LYNN ZECHIEDRICH

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    1981 - 1982Freshman Academic Tuition Scholarship, University of Arkansas
    1989Vanderbilt University Travel Awards (three), Vanderbilt University School of Medicine
    1989First Place, Graduate Student Oral Presentation, The Eastern Student Research Forum, University of Miami School of Medicine
    1989Outstanding (First Place) Graduate Student Presentation, Student Research Day, Vanderbilt University
    1990Travel Award to attend Mathematical Approaches to DNA, Santa Fe, NM
    1991 - 1994National Institutes of Health Postdoctoral Fellowship
    1994National Institutes of Environmental Health Sciences Center Pilot Study Grant , University of California, Berkeley
    1994 - 1997Leukemia Society of America (Leukemia and Lymphoma Society) Special (Senior) Postdoctoral Fellowship
    1997Fellowship from Juan March Institute, Madrid, to speak at International workshop
    1998 - 1999Curtis Hankamer Research Award , Baylor College of Medicine
    1998 - 2002Burroughs Wellcome Fund New Investigator Award in the Toxicological Sciences
    2004Burroughs Wellcome Fund Award
    2007Finalist, NIH Director's Pioneer Award
    2009Applied Biosystems SOLiDTM 3 System $10K Genome Award
    2010 - 2013Human Frontier Science Program Research Grant
    2011 - 2013John S. Dunn Foundation Collaborative Research Award
    2013Baylor Research Advocates for Student Scientists (BRASS) mentor of the year award, Baylor College of Medicine

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blunck BN, Aideyan L, Ye X, Avadhanula V, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. A prospective surveillance study on the kinetics of the humoral immune response to the respiratory syncytial virus fusion protein in adults in Houston, Texas. Vaccine. 2021 Feb 22; 39(8):1248-1256. PMID: 33509697.
      Citations:    Fields:    
    2. Zechiedrich L, Fogg JM. BIOPHYSICS MEETS GENE THERAPY: HOW EXPLORING SUPERCOILING-DEPENDENT STRUCTURAL CHANGES IN DNA LED TO THE DEVELOPMENT OF MINIVECTOR DNA. Technol Innov. 2019 Aug; 20(4):427-439. PMID: 33815681.
      Citations:    
    3. Conley ZC, Carlson-Banning KM, Carter AG, de la Cova A, Song Y, Zechiedrich L. Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli. PLoS One. 2019; 14(1):e0210547. PMID: 30633761.
      Citations: 2     Fields:    Translation:Cells
    4. Conley ZC, Bodine TJ, Chou A, Zechiedrich L. Wicked: The untold story of ciprofloxacin. PLoS Pathog. 2018 03; 14(3):e1006805. PMID: 29494701.
      Citations: 6     Fields:    Translation:HumansCells
    5. Bizard AH, Yang X, Débat H, Fogg JM, Zechiedrich L, Strick TR, Garnier F, Nadal M. TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase. Nucleic Acids Res. 2018 01 25; 46(2):861-872. PMID: 29253195.
      Citations: 3     Fields:    Translation:Cells
    6. Koire A, Gilbert BE, Sucgang R, Zechiedrich L. Correction: Repurposed Transcriptomic Data Reveal Small Viral RNA Produced by Influenza Virus during Infection in Mice. PLoS One. 2017; 12(12):e0189384. PMID: 29206873.
      Citations:    Fields:    
    7. Wang Q, Irobalieva RN, Chiu W, Schmid MF, Fogg JM, Zechiedrich L, Pettitt BM. Influence of DNA sequence on the structure of minicircles under torsional stress. Nucleic Acids Res. 2017 Jul 27; 45(13):7633-7642. PMID: 28609782.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Bodine TJ, Evangelista MA, Chang HT, Ayoub CA, Samuel BS, Sucgang R, Zechiedrich L. Escherichia coli DNA ligase B may mitigate damage from oxidative stress. PLoS One. 2017; 12(7):e0180800. PMID: 28700629.
      Citations: 1     Fields:    Translation:Cells
    9. Hardee CL, Arévalo-Soliz LM, Hornstein BD, Zechiedrich L. Advances in Non-Viral DNA Vectors for Gene Therapy. Genes (Basel). 2017 Feb 10; 8(2). PMID: 28208635.
      Citations: 44     Fields:    
    10. Hornstein BD, Roman D, Arévalo-Soliz LM, Engevik MA, Zechiedrich L. Effects of Circular DNA Length on Transfection Efficiency by Electroporation into HeLa Cells. PLoS One. 2016; 11(12):e0167537. PMID: 27918590.
      Citations: 16     Fields:    Translation:HumansCells
    11. Koire A, Gilbert BE, Sucgang R, Zechiedrich L. Repurposed Transcriptomic Data Reveal Small Viral RNA Produced by Influenza Virus during Infection in Mice. PLoS One. 2016; 11(10):e0165729. PMID: 27788253.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Bates D, Pettitt BM, Buck GR, Zechiedrich L. Importance of disentanglement and entanglement during DNA replication and segregation: Comment on: "Disentangling DNA molecules" by Alexander Vologodskii. Phys Life Rev. 2016 09; 18:160-164. PMID: 27666770.
      Citations:    Fields:    Translation:Cells
    13. Chou A, Nuila RE, Franco LM, Stager CE, Atmar RL, Zechiedrich L. Prevalence of hypervirulent Klebsiella pneumoniae-associated genes rmpA and magA in two tertiary hospitals in Houston, TX, USA. J Med Microbiol. 2016 Sep; 65(9):1047-1048. PMID: 27392968.
      Citations: 2     Fields:    Translation:HumansCells
    14. Chou A, Roa M, Evangelista MA, Sulit AK, Lagamayo E, Torres BC, Klinzing DC, Daroy ML, Navoa-Ng J, Sucgang R, Zechiedrich L. Emergence of Klebsiella pneumoniae ST273 Carrying blaNDM-7 and ST656 Carrying blaNDM-1 in Manila, Philippines. Microb Drug Resist. 2016 Oct; 22(7):585-588. PMID: 27032000.
      Citations: 8     Fields:    Translation:HumansCells
    15. Irobalieva RN, Fogg JM, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. Erratum: Structural diversity of supercoiled DNA. Nat Commun. 2015 Oct 29; 6:8851. PMID: 26511109.
      Citations: 5     Fields:    
    16. Irobalieva RN, Fogg JM, Catanese DJ, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. Structural diversity of supercoiled DNA. Nat Commun. 2015 Oct 12; 6:8440. PMID: 26455586.
      Citations: 31     Fields:    Translation:Cells
    17. Pandey N, Nobles CL, Zechiedrich L, Maresso AW, Silberg JJ. Combining random gene fission and rational gene fusion to discover near-infrared fluorescent protein fragments that report on protein-protein interactions. ACS Synth Biol. 2015 May 15; 4(5):615-24. PMID: 25265085.
      Citations: 8     Fields:    
    18. Carlson-Banning, Kimberly M. Zechiedrich, Lynn. Encyclopedia of Metagenomics (Karen E. Nelson, editor). Antibiotic Classes and Mechanisms of Resistance. 2014; (303370). View Publication.
    19. Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One. 2013; 8(7):e69646. PMID: 23936064.
      Citations: 17     Fields:    Translation:HumansCells
    20. Swick MC, Evangelista MA, Bodine TJ, Easton-Marks JR, Barth P, Shah MJ, Bormann Chung CA, Stanley S, McLaughlin SF, Lee CC, Sheth V, Doan Q, Hamill RJ, Steffen D, Becnel LB, Sucgang R, Zechiedrich L. Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates. PLoS One. 2013; 8(6):e65961. PMID: 23824211.
      Citations: 6     Fields:    Translation:Cells
    21. Fogg JM, Randall GL, Pettitt BM, Sumners WL, Harris SA, Zechiedrich L. Bullied no more: when and how DNA shoves proteins around. Q Rev Biophys. 2012 Aug; 45(3):257-299. PMID: 22850561.
      Citations: 28     Fields:    Translation:HumansCells
    22. Zechiedrich L. Editorial comment to genome-wide transcriptome analysis of fluoroquinolone resistance in clinical isolates of Escherichia coli. Int J Urol. 2012 Apr; 19(4):368-9. PMID: 22394085.
      Citations:    Fields:    Translation:HumansCells
    23. Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH. Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother. 2012 Apr; 56(4):1680-5. PMID: 22232279.
      Citations: 24     Fields:    Translation:Cells
    24. Catanese DJ, Fogg JM, Schrock DE, Gilbert BE, Zechiedrich L. Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery. Gene Ther. 2012 Jan; 19(1):94-100. PMID: 21633394.
      Citations: 21     Fields:    Translation:HumansCells
    25. Swick MC, Morgan-Linnell SK, Carlson KM, Zechiedrich L. Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrob Agents Chemother. 2011 Feb; 55(2):921-4. PMID: 21098250.
      Citations: 49     Fields:    Translation:HumansCells
    26. Zhao N, Fogg JM, Zechiedrich L, Zu Y. Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells. Gene Ther. 2011 Mar; 18(3):220-4. PMID: 20962872.
      Citations: 22     Fields:    Translation:HumansCells
    27. Zechiedrich L, Osheroff N. Topoisomerase IB-DNA interactions: X marks the spot. Structure. 2010 Jun 09; 18(6):661-3. PMID: 20541502.
      Citations: 3     Fields:    
    28. Liu Z, Zechiedrich L, Chan HS. Action at hooked or twisted-hooked DNA juxtapositions rationalizes unlinking preference of type-2 topoisomerases. J Mol Biol. 2010 Jul 30; 400(5):963-82. PMID: 20460130.
      Citations: 14     Fields:    
    29. Liu Z, Zechiedrich L, Chan HS. Local site preference rationalizes disentangling by DNA topoisomerases. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Mar; 81(3 Pt 1):031902. PMID: 20365765.
      Citations: 5     Fields:    Translation:Cells
    30. Randall GL, Zechiedrich L, Pettitt BM. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form. Nucleic Acids Res. 2009 Sep; 37(16):5568-77. PMID: 19586933.
      Citations: 32     Fields:    Translation:Cells
    31. Liu Z, Deibler RW, Chan HS, Zechiedrich L. The why and how of DNA unlinking. Nucleic Acids Res. 2009 Feb; 37(3):661-71. PMID: 19240147.
      Citations: 36     Fields:    Translation:Cells
    32. Becnel Boyd L, Maynard MJ, Morgan-Linnell SK, Horton LB, Sucgang R, Hamill RJ, Jimenez JR, Versalovic J, Steffen D, Zechiedrich L. Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):229-34. PMID: 18838594.
      Citations: 23     Fields:    Translation:Cells
    33. Morgan-Linnell SK, Becnel Boyd L, Steffen D, Zechiedrich L. Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):235-41. PMID: 18838592.
      Citations: 55     Fields:    Translation:HumansCells
    34. Boyd LB, Atmar RL, Randall GL, Hamill RJ, Steffen D, Zechiedrich L. Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location. BMC Infect Dis. 2008 Jan 15; 8:4. PMID: 18197977.
      Citations: 28     Fields:    Translation:HumansCellsPHPublic Health
    35. Morgan-Linnell SK, Hiasa H, Zechiedrich L, Nitiss JL. Assessing sensitivity to antibacterial topoisomerase II inhibitors. Curr Protoc Pharmacol. 2007 Dec; Chapter 3:Unit3.13. PMID: 21948169.
      Citations:    Fields:    
    36. Morgan-Linnell SK, Zechiedrich L. Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother. 2007 Nov; 51(11):4205-8. PMID: 17682104.
      Citations: 23     Fields:    Translation:Cells
    37. Deibler RW, Mann JK, Sumners de WL, Zechiedrich L. Hin-mediated DNA knotting and recombining promote replicon dysfunction and mutation. BMC Mol Biol. 2007 May 25; 8:44. PMID: 17531098.
      Citations: 25     Fields:    Translation:Cells
    38. Liu Z, Mann JK, Zechiedrich EL, Chan HS. Topological information embodied in local juxtaposition geometry provides a statistical mechanical basis for unknotting by type-2 DNA topoisomerases. J Mol Biol. 2006 Aug 11; 361(2):268-85. PMID: 16842819.
      Citations: 20     Fields:    Translation:Cells
    39. Fogg JM, Kolmakova N, Rees I, Magonov S, Hansma H, Perona JJ, Zechiedrich EL. Exploring writhe in supercoiled minicircle DNA. J Phys Condens Matter. 2006 Apr 12; 18(14):S145-S159. PMID: 19337583.
      Citations: 25     Fields:    
    40. Randall GL, Pettitt BM, Buck GR, Zechiedrich EL. Electrostatics of DNA-DNA juxtapositions: consequences for type II topoisomerase function. J Phys Condens Matter. 2006 Apr 12; 18(14):S173-S185. PMID: 19088861.
      Citations: 11     Fields:    
    41. Liu Z, Zechiedrich EL, Chan HS. Inferring global topology from local juxtaposition geometry: interlinking polymer rings and ramifications for topoisomerase action. Biophys J. 2006 Apr 01; 90(7):2344-55. PMID: 16537549.
      Citations: 12     Fields:    Translation:Cells
    42. Yang S, Lopez CR, Zechiedrich EL. Quorum sensing and multidrug transporters in Escherichia coli. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2386-91. PMID: 16467145.
      Citations: 33     Fields:    Translation:Cells
    43. Lopez CR, Yang S, Deibler RW, Ray SA, Pennington JM, Digate RJ, Hastings PJ, Rosenberg SM, Zechiedrich EL. A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol Microbiol. 2005 Oct; 58(1):80-101. PMID: 16164551.
      Citations: 29     Fields:    Translation:Cells
    44. Gruger T, Nitiss JL, Maxwell A, Zechiedrich EL, Heisig P, Seeber S, Pommier Y, Strumberg D. A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II. Antimicrob Agents Chemother. 2004 Dec; 48(12):4495-504. PMID: 15561817.
      Citations: 11     Fields:    Translation:Cells
    45. Buck GR, Zechiedrich EL. DNA disentangling by type-2 topoisomerases. J Mol Biol. 2004 Jul 23; 340(5):933-9. PMID: 15236957.
      Citations: 37     Fields:    Translation:Cells
    46. Yang S, Clayton SR, Zechiedrich EL. Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli. J Antimicrob Chemother. 2003 Mar; 51(3):545-56. PMID: 12615854.
      Citations: 33     Fields:    Translation:Cells
    47. Rahmati S, Yang S, Davidson AL, Zechiedrich EL. Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. Mol Microbiol. 2002 Feb; 43(3):677-85. PMID: 11929524.
      Citations: 47     Fields:    Translation:Cells
    48. Deibler RW, Rahmati S, Zechiedrich EL. Topoisomerase IV, alone, unknots DNA in E. coli. Genes Dev. 2001 Mar 15; 15(6):748-61. PMID: 11274059.
      Citations: 36     Fields:    Translation:Cells
    49. Zechiedrich EL, Khodursky AB, Bachellier S, Schneider R, Chen D, Lilley DM, Cozzarelli NR. Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J Biol Chem. 2000 Mar 17; 275(11):8103-13. PMID: 10713132.
      Citations: 129     Fields:    Translation:Cells
    50. Zechiedrich EL, Crisona NJ. Coating DNA with RecA protein to distinguish DNA path by electron microscopy. Methods Mol Biol. 1999; 94:99-107. PMID: 12844866.
      Citations: 5     Fields:    Translation:Cells
    51. Zechiedrich EL, Khodursky AB, Cozzarelli NR. Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. Genes Dev. 1997 Oct 01; 11(19):2580-92. PMID: 9334322.
      Citations: 74     Fields:    Translation:Cells
    52. Khodursky AB, Zechiedrich EL, Cozzarelli NR. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11801-5. PMID: 8524852.
      Citations: 123     Fields:    Translation:Cells
    53. Zechiedrich EL, Cozzarelli NR. Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 1995 Nov 15; 9(22):2859-69. PMID: 7590259.
      Citations: 110     Fields:    Translation:Cells
    54. Crisona NJ, Kanaar R, Gonzalez TN, Zechiedrich EL, Klippel A, Cozzarelli NR. Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange. J Mol Biol. 1994 Oct 28; 243(3):437-57. PMID: 7966272.
      Citations: 27     Fields:    Translation:Cells
    55. Adams DE, Shekhtman EM, Zechiedrich EL, Schmid MB, Cozzarelli NR. The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication. Cell. 1992 Oct 16; 71(2):277-88. PMID: 1330320.
      Citations: 104     Fields:    Translation:Cells
    56. Corbett AH, Zechiedrich EL, Osheroff N. A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavage. J Biol Chem. 1992 Jan 15; 267(2):683-6. PMID: 1309770.
      Citations: 18     Fields:    Translation:AnimalsCells
    57. Corbett AH, Zechiedrich EL, Lloyd RS, Osheroff N. Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers. J Biol Chem. 1991 Oct 15; 266(29):19666-71. PMID: 1655791.
      Citations: 8     Fields:    Translation:AnimalsCells
    58. Osheroff N, Zechiedrich EL, Gale KC. Catalytic function of DNA topoisomerase II. Bioessays. 1991 Jun; 13(6):269-73. PMID: 1654050.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    59. Zechiedrich EL, Osheroff N. Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers. EMBO J. 1990 Dec; 9(13):4555-62. PMID: 2176156.
      Citations: 75     Fields:    Translation:AnimalsCells
    60. Andersen AH, Christiansen K, Zechiedrich EL, Jensen PS, Osheroff N, Westergaard O. Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction. Biochemistry. 1989 Jul 25; 28(15):6237-44. PMID: 2551368.
      Citations: 13     Fields:    Translation:AnimalsCells
    61. Zechiedrich EL, Christiansen K, Andersen AH, Westergaard O, Osheroff N. Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. Biochemistry. 1989 Jul 25; 28(15):6229-36. PMID: 2551367.
      Citations: 34     Fields:    Translation:AnimalsCells
    62. Osheroff N, Zechiedrich EL. Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form. Biochemistry. 1987 Jul 14; 26(14):4303-9. PMID: 2822084.
      Citations: 44     Fields:    Translation:AnimalsCells
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