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BENJAMIN RUSSELL ARENKIEL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
AddressJan and Dan Duncan Neurological Research Center
1250 Moursund St., Rm. 1165.02
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    K99NS064171     (ARENKIEL, BENJAMIN R.)Mar 1, 2009 - Feb 28, 2011
    NIH/NINDS
    Activity Influence on Adult-Born Neuron Circuit Integration
    Role: Principal Investigator

    R00NS064171     (ARENKIEL, BENJAMIN R.)Mar 1, 2009 - Dec 31, 2013
    NIH/NINDS
    Activity Influence on Adult-Born Neuron Circuit Integration
    Role: Principal Investigator

    R01NS078294     (ARENKIEL, BENJAMIN R.)Apr 1, 2012 - Feb 29, 2024
    NIH/NINDS
    Mapping Connectivity onto Postnatal-Born Neurons
    Role: Principal Investigator

    R01DK109934     (ARENKIEL, BENJAMIN R)Jul 15, 2016 - Jun 30, 2020
    NIH/NIDDK
    R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cassidy RM, Lu Y, Jere M, Tian JB, Xu Y, Mangieri LR, Felix-Okoroji B, Selever J, Xu Y, Arenkiel BR, Tong Q. A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues. Sci Adv. 2019 Mar; 5(3):eaav1640. PMID: 30854429.
      View in: PubMed
    2. Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ. VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy. 2019 Feb 11; 1-20. PMID: 30741620.
      View in: PubMed
    3. Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018 Dec 26; 25(13):3811-3827.e7. PMID: 30590051.
      View in: PubMed
    4. Tepe B, Hill MC, Pekarek BT, Hunt PJ, Martin TJ, Martin JF, Arenkiel BR. Single-Cell RNA-Seq of Mouse Olfactory Bulb Reveals Cellular Heterogeneity and Activity-Dependent Molecular Census of Adult-Born Neurons. Cell Rep. 2018 Dec 04; 25(10):2689-2703.e3. PMID: 30517858.
      View in: PubMed
    5. Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH. The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Cancer Cell. 2018 Nov 12; 34(5):823-839.e7. PMID: 30423299.
      View in: PubMed
    6. McClard CK, Arenkiel BR. Neuropeptide Signaling Networks and Brain Circuit Plasticity. J Exp Neurosci. 2018; 12:1179069518779207. PMID: 29899664.
      View in: PubMed
    7. Liu G, Patel JM, Tepe B, McClard CK, Swanson J, Quast KB, Arenkiel BR. An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice. J Vis Exp. 2018 03 22; (133). PMID: 29630042.
      View in: PubMed
    8. McClard CK, Kochukov MY, Herman I, Liu Z, Eblimit A, Moayedi Y, Ortiz-Guzman J, Colchado D, Pekarek B, Panneerselvam S, Mardon G, Arenkiel BR. POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. J Neurosci. 2018 Feb 07; 38(6):1443-1461. PMID: 29305536.
      View in: PubMed
    9. Mangieri LR, Lu Y, Xu Y, Cassidy RM, Xu Y, Arenkiel BR, Tong Q. A neural basis for antagonistic control of feeding and compulsive behaviors. Nat Commun. 2018 01 04; 9(1):52. PMID: 29302029.
      View in: PubMed
    10. Hanson E, Swanson J, Arenkiel BR. Sensory experience shapes the integration of adult-born neurons into the olfactory bulb. J Nat Sci. 2017 Aug; 3(8). PMID: 28884145.
      View in: PubMed
    11. Liu G, McClard CK, Tepe B, Swanson J, Pekarek B, Panneerselvam S, Arenkiel BR. Olfactory Cued Learning Paradigm. Bio Protoc. 2017 May 05; 7(9). PMID: 28752111.
      View in: PubMed
    12. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219.
      View in: PubMed
    13. Quast KB, Ung K, Froudarakis E, Huang L, Herman I, Addison AP, Ortiz-Guzman J, Cordiner K, Saggau P, Tolias AS, Arenkiel BR. Developmental broadening of inhibitory sensory maps. Nat Neurosci. 2017 02; 20(2):189-199. PMID: 28024159.
      View in: PubMed
    14. Herman AM, Ortiz-Guzman J, Kochukov M, Herman I, Quast KB, Patel JM, Tepe B, Carlson JC, Ung K, Selever J, Tong Q, Arenkiel BR. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. 2016 Oct 13; 538(7624):253-256. PMID: 27698417.
      View in: PubMed
    15. Yang K, Broussard JI, Levine AT, Jenson D, Arenkiel BR, Dani JA. Dopamine receptor activity participates in hippocampal synaptic plasticity associated with novel object recognition. Eur J Neurosci. 2017 01; 45(1):138-146. PMID: 27646422.
      View in: PubMed
    16. Huang L, Ung K, Garcia I, Quast KB, Cordiner K, Saggau P, Arenkiel BR. Task Learning Promotes Plasticity of Interneuron Connectivity Maps in the Olfactory Bulb. J Neurosci. 2016 08 24; 36(34):8856-71. PMID: 27559168.
      View in: PubMed
    17. Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY. Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. 2016 Aug 17; 91(4):739-747. PMID: 27499081.
      View in: PubMed
    18. Huang TW, Kochukov MY, Ward CS, Merritt J, Thomas K, Nguyen T, Arenkiel BR, Neul JL. Progressive Changes in a Distributed Neural Circuit Underlie Breathing Abnormalities in Mice Lacking MeCP2. J Neurosci. 2016 05 18; 36(20):5572-86. PMID: 27194336.
      View in: PubMed
    19. Broussard JI, Yang K, Levine AT, Tsetsenis T, Jenson D, Cao F, Garcia I, Arenkiel BR, Zhou FM, De Biasi M, Dani JA. Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus. Cell Rep. 2016 Mar 01; 14(8):1930-9. PMID: 26904943.
      View in: PubMed
    20. Soiza-Reilly M, Saggau P, Arenkiel BR. Neural circuits revealed. Front Neural Circuits. 2015; 9:35. PMID: 26283927.
      View in: PubMed
    21. Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9. PMID: 25946682.
      View in: PubMed
    22. Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci. 2015 Feb 25; 35(8):3312-8. PMID: 25716832.
      View in: PubMed
    23. Justice NJ, Huang L, Tian JB, Cole A, Pruski M, Hunt AJ, Flores R, Zhu MX, Arenkiel BR, Zheng H. Posttraumatic stress disorder-like induction elevates ß-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015 Feb 11; 35(6):2612-23. PMID: 25673853.
      View in: PubMed
    24. Murphey DK, Herman AM, Arenkiel BR. Dissecting inhibitory brain circuits with genetically-targeted technologies. Front Neural Circuits. 2014; 8:124. PMID: 25368555.
      View in: PubMed
    25. Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR. Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Struct Funct. 2016 Jan; 221(1):1-20. PMID: 25224546.
      View in: PubMed
    26. Garcia I, Quast KB, Huang L, Herman AM, Selever J, Deussing JM, Justice NJ, Arenkiel BR. Local CRH signaling promotes synaptogenesis and circuit integration of adult-born neurons. Dev Cell. 2014 Sep 29; 30(6):645-59. PMID: 25199688.
      View in: PubMed
    27. Wang M, Perova Z, Arenkiel BR, Li B. Synaptic modifications in the medial prefrontal cortex in susceptibility and resilience to stress. J Neurosci. 2014 May 28; 34(22):7485-92. PMID: 24872553.
      View in: PubMed
    28. Herman AM, Huang L, Murphey DK, Garcia I, Arenkiel BR. Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2. Elife. 2014; 3:e01481. PMID: 24473077.
      View in: PubMed
    29. Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y, Tong Q. Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metab. 2013 Dec 03; 18(6):860-70. PMID: 24315371.
      View in: PubMed
    30. Huang L, Garcia I, Jen HI, Arenkiel BR. Reciprocal connectivity between mitral cells and external plexiform layer interneurons in the mouse olfactory bulb. Front Neural Circuits. 2013; 7:32. PMID: 23459611.
      View in: PubMed
    31. Takatoh J, Nelson A, Zhou X, Bolton MM, Ehlers MD, Arenkiel BR, Mooney R, Wang F. New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking. Neuron. 2013 Jan 23; 77(2):346-60. PMID: 23352170.
      View in: PubMed
    32. Garcia I, Kim C, Arenkiel BR. Revealing neuronal circuitry using stem cell-derived neurons. Curr Protoc Stem Cell Biol. 2013; Chapter 2:Unit 2D.15. PMID: 23661247.
      View in: PubMed
    33. Garcia I, Kim C, Arenkiel BR. Genetic strategies to investigate neuronal circuit properties using stem cell-derived neurons. Front Cell Neurosci. 2012; 6:59. PMID: 23264761.
      View in: PubMed
    34. Ung K, Arenkiel BR. Fiber-optic implantation for chronic optogenetic stimulation of brain tissue. J Vis Exp. 2012 Oct 29; (68):e50004. PMID: 23128465.
      View in: PubMed
    35. Arenkiel B, Smitt M, Olsen KS. The duration of fibre-optic intubation is increased by cricoid pressure. A randomised double-blind study. Acta Anaesthesiol Scand. 2013 Mar; 57(3):358-63. PMID: 23075453.
      View in: PubMed
    36. Chen Q, Cichon J, Wang W, Qiu L, Lee SJ, Campbell NR, Destefino N, Goard MJ, Fu Z, Yasuda R, Looger LL, Arenkiel BR, Gan WB, Feng G. Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron. 2012 Oct 18; 76(2):297-308. PMID: 23083733.
      View in: PubMed
    37. Garcia I, Huang L, Ung K, Arenkiel BR. Tracing synaptic connectivity onto embryonic stem cell-derived neurons. Stem Cells. 2012 Oct; 30(10):2140-51. PMID: 22996827.
      View in: PubMed
    38. Güler AD, Rainwater A, Parker JG, Jones GL, Argilli E, Arenkiel BR, Ehlers MD, Bonci A, Zweifel LS, Palmiter RD. Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nat Commun. 2012 Mar 20; 3:746. PMID: 22434189.
      View in: PubMed
    39. Arenkiel BR, Hasegawa H, Yi JJ, Larsen RS, Wallace ML, Philpot BD, Wang F, Ehlers MD. Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing. PLoS One. 2011; 6(12):e29423. PMID: 22216277.
      View in: PubMed
    40. Wulff P, Arenkiel BR. Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity. Curr Opin Neurobiol. 2012 Feb; 22(1):54-60. PMID: 22119143.
      View in: PubMed
    41. Selever J, Kong JQ, Arenkiel BR. A rapid approach to high-resolution fluorescence imaging in semi-thick brain slices. J Vis Exp. 2011 Jul 26; (53). PMID: 21841756.
      View in: PubMed
    42. Arenkiel BR. Genetic approaches to reveal the connectivity of adult-born neurons. Front Neurosci. 2011; 5:48. PMID: 21519388.
      View in: PubMed
    43. Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C. Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell. 2011 Feb 15; 19(2):177-91. PMID: 21316601.
      View in: PubMed
    44. Arenkiel BR. Adult neurogenesis supports short-term olfactory memory. J Neurophysiol. 2010 Jun; 103(6):2935-7. PMID: 20375247.
      View in: PubMed
    45. Arenkiel BR, Ehlers MD. Molecular genetics and imaging technologies for circuit-based neuroanatomy. Nature. 2009 Oct 15; 461(7266):900-7. PMID: 19829369.
      View in: PubMed
    46. Taniguchi E, Cho MJ, Arenkiel BR, Hansen MS, Rivera OJ, McCleish AT, Qualman SJ, Guttridge DC, Scott MP, Capecchi MR, Keller C. Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Aug; 53(2):136-44. PMID: 19213072.
      View in: PubMed
    47. Arenkiel BR, Peca J. Using light to reinstate respiratory plasticity. J Neurophysiol. 2009 Apr; 101(4):1695-8. PMID: 19211655.
      View in: PubMed
    48. Arenkiel BR, Klein ME, Davison IG, Katz LC, Ehlers MD. Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat Methods. 2008 Apr; 5(4):299-302. PMID: 18327266.
      View in: PubMed
    49. Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ, Ehlers MD, Feng G. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron. 2007 Apr 19; 54(2):205-18. PMID: 17442243.
      View in: PubMed
    50. Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Nov 01; 18(21):2614-26. PMID: 15489287.
      View in: PubMed
    51. Boulet AM, Moon AM, Arenkiel BR, Capecchi MR. The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol. 2004 Sep 15; 273(2):361-72. PMID: 15328019.
      View in: PubMed
    52. Arenkiel BR, Tvrdik P, Gaufo GO, Capecchi MR. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev. 2004 Jul 01; 18(13):1539-52. PMID: 15198977.
      View in: PubMed
    53. Macatee TL, Hammond BP, Arenkiel BR, Francis L, Frank DU, Moon AM. Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development. 2003 Dec; 130(25):6361-74. PMID: 14623825.
      View in: PubMed
    54. Arenkiel BR, Gaufo GO, Capecchi MR. Hoxb1 neural crest preferentially form glia of the PNS. Dev Dyn. 2003 Jul; 227(3):379-86. PMID: 12815623.
      View in: PubMed
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