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LISA BOUCHIER-HAYES

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
    Collapse research activities and funding
    R03AI178641     (BOUCHIER-HAYES, LISA)Jun 1, 2023 - May 31, 2025
    NIH
    Development of an in vitro system to study heme-induced caspase activation
    Role: Principal Investigator
    R21CA256606     (BOUCHIER-HAYES, LISA)Jan 15, 2021 - Jun 30, 2023
    NIH
    Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survival
    Role: Principal Investigator
    R01GM121389     (BOUCHIER-HAYES, LISA)May 1, 2018 - Apr 30, 2023
    NIH
    Non-apoptotic functions of caspase-2 in cell division and genomic stability
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brown-Suedel AN, Bouchier-Hayes L. Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome. EMBO J. 2023 10 16; 42(20):e115307. PMID: 37691515; PMCID: PMC10577535.
      Citations: 1     Fields:    Translation:HumansCells
    2. Sakthivel D, Brown-Suedel AN, Keane F, Huang S, Sherry KM, Charendoff CI, Dunne KP, Robichaux DJ, Le B, Shin CS, Carisey AF, Flanagan JM, Bouchier-Hayes L. Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia. bioRxiv. 2023 May 30. PMID: 37398413; PMCID: PMC10312440.
      Citations:    
    3. Sakthivel D, Brown-Suedel A, Bouchier-Hayes L. The role of the nucleolus in regulating the cell cycle and the DNA damage response. Adv Protein Chem Struct Biol. 2023; 135:203-241. PMID: 37061332.
      Citations:    Fields:    Translation:Cells
    4. Salgar S, Flanagan JM, Anum SJ, Bouchier-Hayes L, Bol?var BE. The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions. Transl Res. 2023 02; 252:34-44. PMID: 36041706; PMCID: PMC10351365.
      Citations:    
    5. Boice AG, Lopez KE, Pandita RK, Parsons MJ, Charendoff CI, Charaka V, Carisey AF, Pandita TK, Bouchier-Hayes L. Correction: Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis. Oncogene. 2022 Jul; 41(29):3732-3734. PMID: 35705736.
      Citations:    Fields:    
    6. Lopez KE, Bouchier-Hayes L. Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. 2022 06 10; 11(12). PMID: 35741016; PMCID: PMC9221191.
      Citations:    Fields:    Translation:Humans
    7. Bouchier-Hayes L, Bol?var BE. Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages. J Vis Exp. 2022 04 06; (182). PMID: 35467667.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Sakthivel D, Bouchier-Hayes L, Bol?var BE. Cellular autophagy, an unbidden effect of caspase inhibition by zVAD-fmk. FEBS J. 2022 06; 289(11):3097-3100. PMID: 35043564; PMCID: PMC9177521.
      Citations:    Fields:    Translation:Humans
    9. Boice AG, Lopez KE, Pandita RK, Parsons MJ, Charendoff CI, Charaka V, Carisey AF, Pandita TK, Bouchier-Hayes L. Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis. Oncogene. 2022 01; 41(2):204-219. PMID: 34718349; PMCID: PMC8738157.
      Citations: 1     Fields:    Translation:HumansAnimals
    10. Brown-Suedel AN, Rohrman BA, Yazdani V, Belcher JD, Vercellotti GM, Flanagan JM, Bouchier-Hayes L, Bol?var BE, Charendoff CI. Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death. J Immunol. 2021 04 15; 206(8):1878-1889. PMID: 33741688; PMCID: PMC8026643.
      Citations: 5     Fields:    Translation:HumansCells
    11. Brown-Suedel AN, Bouchier-Hayes L. Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond. Front Cell Dev Biol. 2020; 8:610022. PMID: 33425918; PMCID: PMC7785872.
      Citations: 10     
    12. Boice A, Bouchier-Hayes L. Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118688. PMID: 32087180; PMCID: PMC7155770.
      Citations: 45     Fields:    Translation:HumansCells
    13. Vogel TP, Bouchier-Hayes L, Bol?var BE. Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. FEBS J. 2019 07; 286(14):2628-2644. PMID: 31090171; PMCID: PMC7065599.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    14. Bouchier-Hayes L, Charendoff CI. Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp. 2018 03 05; (133). PMID: 29553529; PMCID: PMC5931437.
      Citations: 1     Fields:    Translation:Humans
    15. Bouchier-Hayes L, Sidi S. The nucleolus: A new home for the PIDDosome. Cell Cycle. 2017; 16(17):1562-1563. PMID: 28749201; PMCID: PMC5587024.
      Citations: 1     Fields:    Translation:Cells
    16. Sidi S, Bouchier-Hayes L. Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Mol Cell Oncol. 2017; 4(5):e1348325. PMID: 29057309; PMCID: PMC5644479.
      Citations: 1     
    17. Ando K, Parsons MJ, Shah RB, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L, Charendoff CI, Paris SL. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017 06 05; 216(6):1795-1810. PMID: 28432080; PMCID: PMC5461015.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    18. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene. 2017 05 11; 36(19):2704-2714. PMID: 27991927; PMCID: PMC5442422.
      Citations: 27     Fields:    Translation:HumansAnimals
    19. Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953. PMID: 26804704; PMCID: PMC4726202.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Parsons MJ, Fassio SR, Bouchier-Hayes L. Detection of Initiator Caspase Induced Proximity in Single Cells by Caspase Bimolecular Fluorescence Complementation. Methods Mol Biol. 2016; 1419:41-56. PMID: 27108430.
      Citations: 1     Fields:    Translation:HumansCells
    21. Sanders MG, Parsons MJ, Howard AG, Liu J, Fassio SR, Martinez JA, Bouchier-Hayes L. Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell Death Dis. 2015 Jul 09; 6:e1813. PMID: 26158519; PMCID: PMC4650733.
      Citations: 19     Fields:    Translation:HumansCells
    22. Hoyos V, Del Bufalo F, Yagyu S, Ando M, Dotti G, Suzuki M, Bouchier-Hayes L, Alemany R, Brenner MK. Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers. Mol Ther. 2015 Sep; 23(9):1497-506. PMID: 26084970; PMCID: PMC4817892.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    23. Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell. 2015 Mar 05; 57(5):860-872. PMID: 25702873; PMCID: PMC4352766.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    24. Parsons MJ, Bouchier-Hayes L. Measuring initiator caspase activation by bimolecular fluorescence complementation. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082552. PMID: 25561623.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    25. Rehm M, Parsons MJ, Bouchier-Hayes L. Measuring caspase activity by F?rster resonance energy transfer. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082560. PMID: 25561624.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Parsons MJ, Rehm M, Bouchier-Hayes L. Imaging-based methods for assessing caspase activity in single cells. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.top070342. PMID: 25561626.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    27. Ando M, Hoyos V, Yagyu S, Tao W, Ramos CA, Dotti G, Brenner MK, Bouchier-Hayes L. Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther. 2014 Nov; 21(11):472-482. PMID: 25323693; PMCID: PMC4245333.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    28. Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti G. Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res. 2014 Sep 15; 74(18):5195-205. PMID: 25060519; PMCID: PMC4167556.
      Citations: 128     Fields:    Translation:AnimalsCells
    29. Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013 Sep; 20(9):1174-82. PMID: 23645210; PMCID: PMC3741497.
      Citations: 35     Fields:    Translation:AnimalsCells
    30. Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93. PMID: 22854598; PMCID: PMC3444620.
      Citations: 52     Fields:    Translation:HumansCells
    31. Bouchier-Hayes L, Green DR. Caspase-2: the orphan caspase. Cell Death Differ. 2012 Jan; 19(1):51-7. PMID: 22075987; PMCID: PMC3252831.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    32. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31. PMID: 22036586; PMCID: PMC3221787.
      Citations: 268     Fields:    Translation:HumansAnimalsCells
    33. Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Green DR, Mu?oz-Pinedo C. Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell. 2010 May 18; 18(5):802-13. PMID: 20493813; PMCID: PMC3004027.
      Citations: 90     Fields:    Translation:HumansCells
    34. Bouchier-Hayes L. The role of caspase-2 in stress-induced apoptosis. J Cell Mol Med. 2010 Jun; 14(6A):1212-24. PMID: 20158568; PMCID: PMC3828840.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    35. Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HM. Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1. Cell Death Differ. 2010 Jun; 17(6):1034-46. PMID: 20150914.
      Citations: 3     Fields:    Translation:HumansCells
    36. Bouchier-Hayes L, Green DR. Real time with caspase-2. Cell Cycle. 2010 Jan 01; 9(1):12-3. PMID: 20016258.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    37. Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell. 2009 Sep 24; 35(6):830-40. PMID: 19782032; PMCID: PMC2755603.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    38. Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR. Live to dead cell imaging. Methods Mol Biol. 2009; 559:33-48. PMID: 19609747.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    39. Bouchier-Hayes L, Connell S, Green DR, Mu?oz-Pinedo C. Measuring apoptosis at the single cell level. Methods. 2008 Mar; 44(3):222-8. PMID: 18314052; PMCID: PMC2423010.
      Citations: 32     Fields:    Translation:HumansAnimals
    40. Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 01; 129(5):983-97. PMID: 17540177.
      Citations: 219     Fields:    Translation:HumansCells
    41. Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 2006 Aug; 13(8):1396-402. PMID: 16710362.
      Citations: 186     Fields:    Translation:HumansAnimalsCells
    42. Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD. Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell. 2006 May; 17(5):2150-7. PMID: 16495337; PMCID: PMC1446087.
      Citations: 62     Fields:    Translation:AnimalsCells
    43. Bouchier-Hayes L, Lartigue L, Newmeyer DD. Mitochondria: pharmacological manipulation of cell death. J Clin Invest. 2005 Oct; 115(10):2640-7. PMID: 16200197; PMCID: PMC1236694.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    44. Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005 Sep 09; 309(5741):1732-5. PMID: 16151013.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    45. Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18; 17(4):525-35. PMID: 15721256.
      Citations: 514     Fields:    Translation:HumansCells
    46. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004 Feb 13; 303(5660):1010-4. PMID: 14963330.
      Citations: 772     Fields:    Translation:HumansAnimalsCells
    47. Bouchier-Hayes L, Martin SJ. CARDINAL roles in apoptosis and NFkappaB activation. Vitam Horm. 2004; 67:133-47. PMID: 15110175.
      Citations: 4     Fields:    Translation:HumansAnimals
    48. Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EO. In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope. Br J Cancer. 2003 Oct 06; 89(7):1327-33. PMID: 14520468; PMCID: PMC2394302.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    49. Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SK. Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography. Appl Radiat Isot. 2003 Jan; 58(1):55-62. PMID: 12485664.
      Citations: 18     Fields:    Translation:HumansCells
    50. Bouchier-Hayes L, Martin SJ. CARD games in apoptosis and immunity. EMBO Rep. 2002 Jul; 3(7):616-21. PMID: 12101092; PMCID: PMC1084193.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    51. Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem. 2001 Nov 23; 276(47):44069-77. PMID: 11551959.
      Citations: 42     Fields:    Translation:HumansCells
    52. Mynett-Johnson L, Kealey C, Claffey E, Curtis D, Bouchier-Hayes L, Powell C, McKeon P. Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder. Am J Med Genet. 2000 Dec 04; 96(6):845-9. PMID: 11121194.
      Citations: 8     Fields:    Translation:Humans
    53. Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ. Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis. FEBS Lett. 2000 Apr 07; 471(1):93-8. PMID: 10760520.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
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