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DAVID ROWLEY

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Urology
    DivisionUrology


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    R23DK035897     (ROWLEY, DAVID R)Apr 1, 1986 - Sep 30, 1987
    NIH/NIDDK
    ANDROGEN REGULATED GROWTH FACTORS FROM PROSTATE STROMA
    Role: Principal Investigator

    R01DK039779     (ROWLEY, DAVID R)Sep 30, 1987 - Aug 31, 1990
    NIH/NIDDK
    GROWTH FACTORS FROM FETAL UROGENITAL SINUS
    Role: Principal Investigator

    R01DK045909     (ROWLEY, DAVID R)Sep 30, 1992 - Sep 29, 1995
    NIH/NIDDK
    STROMAL GROWTH FACTORS IN BENIGN PROSTATIC HYPERPLASIA
    Role: Principal Investigator

    R01CA058093     (ROWLEY, DAVID R)Sep 30, 1992 - Sep 29, 1997
    NIH/NCI
    Mesenchymal Derived Growth Factors in Prostatic Cancer
    Role: Principal Investigator

    R13DK065036     (ROWLEY, DAVID R)Sep 30, 2003 - Aug 31, 2004
    NIH/NIDDK
    2003 AUA/SBUR Summer Research Conference-Prostate Growth
    Role: Principal Investigator

    U54CA126568     (ROWLEY, DAVID R)Sep 25, 2006 - Aug 31, 2012
    NIH/NCI
    Co-evolution of the Reactive Microenvironment in Prostate Cancer Progression
    Role: Principal Investigator

    R56DK083293     (ROWLEY, DAVID R)Sep 28, 2009 - Aug 31, 2010
    NIH/NIDDK
    Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    Role: Principal Investigator

    R01DK083293     (ROWLEY, DAVID R)Sep 1, 2010 - Aug 31, 2014
    NIH/NIDDK
    Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    Role: Principal Investigator

    U01CA143055     (PIENTA, KENNETH J)Sep 7, 2010 - Feb 28, 2013
    NIH/NCI
    Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression
    Role: Co-Principal Investigator

    R01CA221946     (ROWLEY, DAVID R)Sep 5, 2018 - Aug 31, 2023
    NIH/NCI
    Osteogenic Niche Biology in Progression and Endocrine Resistance of Bone Metastases
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199.
      View in: PubMed
    2. Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM, Loda M, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS. The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance. Clin Cancer Res. 2019 12 01; 25(23):6916-6924. PMID: 31363002.
      View in: PubMed
    3. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3089-3101. PMID: 31308490.
      View in: PubMed
    4. Lee YC, Kurtova AV, Xiao J, Nikolos F, Hayashi K, Tramel Z, Jain A, Chen F, Chokshi M, Lee C, Bao G, Zhang X, Shen J, Mo Q, Jung SY, Rowley D, Chan KS. Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung. Nat Commun. 2019 05 13; 10(1):2131. PMID: 31086186.
      View in: PubMed
    5. Miles B, Ittmann M, Wheeler T, Sayeeduddin M, Cubilla A, Rowley D, Bu P, Ding Y, Gao Y, Lee M, Ayala GE. Moving Beyond Gleason Scoring. Arch Pathol Lab Med. 2019 05; 143(5):565-570. PMID: 30865488.
      View in: PubMed
    6. Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH. The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Cancer Cell. 2018 11 12; 34(5):823-839.e7. PMID: 30423299.
      View in: PubMed
    7. Coarfa C, Florentin D, Putluri N, Ding Y, Au J, He D, Ragheb A, Frolov A, Michailidis G, Lee M, Kadmon D, Miles B, Smith C, Ittmann M, Rowley D, Sreekumar A, Creighton CJ, Ayala G. Influence of the neural microenvironment on prostate cancer. Prostate. 2018 Feb; 78(2):128-139. PMID: 29131367.
      View in: PubMed
    8. San Martin R, Pathak R, Jain A, Jung SY, Hilsenbeck SG, Piña-Barba MC, Sikora AG, Pienta KJ, Rowley DR. Tenascin-C and Integrin a9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment. Cancer Res. 2017 11 01; 77(21):5977-5988. PMID: 28916657.
      View in: PubMed
    9. Roberts JM, Martin RS, Piyarathna DB, MacKrell JG, Rocha GV, Dodge JA, Coarfa C, Krishnan V, Rowley DR, Weigel NL. Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG. Oncotarget. 2017 Jul 04; 8(27):44447-44464. PMID: 28591703.
      View in: PubMed
    10. Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia. 2017 May; 19(5):421-428. PMID: 28433771.
      View in: PubMed
    11. De Vivar AD, Sayeeduddin M, Rowley D, Cubilla A, Miles B, Kadmon D, Ayala G. Histologic features of stromogenic carcinoma of the prostate (carcinomas with reactive stroma grade 3). Hum Pathol. 2017 05; 63:202-211. PMID: 28315427.
      View in: PubMed
    12. Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS. Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. 2016 Dec 13; 7(50):82609-82619. PMID: 27655672.
      View in: PubMed
    13. Farach A, Ding Y, Lee M, Creighton C, Delk NA, Ittmann M, Miles B, Rowley D, Farach-Carson MC, Ayala GE. Neuronal Trans-Differentiation in Prostate Cancer Cells. Prostate. 2016 10; 76(14):1312-25. PMID: 27403603.
      View in: PubMed
    14. Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, Xin L. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017 02 02; 36(5):618-627. PMID: 27345403.
      View in: PubMed
    15. Bianchi-Frias D, Basom R, Delrow JJ, Coleman IM, Dakhova O, Qu X, Fang M, Franco OE, Ericson NG, Bielas JH, Hayward SW, True L, Morrissey C, Brown L, Bhowmick NA, Rowley D, Ittmann M, Nelson PS. Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations. Mol Cancer Res. 2016 Apr; 14(4):374-84. PMID: 26753621.
      View in: PubMed
    16. Montico F, Kido LA, San Martin R, Rowley DR, Cagnon VH. Reactive stroma in the prostate during late life: The role of microvasculature and antiangiogenic therapy influences. Prostate. 2015 Oct; 75(14):1643-61. PMID: 26184673.
      View in: PubMed
    17. Yang F, Chen Y, Shen T, Guo D, Dakhova O, Ittmann MM, Creighton CJ, Zhang Y, Dang TD, Rowley DR. Stromal TGF-ß signaling induces AR activation in prostate cancer. Oncotarget. 2014 Nov 15; 5(21):10854-69. PMID: 25333263.
      View in: PubMed
    18. Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16389-94. PMID: 25313057.
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    19. Rowley DR. Reprogramming the tumor stroma: a new paradigm. Cancer Cell. 2014 Oct 13; 26(4):451-2. PMID: 25314074.
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    20. Strand DW, Liang YY, Yang F, Barron DA, Ressler SJ, Schauer IG, Feng XH, Rowley DR. TGF-ß induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways. Am J Clin Exp Urol. 2014; 2(3):239-48. PMID: 25374926.
      View in: PubMed
    21. Ressler SJ, Dang TD, Wu SM, Tse DY, Gilbert BE, Vyakarnam A, Yang F, Schauer IG, Barron DA, Rowley DR. WFDC1 is a key modulator of inflammatory and wound repair responses. Am J Pathol. 2014 Nov; 184(11):2951-64. PMID: 25219356.
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    22. Gill AC, Nelson EA, Mian AI, Raphael JL, Rowley DR, Mcguire AL. Responding to moderate breaches in professionalism: an intervention for medical students. Med Teach. 2015 Feb; 37(2):136-9. PMID: 24819504.
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    23. San Martin R, Barron DA, Tuxhorn JA, Ressler SJ, Hayward SW, Shen X, Laucirica R, Wheeler TM, Gutierrez C, Ayala GE, Ittmann M, Rowley DR. Recruitment of CD34(+) fibroblasts in tumor-associated reactive stroma: the reactive microvasculature hypothesis. Am J Pathol. 2014 Jun; 184(6):1860-70. PMID: 24713391.
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    24. Carstens JL, Shahi P, Van Tsang S, Smith B, Creighton CJ, Zhang Y, Seamans A, Seethammagari M, Vedula I, Levitt JM, Ittmann MM, Rowley DR, Spencer DM. FGFR1-WNT-TGF-ß signaling in prostate cancer mouse models recapitulates human reactive stroma. Cancer Res. 2014 Jan 15; 74(2):609-20. PMID: 24305876.
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    25. Dakhova O, Rowley D, Ittmann M. Genes upregulated in prostate cancer reactive stroma promote prostate cancer progression in vivo. Clin Cancer Res. 2014 Jan 01; 20(1):100-9. PMID: 24150235.
      View in: PubMed
    26. Ding Y, He D, Florentin D, Frolov A, Hilsenbeck S, Ittmann M, Kadmon D, Miles B, Rowley D, Ayala G. Semaphorin 4F as a critical regulator of neuroepithelial interactions and a biomarker of aggressive prostate cancer. Clin Cancer Res. 2013 Nov 15; 19(22):6101-11. PMID: 24097862.
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    27. Kakarla S, Chow KK, Mata M, Shaffer DR, Song XT, Wu MF, Liu H, Wang LL, Rowley DR, Pfizenmaier K, Gottschalk S. Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Mol Ther. 2013 Aug; 21(8):1611-20. PMID: 23732988.
      View in: PubMed
    28. Yang F, Zhang Y, Ressler SJ, Ittmann MM, Ayala GE, Dang TD, Wang F, Rowley DR. FGFR1 is essential for prostate cancer progression and metastasis. Cancer Res. 2013 Jun 15; 73(12):3716-24. PMID: 23576558.
      View in: PubMed
    29. Ayala G, Frolov A, Ittman M, Mohammed S, LeBlanc M, Falcon S, Rowley D, Etzioni R. Biological correlates of biochemical recurrence free survival using multiple markers in a large tissue microarray cohort. Ann Clin Lab Sci. 2013; 43(1):11-21. PMID: 23462601.
      View in: PubMed
    30. Barron DA, Rowley DR. The reactive stroma microenvironment and prostate cancer progression. Endocr Relat Cancer. 2012 Dec; 19(6):R187-204. PMID: 22930558.
      View in: PubMed
    31. Rogers E, Wang BX, Cui Z, Rowley DR, Ressler SJ, Vyakarnam A, Fish EN. WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection. Antiviral Res. 2012 Nov; 96(2):158-68. PMID: 22960155.
      View in: PubMed
    32. Ressler SJ, Rowley DR. The WFDC1 gene: role in wound response and tissue homoeostasis. Biochem Soc Trans. 2011 Oct; 39(5):1455-9. PMID: 21936833.
      View in: PubMed
    33. Schauer IG, Rowley DR. The functional role of reactive stroma in benign prostatic hyperplasia. Differentiation. 2011 Nov-Dec; 82(4-5):200-10. PMID: 21664759.
      View in: PubMed
    34. Ayala GE, Muezzinoglu B, Hammerich KH, Frolov A, Liu H, Scardino PT, Li R, Sayeeduddin M, Ittmann MM, Kadmon D, Miles BJ, Wheeler TM, Rowley DR. Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens. Am J Pathol. 2011 Jan; 178(1):79-87. PMID: 21224046.
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    35. Barron DA, Strand DW, Ressler SJ, Dang TD, Hayward SW, Yang F, Ayala GE, Ittmann M, Rowley DR. TGF-ß1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse. PLoS One. 2010 Oct 29; 5(10):e13751. PMID: 21060787.
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    36. Dixon D, Pollard B, Rowley D, Johnson M. Application of the ICF to referral delay in total joint arthroplasty. Qual Saf Health Care. 2010 Dec; 19(6):e23. PMID: 20584703.
      View in: PubMed
    37. Dakhova O, Ozen M, Creighton CJ, Li R, Ayala G, Rowley D, Ittmann M. Global gene expression analysis of reactive stroma in prostate cancer. Clin Cancer Res. 2009 Jun 15; 15(12):3979-89. PMID: 19509179.
      View in: PubMed
    38. Farrow B, Rowley D, Dang T, Berger DH. Characterization of tumor-derived pancreatic stellate cells. J Surg Res. 2009 Nov; 157(1):96-102. PMID: 19726060.
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    39. Farrow B, Berger DH, Rowley D. Tumor-derived pancreatic stellate cells promote pancreatic cancer cell invasion through release of thrombospondin-2. J Surg Res. 2009 Sep; 156(1):155-60. PMID: 19592030.
      View in: PubMed
    40. Schauer IG, Ressler SJ, Rowley DR. Keratinocyte-derived chemokine induces prostate epithelial hyperplasia and reactive stroma in a novel transgenic mouse model. Prostate. 2009 Mar 01; 69(4):373-84. PMID: 19021203.
      View in: PubMed
    41. Ayala GE, Dai H, Powell M, Li R, Ding Y, Wheeler TM, Shine D, Kadmon D, Thompson T, Miles BJ, Ittmann MM, Rowley D. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res. 2008 Dec 01; 14(23):7593-603. PMID: 19047084.
      View in: PubMed
    42. Shao LJ, Shi HY, Ayala G, Rowley D, Zhang M. Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate. Cancer Res. 2008 Jul 01; 68(13):5143-51. PMID: 18593913.
      View in: PubMed
    43. Schauer IG, Ressler SJ, Tuxhorn JA, Dang TD, Rowley DR. Elevated epithelial expression of interleukin-8 correlates with myofibroblast reactive stroma in benign prostatic hyperplasia. Urology. 2008 Jul; 72(1):205-13. PMID: 18314176.
      View in: PubMed
    44. Yanagisawa N, Li R, Rowley D, Liu H, Kadmon D, Miles BJ, Wheeler TM, Ayala GE. Reprint of: Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. Hum Pathol. 2008 Feb; 39(2):282-91. PMID: 18206496.
      View in: PubMed
    45. Keller ET, Rowley DR, Tomlins SA, Drake CG, Kantoff PW, Pienta KJ, Montie JE, Carter HB, Hruszkewicz AM, Gomez J, Mohla S, Getzenberg RH. Eleventh Prouts Neck Meeting on Prostate Cancer: emerging strategies in prostate cancer therapy. Cancer Res. 2007 Oct 15; 67(20):9613-5. PMID: 17928375.
      View in: PubMed
    46. Yanagisawa N, Li R, Rowley D, Liu H, Kadmon D, Miles BJ, Wheeler TM, Ayala GE. Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. Hum Pathol. 2007 Nov; 38(11):1611-20. PMID: 17868773.
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    47. Yang F, Strand DW, Rowley DR. Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma. Oncogene. 2008 Jan 17; 27(4):450-9. PMID: 17637743.
      View in: PubMed
    48. Dai H, Li R, Wheeler T, Ozen M, Ittmann M, Anderson M, Wang Y, Rowley D, Younes M, Ayala GE. Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach. Hum Pathol. 2007 Feb; 38(2):299-307. PMID: 17097719.
      View in: PubMed
    49. Ayala GE, Dai H, Tahir SA, Li R, Timme T, Ittmann M, Frolov A, Wheeler TM, Rowley D, Thompson TC. Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma. Cancer Res. 2006 May 15; 66(10):5159-64. PMID: 16707439.
      View in: PubMed
    50. Cher ML, Towler DA, Rafii S, Rowley D, Donahue HJ, Keller E, Herlyn M, Cho EA, Chung LW. Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section. Am J Pathol. 2006 May; 168(5):1405-12. PMID: 16651608.
      View in: PubMed
    51. Ayala GE, Dai H, Li R, Ittmann M, Thompson TC, Rowley D, Wheeler TM. Bystin in perineural invasion of prostate cancer. Prostate. 2006 Feb 15; 66(3):266-72. PMID: 16245277.
      View in: PubMed
    52. Dai H, Li R, Wheeler T, Diaz de Vivar A, Frolov A, Tahir S, Agoulnik I, Thompson T, Rowley D, Ayala G. Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer. Prostate. 2005 Nov 01; 65(3):276-86. PMID: 16015593.
      View in: PubMed
    53. Yang F, Tuxhorn JA, Ressler SJ, McAlhany SJ, Dang TD, Rowley DR. Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Res. 2005 Oct 01; 65(19):8887-95. PMID: 16204060.
      View in: PubMed
    54. Singh H, Dang TD, Ayala GE, Rowley DR. Transforming growth factor-beta1 induced myofibroblasts regulate LNCaP cell death. J Urol. 2004 Dec; 172(6 Pt 1):2421-5. PMID: 15538284.
      View in: PubMed
    55. Watson JE, Kamkar S, James K, Kowbel D, Andaya A, Paris PL, Simko J, Carroll P, McAlhany S, Rowley D, Collins C. Molecular analysis of WFDC1/ps20 gene in prostate cancer. Prostate. 2004 Oct 01; 61(2):192-9. PMID: 15305342.
      View in: PubMed
    56. McAlhany SJ, Ayala GE, Frolov A, Ressler SJ, Wheeler TM, Watson JE, Collins C, Rowley DR. Decreased stromal expression and increased epithelial expression of WFDC1/ps20 in prostate cancer is associated with reduced recurrence-free survival. Prostate. 2004 Oct 01; 61(2):182-91. PMID: 15305341.
      View in: PubMed
    57. Ayala GE, Dai H, Ittmann M, Li R, Powell M, Frolov A, Wheeler TM, Thompson TC, Rowley D. Growth and survival mechanisms associated with perineural invasion in prostate cancer. Cancer Res. 2004 Sep 01; 64(17):6082-90. PMID: 15342391.
      View in: PubMed
    58. Gerdes MJ, Larsen M, Dang TD, Ressler SJ, Tuxhorn JA, Rowley DR. Regulation of rat prostate stromal cell myodifferentiation by androgen and TGF-beta1. Prostate. 2004 Feb 15; 58(3):299-307. PMID: 14743470.
      View in: PubMed
    59. Ayala G, Tuxhorn JA, Wheeler TM, Frolov A, Scardino PT, Ohori M, Wheeler M, Spitler J, Rowley DR. Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer. Clin Cancer Res. 2003 Oct 15; 9(13):4792-801. PMID: 14581350.
      View in: PubMed
    60. McAlhany SJ, Ressler SJ, Larsen M, Tuxhorn JA, Yang F, Dang TD, Rowley DR. Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. Cancer Res. 2003 Sep 15; 63(18):5859-65. PMID: 14522910.
      View in: PubMed
    61. Li M, Ittmann MM, Rowley DR, Knowlton AA, Vaid AK, Epner DE. Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. Prostate. 2003 Jul 01; 56(2):98-105. PMID: 12746833.
      View in: PubMed
    62. Freund CT, Tong XW, Rowley D, Engehausen D, Frolov A, Kieback DG, Lerner SP. Combination of adenovirus-mediated thymidine kinase gene therapy with cytotoxic chemotherapy in bladder cancer in vitro. Urol Oncol. 2003 May-Jun; 21(3):197-205. PMID: 12810206.
      View in: PubMed
    63. Cornell RJ, Rowley D, Wheeler T, Ali N, Ayala G. Neuroepithelial interactions in prostate cancer are enhanced in the presence ofprostatic stroma. Urology. 2003 Apr; 61(4):870-5. PMID: 12670591.
      View in: PubMed
    64. Tuxhorn JA, McAlhany SJ, Yang F, Dang TD, Rowley DR. Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Res. 2002 Nov 01; 62(21):6021-5. PMID: 12414622.
      View in: PubMed
    65. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res. 2002 Sep; 8(9):2912-23. PMID: 12231536.
      View in: PubMed
    66. Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR. Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model. Cancer Res. 2002 Jun 01; 62(11):3298-307. PMID: 12036948.
      View in: PubMed
    67. Tuxhorn JA, Ayala GE, Rowley DR. Reactive stroma in prostate cancer progression. J Urol. 2001 Dec; 166(6):2472-83. PMID: 11696814.
      View in: PubMed
    68. Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D. In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate. 2001 Nov 01; 49(3):213-23. PMID: 11746267.
      View in: PubMed
    69. Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR. The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. Mamm Genome. 2000 Sep; 11(9):767-73. PMID: 10967136.
      View in: PubMed
    70. Freund CT, Tong XW, Block A, Contant CF, Kieback DG, Rowley DR, Lerner SP. Adenovirus-mediated suicide gene therapy for bladder cancer: comparison of the cytomegalovirus- and Rous sarcoma virus-promoter. Anticancer Res. 2000 Sep-Oct; 20(5A):2811-6. PMID: 11062688.
      View in: PubMed
    71. Sutton MA, Freund CT, Berkman SA, Dang TD, Kattan MW, Wheeler TM, Rowley DR, Lerner SP. In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer. Mol Ther. 2000 Sep; 2(3):211-7. PMID: 10985951.
      View in: PubMed
    72. Freund CT, Sutton MA, Dang T, Contant CF, Rowley D, Lerner SP. Adenovirus-mediated combination suicide and cytokine gene therapy for bladder cancer. Anticancer Res. 2000 May-Jun; 20(3A):1359-65. PMID: 10928044.
      View in: PubMed
    73. Gerdes MJ, Dang TD, Larsen M, Rowley DR. Transforming growth factor-beta1 induces nuclear to cytoplasmic distribution of androgen receptor and inhibits androgen response in prostate smooth muscle cells. Endocrinology. 1998 Aug; 139(8):3569-77. PMID: 9681509.
      View in: PubMed
    74. Gerdes MJ, Larsen M, McBride L, Dang TD, Lu B, Rowley DR. Localization of transforming growth factor-beta1 and type II receptor in developing normal human prostate and carcinoma tissues. J Histochem Cytochem. 1998 Mar; 46(3):379-88. PMID: 9487120.
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    75. Larsen M, Ressler SJ, Lu B, Gerdes MJ, McBride L, Dang TD, Rowley DR. Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle. J Biol Chem. 1998 Feb 20; 273(8):4574-84. PMID: 9468514.
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    76. Rowley DR. What might a stromal response mean to prostate cancer progression? Cancer Metastasis Rev. 1998-1999; 17(4):411-9. PMID: 10453285.
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    77. Sutton MA, Berkman SA, Chen SH, Block A, Dang TD, Kattan MW, Wheeler TM, Rowley DR, Woo SL, Lerner SP. Adenovirus-mediated suicide gene therapy for experimental bladder cancer. Urology. 1997 Feb; 49(2):173-80. PMID: 9037277.
      View in: PubMed
    78. Gerdes MJ, Dang TD, Lu B, Larsen M, McBride L, Rowley DR. Androgen-regulated proliferation and gene transcription in a prostate smooth muscle cell line (PS-1). Endocrinology. 1996 Mar; 137(3):864-72. PMID: 8603596.
      View in: PubMed
    79. Rowley DR, Dang TD, Larsen M, Gerdes MJ, McBride L, Lu B. Purification of a novel protein (ps20) from urogenital sinus mesenchymal cells with growth inhibitory properties in vitro. J Biol Chem. 1995 Sep 15; 270(37):22058-65. PMID: 7665628.
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    80. Southern J, Rowley D, Kretzer F. Using the MEDLINE database in a histology laboratory. Acad Med. 1995 May; 70(5):439-40. PMID: 7748406.
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    81. Rowley DR, Dang TD, McBride L, Gerdes MJ, Lu B, Larsen M. Beta-2 microglobulin is mitogenic to PC-3 prostatic carcinoma cells and antagonistic to transforming growth factor beta 1 action. Cancer Res. 1995 Feb 15; 55(4):781-6. PMID: 7850789.
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    82. Rowley DR. Glucocorticoid regulation of transforming growth factor-beta activation in urogenital sinus mesenchymal cells. Endocrinology. 1992 Jul; 131(1):471-8. PMID: 1612028.
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    83. Rowley DR. Characterization of a fetal urogenital sinus mesenchymal cell line U4F: secretion of a negative growth regulatory activity. In Vitro Cell Dev Biol. 1992 Jan; 28A(1):29-38. PMID: 1730568.
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    84. Rowley DI, Jain AS. Amputation surgery--a plea for caution. J R Coll Surg Edinb. 1990 Apr; 35(2):112. PMID: 2355376.
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    85. Young CY, Murthy LR, Prescott JL, Johnson MP, Rowley DR, Cunningham GR, Killian CS, Scardino PT, VonEschenbach A, Tindall DJ. Monoclonal antibodies against the androgen receptor: recognition of human and other mammalian androgen receptors. Endocrinology. 1988 Jul; 123(1):601-10. PMID: 2454813.
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    86. Johnson MP, Young CY, Rowley DR, Tindall DJ. A common molecular weight of the androgen receptor monomer in different target tissues. Biochemistry. 1987 Jun 02; 26(11):3174-82. PMID: 2440474.
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    87. Rowley DR, Tindall DJ. Responses of NBT-II bladder carcinoma cells to conditioned medium from normal fetal urogenital sinus. Cancer Res. 1987 Jun 01; 47(11):2955-60. PMID: 3567912.
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    88. Rowley DR, Premont RT, Johnson MP, Young CY, Tindall DJ. Properties of an intermediate-sized androgen receptor: association with RNA. Biochemistry. 1986 Nov 04; 25(22):6988-95. PMID: 2432928.
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    89. Murthy LR, Johnson MP, Rowley DR, Young CY, Scardino PT, Tindall DJ. Characterization of steroid receptors in human prostate using mibolerone. Prostate. 1986; 8(3):241-53. PMID: 2422638.
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    90. Tindall DJ, Rowley DR, Murthy L, Lipshultz LI, Chang CH. Structure and biochemistry of the Sertoli cell. Int Rev Cytol. 1985; 94:127-49. PMID: 2862128.
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    91. Carroll SL, Rowley DR, Chang CH, Tindall DJ. Exchange assay for androgen receptors in the presence of molybdate. J Steroid Biochem. 1984 Oct; 21(4):353-9. PMID: 6387280.
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    92. Chang CH, Lobl TJ, Rowley DR, Tindall DJ. Affinity labeling of the androgen receptor in rat prostate cytosol with 17 beta-[(bromoacetyl)oxy]-5 alpha-androstan-3-one. Biochemistry. 1984 May 22; 23(11):2527-33. PMID: 6477884.
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    93. Rowley DR, Chang CH, Tindall DJ. Effects of sodium molybdate on the androgen receptor from the R3327 prostatic tumor. Endocrinology. 1984 May; 114(5):1776-83. PMID: 6714164.
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    94. Murthy LR, Chang CH, Rowley DR, Scardino PT, Tindall DJ. Physicochemical characterization of the androgen receptor from hyperplastic human prostate. Prostate. 1984; 5(6):567-79. PMID: 6208540.
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    95. Rowley DR, Thompson SA, Lubaroff DM, Heidger PM. Androgen receptor binding characteristics in the cytosol of the rat dorsolateral prostate gland and the Dunning R-3327 prostatic adenocarcinoma. Prostate. 1984; 5(1):101-11. PMID: 6607463.
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    96. Tindall DJ, Chang CH, Lobl TJ, Rowley DR. Molecular properties of the androgen receptor in rat ventral prostate. Ann N Y Acad Sci. 1984; 438:39-53. PMID: 6598324.
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    97. Chang CH, Rowley DR, Tindall DJ. Purification and characterization of the androgen receptor from rat ventral prostate. Biochemistry. 1983 Dec 20; 22(26):6170-5. PMID: 6661431.
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    98. Chang CH, Rowley DR, Lobl TJ, Tindall DJ. Purification and characterization of androgen receptor from steer seminal vesicle. Biochemistry. 1982 Aug 17; 21(17):4102-9. PMID: 6982067.
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    99. Guerriero V, Rowley DR, Means AR. Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme. Cell. 1981 Dec; 27(3 Pt 2):449-58. PMID: 6101199.
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    100. Thompson SA, Rowley DR, Heidger PM. Effects of estrogen upon the fine structure of epithelium and stroma in the rat ventral prostate gland. Invest Urol. 1979 Jul; 17(1):83-9. PMID: 447491.
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