Our laboratory studies the metabolic and transcriptional mechanisms that regulate hematopoietic stem cell (HSC) maintenance and their transformation. We identified fundamental properties that enable metabolic (Nature. 2010) and endocrine regulation of HSCs (Nature. 2014, eLife. 2018). We also study how the niche influences HSC differentiation into adipocyte within the bone marrow (Stem Cell Reports. 2019) and epigenetic regulation of HSCs (Stem Cell Reports. 2021). We developed a CRISPR/Cas9-based method to edit the genome of both murine and human hematopoietic progenitor cells, paving the way to perform genetics-based discovery research using these cells (Cell Reports. 2016, Exp. Hematol. 2018, Blood. 2019). We also study how metabolic processes regulate stem cells, and discovered a metabolic pathway governed by AMPK that is particularly important for cancer stem cells but not normal HSCs, potentially providing an intriguing therapeutic target to kill tumor-initiating cells without harming normal HSCs (Cell Stem Cell. 2015, Blood. 2019, Sci Adv. 2021, Cell Stem Cell. 2022). By improving our understanding of how stem cells proliferate and differentiate, it may be possible to advance a number of clinical goals including improving bone marrow transplantation and treating genetic disorders of metabolism.