LISA BOUCHIER-HAYES

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01GM121389     (BOUCHIER-HAYES, LISA)May 1, 2018 - Apr 30, 2023
    NIH/NIGMS
    Non-apoptotic functions of caspase-2 in cell division and genomic stability
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Boice A, Bouchier-Hayes L. Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118688. PMID: 32087180.
      Citations: 4     Fields:    Translation:HumansCells
    2. Bolívar BE, Vogel TP, Bouchier-Hayes L. Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. FEBS J. 2019 07; 286(14):2628-2644. PMID: 31090171.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Charendoff CI, Bouchier-Hayes L. Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp. 2018 03 05; (133). PMID: 29553529.
      Citations: 1     Fields:    Translation:Humans
    4. Bouchier-Hayes L, Sidi S. The nucleolus: A new home for the PIDDosome. . 2017; 16(17):1562-1563. PMID: 28749201.
      Citations:    
    5. Sidi S, Bouchier-Hayes L. Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Mol Cell Oncol. 2017; 4(5):e1348325. PMID: 29057309.
      Citations:    
    6. Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017 06 05; 216(6):1795-1810. PMID: 28432080.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    7. Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953. PMID: 26804704.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    8. Parsons MJ, Fassio SR, Bouchier-Hayes L. Detection of Initiator Caspase Induced Proximity in Single Cells by Caspase Bimolecular Fluorescence Complementation. Methods Mol Biol. 2016; 1419:41-56. PMID: 27108430.
      Citations: 1     Fields:    Translation:HumansCells
    9. Sanders MG, Parsons MJ, Howard AG, Liu J, Fassio SR, Martinez JA, Bouchier-Hayes L. Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell Death Dis. 2015 Jul 09; 6:e1813. PMID: 26158519.
      Citations: 12     Fields:    Translation:HumansCells
    10. Hoyos V, Del Bufalo F, Yagyu S, Ando M, Dotti G, Suzuki M, Bouchier-Hayes L, Alemany R, Brenner MK. Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers. Mol Ther. 2015 Sep; 23(9):1497-506. PMID: 26084970.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell. 2015 Mar 05; 57(5):860-872. PMID: 25702873.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    12. Parsons MJ, Bouchier-Hayes L. Measuring initiator caspase activation by bimolecular fluorescence complementation. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082552. PMID: 25561623.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. Rehm M, Parsons MJ, Bouchier-Hayes L. Measuring caspase activity by Förster resonance energy transfer. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082560. PMID: 25561624.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    14. Parsons MJ, Rehm M, Bouchier-Hayes L. Imaging-based methods for assessing caspase activity in single cells. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.top070342. PMID: 25561626.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    15. Ando M, Hoyos V, Yagyu S, Tao W, Ramos CA, Dotti G, Brenner MK, Bouchier-Hayes L. Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther. 2014 Nov; 21(11):472-482. PMID: 25323693.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti G. Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res. 2014 Sep 15; 74(18):5195-205. PMID: 25060519.
      Citations: 73     Fields:    Translation:AnimalsCells
    17. Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93. PMID: 22854598.
      Citations: 36     Fields:    Translation:HumansCells
    18. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31. PMID: 22036586.
      Citations: 210     Fields:    Translation:HumansAnimalsCells
    19. Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Muñoz-Pinedo C, Green DR. Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell. 2010 May 18; 18(5):802-13. PMID: 20493813.
      Citations: 65     Fields:    Translation:HumansCells
    20. Bouchier-Hayes L. The role of caspase-2 in stress-induced apoptosis. J Cell Mol Med. 2010 Jun; 14(6A):1212-24. PMID: 20158568.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    21. Bouchier-Hayes L, Green DR. Real time with caspase-2. . 2010 Jan 01; 9(1):12-3. PMID: 20016258.
      Citations:    
    22. Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell. 2009 Sep 24; 35(6):830-40. PMID: 19782032.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    23. Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR. Live to dead cell imaging. Methods Mol Biol. 2009; 559:33-48. PMID: 19609747.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Bouchier-Hayes L, Muñoz-Pinedo C, Connell S, Green DR. Measuring apoptosis at the single cell level. Methods. 2008 Mar; 44(3):222-8. PMID: 18314052.
      Citations: 27     Fields:    Translation:HumansAnimals
    25. Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 01; 129(5):983-97. PMID: 17540177.
      Citations: 178     Fields:    Translation:HumansCells
    26. Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD. Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell. 2006 May; 17(5):2150-7. PMID: 16495337.
      Citations: 56     Fields:    Translation:AnimalsCells
    27. Bouchier-Hayes L, Lartigue L, Newmeyer DD. Mitochondria: pharmacological manipulation of cell death. J Clin Invest. 2005 Oct; 115(10):2640-7. PMID: 16200197.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    28. Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005 Sep 09; 309(5741):1732-5. PMID: 16151013.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    29. Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18; 17(4):525-35. PMID: 15721256.
      Citations: 445     Fields:    Translation:HumansCells
    30. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004 Feb 13; 303(5660):1010-4. PMID: 14963330.
      Citations: 581     Fields:    Translation:HumansAnimalsCells
    31. Bouchier-Hayes L, Martin SJ. CARDINAL roles in apoptosis and NFkappaB activation. Vitam Horm. 2004; 67:133-47. PMID: 15110175.
      Citations: 3     Fields:    Translation:HumansAnimals
    32. Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SK. Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography. Appl Radiat Isot. 2003 Jan; 58(1):55-62. PMID: 12485664.
      Citations: 16     Fields:    Translation:HumansCells
    33. Bouchier-Hayes L, Martin SJ. CARD games in apoptosis and immunity. . 2002 Jul; 3(7):616-21. PMID: 12101092.
      Citations:    
    34. Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ. Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis. FEBS Lett. 2000 Apr 07; 471(1):93-8. PMID: 10760520.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
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