KATHERINE KING

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Biography 
    Collapse education and training
    Harvard University, CambridgeAB06/1996Biochemical Sciences
    Washington University, St. LouisMD PhD06/2003Molecular Microbiology and Microbial Pathogenesis
    Baylor College of Medicine, Houstonresidency06/2006Pediatrics
    Baylor College of Medicine, Houstonfellowship06/2010Infectious Diseases
    Collapse awards and honors
    2015 - 2017Liviya Anderson Research Award, Aplastic Anemia and MDS International Foundation
    2015 - 2017Basil O'Connor Starter Scholar Award, March of Dimes
    2014 - 2015BCM Junior Faculty Seed Grant, Caroline Wiess Law Fund for Research in Molecular Medicine
    2010 - 2015KO8 Mentored Clinical Scientist Training Award, NIH
    2011 - 2012Pediatric Pilot Award, Texas Children's Hospital
    2008 - 2009Collaborative Research Grant, L.E. and Virginia Simmons Family Foundation
    2017 - 2018New Member Outstanding Science Award, Society for Pediatric Research
    2017 - 2018Woman of Excellence Award, Baylor College of Medicine
    2019Presidential Early Career Award for Scientists and Engineers (PECASE), President of the United States
    2020Distiguished Alumni Award, St. John's School
    2021 - 2028Emerging Investigator Award, NIH NHLBI

    Collapse Overview 
    Collapse overview
    The long-term goal of Dr. King’s research is to alleviate deaths from infectious diseases. Given that severe infections are frequently related to weaknesses in the immune system, Dr. King’s research focuses on the molecular mechanisms by which inflammation affects blood and immune cell production by hematopoietic stem cells in the bone marrow. Dr. King has been the recipient of a NIH K08 mentored physician scientist training award, the March of Dimes Basil O’Connor Starter Scholar Award, the Aplastic Anemia and MDS International Foundation Liviya Anderson Award, and the Caroline Wiess Law Foundation in Molecular Medicine Award. Her research has been published in highly regarded journals such as Nature, Cell Reports, and Blood.

    Current projects in the lab include:

    Inflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate Immunity
    We are studying the therapeutic use of hematopoietic stem and progenitors to improve immune responses against bacterial infections including Group A Streptococcal superinfections complicating influenza. Funding to support this project: NIH R01, 2017-2021

    The Contribution of Infection to Preleukemic Clonal Hematopoiesis
    We are studying how the differential responses of hematopoietic stem cells to inflammation contribute to emergence of leukemia. These studies provide a mechanistic understanding of how infections affect cancer risk. Funding to support this project: NIH R01, 2017-2022

    Microbiota-dependent Regulation of Primitive Hematopoiesis
    An adverse side effect of antibiotics is that they may suppress blood and immune cell production by the bone marrow. In a study published last year, we demonstrated that these adverse effects of antibiotics are due to disruption of the intestinal microbiome. Our current work will define the molecular pathways through which the microbiome signals to support normal blood production. Funding to supporting this project: NIH R01 (co-investigator), 2018-2023

    Collapse Research 
    Collapse research activities and funding
    K08HL098898     (KING, KATHERINE YUDEH)May 1, 2010 - Feb 28, 2015
    NIH
    The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    Role: Principal Investigator

    R01HL136333     (KING, KATHERINE YUDEH)May 1, 2017 - Apr 30, 2023
    NIH
    The Contribution ofInfection to Preleukemic Clonal Hematopoiesis
    Role: Principal Investigator

    R01HL134880     (KING, KATHERINE YUDEH)Aug 1, 2017 - Jun 30, 2021
    NIH
    Inflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate Immunity
    Role: Principal Investigator

    R01AI141716     (BALDRIDGE, MEGAN T)Nov 7, 2018 - Oct 31, 2023
    NIH
    Microbiota-dependent regulation of primitive hematopoieses
    Role Description: The goal of this study is to quantify the impact of a variety of environmental stressors on clonal dynamics of a panel of genetically distinct hematopoietic stem cell clones.
    Role: Co-PI

         (Margaret Goodell)Jul 1, 2019 - Jun 30, 2022
    Helis Medical Research Foundation
    Environmental Drivers of Clonal Hematopoiesis
    Role: Co-PI

    R35HL155672     (KING, KATHERINE YUDEH)Jul 1, 2021 - Jun 30, 2028
    NIH
    Impact of Infection and Inflammation on Primitive Hematopoiesis
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hormaechea-Agulla D, Matatall KA, Le DT, Kain B, Long X, Kus P, Jaksik R, Challen GA, Kimmel M, King KY. Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFN? signaling. Cell Stem Cell. 2021 Mar 16. PMID: 33743191.
      Citations: 4     Fields:    
    2. Han H, Yan H, King KY. Broad-Spectrum Antibiotics Deplete Bone Marrow Regulatory T Cells. Cells. 2021 Jan 30; 10(2). PMID: 33573218.
      Citations: 1     Fields:    
    3. Florez MA, Matatall KA, Jeong Y, Ortinau L, Shafer PW, Lynch AM, Jaksik R, Kimmel M, Park D, King KY. Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2. Cell Rep. 2020 12 22; 33(12):108530. PMID: 33357430.
      Citations: 2     Fields:    
    4. Morales-Mantilla DE, Huang X, Erice P, Porter P, Zhang Y, Figueroa M, Chandra J, King KY, Kheradmand F, Rodríguez A. Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System. J Vis Exp. 2020 10 22; (164). PMID: 33165327.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    5. Chen J, Matatall KA, Feng X, Hormaechea-Agulla D, Maharjan M, Young N, King KY. Dnmt3a-null hematopoietic stem and progenitor cells expand after busulfan treatment. Exp Hematol. 2020 11; 91:39-45.e2. PMID: 32961298.
      Citations:    Fields:    Translation:AnimalsCells
    6. Hormaechea-Agulla D, Le DT, King KY. Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology. Curr Stem Cell Rep. 2020 Aug 17; 1-12. PMID: 32837857.
      Citations: 3     
    7. King KY, Huang Y, Nakada D, Goodell MA. Environmental influences on clonal hematopoiesis. Exp Hematol. 2020 03; 83:66-73. PMID: 31893524.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    8. Niles D, Boguniewicz J, Shakeel O, Margolin J, Chelius D, Gupta M, Paul D, King KY, McNeil JC. Candida tropicalis Thyroiditis Presenting With Thyroid Storm in a Pediatric Patient With Acute Lymphocytic Leukemia. Pediatr Infect Dis J. 2019 10; 38(10):1051-1053. PMID: 31365478.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Zeng H, He H, Guo L, Li J, Lee M, Han W, Guzman AG, Zang S, Zhou Y, Zhang X, Goodell MA, King KY, Sun D, Huang Y. Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies. Cancer Lett. 2019 12 28; 467:1-8. PMID: 31563562.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Foster CE, Taylor M, Schallert EK, Rosenfeld S, King KY. Brodie Abscess in Children: A 10-Year Single Institution Retrospective Review. Pediatr Infect Dis J. 2019 02; 38(2):e32-e34. PMID: 29620720.
      Citations: 3     Fields:    Translation:Humans
    11. Kennedy EA, King KY, Baldridge MT. Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria. Front Physiol. 2018; 9:1534. PMID: 30429801.
      Citations: 69     
    12. Morales-Mantilla DE, King KY. The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease. Curr Stem Cell Rep. 2018; 4(3):264-271. PMID: 30148048.
      Citations: 17     
    13. Yan H, Baldridge MT, King KY. Hematopoiesis and the bacterial microbiome. Blood. 2018 08 09; 132(6):559-564. PMID: 29853538.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Kitagawa MG, Ettinger N, Breen D, Erklauer J, Chang E, Herce H, King K, Naik S. Transmission of West Nile Virus Through a Hematopoietic Stem Cell Transplant. J Pediatric Infect Dis Soc. 2018 May 15; 7(2):e52-e54. PMID: 29309636.
      Citations: 1     Fields:    Translation:Humans
    15. Tashi T, Swierczek S, Kim SJ, Salama ME, Song J, Heikal N, King KY, Hickman K, Litton S, Prchal JT. Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses. Leukemia. 2018 08; 32(8):1830-1833. PMID: 29556018.
      Citations: 3     Fields:    Translation:HumansCells
    16. Matatall KA, Kadmon CS, King KY. Detecting Hematopoietic Stem Cell Proliferation Using BrdU Incorporation. Methods Mol Biol. 2018; 1686:91-103. PMID: 29030815.
      Citations: 5     Fields:    Translation:HumansCells
    17. King KY. Saving Stem Cells after Stress. Cell Stem Cell. 2017 12 07; 21(6):709-710. PMID: 29220661.
      Citations:    Fields:    Translation:Cells
    18. Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY. MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol. 2017 12; 56:7-15. PMID: 28911907.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Matatall KA, Jeong M, Chen S, Sun D, Chen F, Mo Q, Kimmel M, King KY. Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation. Cell Rep. 2016 12 06; 17(10):2584-2595. PMID: 27926863.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    20. Josefsdottir KS, Baldridge MT, Kadmon CS, King KY. Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota. Blood. 2017 02 09; 129(6):729-739. PMID: 27879260.
      Citations: 74     Fields:    Translation:AnimalsCells
    21. Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen GA. Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? Exp Hematol. 2016 10; 44(10):908-12. PMID: 27423816.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol. 2016 Sep; 97(3):261-70. PMID: 26660446.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JT. Comparative long-term effects of interferon a and hydroxyurea on human hematopoietic progenitor cells. Exp Hematol. 2015 Oct; 43(10):912-918.e2. PMID: 26072330.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. King KY, Hicks MJ, Mazziotti MV, Eldin KW, Starke JR, Michael M. Persistent cat scratch disease requiring surgical excision in a patient with MPGN. Pediatrics. 2015 Jun; 135(6):e1514-7. PMID: 25963015.
      Citations: 1     Fields:    Translation:Humans
    25. Josefsdottir KS, King KY. Interferons coordinate a multifaceted defense. Cell Host Microbe. 2015 Jan 14; 17(1):6-7. PMID: 25590754.
      Citations:    Translation:AnimalsCells
    26. Trompouki E, King KY, Will B, Lessard J, Flores-Figueroa E, Kokkaliaris KD, Bowman T. Bloody signals: from birth to disease and death. Exp Hematol. 2014 Dec; 42(12):989-94. PMID: 25482344.
      Citations:    Fields:    Translation:HumansAnimalsCells
    27. Matatall KA, Shen CC, Challen GA, King KY. Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells. Stem Cells. 2014 Nov; 32(11):3023-30. PMID: 25078851.
      Citations: 35     Fields:    Translation:AnimalsCells
    28. Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19; 510(7505):393-6. PMID: 24870234.
      Citations: 202     Fields:    Translation:AnimalsCells
    29. Rossi L, Lin KK, Boles NC, Yang L, King KY, Jeong M, Mayle A, Goodell MA. Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 07; 11(3):302-17. PMID: 22958929.
      Citations: 100     Fields:    Translation:AnimalsCells
    30. King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011 Sep 09; 11(10):685-92. PMID: 21904387.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    31. King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MA. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 2011 Aug 11; 118(6):1525-33. PMID: 21633090.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    32. King KY, Goodell MA. Direct conversion of skin cells into blood: alchemy or science? Mol Ther. 2011 Feb; 19(2):227-8. PMID: 21289635.
      Citations:    Fields:    Translation:HumansAnimalsCells
    33. King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA. Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One. 2011 Jan 21; 6(1):e16317. PMID: 21283700.
      Citations: 32     Fields:    Translation:Humans
    34. Baldridge MT, King KY, Goodell MA. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2011 Feb; 32(2):57-65. PMID: 21233016.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    35. Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10; 465(7299):793-7. PMID: 20535209.
      Citations: 324     Fields:    Translation:AnimalsCells
    36. King KY, Edwards MS, Word BM. Hepatitis associated with micafungin use in a preterm infant. J Perinatol. 2009 Apr; 29(4):320-2. PMID: 19325554.
      Citations: 2     Fields:    Translation:Humans
    37. King K, Browning JC, Metry DW, Prestigiacomo J, Scollard D, Schutze GE, Stryjewska B, Schwarzwald H. Leprosy and international adoption: a case report and review of diagnostic and treatment dilemmas. Pediatr Infect Dis J. 2009 Apr; 28(4):322-5. PMID: 19238115.
      Citations: 3     Fields:    Translation:Humans
    38. Brenot A, King KY, Caparon MG. The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes. Mol Microbiol. 2005 Jan; 55(1):221-34. PMID: 15612930.
      Citations: 63     Fields:    Translation:AnimalsCells
    39. Brenot A, King KY, Janowiak B, Griffith O, Caparon MG. Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infect Immun. 2004 Jan; 72(1):408-13. PMID: 14688122.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    40. King KY, Horenstein JA, Caparon MG. Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes. J Bacteriol. 2000 Oct; 182(19):5290-9. PMID: 10986229.
      Citations: 56     Fields:    Translation:Cells
    41. Worley KC, King KY, Chua S, McCabe ER, Smith RF. Identification of new members of a carbohydrate kinase-encoding gene family. J Comput Biol. 1995; 2(3):451-8. PMID: 8521274.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    42. Smith RF, King KY. Identification of a eukaryotic-like protein kinase gene in Archaebacteria. Protein Sci. 1995 Jan; 4(1):126-9. PMID: 7773169.
      Citations: 13     Fields:    Translation:Cells
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