" by people in Profiles.
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Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types. J Neurosci. 2020 07 01; 40(27):5177-5195.
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Diagnosis and management in Pitt-Hopkins syndrome: First international consensus statement. Clin Genet. 2019 04; 95(4):462-478.
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Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome. J Neurosci. 2018 01 24; 38(4):918-936.
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Dual molecular diagnosis contributes to atypical Prader-Willi phenotype in monozygotic twins. Am J Med Genet A. 2017 Sep; 173(9):2451-2455.
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Complex translocation disrupting TCF4 and altering TCF4 isoform expression segregates as mild autosomal dominant intellectual disability. Orphanet J Rare Dis. 2016 05 14; 11(1):62.
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TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls. J Psychiatr Res. 2015 Oct; 69:95-101.
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Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2014 Aug 28; 55(9):6101-7.
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Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine. Genome Biol. 2013 May 28; 14(5):116.
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The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood. 2012 Nov 22; 120(22):4363-73.
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Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. Stem Cells. 2012 Apr; 30(4):753-61.