TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
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    Collapse Research 
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    K99CA125937     (XIN, LI)Sep 1, 2007 - Aug 31, 2009
    Characterization of prostatic stem cells and prostate cancer-initiating cells
    Role: Principal Investigator

    R00CA125937     (XIN, LI)Sep 1, 2007 - Aug 31, 2014
    Characterization of prostatic stem cells and prostate cancer-initiating cells
    Role: Principal Investigator

    R01DK092202     (XIN, LI)Jul 1, 2011 - Aug 31, 2021
    Prostate Epithelial Lineage Hierarchy
    Role: Principal Investigator

    R01CA190378     (XIN, LI)Jul 7, 2015 - Jun 30, 2021
    The Notch signaling in prostate homeostasis and carcinogenesis
    Role: Principal Investigator

    R21CA196570     (XIN, LI)Apr 1, 2016 - Mar 31, 2019
    Reprogramming of Prostate Stromal Cells by Prostate Inflammation
    Role: Principal Investigator

    R01DK107436     (XIN, LI)Jul 1, 2016 - Apr 30, 2025
    Molecular mechanisms of initiation of benign prostatic hyperplasia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L. Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell. 2019 05 02; 24(5):753-768.e6. PMID: 30982770.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    2. Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin L. Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. iScience. 2019 Mar 29; 13:328-338. PMID: 30878879.
      Citations: 15     
    3. Janghorban M, Xin L, Rosen JM, Zhang XH. Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target? Front Immunol. 2018; 9:1649. PMID: 30061899.
      Citations: 36     Fields:    
    4. Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 09 15; 63(6):976-89. PMID: 27594448.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    5. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. PMID: 27374105.
      Citations: 8     Fields:    Translation:HumansAnimals
    6. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44. PMID: 27183469.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    7. Kwon OJ, Zhang B, Zhang L, Xin L. High fat diet promotes prostatic basal-to-luminal differentiation and accelerates initiation of prostate epithelial hyperplasia originated from basal cells. Stem Cell Res. 2016 05; 16(3):682-91. PMID: 27107344.
      Citations: 25     Fields:    Translation:AnimalsCells
    8. Wei X, Orjalo AV, Xin L. CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates. Stem Cell Res. 2016 05; 16(3):597-606. PMID: 27010655.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Su Q, Xin L. Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol. 2016 Feb; 31(2):149-57. PMID: 26521657.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    10. Kwon OJ, Zhang L, Xin L. Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells. 2016 Jan; 34(1):191-202. PMID: 26418304.
      Citations: 29     Fields:    Translation:AnimalsCells
    11. Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 01; 409(1):202-217. PMID: 26526198.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Kwon OJ, Xin L. Prostate epithelial stem and progenitor cells. Am J Clin Exp Urol. 2014; 2(3):209-18. PMID: 25374923.
      Citations: 12     
    13. Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014 Jul 22; 5:4416. PMID: 25048699.
      Citations: 43     Fields:    Translation:AnimalsCells
    14. Kwon OJ, Zhang L, Ittmann MM, Xin L. Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E592-600. PMID: 24367088.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    15. Valdez JM, Xin L. The dual nature of Notch in tissue homeostasis and carcinogenesis. Cell Cycle. 2013 Feb 15; 12(4):541. PMID: 23370389.
      Citations: 2     Fields:    Translation:HumansCells
    16. Xin L. A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance. Asian J Androl. 2013 Jan; 15(1):85-6. PMID: 23223032.
      Citations: 2     Fields:    
    17. Xin L. Cells of origin for cancer: an updated view from prostate cancer. Oncogene. 2013 Aug 08; 32(32):3655-63. PMID: 23178496.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    18. Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L. Notch and TGFß form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell. 2012 Nov 02; 11(5):676-88. PMID: 23122291.
      Citations: 46     Fields:    Translation:AnimalsCells
    19. Rowe JH, Ertelt JM, Xin L, Way SS. Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance. PLoS Pathog. 2012; 8(8):e1002873. PMID: 22916020.
      Citations: 29     Fields:    Translation:AnimalsCells
    20. Xin L, Shelite TR, Gong B, Mendell NL, Soong L, Fang R, Walker DH. Systemic treatment with CpG-B after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (IDO). PLoS One. 2012; 7(3):e34062. PMID: 22470514.
      Citations: 12     Fields:    Translation:AnimalsCells
    21. Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L. Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 2012 Oct; 21(5):1117-23. PMID: 22350718.
      Citations: 13     Fields:    Translation:AnimalsCells
    22. Choi N, Zhang B, Zhang L, Ittmann M, Xin L. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell. 2012 Feb 14; 21(2):253-65. PMID: 22340597.
      Citations: 188     Fields:    Translation:Animals
    23. Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM. Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells. 2011 Apr; 29(4):678-88. PMID: 21308863.
      Citations: 24     Fields:    Translation:AnimalsCells
    24. Zhang L, Valdez JM, Zhang B, Wei L, Chang J, Xin L. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One. 2011 Mar 28; 6(3):e18271. PMID: 21464902.
      Citations: 48     Fields:    Translation:AnimalsCells
    25. Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene. 2011 Aug 11; 30(32):3522-36. PMID: 21423204.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    26. Zhang L, Zhang B, Valdez JM, Wang F, Ittmann M, Xin L. Dicer ablation impairs prostate stem cell activity and causes prostate atrophy. Stem Cells. 2010 Jul; 28(7):1260-9. PMID: 20517984.
      Citations: 16     Fields:    Translation:AnimalsCells
    27. Wang B, Jiao Z, Shao X, Lu L, Yang N, Zhou X, Xin L, Zhou Y, Chou KY. Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells. J Immunol. 2010 Jul 01; 185(1):79-88. PMID: 20498361.
      Citations: 3     Fields:    Translation:AnimalsCells
    28. Xin L, Vargas-Inchaustegui DA, Raimer SS, Kelly BC, Hu J, Zhu L, Sun J, Soong L. Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites. J Immunol. 2010 Jun 15; 184(12):7047-56. PMID: 20483775.
      Citations: 54     Fields:    Translation:AnimalsCells
    29. Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L. Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells. Prostate. 2010 Feb 15; 70(3):297-304. PMID: 19827049.
      Citations: 9     Fields:    Translation:AnimalsCells
    30. Bu W, Xin L, Toneff M, Li L, Li Y. Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo. J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4):401-4. PMID: 19936990.
      Citations: 20     Fields:    Translation:AnimalsCells
    31. Sanabria MX, Vargas-Inchaustegui DA, Xin L, Soong L. Role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection. Infect Immun. 2008 Nov; 76(11):5100-9. PMID: 18794295.
      Citations: 21     Fields:    Translation:AnimalsCells
    32. Xin L, Li K, Soong L. Down-regulation of dendritic cell signaling pathways by Leishmania amazonensis amastigotes. Mol Immunol. 2008 Jul; 45(12):3371-82. PMID: 18538399.
      Citations: 45     Fields:    Translation:AnimalsCells
    33. Vargas-Inchaustegui DA, Xin L, Soong L. Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. J Immunol. 2008 Jun 01; 180(11):7537-45. PMID: 18490754.
      Citations: 41     Fields:    Translation:AnimalsCells
    34. Vasquez RE, Xin L, Soong L. Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection. Infect Immun. 2008 Jan; 76(1):161-9. PMID: 17998308.
      Citations: 23     Fields:    Translation:AnimalsCells
    35. Wanasen N, Xin L, Soong L. Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection. Int J Parasitol. 2008 Mar; 38(3-4):417-29. PMID: 17959178.
      Citations: 36     Fields:    Translation:AnimalsCells
    36. Xin L, Li Y, Soong L. Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo. Infect Immun. 2007 Oct; 75(10):5018-26. PMID: 17682041.
      Citations: 41     Fields:    Translation:AnimalsCells
    37. Zhou X, Jiang Y, Lu L, Ding Q, Jiao Z, Zhou Y, Xin L, Chou KY. MHC class II transactivator represses human IL-4 gene transcription by interruption of promoter binding with CBP/p300, STAT6 and NFAT1 via histone hypoacetylation. Immunology. 2007 Dec; 122(4):476-85. PMID: 17645498.
      Citations: 13     Fields:    Translation:HumansCells
    38. Ding Q, Lu L, Wang B, Zhou Y, Jiang Y, Zhou X, Xin L, Jiao Z, Chou KY. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol. 2006 Sep 15; 177(6):3606-14. PMID: 16951320.
      Citations: 9     Fields:    Translation:AnimalsCells
    39. Benamar K, Xin L, Geller EB, Adler MW. Effect of central and peripheral administration of a nitric oxide synthase inhibitor on morphine hyperthermia in rats. Brain Res. 2001 Mar 16; 894(2):266-73. PMID: 11251200.
      Citations: 5     Fields:    Translation:Animals
    40. Benamar K, Xin L, Geller EB, Adler MW. Blockade of lipopolysaccharide-induced fever by a mu-opioid receptor-selective antagonist in rats. Eur J Pharmacol. 2000 Aug 04; 401(2):161-5. PMID: 10924921.
      Citations: 6     Fields:    Translation:AnimalsCells
    41. Xin L, Geller EB, Liu-Chen LY, Chen C, Adler MW. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. J Pharmacol Exp Ther. 1997 Aug; 282(2):1055-63. PMID: 9262375.
      Citations: 10     Fields:    Translation:Animals
    42. Xin L, Geller EB, Adler MW. Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J Pharmacol Exp Ther. 1997 Apr; 281(1):499-507. PMID: 9103537.
      Citations: 22     Fields:    Translation:AnimalsCells
    43. Xin L, Zhao SF, Geller EB, McCafferty MR, Sterling GH, Adler MW. Involvement of beta-endorphin in the preoptic anterior hypothalamus during interleukin-1 beta-induced fever in rats. Ann N Y Acad Sci. 1997 Mar 15; 813:324-6. PMID: 9100902.
      Citations: 1     Fields:    Translation:Animals
    44. Abood LG, Michael GJ, Xin L, Knigge KM. Interaction of putative vasopressin receptor proteins of rat brain and bovine pituitary gland with an antibody against a nanopeptide encoded by the reverse message of the complementary mRNA to vasopressin. J Recept Res. 1989; 9(1):19-25. PMID: 2521669.
      Citations:    Fields:    Translation:AnimalsCells
    45. Abood LG, Xin L, Michael G, Knigge KM. Interaction of putative vasopressin receptors in rat brain and bovine pituitary gland with a vasopressin anti-idiotype antibody as revealed by immunoblotting. Peptides. 1988 Nov-Dec; 9(6):1407-9. PMID: 2977644.
      Citations: 1     Fields:    Translation:AnimalsCells
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