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Ming Zhou

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Overview 
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    Lipid bilayer membranes form water-impermeable barriers that define the boundaries of biological cells and of specialized compartments within cells. Membrane proteins are embedded in lipid bilayers and serve a wide range of essential cellular functions, such as mediating signal transduction through the membrane, facilitating uptake of nutrients and excretion of wastes, and metabolizing of lipids and fatty acids. The main impetus behind my research program is the desire to understand how membrane proteins work at the molecular level, both to improve our understanding of biological mechanisms and to provide information on protein-ligand interactions of physiological and pharmacological significance. In particular, our focus is on two families of proteins, membrane transport proteins that facilitate transmembrane flux of ions and small molecules, and membrane-embedded enzymes that are involved in synthesis and modification of lipids, fatty acids, and cholesterol.

    Collapse Research 
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    R03MH076402     (ZHOU, MING)Sep 15, 2005 - Sep 14, 2006
    NIH/NIMH
    Molecule Modulators:Voltage-Dependent Potassium (RMI)
    Role: Principal Investigator

    R01HL086392     (ZHOU, MING)Mar 15, 2006 - Nov 30, 2018
    NIH/NHLBI
    Mechanism of Gating and Permeation in The TRKH K+ Channels
    Role: Principal Investigator

    R01DK088057     (ZHOU, MING)Jun 1, 2010 - May 31, 2015
    NIH/NIDDK
    Structure and function of urea transporters
    Role: Principal Investigator

    R01GM098878     (ZHOU, MING)Sep 1, 2011 - May 31, 2015
    NIH/NIGMS
    Structure and Function of a Phosphorylation Coupled Saccharide Transporter
    Role: Principal Investigator

    R01DK122784     (ZHOU, MING)Jul 1, 2019 - May 31, 2024
    NIH/NIDDK
    Structure and mechanism of mammalian stearoyl-CoA desaturases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C. Integrin avß3-Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjug Chem. 2018 12 19; 29(12):4062-4071. PMID: 30404438.
      View in: PubMed
    2. Xiong C, Lu W, Zhou M, Wen X, Li C. Cisplatin-loaded hollow gold nanoparticles for laser-triggered release. Cancer Nanotechnol. 2018; 9(1):6. PMID: 30147806.
      View in: PubMed
    3. Ren Z, Lee J, Moosa MM, Nian Y, Hu L, Xu Z, McCoy JG, Ferreon ACM, Im W, Zhou M. Structure of an EIIC sugar transporter trapped in an inward-facing conformation. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):5962-5967. PMID: 29784777.
      View in: PubMed
    4. Kim K, Mitra S, Wu G, Berka V, Song J, Yu Y, Poget S, Wang DN, Tsai AL, Zhou M. Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen. Biochemistry. 2016 Dec 06; 55(48):6673-6684. PMID: 27792302.
      View in: PubMed
    5. Zhao J, Zhou M, Li C. Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnol. 2016; 7(1):9. PMID: 27909463.
      View in: PubMed
    6. Li J, Zhou M, Liu F, Xiong C, Wang W, Cao Q, Wen X, Robertson JD, Ji X, Wang YA, Gupta S, Li C. Hepatocellular Carcinoma: Intra-arterial Delivery of Doxorubicin-loaded Hollow Gold Nanospheres for Photothermal Ablation-Chemoembolization Therapy in Rats. Radiology. 2016 Nov; 281(2):427-435. PMID: 27347765.
      View in: PubMed
    7. Zhou M, Melancon M, Stafford RJ, Li J, Nick AM, Tian M, Sood AK, Li C. Precision Nanomedicine Using Dual PET and MR Temperature Imaging-Guided Photothermal Therapy. J Nucl Med. 2016 Nov; 57(11):1778-1783. PMID: 27283932.
      View in: PubMed
    8. McCoy JG, Ren Z, Stanevich V, Lee J, Mitra S, Levin EJ, Poget S, Quick M, Im W, Zhou M. The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport. Structure. 2016 06 07; 24(6):956-64. PMID: 27161976.
      View in: PubMed
    9. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale. 2015 Dec 14; 7(46):19438-47. PMID: 26376843.
      View in: PubMed
    10. Zhou M, Song S, Zhao J, Tian M, Li C. Theranostic CuS Nanoparticles Targeting Folate Receptors for PET Image-Guided Photothermal Therapy. J Mater Chem B. 2015 Dec 14; 3(46):8939-8948. PMID: 27725882.
      View in: PubMed
    11. Zhao J, Qiao J, Zhou M, Gupta S, Li C, Melancon MP. Anti-tumor Efficacy Study using Irreversible Electroporation and Doxorubicin-loaded Polymeric Micelles. ACS Macro Lett. 2015 Oct 20; 4(10):1081-1084. PMID: 28529822.
      View in: PubMed
    12. Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M. X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 2015 Aug 13; 524(7564):252-6. PMID: 26098370.
      View in: PubMed
    13. Zhao J, Melancon M, Zhou M. Nanoparticle Formulation to Improve the Efficacy of Radiation Therapy Against Radiation-resistant Leukemia. EBioMedicine. 2015 Jun; 2(6):486. PMID: 26288809.
      View in: PubMed
    14. Zhou M, Chen Y, Adachi M, Wen X, Erwin B, Mawlawi O, Lai SY, Li C. Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer. Biomaterials. 2015 Jul; 57:41-9. PMID: 25913249.
      View in: PubMed
    15. Zhou M, Ku G, Pageon L, Li C. Theranostic probe for simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model. Nanoscale. 2014 Dec 21; 6(24):15228-35. PMID: 25379880.
      View in: PubMed
    16. Huang H, Levin EJ, Liu S, Bai Y, Lockless SW, Zhou M. Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. PLoS Biol. 2014 Jul; 12(7):e1001911. PMID: 25051182.
      View in: PubMed
    17. Levin EJ, Zhou M. Recent progress on the structure and function of the TrkH/KtrB ion channel. Curr Opin Struct Biol. 2014 Aug; 27:95-101. PMID: 25011047.
      View in: PubMed
    18. McCoy JG, Levin EJ, Zhou M. Structural insight into the PTS sugar transporter EIIC. Biochim Biophys Acta. 2015 Mar; 1850(3):577-85. PMID: 24657490.
      View in: PubMed
    19. Levin EJ, Zhou M. Structure of urea transporters. Subcell Biochem. 2014; 73:65-78. PMID: 25298339.
      View in: PubMed
    20. Zhou X, Levin EJ, Pan Y, McCoy JG, Sharma R, Kloss B, Bruni R, Quick M, Zhou M. Structural basis of the alternating-access mechanism in a bile acid transporter. Nature. 2014 Jan 23; 505(7484):569-73. PMID: 24317697.
      View in: PubMed
    21. Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, Zhou M. Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature. 2013 Apr 18; 496(7445):317-22. PMID: 23598339.
      View in: PubMed
    22. Pan Y, Levin EJ, Quick M, Zhou M. Potentiation of the Kv1 family K(+) channel by cortisone analogues. ACS Chem Biol. 2012 10 19; 7(10):1641-6. PMID: 22803826.
      View in: PubMed
    23. Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11194-9. PMID: 22733730.
      View in: PubMed
    24. Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M. Crystal structure of a phosphorylation-coupled saccharide transporter. Nature. 2011 May 05; 473(7345):50-4. PMID: 21471968.
      View in: PubMed
    25. Pan Y, Weng J, Levin EJ, Zhou M. Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5885-90. PMID: 21436029.
      View in: PubMed
    26. Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M. Crystal structure of a potassium ion transporter, TrkH. Nature. 2011 Mar 17; 471(7338):336-40. PMID: 21317882.
      View in: PubMed
    27. Levin EJ, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009 Dec 10; 462(7274):757-61. PMID: 19865084.
      View in: PubMed
    28. Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M. Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat Chem Biol. 2008 Nov; 4(11):708-14. PMID: 18806782.
      View in: PubMed
    29. Pan Y, Weng J, Cao Y, Bhosle RC, Zhou M. Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1. J Biol Chem. 2008 Mar 28; 283(13):8634-42. PMID: 18222921.
      View in: PubMed
    30. Lockless SW, Zhou M, MacKinnon R. Structural and thermodynamic properties of selective ion binding in a K+ channel. PLoS Biol. 2007 May; 5(5):e121. PMID: 17472437.
      View in: PubMed
    31. Weng J, Cao Y, Moss N, Zhou M. Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem. 2006 Jun 02; 281(22):15194-200. PMID: 16569641.
      View in: PubMed
    32. Zhou M, MacKinnon R. A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J Mol Biol. 2004 May 07; 338(4):839-46. PMID: 15099749.
      View in: PubMed
    33. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 2001 Jun 07; 411(6838):657-61. PMID: 11395760.
      View in: PubMed
    34. Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science. 2000 Jul 07; 289(5476):123-7. PMID: 10884227.
      View in: PubMed
    35. Grosman C, Zhou M, Auerbach A. Mapping the conformational wave of acetylcholine receptor channel gating. Nature. 2000 Feb 17; 403(6771):773-6. PMID: 10693806.
      View in: PubMed
    36. Zhou M, Engel AG, Auerbach A. Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10466-71. PMID: 10468632.
      View in: PubMed
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