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MICHELE SIMMONS REDELL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
Address1102 Bates St., C750
Houston TX 77030
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    Collapse Verify Publications

    Collapse Overview 
    Collapse keywords
    leukemia
    acute myeloid leukemia
    pediatric leukemia
    bone marrow
    microenvironment
    Stat3
    Stat5
    G-CSF
    IL-6
    stroma
    histone methylation
    DOT1L
    decitabine
    MLL


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018; 8(8):2189-2201. PMID: 29721072.
      View in: PubMed
    2. Long X, Gerbing RB, Alonzo TA, Redell MS. Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children's Oncology Group report. Oncotarget. 2017 Oct 27; 8(52):90037-90049. PMID: 29163809.
      View in: PubMed
    3. Stevens AM, Miller JM, Munoz JO, Gaikwad AS, Redell MS. Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance. Blood Adv. 2017 Aug 08; 1(18):1387-1397. PMID: 29296780.
      View in: PubMed
    4. Minus MB, Kang MK, Knudsen SE, Liu W, Krueger MJ, Smith ML, Redell MS, Ball ZT. Assessing the intracellular fate of rhodium(ii) complexes. Chem Commun (Camb). 2016 Sep 22; 52(78):11685-11688. PMID: 27709185.
      View in: PubMed
    5. Bonifant CL, Szoor A, Torres D, Joseph N, Velasquez MP, Iwahori K, Gaikwad A, Nguyen P, Arber C, Song XT, Redell M, Gottschalk S. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Mol Ther. 2016 Sep 29; 24(9):1615-26. PMID: 27401038.
      View in: PubMed
    6. Redell MS. A STAT3 decoy lures AML out of hiding. Blood. 2016 Mar 31; 127(13):1628-9. PMID: 27034418.
      View in: PubMed
    7. Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016; 9:24. PMID: 26970896; PMCID: PMC4789278.
    8. Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13085-9. PMID: 26480340.
      View in: PubMed
    9. Stevens AM, Ruiz MJ, Gerbing RB, Alonzo TA, Gamis AS, Redell MS. Ligand-induced STAT3 signaling increases at relapse and is associated with outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Haematologica. 2015 Dec; 100(12):e496-500. PMID: 26294728.
      View in: PubMed
    10. Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X. Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients. Am J Clin Pathol. 2015 Aug; 144(2):263-70. PMID: 26185311.
      View in: PubMed
    11. Long X, Yu Y, Perlaky L, Man TK, Redell MS. Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia. Br J Haematol. 2015 May 14. PMID: 25974135.
      View in: PubMed
    12. Liu W, Deng L, Song Y, Redell M. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS One. 2014; 9(5):e98270. PMID: 24858818; PMCID: PMC4032273.
    13. Blanco EM, Curry CV, Lu XY, Sarabia SF, Redell MS, Lopez-Terrada DH, Roy A. Cytogenetically cryptic and FISH-negative PML/RARA rearrangement in acute promyelocytic leukemia detected only by PCR: an exceedingly rare phenomenon. Cancer Genet. 2014 Jan-Feb; 207(1-2):48-9. PMID: 24561214.
      View in: PubMed
    14. Deng L, Zhang L, Yao Y, Wang C, Redell MS, Dong S, Song Y. Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm. 2013 May 1; 4(5):822-826. PMID: 23795283.
      View in: PubMed
    15. Fallon SC, Redell MS, El-Bietar J, Lopez ME, Vasudevan SA, Brandt ML. Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature. J Pediatr Surg. 2013 Feb; 48(2):436-40. PMID: 23414881.
      View in: PubMed
    16. Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood. 2013 Feb 14; 121(7):1083-93. PMID: 23243289; PMCID: PMC3575754.
    17. Rathore N, Eissa HM, Margolin JF, Liu H, Wu MF, Horton T, Kamdar K, Dreyer Z, Steuber P, Rabin KR, Redell M, Allen CE, McClain KL, Guillerman RP, Bollard CM. Pediatric Hodgkin lymphoma: are we over-scanning our patients? Pediatr Hematol Oncol. 2012 Aug; 29(5):415-23. PMID: 22632168; PMCID: PMC3685486.
    18. Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26; 117(21):5701-9. PMID: 21447830; PMCID: PMC3110027.
    19. Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem. 2007 Nov 30; 282(48):34958-67. PMID: 17855361.
      View in: PubMed
    20. Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol. 2007 Oct; 82(4):975-85. PMID: 17634277.
      View in: PubMed
    21. Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol. 2006; 3(3):261-7. PMID: 24980527.
      View in: PubMed
    22. Redell MS, Tweardy DJ. Targeting transcription factors for cancer therapy. Curr Pharm Des. 2005; 11(22):2873-87. PMID: 16101443.
      View in: PubMed
    23. Terman GW, Drake CT, Simmons ML, Milner TA, Chavkin C. Opioid modulation of recurrent excitation in the hippocampal dentate gyrus. J Neurosci. 2000 Jun 15; 20(12):4379-88. PMID: 10844006.
      View in: PubMed
    24. Simmons ML, Terman GW, Chavkin C. Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J Neurophysiol. 1997 Oct; 78(4):1860-8. PMID: 9325355.
      View in: PubMed
    25. Drake CT, Patterson TA, Simmons ML, Chavkin C, Milner TA. Kappa opioid receptor-like immunoreactivity in guinea pig brain: ultrastructural localization in presynaptic terminals in hippocampal formation. J Comp Neurol. 1996 Jul 1; 370(3):377-95. PMID: 8799863.
      View in: PubMed
    26. Simmons ML, Chavkin C. k-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. Mol Pharmacol. 1996 Jul; 50(1):80-5. PMID: 8700123.
      View in: PubMed
    27. Simmons ML, Terman GW, Gibbs SM, Chavkin C. L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron. 1995 Jun; 14(6):1265-72. PMID: 7605635.
      View in: PubMed
    28. Wu ZL, Thomas SA, Villacres EC, Xia Z, Simmons ML, Chavkin C, Palmiter RD, Storm DR. Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3; 92(1):220-4. PMID: 7816821; PMCID: PMC42849.
    29. Simmons ML, Terman GW, Drake CT, Chavkin C. Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus. J Neurophysiol. 1994 Oct; 72(4):1697-705. PMID: 7823095.
      View in: PubMed
    30. Drake CT, Terman GW, Simmons ML, Milner TA, Kunkel DD, Schwartzkroin PA, Chavkin C. Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. J Neurosci. 1994 Jun; 14(6):3736-50. PMID: 7911518.
      View in: PubMed
    31. Simmons ML, Wagner JJ, Caudle RM, Chavkin C. Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus. Neurosci Lett. 1992 Jul 6; 141(1):84-8. PMID: 1508405.
      View in: PubMed
    32. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 1991; 45(1):37-45. PMID: 1754068.
      View in: PubMed
    33. Slusher BS, Robinson MB, Tsai G, Simmons ML, Richards SS, Coyle JT. Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization. J Biol Chem. 1990 Dec 5; 265(34):21297-301. PMID: 2250024.
      View in: PubMed
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