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LI XIN

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Collapse ORNG Applications 
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    Collapse Research 
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    K99CA125937     (XIN, LI)Sep 1, 2007 - Aug 31, 2009
    NIH/NCI
    Characterization of prostatic stem cells and prostate cancer-initiating cells
    Role: Principal Investigator

    R00CA125937     (XIN, LI)Sep 1, 2007 - Aug 31, 2014
    NIH/NCI
    Characterization of prostatic stem cells and prostate cancer-initiating cells
    Role: Principal Investigator

    R01DK092202     (XIN, LI)Jul 1, 2011 - Aug 31, 2020
    NIH/NIDDK
    Prostate Epithelial Lineage Hierarchy
    Role: Principal Investigator

    R01CA190378     (XIN, LI)Jul 7, 2015 - Jun 30, 2020
    NIH/NCI
    The Notch signaling in prostate homeostasis and carcinogenesis
    Role: Principal Investigator

    R21CA196570     (XIN, LI)Apr 1, 2016 - Mar 31, 2018
    NIH/NCI
    Reprogramming of Prostate Stromal Cells by Prostate Inflammation
    Role: Principal Investigator

    R01DK107436     (XIN, LI)Jul 1, 2016 - Jun 30, 2021
    NIH/NIDDK
    Molecular Mechanisms of Initiation of Benign Prostatic Hyperplasia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L. Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell. 2019 May 02; 24(5):753-768.e6. PMID: 30982770.
      View in: PubMed
    2. Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin L. Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. iScience. 2019 Mar 29; 13:328-338. PMID: 30878879.
      View in: PubMed
    3. Janghorban M, Xin L, Rosen JM, Zhang XH. Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target? Front Immunol. 2018; 9:1649. PMID: 30061899.
      View in: PubMed
    4. Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017 08 17; 36(33):4767-4777. PMID: 28414305.
      View in: PubMed
    5. Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 09 15; 63(6):976-89. PMID: 27594448.
      View in: PubMed
    6. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. PMID: 27374105.
      View in: PubMed
    7. Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, Xin L. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017 02 02; 36(5):618-627. PMID: 27345403.
      View in: PubMed
    8. Toneff MJ, Sreekumar A, Tinnirello A, Hollander PD, Habib S, Li S, Ellis MJ, Xin L, Mani SA, Rosen JM. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016 06 17; 14:47. PMID: 27317311.
      View in: PubMed
    9. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44. PMID: 27183469.
      View in: PubMed
    10. Kwon OJ, Zhang B, Zhang L, Xin L. High fat diet promotes prostatic basal-to-luminal differentiation and accelerates initiation of prostate epithelial hyperplasia originated from basal cells. Stem Cell Res. 2016 05; 16(3):682-91. PMID: 27107344.
      View in: PubMed
    11. Wei X, Orjalo AV, Xin L. CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates. Stem Cell Res. 2016 05; 16(3):597-606. PMID: 27010655.
      View in: PubMed
    12. Su Q, Xin L. Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol. 2016 Feb; 31(2):149-57. PMID: 26521657.
      View in: PubMed
    13. Kwon OJ, Zhang L, Xin L. Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells. 2016 Jan; 34(1):191-202. PMID: 26418304.
      View in: PubMed
    14. Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 01; 409(1):202-217. PMID: 26526198.
      View in: PubMed
    15. Kwon OJ, Xin L. Prostate epithelial stem and progenitor cells. Am J Clin Exp Urol. 2014; 2(3):209-18. PMID: 25374923.
      View in: PubMed
    16. Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014 Jul 22; 5:4416. PMID: 25048699.
      View in: PubMed
    17. Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L, Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis. 2014 May 26; 3:e103. PMID: 24861463.
      View in: PubMed
    18. Kwon OJ, Zhang L, Ittmann MM, Xin L. Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E592-600. PMID: 24367088.
      View in: PubMed
    19. Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick FG, Schally AV, Frigo DE. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1a-mediated metabolic switch. Oncogene. 2014 Nov 06; 33(45):5251-61. PMID: 24186207.
      View in: PubMed
    20. Zhang B, Chen H, Zhang L, Dakhova O, Zhang Y, Lewis MT, Creighton CJ, Ittmann MM, Xin L. A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 2014 Jun 12; 33(24):3099-108. PMID: 23851498.
      View in: PubMed
    21. Valdez JM, Xin L. The dual nature of Notch in tissue homeostasis and carcinogenesis. Cell Cycle. 2013 Feb 15; 12(4):541. PMID: 23370389.
      View in: PubMed
    22. Xin L. A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance. Asian J Androl. 2013 Jan; 15(1):85-6. PMID: 23223032.
      View in: PubMed
    23. Xin L. Cells of origin for cancer: an updated view from prostate cancer. Oncogene. 2013 Aug 08; 32(32):3655-63. PMID: 23178496.
      View in: PubMed
    24. Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L. Notch and TGFß form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell. 2012 Nov 02; 11(5):676-88. PMID: 23122291.
      View in: PubMed
    25. Rowe JH, Ertelt JM, Xin L, Way SS. Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance. PLoS Pathog. 2012; 8(8):e1002873. PMID: 22916020.
      View in: PubMed
    26. Xin L, Shelite TR, Gong B, Mendell NL, Soong L, Fang R, Walker DH. Systemic treatment with CpG-B after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (IDO). PLoS One. 2012; 7(3):e34062. PMID: 22470514.
      View in: PubMed
    27. Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L. Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 2012 Oct; 21(5):1117-23. PMID: 22350718.
      View in: PubMed
    28. Choi N, Zhang B, Zhang L, Ittmann M, Xin L. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell. 2012 Feb 14; 21(2):253-65. PMID: 22340597.
      View in: PubMed
    29. Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM. Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells. 2011 Apr; 29(4):678-88. PMID: 21308863.
      View in: PubMed
    30. Zhang L, Valdez JM, Zhang B, Wei L, Chang J, Xin L. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One. 2011 Mar 28; 6(3):e18271. PMID: 21464902.
      View in: PubMed
    31. Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene. 2011 Aug 11; 30(32):3522-36. PMID: 21423204.
      View in: PubMed
    32. Zhang L, Zhang B, Valdez JM, Wang F, Ittmann M, Xin L. Dicer ablation impairs prostate stem cell activity and causes prostate atrophy. Stem Cells. 2010 Jul; 28(7):1260-9. PMID: 20517984.
      View in: PubMed
    33. Wang B, Jiao Z, Shao X, Lu L, Yang N, Zhou X, Xin L, Zhou Y, Chou KY. Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells. J Immunol. 2010 Jul 01; 185(1):79-88. PMID: 20498361.
      View in: PubMed
    34. Xin L, Vargas-Inchaustegui DA, Raimer SS, Kelly BC, Hu J, Zhu L, Sun J, Soong L. Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites. J Immunol. 2010 Jun 15; 184(12):7047-56. PMID: 20483775.
      View in: PubMed
    35. Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L. Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells. Prostate. 2010 Feb 15; 70(3):297-304. PMID: 19827049.
      View in: PubMed
    36. Bu W, Xin L, Toneff M, Li L, Li Y. Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo. J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4):401-4. PMID: 19936990.
      View in: PubMed
    37. Sanabria MX, Vargas-Inchaustegui DA, Xin L, Soong L. Role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection. Infect Immun. 2008 Nov; 76(11):5100-9. PMID: 18794295.
      View in: PubMed
    38. Xin L, Li K, Soong L. Down-regulation of dendritic cell signaling pathways by Leishmania amazonensis amastigotes. Mol Immunol. 2008 Jul; 45(12):3371-82. PMID: 18538399.
      View in: PubMed
    39. Vargas-Inchaustegui DA, Xin L, Soong L. Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. J Immunol. 2008 Jun 01; 180(11):7537-45. PMID: 18490754.
      View in: PubMed
    40. Vasquez RE, Xin L, Soong L. Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection. Infect Immun. 2008 Jan; 76(1):161-9. PMID: 17998308.
      View in: PubMed
    41. Wanasen N, Xin L, Soong L. Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection. Int J Parasitol. 2008 Mar; 38(3-4):417-29. PMID: 17959178.
      View in: PubMed
    42. Xin L, Li Y, Soong L. Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo. Infect Immun. 2007 Oct; 75(10):5018-26. PMID: 17682041.
      View in: PubMed
    43. Zhou X, Jiang Y, Lu L, Ding Q, Jiao Z, Zhou Y, Xin L, Chou KY. MHC class II transactivator represses human IL-4 gene transcription by interruption of promoter binding with CBP/p300, STAT6 and NFAT1 via histone hypoacetylation. Immunology. 2007 Dec; 122(4):476-85. PMID: 17645498.
      View in: PubMed
    44. Ding Q, Lu L, Wang B, Zhou Y, Jiang Y, Zhou X, Xin L, Jiao Z, Chou KY. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol. 2006 Sep 15; 177(6):3606-14. PMID: 16951320.
      View in: PubMed
    45. Benamar K, Xin L, Geller EB, Adler MW. Effect of central and peripheral administration of a nitric oxide synthase inhibitor on morphine hyperthermia in rats. Brain Res. 2001 Mar 16; 894(2):266-73. PMID: 11251200.
      View in: PubMed
    46. Benamar K, Xin L, Geller EB, Adler MW. Blockade of lipopolysaccharide-induced fever by a mu-opioid receptor-selective antagonist in rats. Eur J Pharmacol. 2000 Aug 04; 401(2):161-5. PMID: 10924921.
      View in: PubMed
    47. Xin L, Geller EB, Liu-Chen LY, Chen C, Adler MW. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. J Pharmacol Exp Ther. 1997 Aug; 282(2):1055-63. PMID: 9262375.
      View in: PubMed
    48. Xin L, Geller EB, Adler MW. Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J Pharmacol Exp Ther. 1997 Apr; 281(1):499-507. PMID: 9103537.
      View in: PubMed
    49. Xin L, Zhao SF, Geller EB, McCafferty MR, Sterling GH, Adler MW. Involvement of beta-endorphin in the preoptic anterior hypothalamus during interleukin-1 beta-induced fever in rats. Ann N Y Acad Sci. 1997 Mar 15; 813:324-6. PMID: 9100902.
      View in: PubMed
    50. Abood LG, Michael GJ, Xin L, Knigge KM. Interaction of putative vasopressin receptor proteins of rat brain and bovine pituitary gland with an antibody against a nanopeptide encoded by the reverse message of the complementary mRNA to vasopressin. J Recept Res. 1989; 9(1):19-25. PMID: 2521669.
      View in: PubMed
    51. Abood LG, Xin L, Michael G, Knigge KM. Interaction of putative vasopressin receptors in rat brain and bovine pituitary gland with a vasopressin anti-idiotype antibody as revealed by immunoblotting. Peptides. 1988 Nov-Dec; 9(6):1407-9. PMID: 2977644.
      View in: PubMed
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