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ANTHONY ROSS MEANS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    R01HD007503     (MEANS, ANTHONY R)May 1, 1977 - Mar 31, 2006
    NIH/NICHD
    BIOLOGY OF THE TESTIS
    Role: Principal Investigator

    R01DK074701     (MEANS, ANTHONY R)May 1, 1977 - Jun 30, 2011
    NIH/NIDDK
    CaM Kinase Cascades in Endocrine Cells
    Role: Principal Investigator

    R01GM033976     (MEANS, ANTHONY R)Jul 1, 1984 - Jun 30, 2016
    NIH/NIGMS
    Hormonal regulation of a Ca2+/AMPK signaling pathway
    Role: Principal Investigator

    R13GM041595     (MEANS, ANTHONY R)Jun 1, 1989 - May 31, 1990
    NIH/NIGMS
    FASEB CONFERENCE--CALCIUM AND CELL FUNCTION
    Role: Principal Investigator

    R01DK043071     (MEANS, ANTHONY R)Jul 1, 1990 - Jun 30, 1995
    NIH/NIDDK
    NEW MODEL FOR EARLY ONSET NONIMMUNE DIABETES
    Role: Principal Investigator

    T32CA059365     (WANG, XIAO-FAN)Jul 1, 1993 - Jun 30, 2015
    NIH/NCI
    Cancer Biology Training Grant
    Role: Co-Principal Investigator

    R01CA082845     (MEANS, ANTHONY R)Aug 6, 1999 - Apr 30, 2011
    NIH/NCI
    Biological Roles of the Prolyl Isomerase, PIN1
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Racioppi L, Nelson ER, Huang W, Mukherjee D, Lawrence SA, Lento W, Masci AM, Jiao Y, Park S, York B, Liu Y, Baek AE, Drewry DH, Zuercher WJ, Bertani FR, Businaro L, Geradts J, Hall A, Means AR, Chao N, Chang CY, McDonnell DP. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nat Commun. 2019 06 04; 10(1):2450. PMID: 31164648.
      View in: PubMed
    2. York B, Li F, Lin F, Marcelo KL, Mao J, Dean A, Gonzales N, Gooden D, Maity S, Coarfa C, Putluri N, Means AR. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017 09 18; 7(1):11793. PMID: 28924233.
      View in: PubMed
    3. O'Brien MT, Oakhill JS, Ling NX, Langendorf CG, Hoque A, Dite TA, Means AR, Kemp BE, Scott JW. Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation. Sci Rep. 2017 02 23; 7:43264. PMID: 28230171.
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    4. Means AR. Editorial Reflections on the Demise of Molecular Endocrinology and the Future of Molecular Hormone Action Research. Mol Endocrinol. 2016 10; 30(10):1021-1022. PMID: 27690770.
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    5. Marcelo KL, Means AR, York B. The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft. Trends Endocrinol Metab. 2016 10; 27(10):706-718. PMID: 27449752.
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    6. Marcelo KL, Ribar T, Means CR, Tsimelzon A, Stevens RD, Ilkayeva O, Bain JR, Hilsenbeck SG, Newgard CB, Means AR, York B. Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. Mol Endocrinol. 2016 May; 30(5):557-72. PMID: 27003444.
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    7. Marcelo KL, Lin F, Rajapakshe K, Dean A, Gonzales N, Coarfa C, Means AR, Goldie LC, York B. Deciphering hepatocellular responses to metabolic and oncogenic stress. J Biol Methods. 2015; 2(3). PMID: 26504887.
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    8. Scott JW, Park E, Rodriguiz RM, Oakhill JS, Issa SM, O'Brien MT, Dite TA, Langendorf CG, Wetsel WC, Means AR, Kemp BE. Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. Sci Rep. 2015 Sep 23; 5:14436. PMID: 26395653.
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    9. Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York B. The camKK2/camKIV relay is an essential regulator of hepatic cancer. Hepatology. 2015 Aug; 62(2):505-20. PMID: 25847065.
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    10. McCullough LD, Tarabishy S, Liu L, Benashski S, Xu Y, Ribar T, Means A, Li J. Inhibition of calcium/calmodulin-dependent protein kinase kinase ß and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemia. Stroke. 2013 Sep; 44(9):2559-66. PMID: 23868268.
      View in: PubMed
    11. Racioppi L, Means AR. Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J Biol Chem. 2012 Sep 14; 287(38):31658-65. PMID: 22778263.
      View in: PubMed
    12. Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR. Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. J Biol Chem. 2012 Mar 30; 287(14):11579-91. PMID: 22334678.
      View in: PubMed
    13. Anderson KA, Lin F, Ribar TJ, Stevens RD, Muehlbauer MJ, Newgard CB, Means AR. Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Mol Endocrinol. 2012 Feb; 26(2):281-91. PMID: 22240810.
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    14. Barberi TJ, Dunkle A, He YW, Racioppi L, Means AR. The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. PLoS One. 2012; 7(1):e29808. PMID: 22238658.
      View in: PubMed
    15. Lin F, Ribar TJ, Means AR. The Ca2+/calmodulin-dependent protein kinase kinase, CaMKK2, inhibits preadipocyte differentiation. Endocrinology. 2011 Oct; 152(10):3668-79. PMID: 21862616.
      View in: PubMed
    16. Teng EC, Racioppi L, Means AR. A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. J Leukoc Biol. 2011 Nov; 90(5):897-909. PMID: 21816924.
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    17. Green MF, Anderson KA, Means AR. Characterization of the CaMKKß-AMPK signaling complex. Cell Signal. 2011 Dec; 23(12):2005-12. PMID: 21807092.
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    18. Sankar U, Means AR. Gfer is a critical regulator of HSC proliferation. Cell Cycle. 2011 Jul 15; 10(14):2263-8. PMID: 21636978.
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    19. Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, Lozano G, Schneider C, Del Sal G. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell. 2011 Jul 12; 20(1):79-91. PMID: 21741598.
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    20. Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B. Systems biology of vaccination for seasonal influenza in humans. Nat Immunol. 2011 Jul 10; 12(8):786-95. PMID: 21743478.
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    21. Teng BL, Hacker KE, Chen S, Means AR, Rathmell WK. Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma. Mol Oncol. 2011 Oct; 5(5):465-74. PMID: 21764651.
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    22. Green MF, Scott JW, Steel R, Oakhill JS, Kemp BE, Means AR. Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation. J Biol Chem. 2011 Aug 12; 286(32):28066-79. PMID: 21669867.
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    23. Teng EC, Todd LR, Ribar TJ, Lento W, Dimascio L, Means AR, Sankar U. Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells. Mol Biol Cell. 2011 Apr 15; 22(8):1312-20. PMID: 21346186.
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    24. Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Res. 2011 Jan 15; 71(2):528-37. PMID: 21098087.
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    25. Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, Karsenty G. CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 2010 Oct 15; 24(20):2330-42. PMID: 20952540.
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    26. Colomer J, Schmitt AA, Toone EJ, Means AR. Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist. Biochemistry. 2010 May 18; 49(19):4244-54. PMID: 20392081.
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    27. Todd LR, Damin MN, Gomathinayagam R, Horn SR, Means AR, Sankar U. Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. Mol Biol Cell. 2010 Apr 01; 21(7):1225-36. PMID: 20147447.
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    28. Kokubo M, Nishio M, Ribar TJ, Anderson KA, West AE, Means AR. BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. J Neurosci. 2009 Jul 15; 29(28):8901-13. PMID: 19605628.
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    29. Anderson KA, Means AR. Central control of feeding. F1000 Biol Rep. 2009 Jan 21; 1:10. PMID: 20948676.
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    30. Racioppi L, Means AR. Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. Trends Immunol. 2008 Dec; 29(12):600-7. PMID: 18930438.
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    31. Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. Mol Cell. 2008 Oct 10; 32(1):43-56. PMID: 18851832.
      View in: PubMed
    32. Means AR. The Year in Basic Science: calmodulin kinase cascades. Mol Endocrinol. 2008 Dec; 22(12):2759-65. PMID: 18845671.
      View in: PubMed
    33. Sandquist JC, Means AR. The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells. Mol Biol Cell. 2008 Dec; 19(12):5156-67. PMID: 18843042.
      View in: PubMed
    34. Stanya KJ, Liu Y, Means AR, Kao HY. Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. J Cell Biol. 2008 Oct 06; 183(1):49-61. PMID: 18838553.
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    35. Zhang X, Wheeler D, Tang Y, Guo L, Shapiro RA, Ribar TJ, Means AR, Billiar TR, Angus DC, Rosengart MR. Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J Immunol. 2008 Oct 01; 181(7):5015-23. PMID: 18802105.
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    36. Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, Muehlbauer MJ, Witters LA, Kemp BE, Means AR. Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab. 2008 May; 7(5):377-88. PMID: 18460329.
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    37. Reineke EL, Lam M, Liu Q, Liu Y, Stanya KJ, Chang KS, Means AR, Kao HY. Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. Mol Cell Biol. 2008 Feb; 28(3):997-1006. PMID: 18039859.
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    38. Illario M, Giardino-Torchia ML, Sankar U, Ribar TJ, Galgani M, Vitiello L, Masci AM, Bertani FR, Ciaglia E, Astone D, Maulucci G, Cavallo A, Vitale M, Cimini V, Pastore L, Means AR, Rossi G, Racioppi L. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood. 2008 Jan 15; 111(2):723-31. PMID: 17909078.
      View in: PubMed
    39. Phan RT, Saito M, Kitagawa Y, Means AR, Dalla-Favera R. Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. Nat Immunol. 2007 Oct; 8(10):1132-9. PMID: 17828269.
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    40. Yeh ES, Means AR. PIN1, the cell cycle and cancer. Nat Rev Cancer. 2007 05; 7(5):381-8. PMID: 17410202.
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    41. Hurley RL, Barré LK, Wood SD, Anderson KA, Kemp BE, Means AR, Witters LA. Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem. 2006 Dec 01; 281(48):36662-72. PMID: 17023420.
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    42. Sandquist JC, Swenson KI, Demali KA, Burridge K, Means AR. Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem. 2006 Nov 24; 281(47):35873-83. PMID: 17020881.
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    43. van Drogen F, Sangfelt O, Malyukova A, Matskova L, Yeh E, Means AR, Reed SI. Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol Cell. 2006 Jul 07; 23(1):37-48. PMID: 16818231.
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    44. Witters LA, Kemp BE, Means AR. Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci. 2006 Jan; 31(1):13-6. PMID: 16356723.
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    45. Yi P, Wu RC, Sandquist J, Wong J, Tsai SY, Tsai MJ, Means AR, O'Malley BW. Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 2005 Nov; 25(21):9687-99. PMID: 16227615.
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    46. Yeh ES, Lew BO, Means AR. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem. 2006 Jan 06; 281(1):241-51. PMID: 16223725.
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    47. Kitsos CM, Sankar U, Illario M, Colomer-Font JM, Duncan AW, Ribar TJ, Reya T, Means AR. Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem. 2005 Sep 30; 280(39):33101-8. PMID: 16020540.
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    48. Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem. 2005 Aug 12; 280(32):29060-6. PMID: 15980064.
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    49. Pan F, Means AR, Liu JO. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. EMBO J. 2005 Jun 15; 24(12):2104-13. PMID: 15902271.
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    50. Chow FA, Anderson KA, Noeldner PK, Means AR. The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription. J Biol Chem. 2005 May 27; 280(21):20530-8. PMID: 15769749.
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    51. Atchison FW, Means AR. A role for Pin1 in mammalian germ cell development and spermatogenesis. Front Biosci. 2004 Sep 01; 9:3248-56. PMID: 15353353.
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    52. Joseph JD, Daigle SN, Means AR. PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. J Biol Chem. 2004 Jul 30; 279(31):32373-84. PMID: 15178679.
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    53. Anderson KA, Noeldner PK, Reece K, Wadzinski BE, Means AR. Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. J Biol Chem. 2004 Jul 23; 279(30):31708-16. PMID: 15143065.
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    54. Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, Counter CM, Nevins JR, Means AR, Sears R. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol. 2004 Apr; 6(4):308-18. PMID: 15048125.
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    55. Kahl CR, Means AR. Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. Mol Biol Cell. 2004 Apr; 15(4):1833-42. PMID: 14767060.
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    56. Kahl CR, Means AR. Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. J Biol Chem. 2004 Apr 09; 279(15):15411-9. PMID: 14754892.
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    57. Lemrow SM, Anderson KA, Joseph JD, Ribar TJ, Noeldner PK, Means AR. Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. J Biol Chem. 2004 Mar 19; 279(12):11664-71. PMID: 14701808.
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    58. Colomer JM, Terasawa M, Means AR. Targeted expression of calmodulin increases ventricular cardiomyocyte proliferation and deoxyribonucleic acid synthesis during mouse development. Endocrinology. 2004 Mar; 145(3):1356-66. PMID: 14670993.
      View in: PubMed
    59. Kahl CR, Means AR. Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev. 2003 Dec; 24(6):719-36. PMID: 14671000.
      View in: PubMed
    60. Atchison FW, Means AR. Spermatogonial depletion in adult Pin1-deficient mice. Biol Reprod. 2003 Dec; 69(6):1989-97. PMID: 12930711.
      View in: PubMed
    61. Atchison FW, Capel B, Means AR. Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development. 2003 Aug; 130(15):3579-86. PMID: 12810604.
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    62. Colomer JM, Mao L, Rockman HA, Means AR. Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Mol Endocrinol. 2003 Feb; 17(2):183-92. PMID: 12554746.
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    63. Corcoran EE, Joseph JD, MacDonald JA, Kane CD, Haystead TA, Means AR. Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. J Biol Chem. 2003 Mar 21; 278(12):10516-22. PMID: 12538590.
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    64. Joseph JD, Yeh ES, Swenson KI, Means AR. The peptidyl-prolyl isomerase Pin1. Prog Cell Cycle Res. 2003; 5:477-87. PMID: 14593743.
      View in: PubMed
    65. Swenson KI, Winkler KE, Means AR. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. Mol Biol Cell. 2003 Jan; 14(1):156-72. PMID: 12529434.
      View in: PubMed
    66. Chin D, Means AR. Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. Biochemistry. 2002 Nov 26; 41(47):14001-9. PMID: 12437357.
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    67. Kimura Y, Corcoran EE, Eto K, Gengyo-Ando K, Muramatsu MA, Kobayashi R, Freedman JH, Mitani S, Hagiwara M, Means AR, Tokumitsu H. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep. 2002 Oct; 3(10):962-6. PMID: 12231504.
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    68. Yu W, Niwa T, Miura Y, Horio F, Teradaira S, Ribar TJ, Means AR, Hasegawa Y, Senda T, Niki I. Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. Lab Invest. 2002 Sep; 82(9):1229-39. PMID: 12218084.
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    69. Klee CB, Means AR. Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease. EMBO Rep. 2002 Sep; 3(9):823-7. PMID: 12223462.
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    70. Hamilton SR, O'Donnell JB, Hammet A, Stapleton D, Habinowski SA, Means AR, Kemp BE, Witters LA. AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. Biochem Biophys Res Commun. 2002 May 10; 293(3):892-8. PMID: 12051742.
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    71. Joseph JD, Means AR. Calcium binding is required for calmodulin function in Aspergillus nidulans. Eukaryot Cell. 2002 Feb; 1(1):119-25. PMID: 12455978.
      View in: PubMed
    72. Flory MR, Morphew M, Joseph JD, Means AR, Davis TN. Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. Cell Growth Differ. 2002 Feb; 13(2):47-58. PMID: 11864908.
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    73. Anderson KA, Means AR. Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. Mol Cell Biol. 2002 Jan; 22(1):23-9. PMID: 11739719.
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