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MIRJANA MALETIC-SAVATIC

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Neur NRI
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neurology
    DivisionNeurology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    K08NS044276     (MALETIC-SAVATIC, MIRJANA)Jul 5, 2002 - Jun 30, 2007
    NIH/NINDS
    Activity-dependent control: neural progenitor cell fate
    Role: Principal Investigator

    R21NS053875     (MALETIC-SAVATIC, MIRJANA)Sep 15, 2006 - Nov 30, 2008
    NIH/NINDS
    Identification and tracking of neural stem cells in vivo: a metabolomic approach
    Role: Principal Investigator

    R01GM120033     (MALETIC-SAVATIC, MIRJANA)Jan 1, 2017 - Dec 31, 2021
    NIH/NIGMS
    Advanced Computational Approaches for NMR Data-mining
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen K, Baluya D, Tosun M, Li F, Maletic-Savatic M. Imaging Mass Spectrometry: A New Tool to Assess Molecular Underpinnings of Neurodegeneration. Metabolites. 2019 Jul 10; 9(7). PMID: 31295847.
      View in: PubMed
    2. Tosun M, Semerci F, Maletic-Savatic M. Heterogeneity of Stem Cells in the Hippocampus. Adv Exp Med Biol. 2019; 1169:31-53. PMID: 31487017.
      View in: PubMed
    3. Choi WT, Tosun M, Jeong HH, Karakas C, Semerci F, Liu Z, Maletic-Savatic M. Metabolomics of mammalian brain reveals regional differences. BMC Syst Biol. 2018 12 21; 12(Suppl 8):127. PMID: 30577853.
      View in: PubMed
    4. Jiang X, Zhang C, Chen J, Choi S, Zhou Y, Zhao M, Song X, Chen X, Maletic-Savatic M, Palzkill T, Moore D, Wang MC, Wang J. Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution. Antioxid Redox Signal. 2019 Jun 01; 30(16):1900-1910. PMID: 30358421.
      View in: PubMed
    5. Kadur Lakshminarasimha Murthy P, Srinivasan T, Bochter MS, Xi R, Varanko AK, Tung KL, Semerci F, Xu K, Maletic-Savatic M, Cole SE, Shen X. Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis. Elife. 2018 04 09; 7. PMID: 29629872.
      View in: PubMed
    6. Tang C, Chen K, Bajic A, Choi WT, Baluya DL, Maletic-Savatic M. Analytical Platforms and Techniques to Study Stem Cell Metabolism. Methods Mol Biol. 2018; 1842:265-281. PMID: 30196417.
      View in: PubMed
    7. Beccari S, Valero J, Maletic-Savatic M, Sierra A. A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis. Sci Rep. 2017 11 28; 7(1):16528. PMID: 29184142.
      View in: PubMed
    8. Gandy K, Kim S, Sharp C, Dindo L, Maletic-Savatic M, Calarge C. Pattern Separation: A Potential Marker of Impaired Hippocampal Adult Neurogenesis in Major Depressive Disorder. Front Neurosci. 2017; 11:571. PMID: 29123464.
      View in: PubMed
    9. Li B, Sierra A, Deudero JJ, Semerci F, Laitman A, Kimmel M, Maletic-Savatic M. Multitype Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis. BMC Syst Biol. 2017 Oct 03; 11(Suppl 5):90. PMID: 28984196.
      View in: PubMed
    10. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Corrigendum: Quantitative real-time imaging of glutathione. Nat Commun. 2017 10 03; 8:16163. PMID: 28972204.
      View in: PubMed
    11. Liu L, MacKenzie KR, Putluri N, Maletic-Savatic M, Bellen HJ. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 07; 26(5):719-737.e6. PMID: 28965825.
      View in: PubMed
    12. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087. PMID: 28703127.
      View in: PubMed
    13. Semerci F, Choi WT, Bajic A, Thakkar A, Encinas JM, Depreux F, Segil N, Groves AK, Maletic-Savatic M. Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance. Elife. 2017 07 12; 6. PMID: 28699891.
      View in: PubMed
    14. Maletic-Savatic M. A question of fate. PLoS Biol. 2017 05; 15(5):e2002329. PMID: 28505150.
      View in: PubMed
    15. Bielefeld P, Sierra A, Encinas JM, Maletic-Savatic M, Anderson A, Fitzsimons CP. A Standardized Protocol for Stereotaxic Intrahippocampal Administration of Kainic Acid Combined with Electroencephalographic Seizure Monitoring in Mice. Front Neurosci. 2017; 11:160. PMID: 28405182.
      View in: PubMed
    16. Basch ML, Brown RM, Jen HI, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife. 2016 12 14; 5. PMID: 27966429.
      View in: PubMed
    17. Cvoro A, Bajic A, Zhang A, Simon M, Golic I, Sieglaff DH, Maletic-Savatic M, Korac A, Webb P. Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells. PLoS One. 2016; 11(10):e0164407. PMID: 27732649.
      View in: PubMed
    18. Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco MD, Matute C, Maletic-Savatic M, Encinas JM, Sierra A. Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol. 2016 09; 14(9):e1002554. PMID: 27649285.
      View in: PubMed
    19. Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco MD, Matute C, Maletic-Savatic M, Encinas JM, Sierra A. Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol. 2016 Jun; 14(6):e1002508. PMID: 27362865.
      View in: PubMed
    20. Semerci F, Maletic-Savatic M. Transgenic mouse models for studying adult neurogenesis. Front Biol (Beijing). 2016 Jun; 11(3):151-167. PMID: 28473846.
      View in: PubMed
    21. Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco Md, Matute C, Maletic-Savatic M, Encinas JM, Sierra A. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol. 2016 05; 14(5):e1002466. PMID: 27228556.
      View in: PubMed
    22. Zhang X, Tang Y, Maletic-Savatic M, Sheng J, Zhang X, Zhu Y, Zhang T, Wang J, Tong S, Wang J, Li Y. Altered neuronal spontaneous activity correlates with glutamate concentration in medial prefrontal cortex of major depressed females: An fMRI-MRS study. J Affect Disord. 2016 Sep 01; 201:153-61. PMID: 27235818.
      View in: PubMed
    23. Pati S, Muthuraju S, Hadi RA, Huat TJ, Singh S, Maletic-Savatic M, Abdullah JM, Jaafar H. Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury. Curr Stem Cell Res Ther. 2016; 11(2):149-57. PMID: 26763886.
      View in: PubMed
    24. Hasan KM, Mwangi B, Cao B, Keser Z, Tustison NJ, Kochunov P, Frye RE, Savatic M, Soares J. Entorhinal Cortex Thickness across the Human Lifespan. J Neuroimaging. 2016 05; 26(3):278-82. PMID: 26565394.
      View in: PubMed
    25. Botas A, Campbell HM, Han X, Maletic-Savatic M. Metabolomics of neurodegenerative diseases. Int Rev Neurobiol. 2015; 122:53-80. PMID: 26358890.
      View in: PubMed
    26. Erramuzpe A, Encinas JM, Sierra A, Maletic-Savatic M, Brewster AL, Anderson AE, Stramaglia S, Cortes JM. Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy. F1000Res. 2015; 4:144. PMID: 26167275.
      View in: PubMed
    27. Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletic-Savatic M, Encinas JM. Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis. Cell Stem Cell. 2015 May 07; 16(5):488-503. PMID: 25957904.
      View in: PubMed
    28. Arnold JM, Choi WT, Sreekumar A, Maletic-Savatic M. Analytical strategies for studying stem cell metabolism. Front Biol (Beijing). 2015 Apr; 10(2):141-153. PMID: 26213533.
      View in: PubMed
    29. Zhu Y, Fan Q, Han X, Zhang H, Chen J, Wang Z, Zhang Z, Tan L, Xiao Z, Tong S, Maletic-Savatic M, Li Y. Decreased thalamic glutamate level in unmedicated adult obsessive-compulsive disorder patients detected by proton magnetic resonance spectroscopy. J Affect Disord. 2015 Jun 01; 178:193-200. PMID: 25819113.
      View in: PubMed
    30. Pati S, Supeno NE, Muthuraju S, Abdul Hadi R, Ghani AR, Idris FM, Maletic-Savatic M, Abdullah JM, Jaafar H. MicroRNA profiling reveals unique miRNA signatures in IGF-1 treated embryonic striatal stem cell fate decisions in striatal neurogenesis in vitro. Biomed Res Int. 2014; 2014:503162. PMID: 25254208.
      View in: PubMed
    31. Shetty AN, Chiang S, Maletic-Savatic M, Kasprian G, Vannucci M, Lee W. Spatial Mapping of Translational Diffusion Coefficients Using Diffusion Tensor Imaging: A Mathematical Description. Concepts Magn Reson Part A Bridg Educ Res. 2014 Jan; 43(1):1-27. PMID: 27441031.
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    32. Abraham AB, Bronstein R, Reddy AS, Maletic-Savatic M, Aguirre A, Tsirka SE. Aberrant neural stem cell proliferation and increased adult neurogenesis in mice lacking chromatin protein HMGB2. PLoS One. 2013; 8(12):e84838. PMID: 24391977.
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    33. Peterson C, Vannucci M, Karakas C, Choi W, Ma L, Maletic-Savatic M. Inferring metabolic networks using the Bayesian adaptive graphical lasso with informative priors. Stat Interface. 2013 Oct 01; 6(4):547-558. PMID: 24533172.
      View in: PubMed
    34. Allen GI, Peterson C, Vannucci M, Maletic-Savatic M. Regularized Partial Least Squares with an Application to NMR Spectroscopy. Stat Anal Data Min. 2013 Aug 01; 6(4):302-314. PMID: 24511361.
      View in: PubMed
    35. Wiszniewski W, Hunter JV, Hanchard NA, Willer JR, Shaw C, Tian Q, Illner A, Wang X, Cheung SW, Patel A, Campbell IM, Gelowani V, Hixson P, Ester AR, Azamian MS, Potocki L, Zapata G, Hernandez PP, Ramocki MB, Santos-Cortez RL, Wang G, York MK, Justice MJ, Chu ZD, Bader PI, Omo-Griffith L, Madduri NS, Scharer G, Crawford HP, Yanatatsaneejit P, Eifert A, Kerr J, Bacino CA, Franklin AI, Goin-Kochel RP, Simpson G, Immken L, Haque ME, Stosic M, Williams MD, Morgan TM, Pruthi S, Omary R, Boyadjiev SA, Win KK, Thida A, Hurles M, Hibberd ML, Khor CC, Van Vinh Chau N, Gallagher TE, Mutirangura A, Stankiewicz P, Beaudet AL, Maletic-Savatic M, Rosenfeld JA, Shaffer LG, Davis EE, Belmont JW, Dunstan S, Simmons CP, Bonnen PE, Leal SM, Katsanis N, Lupski JR, Lalani SR. TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. Am J Hum Genet. 2013 Aug 08; 93(2):197-210. PMID: 23810381.
      View in: PubMed
    36. Vingara LK, Yu HJ, Wagshul ME, Serafin D, Christodoulou C, Pelczer I, Krupp LB, Maletic-Savatic M. Metabolomic approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis. Neuroimage. 2013 Nov 15; 82:586-94. PMID: 23751863.
      View in: PubMed
    37. Abraham AB, Bronstein R, Chen EI, Koller A, Ronfani L, Maletic-Savatic M, Tsirka SE. Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells. Proteome Sci. 2013 Apr 27; 11(1):18. PMID: 23621913.
      View in: PubMed
    38. Valenzuela M, Bartres-Faz D, Bullmore E, Fjell A, Maletic-Savetic M, Martins R, Solowij N, Yücel M. More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Mol Psychiatry. 2013 May; 18(5):524-5. PMID: 23478747.
      View in: PubMed
    39. Yu HJ, Christodoulou C, Bhise V, Greenblatt D, Patel Y, Serafin D, Maletic-Savatic M, Krupp LB, Wagshul ME. Multiple white matter tract abnormalities underlie cognitive impairment in RRMS. Neuroimage. 2012 Feb 15; 59(4):3713-22. PMID: 22062194.
      View in: PubMed
    40. Allen GI, Maletic-Savatic M. Sparse non-negative generalized PCA with applications to metabolomics. Bioinformatics. 2011 Nov 01; 27(21):3029-35. PMID: 21930672.
      View in: PubMed
    41. Sierra A, Encinas JM, Maletic-Savatic M. Adult human neurogenesis: from microscopy to magnetic resonance imaging. Front Neurosci. 2011; 5:47. PMID: 21519376.
      View in: PubMed
    42. Ma LH, Li Y, Djuric PM, Maletic-Savatic M. Systems biology approach to imaging of neural stem cells. Methods Mol Biol. 2011; 711:421-34. PMID: 21279615.
      View in: PubMed
    43. Sierra A, Encinas JM, Deudero JJ, Chancey JH, Enikolopov G, Overstreet-Wadiche LS, Tsirka SE, Maletic-Savatic M. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 2010 Oct 08; 7(4):483-95. PMID: 20887954.
      View in: PubMed
    44. Malinow R, Hayashi Y, Maletic-Savatic M, Zaman SH, Poncer JC, Shi SH, Esteban JA, Osten P, Seidenman K. Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5406. PMID: 20360360.
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    45. Maletic-Savatic M, Vingara LK, Manganas LN, Li Y, Zhang S, Sierra A, Hazel R, Smith D, Wagshul ME, Henn F, Krupp L, Enikolopov G, Benveniste H, Djuric PM, Pelczer I. Metabolomics of neural progenitor cells: a novel approach to biomarker discovery. Cold Spring Harb Symp Quant Biol. 2008; 73:389-401. PMID: 19022759.
      View in: PubMed
    46. Djuric PM, Benveniste H, Wagshul ME, Henn F, Enikolopov G, Maletic-Savatic M. Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain". Science. 2008 Aug 01; 321(5889):640. PMID: 26380846.
      View in: PubMed
    47. Manganas LN, Zhang X, Li Y, Hazel RD, Smith SD, Wagshul ME, Henn F, Benveniste H, Djuric PM, Enikolopov G, Maletic-Savatic M. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science. 2007 Nov 09; 318(5852):980-5. PMID: 17991865.
      View in: PubMed
    48. Mignone JL, Roig-Lopez JL, Fedtsova N, Schones DE, Manganas LN, Maletic-Savatic M, Keyes WM, Mills AA, Gleiberman A, Zhang MQ, Enikolopov G. Neural potential of a stem cell population in the hair follicle. Cell Cycle. 2007 Sep 01; 6(17):2161-70. PMID: 17873521.
      View in: PubMed
    49. Manganas LN, Maletic-Savatic M. Stem cell therapy for central nervous system demyelinating disease. Curr Neurol Neurosci Rep. 2005 May; 5(3):225-31. PMID: 15865888.
      View in: PubMed
    50. Nasr JT, Gabis L, Savatic M, Andriola MR. The Electroencephalogram in Children with Developmental Dysphasia. Epilepsy Behav. 2001 Apr; 2(2):115-118. PMID: 12609193.
      View in: PubMed
    51. Mainen ZF, Maletic-Savatic M, Shi SH, Hayashi Y, Malinow R, Svoboda K. Two-photon imaging in living brain slices. Methods. 1999 Jun; 18(2):231-9, 181. PMID: 10356355.
      View in: PubMed
    52. Maletic-Savatic M, Malinow R, Svoboda K. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science. 1999 Mar 19; 283(5409):1923-7. PMID: 10082466.
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    53. Maletic-Savatic M, Koothan T, Malinow R. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part II: mediation by calcium/calmodulin-dependent protein kinase II. J Neurosci. 1998 Sep 01; 18(17):6814-21. PMID: 9712652.
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    54. Maletic-Savatic M, Malinow R. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part I: trans-Golgi network-derived organelles undergo regulated exocytosis. J Neurosci. 1998 Sep 01; 18(17):6803-13. PMID: 9712651.
      View in: PubMed
    55. Maletic-Savatic M, Lenn NJ, Trimmer JS. Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci. 1995 May; 15(5 Pt 2):3840-51. PMID: 7751950.
      View in: PubMed
    56. Petrovchich I, Sosinsky A, Konde A, Archibald A, Henderson D, Maletic-Savatic M, Milanovic S . Metabolomics in Schizophrenia and Major Depressive Disorder. 3(11):222-231. .
    57. Bielefeld P, Sierra A, Encinas JM, Maletic-Savatic M, Anderson A. A, Fitzsimons CP. . Standardized Protocol for Stereotaxic Intrahippocampal Administration of Kainic Acid Combined with Electroencephalographic Seizure Monitoring in Mice. Front Neurosci. (11):160.
    58. Maletic-Savatic M, Valenzuela M . Front Biol. Adult neurogenesis in Provence: Where history meets science. 3(11):149-150.
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