Last Name


TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES STREET
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hu Y, Wu Q, Peng Z, Sprague SA, Wang W, Park J, Akhunov E, Jagadish KSV, Nakata PA, Cheng N, Hirschi KD, White FF, Park S. Silencing of OsGRXS17 in rice improves drought stress tolerance by modulating ROS accumulation and stomatal closure. Sci Rep. 2017 Nov 21; 7(1):15950. PMID: 29162892.
      View in: PubMed
    2. Wu Q, Hu Y, Sprague SA, Kakeshpour T, Park J, Nakata PA, Cheng N, Hirschi KD, White FF, Park S. Expression of a monothiol glutaredoxin, AtGRXS17, in tomato (Solanum lycopersicum) enhances drought tolerance. Biochem Biophys Res Commun. 2017 Aug 02. PMID: 28780355.
      View in: PubMed
    3. Hao J, Unternaehrer J, Cui X, Cheng N, Oji Y. Regulation of Stemness in Carcinoma Cells. Stem Cells Int. 2017; 2017:7681769. PMID: 28819365.
      View in: PubMed
    4. Jiang X, Chen J, Baji? A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maleti?-Savati? M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 Jul 13; 8:16087. PMID: 28703127.
      View in: PubMed
    5. Wu, Q., Yang, J., Cheng, N., Hirschi, K.D., White, F.F., and Park, S. . Glutaredoxins in plant development, abiotic stress response, and iron homeostasis: From model organisms to crops. Environmental and Experimental Botany. 2017; (139):91-98.
    6. Yu H, Yang J, Shi Y, Donelson J, Thompson SM, Sprague S, Roshan T, Wang DL, Liu J, Park S, Nakata PA, Connolly EL, Hirschi KD, Grusak MA, Cheng N. Arabidopsis Glutaredoxin S17 Contributes to Vegetative Growth, Mineral Accumulation, and Redox Balance during Iron Deficiency. Front Plant Sci. 2017; 8:1045. PMID: 28674546.
      View in: PubMed
    7. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of Glutaredoxin 3 Impedes Mammary Lobuloalveolar Development during Pregnancy and Lactation. Am J Physiol Endocrinol Metab. 2016 Nov 15; ajpendo.00150.2016. PMID: 27894063.
      View in: PubMed
    8. Hu Y, Wu Q, Sprague SA, Park J, Oh M, Rajashekar CB, Koiwa H, Nakata PA, Cheng N, Hirschi KD, White FF, Park S. Tomato expressing Arabidopsis glutaredoxin gene AtGRXS17 confers tolerance to chilling stress via modulating cold responsive components. Hortic Res. 2015; 2:15051. PMID: 26623076.
      View in: PubMed
    9. Ding S, Li C, Cheng N, Cui X, Xu X, Zhou G. Redox Regulation in Cancer Stem Cells. Oxid Med Cell Longev. 2015; 2015:750798. PMID: 26273424; PMCID: PMC4529979.
    10. Pham K, Pal R, Qu Y, Liu X, Yu H, Shiao SL, Wang X, O'Brian Smith E, Cui X, Rodney GG, Cheng N. Nuclear glutaredoxin 3 is critical for protection against oxidative stress-induced cell death. Free Radic Biol Med. 2015 Aug; 85:197-206. PMID: 25975981.
      View in: PubMed
    11. Jiang X, Yu Y, Chen J, Zhao M, Chen H, Song X, Matzuk AJ, Carroll SL, Tan X, Sizovs A, Cheng N, Wang MC, Wang J. Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe. ACS Chem Biol. 2015 Mar 20; 10(3):864-74. PMID: 25531746; PMCID: PMC4371605.
    12. Ying Qu, Xiaojiang Cui, Ninghui Cheng. GLUTAREDOXIN IN CANCER DEVELOPMENT, PROGRESSION, CHEMO-RESISTENCE AND CLINICAL APPLICATIONS. In Free Radicals: The Role of Antioxidants and Pro-Oxidants in Cancer Development. Editor: Bill Stone. 2014; 139-158.
    13. Liu X, Liu S, Feng Y, Liu JZ, Chen Y, Pham K, Deng H, Hirschi KD, Wang X, Cheng N. Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23):9565-70. PMID: 23690600; PMCID: PMC3677505.
    14. Connorton JM, Webster RE, Cheng N, Pittman JK. Knockout of multiple Arabidopsis cation/H(+) exchangers suggests isoform-specific roles in metal stress response, germination and seed mineral nutrition. PLoS One. 2012; 7(10):e47455. PMID: 23071810; PMCID: PMC3470555.
    15. Wu Q, Lin J, Liu JZ, Wang X, Lim W, Oh M, Park J, Rajashekar CB, Whitham SA, Cheng NH, Hirschi KD, Park S. Ectopic expression of Arabidopsis glutaredoxin AtGRXS17 enhances thermotolerance in tomato. Plant Biotechnol J. 2012 Oct; 10(8):945-55. PMID: 22762155.
      View in: PubMed
    16. Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KD. A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J. 2011 Jul; 278(14):2525-39. PMID: 21575136; PMCID: PMC4038268.
    17. Cheng NH, Liu JZ, Liu X, Wu Q, Thompson SM, Lin J, Chang J, Whitham SA, Park S, Cohen JD, Hirschi KD. Arabidopsis monothiol glutaredoxin, AtGRXS17, is critical for temperature-dependent postembryonic growth and development via modulating auxin response. J Biol Chem. 2011 Jun 10; 286(23):20398-406. PMID: 21515673; PMCID: PMC3121514.
    18. Conn SJ, Gilliham M, Athman A, Schreiber AW, Baumann U, Moller I, Cheng NH, Stancombe MA, Hirschi KD, Webb AA, Burton R, Kaiser BN, Tyerman SD, Leigh RA. Cell-specific vacuolar calcium storage mediated by CAX1 regulates apoplastic calcium concentration, gas exchange, and plant productivity in Arabidopsis. Plant Cell. 2011 Jan; 23(1):240-57. PMID: 21258004; PMCID: PMC3051233.
    19. Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-?B signaling. J Clin Invest. 2011 Jan; 121(1):212-25. PMID: 21123948; PMCID: PMC3007146.
    20. Li L, Cheng N, Hirschi KD, Wang X. Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp. Acta Crystallogr D Biol Crystallogr. 2010 Jun; 66(Pt 6):725-32. PMID: 20516625; PMCID: PMC2879357.
    21. Mei H, Cheng NH, Zhao J, Park S, Escareno RA, Pittman JK, Hirschi KD. Root development under metal stress in Arabidopsis thaliana requires the H+/cation antiporter CAX4. New Phytol. 2009; 183(1):95-105. PMID: 19368667.
      View in: PubMed
    22. Zhao J, Shigaki T, Mei H, Guo YQ, Cheng NH, Hirschi KD. Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3. J Biol Chem. 2009 Feb 13; 284(7):4605-15. PMID: 19098009.
      View in: PubMed
    23. Zhao J, Cheng NH, Motes CM, Blancaflor EB, Moore M, Gonzales N, Padmanaban S, Sze H, Ward JM, Hirschi KD. AtCHX13 is a plasma membrane K+ transporter. Plant Physiol. 2008 Oct; 148(2):796-807. PMID: 18676662.
      View in: PubMed
    24. Cheng NH. AtGRX4, an Arabidopsis chloroplastic monothiol glutaredoxin, is able to suppress yeast grx5 mutant phenotypes and respond to oxidative stress. FEBS Lett. 2008 Mar 19; 582(6):848-54. PMID: 18275854.
      View in: PubMed
    25. Cheng NH, Liu JZ, Brock A, Nelson RS, Hirschi KD. AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage. J Biol Chem. 2006 Sep 8; 281(36):26280-8. PMID: 16829529.
      View in: PubMed
    26. Park S, Cheng NH, Pittman JK, Yoo KS, Park J, Smith RH, Hirschi KD. Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters. Plant Physiol. 2005 Nov; 139(3):1194-206. PMID: 16244156; PMCID: PMC1283758.
    27. Cheng NH, Pittman JK, Shigaki T, Lachmansingh J, LeClere S, Lahner B, Salt DE, Hirschi KD. Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis. Plant Physiol. 2005 Aug; 138(4):2048-60. PMID: 16055687; PMCID: PMC1183394.
    28. Pittman JK, Shigaki T, Marshall JL, Morris JL, Cheng NH, Hirschi KD. Functional and regulatory analysis of the Arabidopsis thaliana CAX2 cation transporter. Plant Mol Biol. 2004 Dec; 56(6):959-71. PMID: 15821993.
      View in: PubMed
    29. Pittman JK, Cheng NH, Shigaki T, Kunta M, Hirschi KD. Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p. Mol Microbiol. 2004 Nov; 54(4):1104-16. PMID: 15522090.
      View in: PubMed
    30. Sze H, Padmanaban S, Cellier F, Honys D, Cheng NH, Bock KW, Conéjéro G, Li X, Twell D, Ward JM, Hirschi KD. Expression patterns of a novel AtCHX gene family highlight potential roles in osmotic adjustment and K+ homeostasis in pollen development. Plant Physiol. 2004 Sep; 136(1):2532-47. PMID: 15347787; PMCID: PMC523320.
    31. Ding XS, Liu J, Cheng NH, Folimonov A, Hou YM, Bao Y, Katagi C, Carter SA, Nelson RS. The Tobacco mosaic virus 126-kDa protein associated with virus replication and movement suppresses RNA silencing. Mol Plant Microbe Interact. 2004 Jun; 17(6):583-92. PMID: 15195941.
      View in: PubMed
    32. Yang SJ, Carter SA, Cole AB, Cheng NH, Nelson RS. A natural variant of a host RNA-dependent RNA polymerase is associated with increased susceptibility to viruses by Nicotiana benthamiana. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6297-302. PMID: 15079073; PMCID: PMC395963.
    33. Cheng NH, Liu JZ, Nelson RS, Hirschi KD. Characterization of CXIP4, a novel Arabidopsis protein that activates the H+/Ca2+ antiporter, CAX1. FEBS Lett. 2004 Feb 13; 559(1-3):99-106. PMID: 14960315.
      View in: PubMed
    34. Cheng NH, Pittman JK, Zhu JK, Hirschi KD. The protein kinase SOS2 activates the Arabidopsis H(+)/Ca(2+) antiporter CAX1 to integrate calcium transport and salt tolerance. J Biol Chem. 2004 Jan 23; 279(4):2922-6. PMID: 14583601.
      View in: PubMed
    35. Cheng NH, Pittman JK, Barkla BJ, Shigaki T, Hirschi KD. The Arabidopsis cax1 mutant exhibits impaired ion homeostasis, development, and hormonal responses and reveals interplay among vacuolar transporters. Plant Cell. 2003 Feb; 15(2):347-64. PMID: 12566577; PMCID: PMC141206.
    36. Cheng NH, Hirschi KD. Cloning and characterization of CXIP1, a novel PICOT domain-containing Arabidopsis protein that associates with CAX1. J Biol Chem. 2003 Feb 21; 278(8):6503-9. PMID: 12480930.
      View in: PubMed
    37. Li XB, Cai L, Cheng NH, Liu JW. Molecular characterization of the cotton GhTUB1 gene that is preferentially expressed in fiber. Plant Physiol. 2002 Oct; 130(2):666-74. PMID: 12376634; PMCID: PMC166596.
    38. Pittman JK, Shigaki T, Cheng NH, Hirschi KD. Mechanism of N-terminal autoinhibition in the Arabidopsis Ca(2+)/H(+) antiporter CAX1. J Biol Chem. 2002 Jul 19; 277(29):26452-9. PMID: 12006570.
      View in: PubMed
    39. Cheng NH, Pittman JK, Shigaki T, Hirschi KD. Characterization of CAX4, an Arabidopsis H(+)/cation antiporter. Plant Physiol. 2002 Apr; 128(4):1245-54. PMID: 11950973; PMCID: PMC154252.
    40. Shigaki T, Cheng NH, Pittman JK, Hirschi K. Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+ antiporter CAX1. J Biol Chem. 2001 Nov 16; 276(46):43152-9. PMID: 11562366.
      View in: PubMed
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