InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Overview 
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    Lipid bilayer membranes form water-impermeable barriers that define the boundaries of biological cells and of specialized compartments within cells. Membrane proteins are embedded in lipid bilayers and serve a wide range of essential cellular functions, such as mediating signal transduction through the membrane, facilitating uptake of nutrients and excretion of wastes, and metabolizing of lipids and fatty acids. The main impetus behind my research program is the desire to understand how membrane proteins work at the molecular level, both to improve our understanding of biological mechanisms and to provide information on protein-ligand interactions of physiological and pharmacological significance. In particular, our focus is on two families of proteins, membrane transport proteins that facilitate transmembrane flux of ions and small molecules, and membrane-embedded enzymes that are involved in synthesis and modification of lipids, fatty acids, and cholesterol.

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    R01GM151548     (QUICK, MATTHIAS)Sep 1, 2023 - May 31, 2027
    Structure and mechanism of pendrin and the mutations that cause Pendred's Syndrome
    Role: Co-Principal Investigator

    R01DK122784     (TSAI, AH-LIM ;ZHOU, MING)Jul 1, 2019 - May 31, 2024
    Structure and mechanism of mammalian stearoyl-CoA desaturases
    Role: Principal Investigator

    R01GM098878     (ZHOU, MING)Sep 1, 2011 - May 31, 2016
    Structure and Function of a Phosphorylation Coupled Saccharide Transporter
    Role: Principal Investigator

    R01DK088057     (ZHOU, MING)Jun 1, 2010 - May 31, 2016
    Structure and function of urea transporters
    Role: Principal Investigator

    R01HL086392     (ZHOU, MING)Mar 15, 2006 - Nov 30, 2019
    Mechanism of Gating and Permeation in The TRKH K+ Channels
    Role: Principal Investigator

    R03MH076402     (ZHOU, MING)Sep 15, 2005 - Sep 14, 2006
    Molecule Modulators:Voltage-Dependent Potassium (RMI)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M. Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat Commun. 2024 Jan 06; 15(1):346. PMID: 38184688; PMCID: PMC10771415.
      Citations:    Fields:    Translation:HumansAnimals
    2. Chen K, Wang L, Shen J, Tsai AL, Zhou M, Wu G. Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2. Elife. 2023 Nov 20; 12. PMID: 37983176; PMCID: PMC10659578.
      Citations:    Fields:    Translation:Humans
    3. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Retraction: Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale. 2023 Sep 01; 15(34):14268. PMID: 37592914; PMCID: PMC10528023.
      Citations:    Fields:    
    4. Diab A, Gogas H, Sandhu S, Long GV, Ascierto PA, Larkin J, Sznol M, Franke F, Ciuleanu TE, Pereira C, Mu?oz Couselo E, Bronzon Damian F, Schenker M, Perfetti A, Lebbe C, Qu?reux G, Meier F, Curti BD, Rojas C, Arriaga Y, Yang H, Ravimohan S, Tagliaferri MA, Khushalani NI, Zhou M, Statkevich P. Bempegaldesleukin Plus Nivolumab in Untreated Advanced Melanoma: The Open-Label, Phase III PIVOT IO 001 Trial Results. J Clin Oncol. 2023 10 20; 41(30):4756-4767. PMID: 37651676; PMCID: PMC10602507.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    5. Shen J, Wu G, Pierce BS, Tsai AL, Zhou M. Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1. J Biol Chem. 2023 07; 299(7):104897. PMID: 37290533; PMCID: PMC10359943.
      Citations:    Fields:    Translation:AnimalsCells
    6. Wang L, Zhou M. Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis. Nat Commun. 2023 05 13; 14(1):2753. PMID: 37179328; PMCID: PMC10182977.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Shen J, Wu G, Pierce BS, Tsai AL, Zhou M. Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1. bioRxiv. 2023 Mar 18. PMID: 36993326; PMCID: PMC10055294.
    8. Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y. Structural basis of ferroportin inhibition by minihepcidin PR73. PLoS Biol. 2023 01; 21(1):e3001936. PMID: 36649314; PMCID: PMC9882908.
      Citations: 2     Fields:    Translation:Humans
    9. Shen J, Wilbon AS, Zhou M, Pan Y. Mechanism of Ca2+ transport by ferroportin. Elife. 2023 01 17; 12. PMID: 36648329; PMCID: PMC9883014.
      Citations: 4     Fields:    Translation:HumansCells
    10. Shen J, Wu G, Tsai AL, Zhou M. Transmembrane helices mediate the formation of a stable ternary complex of b5R, cyt b5, and SCD1. Commun Biol. 2022 09 12; 5(1):956. PMID: 36097052; PMCID: PMC9468158.
    11. Shen J, Hu M, Fan X, Ren Z, Portioli C, Yan X, Rong M, Zhou M. Extracellular domain of PepT1 interacts with TM1 to facilitate substrate transport. Structure. 2022 07 07; 30(7):1035-1041.e3. PMID: 35580608; PMCID: PMC10404463.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Wang L, Chen K, Zhou M. Structure and function of an Arabidopsis thaliana sulfate transporter. Nat Commun. 2021 07 22; 12(1):4455. PMID: 34294705; PMCID: PMC8298490.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M. Structural basis of ion transport and inhibition in ferroportin. Nat Commun. 2020 11 10; 11(1):5686. PMID: 33173040; PMCID: PMC7655804.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Shen J, Wu G, Tsai AL, Zhou M. Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase. J Mol Biol. 2020 08 21; 432(18):5152-5161. PMID: 32470559; PMCID: PMC7483794.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    15. Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase?1. Nature. 2020 05; 581(7808):329-332. PMID: 32433610; PMCID: PMC7255049.
      Citations: 13     Fields:    Translation:HumansCells
    16. Lee S, Zhao L, Rojas C, Bateman NW, Yao H, Lara OD, Celestino J, Morgan MB, Nguyen TV, Conrads KA, Rangel KM, Dood RL, Hajek RA, Fawcett GL, Chu RA, Wilson K, Loffredo JL, Viollet C, Jazaeri AA, Dalgard CL, Mao X, Song X, Zhou M, Hood BL, Banskota N, Wilkerson MD, Te J, Soltis AR, Roman K, Dunn A, Cordover D, Eterovic AK, Liu J, Burks JK, Baggerly KA, Fleming ND, Lu KH, Westin SN, Coleman RL, Mills GB, Casablanca Y, Zhang J, Conrads TP, Maxwell GL, Futreal PA, Sood AK. Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer. Cell Rep. 2020 04 14; 31(2):107502. PMID: 32294438; PMCID: PMC7234854.
      Citations: 26     Fields:    Translation:Humans
    17. Cao Q, Wang W, Zhou M, Huang Q, Wen X, Zhao J, Shi S, Geng K, Li F, Hatakeyama H, Xu C, Piwnica-Worms D, Peng W, Zhou D, Sood AK, Li C. Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine. 2020 04; 25:102169. PMID: 32059873; PMCID: PMC7181381.
      Citations: 7     Fields:    Translation:HumansAnimals
    18. Zhang H, Pan Y, Hu L, Hudson MA, Hofstetter KS, Xu Z, Rong M, Wang Z, Prasad BVV, Lockless SW, Chiu W, Zhou M. TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun. 2020 Jan 28; 11(1):547. PMID: 31992706; PMCID: PMC6987127.
      Citations: 6     Fields:    Translation:Cells
    19. Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C. Integrin av?3-Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjug Chem. 2018 12 19; 29(12):4062-4071. PMID: 30404438; PMCID: PMC6693325.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Xiong C, Lu W, Zhou M, Wen X, Li C. Cisplatin-loaded hollow gold nanoparticles for laser-triggered release. Cancer Nanotechnol. 2018; 9(1):6. PMID: 30147806; PMCID: PMC6096947.
    21. Ren Z, Lee J, Moosa MM, Nian Y, Hu L, Xu Z, McCoy JG, Ferreon ACM, Im W, Zhou M. Structure of an EIIC sugar transporter trapped in an inward-facing conformation. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):5962-5967. PMID: 29784777; PMCID: PMC6003338.
      Citations: 6     Fields:    Translation:Cells
    22. Kim K, Mitra S, Wu G, Berka V, Song J, Yu Y, Poget S, Wang DN, Tsai AL, Zhou M. Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen. Biochemistry. 2016 Dec 06; 55(48):6673-6684. PMID: 27792302; PMCID: PMC7251975.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    23. Zhao J, Zhou M, Li C. Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnol. 2016; 7(1):9. PMID: 27909463; PMCID: PMC5112292.
      Citations: 11     
    24. Li J, Zhou M, Liu F, Xiong C, Wang W, Cao Q, Wen X, Robertson JD, Ji X, Wang YA, Gupta S, Li C. Hepatocellular Carcinoma: Intra-arterial Delivery of Doxorubicin-loaded Hollow Gold Nanospheres for Photothermal Ablation-Chemoembolization Therapy in Rats. Radiology. 2016 Nov; 281(2):427-435. PMID: 27347765; PMCID: PMC5069072.
      Citations: 10     Fields:    Translation:AnimalsCells
    25. Zhou M, Melancon M, Stafford RJ, Li J, Nick AM, Tian M, Sood AK, Li C. Precision Nanomedicine Using Dual PET and MR Temperature Imaging-Guided Photothermal Therapy. J Nucl Med. 2016 Nov; 57(11):1778-1783. PMID: 27283932; PMCID: PMC5093070.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    26. McCoy JG, Ren Z, Stanevich V, Lee J, Mitra S, Levin EJ, Poget S, Quick M, Im W, Zhou M. The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport. Structure. 2016 06 07; 24(6):956-64. PMID: 27161976; PMCID: PMC4899283.
      Citations: 19     Fields:    Translation:Cells
    27. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale. 2015 Dec 14; 7(46):19438-47. PMID: 26376843; PMCID: PMC4993020.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    28. Zhou M, Song S, Zhao J, Tian M, Li C. Theranostic CuS Nanoparticles Targeting Folate Receptors for PET Image-Guided Photothermal Therapy. J Mater Chem B. 2015 Dec 14; 3(46):8939-8948. PMID: 27725882; PMCID: PMC5055749.
      Citations: 13     Fields:    
    29. Zhao J, Qiao J, Zhou M, Gupta S, Li C, Melancon MP. Anti-tumor Efficacy Study using Irreversible Electroporation and Doxorubicin-loaded Polymeric Micelles. ACS Macro Lett. 2015 Oct 20; 4(10):1081-1084. PMID: 28529822; PMCID: PMC5435371.
      Citations: 4     Fields:    
    30. Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M. X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 2015 Aug 13; 524(7564):252-6. PMID: 26098370; PMCID: PMC4689147.
      Citations: 81     Fields:    Translation:AnimalsCells
    31. Zhao J, Melancon M, Zhou M. Nanoparticle Formulation to Improve the Efficacy of Radiation Therapy Against Radiation-resistant Leukemia. EBioMedicine. 2015 Jun; 2(6):486. PMID: 26288809; PMCID: PMC4535157.
      Citations: 1     Fields:    Translation:HumansAnimals
    32. Zhou M, Chen Y, Adachi M, Wen X, Erwin B, Mawlawi O, Lai SY, Li C. Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer. Biomaterials. 2015 Jul; 57:41-9. PMID: 25913249; PMCID: PMC4426239.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    33. Zhou M, Ku G, Pageon L, Li C. Theranostic probe for simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model. Nanoscale. 2014 Dec 21; 6(24):15228-35. PMID: 25379880; PMCID: PMC4389689.
      Citations: 18     Fields:    Translation:AnimalsCells
    34. Huang H, Levin EJ, Liu S, Bai Y, Lockless SW, Zhou M. Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. PLoS Biol. 2014 Jul; 12(7):e1001911. PMID: 25051182; PMCID: PMC4106721.
      Citations: 38     Fields:    Translation:HumansCells
    35. Levin EJ, Zhou M. Recent progress on the structure and function of the TrkH/KtrB ion channel. Curr Opin Struct Biol. 2014 Aug; 27:95-101. PMID: 25011047; PMCID: PMC4182332.
      Citations: 6     Fields:    Translation:AnimalsCells
    36. McCoy JG, Levin EJ, Zhou M. Structural insight into the PTS sugar transporter EIIC. Biochim Biophys Acta. 2015 Mar; 1850(3):577-85. PMID: 24657490; PMCID: PMC4169766.
      Citations: 19     Fields:    Translation:Cells
    37. Levin EJ, Zhou M. Structure of urea transporters. Subcell Biochem. 2014; 73:65-78. PMID: 25298339; PMCID: PMC4422644.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    38. Zhou X, Levin EJ, Pan Y, McCoy JG, Sharma R, Kloss B, Bruni R, Quick M, Zhou M. Structural basis of the alternating-access mechanism in a bile acid transporter. Nature. 2014 Jan 23; 505(7484):569-73. PMID: 24317697; PMCID: PMC4142352.
      Citations: 55     Fields:    Translation:Cells
    39. Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, Zhou M. Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature. 2013 Apr 18; 496(7445):317-22. PMID: 23598339; PMCID: PMC3726529.
      Citations: 43     Fields:    Translation:Cells
    40. Pan Y, Levin EJ, Quick M, Zhou M. Potentiation of the Kv1 family K(+) channel by cortisone analogues. ACS Chem Biol. 2012 10 19; 7(10):1641-6. PMID: 22803826; PMCID: PMC3567311.
      Citations: 4     Fields:    Translation:HumansCells
    41. Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11194-9. PMID: 22733730; PMCID: PMC3396522.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    42. Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M. Crystal structure of a phosphorylation-coupled saccharide transporter. Nature. 2011 May 05; 473(7345):50-4. PMID: 21471968; PMCID: PMC3201810.
      Citations: 33     Fields:    Translation:Cells
    43. Pan Y, Weng J, Levin EJ, Zhou M. Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5885-90. PMID: 21436029; PMCID: PMC3078402.
      Citations: 17     Fields:    Translation:AnimalsCells
    44. Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M. Crystal structure of a potassium ion transporter, TrkH. Nature. 2011 Mar 17; 471(7338):336-40. PMID: 21317882; PMCID: PMC3077569.
      Citations: 61     Fields:    Translation:Cells
    45. Levin EJ, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009 Dec 10; 462(7274):757-61. PMID: 19865084; PMCID: PMC2871279.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    46. Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M. Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat Chem Biol. 2008 Nov; 4(11):708-14. PMID: 18806782; PMCID: PMC2633621.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    47. Pan Y, Weng J, Cao Y, Bhosle RC, Zhou M. Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1. J Biol Chem. 2008 Mar 28; 283(13):8634-42. PMID: 18222921; PMCID: PMC2417172.
      Citations: 31     Fields:    Translation:AnimalsCells
    48. Lockless SW, Zhou M, MacKinnon R. Structural and thermodynamic properties of selective ion binding in a K+ channel. PLoS Biol. 2007 May; 5(5):e121. PMID: 17472437; PMCID: PMC1858713.
      Citations: 107     Fields:    Translation:Cells
    49. Weng J, Cao Y, Moss N, Zhou M. Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem. 2006 Jun 02; 281(22):15194-200. PMID: 16569641; PMCID: PMC2862575.
      Citations: 56     Fields:    Translation:AnimalsCells
    50. Zhou M, MacKinnon R. A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J Mol Biol. 2004 May 07; 338(4):839-46. PMID: 15099749.
      Citations: 62     Fields:    Translation:Cells
    51. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 2001 Jun 07; 411(6838):657-61. PMID: 11395760.
      Citations: 240     Fields:    Translation:AnimalsCells
    52. Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science. 2000 Jul 07; 289(5476):123-7. PMID: 10884227.
      Citations: 118     Fields:    Translation:AnimalsCells
    53. Grosman C, Zhou M, Auerbach A. Mapping the conformational wave of acetylcholine receptor channel gating. Nature. 2000 Feb 17; 403(6771):773-6. PMID: 10693806.
      Citations: 170     Fields:    Translation:Cells
    54. Zhou M, Engel AG, Auerbach A. Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10466-71. PMID: 10468632; PMCID: PMC17912.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
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