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Susan L. Hamilton

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
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    Other Positions
    TitleChair
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


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    R01HL032935     (HAMILTON, SUSAN L)Aug 1, 1984 - Nov 30, 1985
    NIH/NHLBI
    DIHYDROPYRIDINE BINDING SITES AND CALCIUM CHANNELS
    Role: Principal Investigator

    R01HL037028     (HAMILTON, SUSAN L)Dec 1, 1985 - Feb 28, 1993
    NIH/NHLBI
    DIHYDROPYRIDINE BINDING SITES AND CALCIUM CHANNELS
    Role: Principal Investigator

    K04HL002063     (HAMILTON, SUSAN L)Mar 1, 1988 - Feb 28, 1993
    NIH/NHLBI
    DIHYDROPYRIDINE BINDING SITES AND CALCIUM CHANNELS
    Role: Principal Investigator

    T32HL007676     (HAMILTON, SUSAN L)Jul 1, 1989 - Jun 30, 2021
    NIH/NHLBI
    Molecular Physiology of the Cardiovascular System
    Role: Principal Investigator

    U09RG000141     (ALMO, STEVEN C.)Jun 1, 1991 - Sep 29, 2006
    NIH/CSR
    DIVISION OF MOLECULAR AND CELLULAR MECHANISMS SEPS
    Role: Co-Principal Investigator

    R55AR041729     (HAMILTON, SUSAN L)Sep 1, 1992 - Mar 31, 1995
    NIH/NIAMS
    STRUCTURE-FUNCTION OF MUTANT CA2+ RELEASE CHANNELS
    Role: Principal Investigator

    R01AR041802     (HAMILTON, SUSAN L)Aug 1, 1993 - Nov 30, 2014
    NIH/NIAMS
    Modulation of Sarcoplasmic Reticulum Calcium Release
    Role: Principal Investigator

    R01AR041729     (HAMILTON, SUSAN L)Jun 1, 1996 - Sep 30, 2003
    NIH/NIAMS
    STRUCTURAL ANALYSIS OF THE CA++ RELEASE CHANNEL
    Role: Principal Investigator

    R01AR044864     (HAMILTON, SUSAN L)Sep 27, 1999 - Aug 31, 2010
    NIH/NIAMS
    Molecular Determinants of E-C Coupling
    Role: Principal Investigator

    R13AR050615     (HAMILTON, SUSAN L)Sep 29, 2003 - Oct 2, 2003
    NIH/NIAMS
    Calcium Release and Cellular Calcium Signaling Domains
    Role: Principal Investigator

    R01AR050503     (HAMILTON, SUSAN L)Jan 15, 2004 - Dec 31, 2009
    NIH/NIAMS
    Nitrosylation and Oxidation of RYR1 in Muscle Function
    Role: Principal Investigator

    R13AR053443     (HAMILTON, SUSAN L)Sep 30, 2005 - Aug 31, 2006
    NIH/NIAMS
    2006 Muscle: Excitation/Contraction Coupling Gordan Conference
    Role: Principal Investigator

    R01AR053349     (HAMILTON, SUSAN L)Dec 1, 2005 - Mar 31, 2021
    NIH/NIAMS
    Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core Disease
    Role: Principal Investigator

    R01AR072475     (HAMILTON, SUSAN L)Mar 22, 2018 - Feb 28, 2023
    NIH/NIAMS
    Redefining the Role of FKBP12 in Skeletal Muscle
    Role: Principal Investigator

    R01AR072602     (HAMILTON, SUSAN L)Aug 1, 2018 - Jun 30, 2023
    NIH/NIAMS
    Mechanisms of couplon-linked skeletal muscle myopathies
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659. PMID: 28337975.
      View in: PubMed
    2. Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. 2015 Sep 25; 290(39):23751-65. PMID: 26245899.
      View in: PubMed
    3. Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skelet Muscle. 2015; 5:4. PMID: 25717360.
      View in: PubMed
    4. Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem. 2014 Sep 12; 289(37):25556-70. PMID: 25053409.
      View in: PubMed
    5. Potts LE, Longwell JJ, Bedocs P, Sambuughin N, Bina S, Cooper PB, Carroll CG, O'Connor F, Deuster P, Muldoon SM, Hamilton S, Capacchione JF. Improving awareness of nonanesthesia-related malignant hyperthermia presentations: a tale of two brothers. A A Case Rep. 2014 Jul 15; 3(2):23-6. PMID: 25611019.
      View in: PubMed
    6. Knoblauch M, Dagnino-Acosta A, Hamilton SL. Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin. Skelet Muscle. 2013 Sep 03; 3(1):22. PMID: 24004537.
      View in: PubMed
    7. Manno C, Figueroa L, Royer L, Pouvreau S, Lee CS, Volpe P, Nori A, Zhou J, Meissner G, Hamilton SL, Ríos E. Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia. J Physiol. 2013 Sep 15; 591(18):4439-57. PMID: 23798496.
      View in: PubMed
    8. Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Jan 08; 18(2):244-51. PMID: 22231556.
      View in: PubMed
    9. Lanner JT, Georgiou DK, Joshi AD, Hamilton SL. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol. 2010 Nov; 2(11):a003996. PMID: 20961976.
      View in: PubMed
    10. Corona BT, Hamilton SL, Ingalls CP. Effect of prior exercise on thermal sensitivity of malignant hyperthermia-susceptible muscle. Muscle Nerve. 2010 Aug; 42(2):270-2. PMID: 20544946.
      View in: PubMed
    11. Boncompagni S, Rossi AE, Micaroni M, Hamilton SL, Dirksen RT, Franzini-Armstrong C, Protasi F. Characterization and temporal development of cores in a mouse model of malignant hyperthermia. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21996-2001. PMID: 19966218.
      View in: PubMed
    12. Halling DB, Georgiou DK, Black DJ, Yang G, Fallon JL, Quiocho FA, Pedersen SE, Hamilton SL. Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin. J Biol Chem. 2009 Jul 24; 284(30):20041-51. PMID: 19473981.
      View in: PubMed
    13. Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA. Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5135-40. PMID: 19279214.
      View in: PubMed
    14. Andronache Z, Hamilton SL, Dirksen RT, Melzer W. A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4531-6. PMID: 19246389.
      View in: PubMed
    15. Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E. Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008 Dec 10; 60(5):832-45. PMID: 19081378.
      View in: PubMed
    16. Hamilton SL, Serysheva II. Ryanodine receptor structure: progress and challenges. J Biol Chem. 2009 Feb 13; 284(7):4047-51. PMID: 18927076.
      View in: PubMed
    17. Corona BT, Rouviere C, Hamilton SL, Ingalls CP. Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice. J Appl Physiol (1985). 2008 Nov; 105(5):1542-53. PMID: 18787086.
      View in: PubMed
    18. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9610-5. PMID: 18621707.
      View in: PubMed
    19. Corona BT, Rouviere C, Hamilton SL, Ingalls CP. FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury. J Appl Physiol (1985). 2008 Aug; 105(2):527-37. PMID: 18511525.
      View in: PubMed
    20. Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL. RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice. Cell. 2008 Apr 04; 133(1):53-65. PMID: 18394989.
      View in: PubMed
    21. Huddleston AT, Tang W, Takeshima H, Hamilton SL, Klann E. Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK. J Neurophysiol. 2008 Mar; 99(3):1565-71. PMID: 18199822.
      View in: PubMed
    22. Long C, Cook LG, Hamilton SL, Wu GY, Mitchell BM. FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. Hypertension. 2007 Mar; 49(3):569-76. PMID: 17261647.
      View in: PubMed
    23. Hamilton SL, Serysheva I, Strasburg GM. Calmodulin and Excitation-Contraction Coupling. News Physiol Sci. 2000 Dec; 15:281-284. PMID: 11390927.
      View in: PubMed
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