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Lisa Bouchier-Hayes

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01GM121389     (BOUCHIER-HAYES, LISA)May 1, 2018 - Apr 30, 2023
    NIH
    Non-apoptotic functions of caspase-2 in cell division and genomic stability
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bolívar BE, Vogel TP, Bouchier-Hayes L. Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. FEBS J. 2019 Jul; 286(14):2628-2644. PMID: 31090171.
      View in: PubMed
    2. Charendoff CI, Bouchier-Hayes L. Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp. 2018 03 05; (133). PMID: 29553529.
      View in: PubMed
    3. Bouchier-Hayes L, Sidi S. The nucleolus: A new home for the PIDDosome. Cell Cycle. 2017; 16(17):1562-1563. PMID: 28749201.
      View in: PubMed
    4. Sidi S, Bouchier-Hayes L. Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Mol Cell Oncol. 2017; 4(5):e1348325. PMID: 29057309.
      View in: PubMed
    5. Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017 06 05; 216(6):1795-1810. PMID: 28432080.
      View in: PubMed
    6. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene. 2017 05 11; 36(19):2704-2714. PMID: 27991927.
      View in: PubMed
    7. Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953. PMID: 26804704.
      View in: PubMed
    8. Parsons MJ, Fassio SR, Bouchier-Hayes L. Detection of Initiator Caspase Induced Proximity in Single Cells by Caspase Bimolecular Fluorescence Complementation. Methods Mol Biol. 2016; 1419:41-56. PMID: 27108430.
      View in: PubMed
    9. Sanders MG, Parsons MJ, Howard AG, Liu J, Fassio SR, Martinez JA, Bouchier-Hayes L. Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell Death Dis. 2015 Jul 09; 6:e1813. PMID: 26158519.
      View in: PubMed
    10. Hoyos V, Del Bufalo F, Yagyu S, Ando M, Dotti G, Suzuki M, Bouchier-Hayes L, Alemany R, Brenner MK. Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers. Mol Ther. 2015 Sep; 23(9):1497-506. PMID: 26084970.
      View in: PubMed
    11. Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell. 2015 Mar 05; 57(5):860-872. PMID: 25702873.
      View in: PubMed
    12. Parsons MJ, Bouchier-Hayes L. Measuring initiator caspase activation by bimolecular fluorescence complementation. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082552. PMID: 25561623.
      View in: PubMed
    13. Rehm M, Parsons MJ, Bouchier-Hayes L. Measuring caspase activity by Förster resonance energy transfer. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.prot082560. PMID: 25561624.
      View in: PubMed
    14. Parsons MJ, Rehm M, Bouchier-Hayes L. Imaging-based methods for assessing caspase activity in single cells. Cold Spring Harb Protoc. 2015 Jan 05; 2015(1):pdb.top070342. PMID: 25561626.
      View in: PubMed
    15. Ando M, Hoyos V, Yagyu S, Tao W, Ramos CA, Dotti G, Brenner MK, Bouchier-Hayes L. Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther. 2014 Nov; 21(11):472-482. PMID: 25323693.
      View in: PubMed
    16. Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti G. Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res. 2014 Sep 15; 74(18):5195-205. PMID: 25060519.
      View in: PubMed
    17. Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013 Sep; 20(9):1174-82. PMID: 23645210.
      View in: PubMed
    18. Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93. PMID: 22854598.
      View in: PubMed
    19. Bouchier-Hayes L, Green DR. Caspase-2: the orphan caspase. Cell Death Differ. 2012 Jan; 19(1):51-7. PMID: 22075987.
      View in: PubMed
    20. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31. PMID: 22036586.
      View in: PubMed
    21. Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Muñoz-Pinedo C, Green DR. Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell. 2010 May 18; 18(5):802-13. PMID: 20493813.
      View in: PubMed
    22. Bouchier-Hayes L. The role of caspase-2 in stress-induced apoptosis. J Cell Mol Med. 2010 Jun; 14(6A):1212-24. PMID: 20158568.
      View in: PubMed
    23. Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HM. Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1. Cell Death Differ. 2010 Jun; 17(6):1034-46. PMID: 20150914.
      View in: PubMed
    24. Bouchier-Hayes L, Green DR. Real time with caspase-2. Cell Cycle. 2010 Jan 01; 9(1):12-3. PMID: 20016258.
      View in: PubMed
    25. Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell. 2009 Sep 24; 35(6):830-40. PMID: 19782032.
      View in: PubMed
    26. Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR. Live to dead cell imaging. Methods Mol Biol. 2009; 559:33-48. PMID: 19609747.
      View in: PubMed
    27. Bouchier-Hayes L, Muñoz-Pinedo C, Connell S, Green DR. Measuring apoptosis at the single cell level. Methods. 2008 Mar; 44(3):222-8. PMID: 18314052.
      View in: PubMed
    28. Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 2007 Jun 01; 129(5):983-97. PMID: 17540177.
      View in: PubMed
    29. Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 2006 Aug; 13(8):1396-402. PMID: 16710362.
      View in: PubMed
    30. Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD. Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell. 2006 May; 17(5):2150-7. PMID: 16495337.
      View in: PubMed
    31. Bouchier-Hayes L, Lartigue L, Newmeyer DD. Mitochondria: pharmacological manipulation of cell death. J Clin Invest. 2005 Oct; 115(10):2640-7. PMID: 16200197.
      View in: PubMed
    32. Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005 Sep 09; 309(5741):1732-5. PMID: 16151013.
      View in: PubMed
    33. Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18; 17(4):525-35. PMID: 15721256.
      View in: PubMed
    34. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004 Feb 13; 303(5660):1010-4. PMID: 14963330.
      View in: PubMed
    35. Bouchier-Hayes L, Martin SJ. CARDINAL roles in apoptosis and NFkappaB activation. Vitam Horm. 2004; 67:133-47. PMID: 15110175.
      View in: PubMed
    36. Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EO. In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope. Br J Cancer. 2003 Oct 06; 89(7):1327-33. PMID: 14520468.
      View in: PubMed
    37. Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SK. Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography. Appl Radiat Isot. 2003 Jan; 58(1):55-62. PMID: 12485664.
      View in: PubMed
    38. Bouchier-Hayes L, Martin SJ. CARD games in apoptosis and immunity. EMBO Rep. 2002 Jul; 3(7):616-21. PMID: 12101092.
      View in: PubMed
    39. Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem. 2001 Nov 23; 276(47):44069-77. PMID: 11551959.
      View in: PubMed
    40. Mynett-Johnson L, Kealey C, Claffey E, Curtis D, Bouchier-Hayes L, Powell C, McKeon P. Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder. Am J Med Genet. 2000 Dec 04; 96(6):845-9. PMID: 11121194.
      View in: PubMed
    41. Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ. Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis. FEBS Lett. 2000 Apr 07; 471(1):93-8. PMID: 10760520.
      View in: PubMed
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