TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor Emeritus
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Tropical Medicine

    Collapse Research 
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    R29AI027779     (RICO-HESSE, REBECA)Apr 1, 1989 - Mar 31, 1994
    Role: Principal Investigator

    R03TW000128     (RICO-HESSE, REBECA)Aug 10, 1992 - Aug 9, 1994
    Role: Principal Investigator

    K04AI001124     (RICO-HESSE, REBECA)May 1, 1993 - Apr 30, 1998
    Role: Principal Investigator

    P01AI034533     (ROTHMAN, ALAN L)Jan 1, 1994 - Jul 31, 2023
    Flavivirus Infections: Pathogenesis and Prevention
    Role: Co-Investigator

    R01AI042795     (RICO-HESSE, REBECA)Sep 30, 1998 - Sep 29, 2000
    Role: Principal Investigator

    R01AI050123     (RICO-HESSE, REBECCA R)Aug 15, 2001 - May 31, 2011
    Dengue Virus Determinants of Virulence and Transmission
    Role: Principal Investigator

    R01AI098715     (RICO-HESSE, REBECCA R)Jun 5, 2012 - May 31, 2017
    Therapy of Dengue with Modified Antibodies in Humanized Mice
    Role: Principal Investigator

    R01AI099483     (RICO-HESSE, REBECCA R)Dec 12, 2012 - Nov 30, 2018
    Mosquito Saliva in Dengue Virus Pathogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hibl BM, Dailey Garnes NJM, Kneubehl AR, Vogt MB, Spencer Clinton JL, Rico-Hesse RR. Correction: Mosquito-bite infection of humanized mice with chikungunya virus produces systemic disease with long-term effects. PLoS Negl Trop Dis. 2022 Jun; 16(6):e0010503. PMID: 35653345.
      Citations:    Fields:    
    2. Nie S, Zhao J, Wu X, Yao Y, Wu F, Lin YL, Li X, Kneubehl AR, Vogt MB, Rico-Hesse R, Song Y. Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease. Eur J Med Chem. 2021 Dec 05; 225:113767. PMID: 34450494.
      Citations: 2     Fields:    Translation:Cells
    3. Hibl BM, Dailey Garnes NJM, Kneubehl AR, Vogt MB, Spencer Clinton JL, Rico-Hesse RR. Mosquito-bite infection of humanized mice with chikungunya virus produces systemic disease with long-term effects. PLoS Negl Trop Dis. 2021 06; 15(6):e0009427. PMID: 34106915.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    4. Nie S, Yao Y, Wu F, Wu X, Zhao J, Hua Y, Wu J, Huo T, Lin YL, Kneubehl AR, Vogt MB, Ferreon J, Rico-Hesse R, Song Y. Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J Med Chem. 2021 03 11; 64(5):2777-2800. PMID: 33596380.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Spencer Clinton JL, Tran LL, Vogt MB, Rowley DR, Kimata JT, Rico-Hesse R. IP-10 and CXCR3 signaling inhibit Zika virus replication in human prostate cells. PLoS One. 2020; 15(12):e0244587. PMID: 33378361.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Vogt MB, Lahon A, Arya RP, Spencer Clinton JL, Rico-Hesse R. Dengue viruses infect human megakaryocytes, with probable clinical consequences. PLoS Negl Trop Dis. 2019 11; 13(11):e0007837. PMID: 31765380.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    7. Yao Y, Huo T, Lin YL, Nie S, Wu F, Hua Y, Wu J, Kneubehl AR, Vogt MB, Rico-Hesse R, Song Y. Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J Am Chem Soc. 2019 05 01; 141(17):6832-6836. PMID: 31017399.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    8. Vogt MB, Lahon A, Arya RP, Kneubehl AR, Spencer Clinton JL, Paust S, Rico-Hesse R. Mosquito saliva alone has profound effects on the human immune system. PLoS Negl Trop Dis. 2018 05; 12(5):e0006439. PMID: 29771921.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    9. Spencer JL, Lahon A, Tran LL, Arya RP, Kneubehl AR, Vogt MB, Xavier D, Rowley DR, Kimata JT, Rico-Hesse RR. Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus. J Infect Dis. 2018 01 30; 217(4):538-547. PMID: 28968863.
      Citations: 20     Fields:    Translation:HumansCells
    10. Smith DB, Meyers G, Bukh J, Gould EA, Monath T, Scott Muerhoff A, Pletnev A, Rico-Hesse R, Stapleton JT, Simmonds P, Becher P. Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae. J Gen Virol. 2017 Aug; 98(8):2106-2112. PMID: 28786787.
      Citations: 117     Fields:    Translation:AnimalsCells
    11. Aagaard KM, Lahon A, Suter MA, Arya RP, Seferovic MD, Vogt MB, Hu M, Stossi F, Mancini MA, Harris RA, Kahr M, Eppes C, Rac M, Belfort MA, Park CS, Lacorazza D, Rico-Hesse R. Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication. Sci Rep. 2017 01 27; 7:41389. PMID: 28128342.
      Citations: 56     Fields:    Translation:HumansCells
    12. Simmonds P, Becher P, Bukh J, Gould EA, Meyers G, Monath T, Muerhoff S, Pletnev A, Rico-Hesse R, Smith DB, Stapleton JT. ICTV Virus Taxonomy Profile: Flaviviridae. J Gen Virol. 2017 01; 98(1):2-3. PMID: 28218572.
      Citations: 229     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    13. Rico-Hesse R. Editorial Overview: Virus-vector interactions. Curr Opin Virol. 2016 12; 21:v-vi. PMID: 27916283.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    14. Smith DB, Becher P, Bukh J, Gould EA, Meyers G, Monath T, Muerhoff AS, Pletnev A, Rico-Hesse R, Stapleton JT, Simmonds P. Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family. J Gen Virol. 2016 Nov; 97(11):2894-2907. PMID: 27692039.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    15. Lahon A, Arya RP, Kneubehl AR, Vogt MB, Dailey Garnes NJ, Rico-Hesse R. Characterization of a Zika Virus Isolate from Colombia. PLoS Negl Trop Dis. 2016 Sep; 10(9):e0005019. PMID: 27654889.
      Citations: 15     Fields:    
    16. Andrus J, Bottazzi ME, Chow J, Goraleski KA, Fisher-Hoch SP, Lambuth JK, Lee BY, Margolis HS, McCormick JB, Melby P, Murray KO, Rico-Hesse R, Valenzuela JG, Hotez PJ. Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas. PLoS Negl Trop Dis. 2013 Jun; 7(6):e2021. PMID: 23826397.
      Citations: 9     Fields:    
    17. Cox J, Mota J, Sukupolvi-Petty S, Diamond MS, Rico-Hesse R. Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice. J Virol. 2012 Jul; 86(14):7637-49. PMID: 22573866.
      Citations: 100     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Mota J, Rico-Hesse R. Dengue virus tropism in humanized mice recapitulates human dengue fever. PLoS One. 2011; 6(6):e20762. PMID: 21695193.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    19. Cox J, Brown HE, Rico-Hesse R. Variation in vector competence for dengue viruses does not depend on mosquito midgut binding affinity. PLoS Negl Trop Dis. 2011 May; 5(5):e1172. PMID: 21610852.
      Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Sukupolvi-Petty S, Austin SK, Engle M, Brien JD, Dowd KA, Williams KL, Johnson S, Rico-Hesse R, Harris E, Pierson TC, Fremont DH, Diamond MS. Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2. J Virol. 2010 Sep; 84(18):9227-39. PMID: 20592088.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    21. Cassetti MC, Durbin A, Harris E, Rico-Hesse R, Roehrig J, Rothman A, Whitehead S, Natarajan R, Laughlin C. Report of an NIAID workshop on dengue animal models. Vaccine. 2010 Jun 11; 28(26):4229-34. PMID: 20434551.
      Citations: 36     Fields:    Translation:HumansAnimals
    22. Vasilakis N, Cardosa J, Diallo M, Sall AA, Holmes EC, Hanley KA, Weaver SC, Mota J, Rico-Hesse R. Sylvatic dengue viruses share the pathogenic potential of urban/endemic dengue viruses. J Virol. 2010 Apr; 84(7):3726-7; author reply 3727-8. PMID: 20212326.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    23. Rico-Hesse R. Dengue virus virulence and transmission determinants. Curr Top Microbiol Immunol. 2010; 338:45-55. PMID: 19802577.
      Citations: 39     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Rico-Hesse R. Dengue virus markers of virulence and pathogenicity. Future Virol. 2009 Nov 01; 4(6):581. PMID: 20161679.
      Citations: 11     
    25. Mota J, Rico-Hesse R. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol. 2009 Sep; 83(17):8638-45. PMID: 19535452.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    26. Rico-Hesse R. Dengue virus evolution and virulence models. Clin Infect Dis. 2007 Jun 01; 44(11):1462-6. PMID: 17479944.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    27. Anderson JR, Rico-Hesse R. Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus. Am J Trop Med Hyg. 2006 Nov; 75(5):886-92. PMID: 17123982.
      Citations: 85     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Bente DA, Rico-Hesse R. Models of dengue virus infection. Drug Discov Today Dis Models. 2006; 3(1):97-103. PMID: 18087566.
      Citations: 39     
    29. Bente DA, Melkus MW, Garcia JV, Rico-Hesse R. Dengue fever in humanized NOD/SCID mice. J Virol. 2005 Nov; 79(21):13797-9. PMID: 16227299.
      Citations: 83     Fields:    Translation:AnimalsCells
    30. Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond J, Lang J, Quentin-Millet MJ, Barrett AD, Brinton MA, Cetron MS, Barwick RS, Chambers TJ, Halstead SB, Roehrig JT, Kinney RM, Rico-Hesse R, Strauss JH. Recombination and flavivirus vaccines: a commentary. Vaccine. 2005 Apr 27; 23(23):2956-8. PMID: 15811640.
      Citations: 13     Fields:    Translation:Cells
    31. Cologna R, Armstrong PM, Rico-Hesse R. Selection for virulent dengue viruses occurs in humans and mosquitoes. J Virol. 2005 Jan; 79(2):853-9. PMID: 15613313.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    32. Armstrong PM, Rico-Hesse R. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. Am J Trop Med Hyg. 2003 May; 68(5):539-44. PMID: 12812340.
      Citations: 76     Fields:    Translation:AnimalsCellsPHPublic Health
    33. Cologna R, Rico-Hesse R. American genotype structures decrease dengue virus output from human monocytes and dendritic cells. J Virol. 2003 Apr; 77(7):3929-38. PMID: 12634353.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    34. Rico-Hesse R. Microevolution and virulence of dengue viruses. Adv Virus Res. 2003; 59:315-41. PMID: 14696333.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    35. Archer AM, Rico-Hesse R. High genetic divergence and recombination in Arenaviruses from the Americas. Virology. 2002 Dec 20; 304(2):274-81. PMID: 12504568.
      Citations: 29     Fields:    Translation:Cells
    36. Mota J, Ramos-CastaƱeda J, Rico-Hesse R, Ramos C. Phylogenetic analysis of the envelope protein (domain III) of dengue 4 viruses. Salud Publica Mex. 2002 May-Jun; 44(3):228-36. PMID: 12132320.
      Citations:    Fields:    Translation:Cells
    37. Armstrong PM, Rico-Hesse R. Differential susceptibility of Aedes aegypti to infection by the American and Southeast Asian genotypes of dengue type 2 virus. Vector Borne Zoonotic Dis. 2001; 1(2):159-68. PMID: 12680353.
      Citations: 72     Fields:    Translation:AnimalsCellsPHPublic Health
    38. Rico-Hesse R. Venezuelan equine encephalomyelitis. Vet Clin North Am Equine Pract. 2000 Dec; 16(3):553-63. PMID: 11219349.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    39. Lanford RE, Chavez D, Rico-Hesse R, Mootnick A. Hepadnavirus infection in captive gibbons. J Virol. 2000 Mar; 74(6):2955-9. PMID: 10684318.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    40. Leitmeyer KC, Vaughn DW, Watts DM, Salas R, Villalobos I, Ramos C, Rico-Hesse R. Dengue virus structural differences that correlate with pathogenesis. J Virol. 1999 Jun; 73(6):4738-47. PMID: 10233934.
      Citations: 190     Fields:    Translation:HumansCells
    41. Oberste MS, Fraire M, Navarro R, Zepeda C, Zarate ML, Ludwig GV, Kondig JF, Weaver SC, Smith JF, Rico-Hesse R. Association of Venezuelan equine encephalitis virus subtype IE with two equine epizootics in Mexico. Am J Trop Med Hyg. 1998 Jul; 59(1):100-7. PMID: 9684636.
      Citations: 33     Fields:    Translation:AnimalsCellsPHPublic Health
    42. Lanford RE, Chavez D, Brasky KM, Burns RB, Rico-Hesse R. Isolation of a hepadnavirus from the woolly monkey, a New World primate. Proc Natl Acad Sci U S A. 1998 May 12; 95(10):5757-61. PMID: 9576957.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    43. Salas RA, Tovar D, Barreto A, de Miller E, Leitmeyer K, Rico-Hesse R. [Serotypes and genotypes of dengue virus circulating in Venezuela, 1990-1997]. Acta Cient Venez. 1998; 49 Suppl 1:33-7. PMID: 10030052.
      Citations: 3     Fields:    Translation:HumansCells
    44. Rico-Hesse R, Harrison LM, Nisalak A, Vaughn DW, Kalayanarooj S, Green S, Rothman AL, Ennis FA. Molecular evolution of dengue type 2 virus in Thailand. Am J Trop Med Hyg. 1998 Jan; 58(1):96-101. PMID: 9452299.
      Citations: 38     Fields:    Translation:HumansCells
    45. Leitmeyer K, Rico-Hesse R. Viral evolution and epidemiology. Curr Opin Infect Dis. 1997 Oct; 10(5):367-371. PMID: 26279607.
      Citations: 1     Fields:    
    46. Powers AM, Oberste MS, Brault AC, Rico-Hesse R, Schmura SM, Smith JF, Kang W, Sweeney WP, Weaver SC. Repeated emergence of epidemic/epizootic Venezuelan equine encephalitis from a single genotype of enzootic subtype ID virus. J Virol. 1997 Sep; 71(9):6697-705. PMID: 9261393.
      Citations: 43     Fields:    Translation:CellsPHPublic Health
    47. Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa MT, Nogueira RM, da Rosa AT. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology. 1997 Apr 14; 230(2):244-51. PMID: 9143280.
      Citations: 195     Fields:    Translation:HumansCells
    48. Weaver SC, Salas R, Rico-Hesse R, Ludwig GV, Oberste MS, Boshell J, Tesh RB. Re-emergence of epidemic Venezuelan equine encephalomyelitis in South America. VEE Study Group. Lancet. 1996 Aug 17; 348(9025):436-40. PMID: 8709783.
      Citations: 113     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Gonzalez JP, Bowen MD, Nichol ST, Rico-Hesse R. Genetic characterization and phylogeny of SabiĆ” virus, an emergent pathogen in Brazil. Virology. 1996 Jul 15; 221(2):318-24. PMID: 8661442.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    50. Gonzalez JP, Sanchez A, Rico-Hesse R. Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting humans. Am J Trop Med Hyg. 1995 Jul; 53(1):1-6. PMID: 7542842.
      Citations: 13     Fields:    Translation:HumansCells
    51. Rico-Hesse R, Weaver SC, de Siger J, Medina G, Salas RA. Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5278-81. PMID: 7777497.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    52. Weaver SC, Bellew LA, Rico-Hesse R. Phylogenetic analysis of alphaviruses in the Venezuelan equine encephalitis complex and identification of the source of epizootic viruses. Virology. 1992 Nov; 191(1):282-90. PMID: 1413507.
      Citations: 32     Fields:    Translation:Cells
    53. Chen WR, Rico-Hesse R, Tesh RB. A new genotype of Japanese encephalitis virus from Indonesia. Am J Trop Med Hyg. 1992 Jul; 47(1):61-9. PMID: 1322071.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    54. Weaver SC, Rico-Hesse R, Scott TW. Genetic diversity and slow rates of evolution in New World alphaviruses. Curr Top Microbiol Immunol. 1992; 176:99-117. PMID: 1318187.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    55. Salas R, de Manzione N, Tesh RB, Rico-Hesse R, Shope RE, Betancourt A, Godoy O, Bruzual R, Pacheco ME, Ramos B, et al. Venezuelan haemorrhagic fever. Lancet. 1991 Oct 26; 338(8774):1033-6. PMID: 1681354.
      Citations: 37     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    56. Weaver SC, Scott TW, Rico-Hesse R. Molecular evolution of eastern equine encephalomyelitis virus in North America. Virology. 1991 Jun; 182(2):774-84. PMID: 2024496.
      Citations: 32     Fields:    Translation:Cells
    57. Chen WR, Tesh RB, Rico-Hesse R. Genetic variation of Japanese encephalitis virus in nature. J Gen Virol. 1990 Dec; 71 ( Pt 12):2915-22. PMID: 2273391.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    58. Rico-Hesse R. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology. 1990 Feb; 174(2):479-93. PMID: 2129562.
      Citations: 165     Fields:    Translation:Cells
    59. Rico-Hesse R, Roehrig JT, Trent DW, Dickerman RW. Genetic variation of Venezuelan equine encephalitis virus strains of the ID variety in Colombia. Am J Trop Med Hyg. 1988 Jan; 38(1):195-204. PMID: 3341520.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    60. Rico-Hesse R, Roehrig JT, Dickerman RW. Monoclonal antibodies define antigenic variation in the ID variety of Venezuelan equine encephalitis virus. Am J Trop Med Hyg. 1988 Jan; 38(1):187-94. PMID: 2449089.
      Citations: 6     Fields:    Translation:AnimalsCells
    61. Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM. Geographic distribution of wild poliovirus type 1 genotypes. Virology. 1987 Oct; 160(2):311-22. PMID: 2821678.
      Citations: 98     Fields:    Translation:CellsPHPublic Health
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