InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
vCardDownload vCard

    Collapse Biography 
    Collapse awards and honors
    1991Prize for scientific vocation, French Ministry of Women’s rights
    1998 - 2000Pre-doctoral Fellowship, French Multiple Sclerosis Society (Association pour la Recherche sur la Sclérose en Plaques)
    2001Dissertation Fellowship, French Medical Research Association (Fondation pour la Recherche Médicale)
    2001 - 2004Postdoctoral Fellowship , National Multiple Sclerosis Society
    2005Laverna Titus Award, American Heart Association
    2012Co-chair, session Toxins and Ion Channels, 17th World Congress of the International Society on Toxinology
    2018Clark Faculty Service Award, Baylor College of Medicine

    Collapse Overview 
    Collapse overview
    Christine Beeton is an immunologist with an interest in autoimmunity and inflammation. She received a Bachelor and a Master of Science in Biochemistry from the Faculté des Sciences de Luminy within the Université de la Mediterranée in Marseille, France. She joined Dr. Evelyne Béraud’s group for her PhD in Immunology and then moved to the University of California, Irvine, to join Dr. K. George Chandy’s group in the Department of Physiology and Biophysics as a Postdoctoral Fellow in 2001. She was promoted to Assistant Researcher in 2006 and joined the faculty of the Department of Molecular Physiology and Biophysics at Baylor College of Medicine in 2008. In 2010 she assumed the role of Academic Director of the Cytometry and Cell Sorting Core for the Dan L. Duncan Cancer Center at Baylor College of Medicine.

    As a Graduate Student, Christine Beeton was the first to show the benefits of blocking Kv1.1 and Kv1.3 channels with the scorpion venom peptide kaliotoxin to prevent and treat adoptive acute experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. She went on showing, in collaboration with Drs. Chandy and Wulff, that encephalitogenic T lymphocytes express more Kv1.3 channels than naïve T lymphocytes do and that targeting Kv1.3 channels only with ShK-Dap22 was sufficient to treat this model of multiple sclerosis. As a Postdoctoral Fellow, she continued her collaborative work with Dr. Wulff who showed that terminally differentiated human CCR7- effector memory T (TEM) lymphocytes up-regulate Kv1.3 channels upon activation whereas CCR7+ naïve and central memory T (TCM) lymphocytes up-regulate KCa3.1 channels. She demonstrated a similar switch in potassium channel phenotype in rat, but not mouse, T lymphocytes. In collaboration with the groups of Drs. Nepom, Andrews, and Calabresi she showed that T lymphocyte isolated from the synovial fluid of patients with rheumatoid arthritis and from the cerebrospinal fluid of patients with multiple sclerosis express high numbers of Kv1.3 channels. Through collaborative work with the groups of Drs. Pennington and Norton, she developed a novel analog of ShK, ShK-186 (now known as dalazatide), as a highly potent and selective blocker of Kv1.3 channels. ShK-186 preferentially inhibits human and rat TEM lymphocytes in vitro and in vivo and treats animal models of delayed type hypersensitivity, multiple sclerosis, rheumatoid arthritis, and asthma without preventing the clearance of acute viral or bacterial infections. Drs. Chandy, Beeton, and Pennington are inventors of a world-wide patent on ShK-186 and related compounds. This patent was licensed to Kineta, Inc. for the development of a new class of immunomodulators for the treatment of autoimmune diseases. Phase 1a and 1b clinical trials in healthy volunteers have shown that ShK-196 is well tolerated.

    The Beeton Lab is interested in all aspects of translational research surrounding autoimmune and other chronic inflammatory diseases. Our expertise ranges from the isolation and culture of primary human and rodent cells (lymphocytes, monocyte/macrophages, and other immune cells; fibroblast-like synoviocytes; myoblasts), functional assays ex vivo (proliferation, production and secretion of cytokines, chemokines, proteases, migration, invasion, cytotoxicity, and more) and in vivo (trafficking, production and secretion of cytokines, chemokines, proteases, and more), patch-clamp electrophysiology on excitable and non-excitable cells for identification of ion channels and pharmacology of novel ion channel modulators, and animal models of inflammatory diseases in rats and mice (active and adoptive delayed type hypersensitivity, active and adoptive acute experimental autoimmune encephalomyelitis, chronic-relapsing experimental autoimmune encephalomyelitis, collagen-induced arthritis, pristane-induced arthritis, and adjuvant-induced arthritis). Our current work revolves around two main topics: targeting potassium channels for the treatment of chronic diseases (multiple sclerosis, rheumatoid arthritis, and type 1 myotonic dystrophy) and using antioxidant nanomaterials for the treatment of T lymphocyte-mediated autoimmune diseases (multiple sclerosis and rheumatoid arthritis).

    Collapse Research 
    Collapse research activities and funding
    R21AI136876     (BEETON, CHRISTINE)Dec 1, 2018 - Jun 30, 2021
    In vivo production of a potassium channel inhibitor for immunomodulation
    Role: Principal Investigator

    RP1806721     (Beeton, Christine)Aug 31, 2018 - Aug 30, 2023
    Cancer prevention and Research Institute of Texas (CPRIT)
    Advanced multiparametric cytometry and cell sorting core
    Role: Principal Investigator

    S10OD025251     (BEETON, CHRISTINE)Mar 13, 2018 - Mar 12, 2019
    Union Biometrica BioSorter
    Role: Principal Investigator

    R01NS073712     (BEETON, CHRISTINE)Sep 1, 2011 - May 31, 2017
    New Peptides for the Treatment of Multiple Sclerosis
    Role: Principal Investigator

    R56AI084981     (BEETON, CHRISTINE)Aug 18, 2010 - Jan 31, 2012
    Targeting T lymphocyte potassium channels for the treatment of asthma--OLD
    Role: Principal Investigator

    R03AR059838     (BEETON, CHRISTINE)Jul 1, 2010 - Jun 30, 2013
    Potassium channels in myotonic dystrophy type 1
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, Gulko PS. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023 Jun; 92:104603. PMID: 37201335; PMCID: PMC10203746.
      Citations:    Fields:    Translation:AnimalsCells
    2. Wang Y, Hurley A, De Giorgi M, Tanner MR, Hu RC, Pennington MW, Lagor WR, Beeton C. Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. PLoS One. 2023; 18(4):e0283996. PMID: 37040361; PMCID: PMC10089316.
      Citations:    Fields:    Translation:AnimalsCells
    3. Wang Y, Zhu D, Ortiz-Velez LC, Perry JL, Pennington MW, Hyser JM, Britton RA, Beeton C. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2211977120. PMID: 36595694; PMCID: PMC9926172.
      Citations: 4     Fields:    Translation:HumansAnimals
    4. Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO. Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Sci Rep. 2022 02 18; 12(1):2847. PMID: 35181688; PMCID: PMC8857282.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Markakis I, Charitakis I, Beeton C, Galani M, Repousi E, Aggeloglou S, Sfikakis PP, Pennington MW, Chandy KG, Poulopoulou C. Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis. Front Pharmacol. 2021; 12:714841. PMID: 34630091; PMCID: PMC8495199.
    6. Tanner MR, Huq R, Sikkema WKA, Nilewski LG, Yosef N, Schmitt C, Flores-Suarez CP, Raugh A, Laragione T, Tour JM, Beeton C, Gulko PS. Antioxidant Carbon Nanoparticles Inhibit Fibroblast-Like Synoviocyte Invasiveness and Reduce Disease Severity in a Rat Model of Rheumatoid Arthritis. Antioxidants (Basel). 2020 Oct 16; 9(10). PMID: 33081234; PMCID: PMC7602875.
    7. Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736. PMID: 32832873; PMCID: PMC7432667.
      Citations: 3     
    8. Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WR. AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9. Mol Ther. 2020 Jun 03; 28(6):1432-1441. PMID: 32348718; PMCID: PMC7264438.
      Citations: 49     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Johnson JL, Stoica L, Liu Y, Zhu PJ, Bhattacharya A, Buffington SA, Huq R, Eissa NT, Larsson O, Porse BT, Domingo D, Nawaz U, Carroll R, Jolly L, Scerri TS, Kim HG, Brignell A, Coleman MJ, Braden R, Kini U, Jackson V, Baxter A, Bahlo M, Scheffer IE, Amor DJ, Hildebrand MS, Bonnen PE, Beeton C, Gecz J, Morgan AT, Costa-Mattioli M. Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Neuron. 2019 11 20; 104(4):665-679.e8. PMID: 31585809; PMCID: PMC7312756.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    10. Tanner MR, Pennington MW, Chauhan SS, Laragione T, Beeton C, Gulko PS. KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis. Arthritis Res Ther. 2019 01 07; 21(1):6. PMID: 30612588; PMCID: PMC6322314.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N, Schmitz W, M?ller FU. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242. PMID: 29802206; PMCID: PMC6252285.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    12. Tanner MR, Pennington MW, Chamberlain BH, Huq R, Gehrmann EJ, Laragione T, Beeton C, Gulko PS. Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. J Pharmacol Exp Ther. 2018 05; 365(2):227-236. PMID: 29453198; PMCID: PMC5878672.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Tanner MR, Beeton C. Differences in ion channel phenotype and function between humans and animal models. Front Biosci (Landmark Ed). 2018 01 01; 23(1):43-64. PMID: 28930537; PMCID: PMC5626566.
      Citations: 18     Fields:    Translation:HumansAnimals
    14. Beeton C. KCa1.1 channels as therapeutic targets for rheumatoid arthritis. Expert Opin Ther Targets. 2017 12; 21(12):1077-1081. PMID: 29076378; PMCID: PMC5676537.
      Citations: 2     Fields:    Translation:HumansAnimals
    15. Bergmann R, Kubeil M, Zarschler K, Chhabra S, Tajhya RB, Beeton C, Pennington MW, Bachmann M, Norton RS, Stephan H. Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats. Sci Rep. 2017 06 16; 7(1):3756. PMID: 28623364; PMCID: PMC5473807.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Tanner MR, Pennington MW, Laragione T, Beeton C, Gulko PS. KCa1.1 channels regulate ?1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes. FASEB J. 2017 08; 31(8):3309-3320. PMID: 28428266; PMCID: PMC5503717.
      Citations: 11     Fields:    Translation:HumansCells
    17. Tanner MR, Tajhya RB, Huq R, Gehrmann EJ, Rodarte KE, Atik MA, Norton RS, Pennington MW, Beeton C. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clin Immunol. 2017 07; 180:45-57. PMID: 28389388; PMCID: PMC5484050.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. Tajhya RB, Patel RS, Beeton C. Detection of Matrix Metalloproteinases by Zymography. Methods Mol Biol. 2017; 1579:231-244. PMID: 28299740; PMCID: PMC5465868.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    19. Fortune RD, Grill RJ, Beeton C, Tanner M, Huq R, Loose DS. Changes in Gene Expression and Metabolism in the Testes of the Rat following Spinal Cord Injury. J Neurotrauma. 2017 03 15; 34(6):1175-1186. PMID: 27750479; PMCID: PMC5359692.
      Citations: 3     Fields:    Translation:Animals
    20. Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 10 20; 7(10):e2426. PMID: 27763639; PMCID: PMC5133989.
      Citations: 10     Fields:    Translation:HumansCells
    21. Huq R, Samuel EL, Sikkema WK, Nilewski LG, Lee T, Tanner MR, Khan FS, Porter PC, Tajhya RB, Patel RS, Inoue T, Pautler RG, Corry DB, Tour JM, Beeton C. Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation. Sci Rep. 2016 Sep 22; 6:33808. PMID: 27654170; PMCID: PMC5031970.
      Citations: 15     Fields:    
    22. Inoue T, Griffin DM, Huq R, Samuel EL, Ruano SH, Stinnett G, Majid TJ, Beeton C, Tour JM, Pautler RG. Characterization of a novel MR-detectable nanoantioxidant that mitigates the recall immune response. NMR Biomed. 2016 10; 29(10):1436-44. PMID: 27552925; PMCID: PMC5035207.
      Citations: 2     Fields:    Translation:AnimalsCells
    23. Tanner MR, Tajhya RB, Huq R, Laragione T, Panyi G, Beeton C, Petho Z, Gulko PS. Different expression of ? subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther. 2016 05 10; 18(1):103. PMID: 27165430; PMCID: PMC4863321.
      Citations: 12     Fields:    Translation:HumansCells
    24. Ayyar BV, Tajhya RB, Beeton C, Atassi MZ. Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin. Sci Rep. 2015 Oct 28; 5:15776. PMID: 26508475; PMCID: PMC4623786.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    25. Chang SC, Huq R, Chhabra S, Beeton C, Pennington MW, Smith BJ, Norton RS. N-Terminally extended analogues of the K? channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. FEBS J. 2015 Jun; 282(12):2247-59. PMID: 25864722; PMCID: PMC4472561.
      Citations: 8     Fields:    Translation:AnimalsCells
    26. Laragione T, Cheng KF, Tanner MR, He M, Beeton C, Al-Abed Y, Gulko PS. The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Clin Immunol. 2015 Jun; 158(2):183-92. PMID: 25869297; PMCID: PMC4617367.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Norton RS, Pennington MW, BEETON C. Venoms to drugs: Venom as a source for the development of human therapeutics, G.F. King, Editor. Transforming a toxin into a therapeutic: the sea anemone potassium channel blocker ShK toxin for treatment of autoimmune diseases. 2015. View Publication.
    28. Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL, Poch? RA. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skelet Muscle. 2015; 5:4. PMID: 25717360; PMCID: PMC4340672.
      Citations: 29     Fields:    
    29. Pennington MW, Chang SC, Chauhan S, Huq R, Tajhya RB, Chhabra S, Norton RS, Beeton C. Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK. Mar Drugs. 2015 Jan 16; 13(1):529-42. PMID: 25603346; PMCID: PMC4306950.
      Citations: 16     Fields:    Translation:AnimalsCells
    30. Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Beeton C, Gulko PS. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Jan; 67(1):96-106. PMID: 25252152; PMCID: PMC4280298.
      Citations: 14     Fields:    Translation:AnimalsCells
    31. Ge L, Hoa NT, Wilson Z, Arismendi-Morillo G, Kong XT, Tajhya RB, Beeton C, Jadus MR. Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy. Int Immunopharmacol. 2014 Oct; 22(2):427-43. PMID: 25027630; PMCID: PMC5472047.
      Citations: 30     Fields:    Translation:HumansAnimals
    32. Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64. PMID: 24891519; PMCID: PMC4139903.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    33. Hoa NT, Ge L, Tajhya RB, Beeton C, Cornforth AN, Abolhoda A, Lambrecht N, DaCosta-Iyer M, Ouyang Y, Mai AP, Hong E, Shon J, Hickey MJ, Erickson KL, Kruse CA, Jadus MR. Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease. Am J Transl Res. 2014; 6(3):188-205. PMID: 24936214; PMCID: PMC4058303.
      Citations: 10     
    34. Rashid MH, Huq R, Tanner MR, Chhabra S, Khoo KK, Estrada R, Dhawan V, Chauhan S, Pennington MW, Beeton C, Kuyucak S, Norton RS. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. 2014 Mar 28; 4:4509. PMID: 24676092; PMCID: PMC3968461.
      Citations: 31     Fields:    Translation:AnimalsCells
    35. Koshy S, Huq R, Tanner MR, Atik MA, Porter PC, Khan FS, Pennington MW, Hanania NA, Corry DB, Beeton C. Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma. J Biol Chem. 2014 May 02; 289(18):12623-32. PMID: 24644290; PMCID: PMC4007452.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    36. Panyi G, Beeton C, Felipe A. Ion channels and anti-cancer immunity. Philos Trans R Soc Lond B Biol Sci. 2014 Mar 19; 369(1638):20130106. PMID: 24493754; PMCID: PMC3917360.
      Citations: 19     Fields:    Translation:HumansCells
    37. Rashid MH, Heinzelmann G, Huq R, Tajhya RB, Chang SC, Chhabra S, Pennington MW, Beeton C, Norton RS, Kuyucak S. A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation. PLoS One. 2013; 8(11):e78712. PMID: 24244345; PMCID: PMC3820677.
      Citations: 25     Fields:    Translation:AnimalsCells
    38. Koshy S, Wu D, Hu X, Tajhya RB, Huq R, Khan FS, Pennington MW, Wulff H, Yotnda P, Beeton C. Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes. PLoS One. 2013; 8(10):e76740. PMID: 24146918; PMCID: PMC3795664.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    39. BEETON C. The handbook of peptides, 2nd edition, A.J. Kastin, Editor. Targets and therapeutic properties of venom peptides. 2013; ISBN 978-0-12-385095-9.
    40. Anangi R, Koshy S, Huq R, Beeton C, Chuang WJ, King GF. Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. PLoS One. 2012; 7(12):e52965. PMID: 23300835; PMCID: PMC3530466.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Pennington MW, Harunur Rashid M, Tajhya RB, Beeton C, Kuyucak S, Norton RS. A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3. FEBS Lett. 2012 Nov 16; 586(22):3996-4001. PMID: 23063513; PMCID: PMC3496055.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    42. Chang SC, Galea CA, Leung EW, Tajhya RB, Beeton C, Pennington MW, Norton RS. Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria. Toxicon. 2012 Oct; 60(5):840-50. PMID: 22659540; PMCID: PMC3411878.
      Citations: 13     Fields:    Translation:Cells
    43. Tarcha EJ, Chi V, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, Knapp B, Kentala D, Hansen Z, Pennington MW, Beeton C, Chandy KG, Iadonato SP, Mu?oz-El?as EJ. Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. J Pharmacol Exp Ther. 2012 Sep; 342(3):642-53. PMID: 22637724; PMCID: PMC3422530.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    44. Varga Z, Gurrola-Briones G, Papp F, Pedraza-Alva G, Tajhya RB, Gaspar R, Cardenas L, Rosenstein Y, Beeton C, Possani LD, Panyi G, Rodr?guez de la Vega RC. Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. Mol Pharmacol. 2012 Sep; 82(3):372-82. PMID: 22622363; PMCID: PMC3422703.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    45. Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Beeton C, Gulko PS. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 03; 287(6):4014-22. PMID: 22074915; PMCID: PMC3281680.
      Citations: 23     Fields:    Translation:HumansCells
    46. Beeton C, Pennington MW, Norton RS. Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases. Inflamm Allergy Drug Targets. 2011 Oct; 10(5):313-21. PMID: 21824083; PMCID: PMC3398462.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    47. Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46. PMID: 21867724; PMCID: PMC3397671.
      Citations: 86     Fields:    Translation:AnimalsCells
    48. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334. PMID: 21629267; PMCID: PMC3133923.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    49. Hu X, Beeton C. Detection of functional matrix metalloproteinases by zymography. J Vis Exp. 2010 Nov 08; (45). PMID: 21085107; PMCID: PMC3159606.
      Citations: 58     Fields:    
    50. Koshy S, Alizadeh P, Timchenko LT, Beeton C. Quantitative measurement of GLUT4 translocation to the plasma membrane by flow cytometry. J Vis Exp. 2010 Nov 07; (45). PMID: 21085106; PMCID: PMC3159605.
      Citations: 10     Fields:    Translation:HumansCells
    51. Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr; 75(4):762-73. PMID: 19122005; PMCID: PMC2684922.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    52. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Pennington MW, Parker I, Chandy KG, Cahalan MD, Fl?gel A. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. PMID: 18835197; PMCID: PMC2732399.
      Citations: 119     Fields:    Translation:AnimalsCells
    53. Matheu MP, Beeton C, Parker I, Chandy KG, D Cahalan M. Imaging effector memory T cells in the ear after induction of adoptive DTH. J Vis Exp. 2008 Aug 14; (18). PMID: 19066497; PMCID: PMC3253563.
      Citations: 1     Fields:    Translation:AnimalsCells
    54. Beeton C, Chandy KG. Isolation of mononuclear cells from the central nervous system of rats with EAE. J Vis Exp. 2007; (10):527. PMID: 18989401; PMCID: PMC2557079.
      Citations: 13     Fields:    Translation:AnimalsCells
    55. Beeton C. Discovery on Target 2007--CHI's Fifth Annual Conference. Ion channels. IDrugs. 2007 Dec; 10(12):851-4. PMID: 18041678.
      Citations:    Fields:    Translation:HumansAnimals
    56. Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11; 283(2):988-97. PMID: 17984097.
      Citations: 26     Fields:    Translation:HumansCells
    57. Beeton C, Chandy KG. Preparing T cell growth factor from rat splenocytes. J Vis Exp. 2007; (10):402. PMID: 18989399; PMCID: PMC2557076.
      Citations: 11     Fields:    Translation:AnimalsCells
    58. Beeton C, Chandy KG. Induction and monitoring of adoptive delayed-type hypersensitivity in rats. J Vis Exp. 2007 Oct 01; (8). PMID: 19252470; PMCID: PMC2956222.
      Citations: 10     Fields:    Translation:AnimalsCells
    59. Beeton C, Chandy KG. Enrichment of NK cells from human blood with the RosetteSep kit from StemCell technologies. J Vis Exp. 2007; (8):326. PMID: 18989426; PMCID: PMC2562500.
      Citations: 5     Fields:    Translation:HumansCells
    60. Beeton C, Garcia A, Chandy KG. Drawing blood from rats through the saphenous vein and by cardiac puncture. J Vis Exp. 2007; (7):266. PMID: 18989437; PMCID: PMC2565848.
      Citations: 17     Fields:    Translation:Animals
    61. Beeton C, Chandy KG. Induction and monitoring of active delayed type hypersensitivity (DTH) in rats. J Vis Exp. 2007; (6):237. PMID: 18997885; PMCID: PMC2557114.
      Citations: 8     Fields:    Translation:AnimalsCells
    62. Beeton C, Garcia A, Chandy KG. Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis. J Vis Exp. 2007; (5):224. PMID: 18979022; PMCID: PMC2557091.
      Citations: 13     Fields:    Translation:Animals
    63. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. PMID: 17088564; PMCID: PMC1859943.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    64. BEETON C, Gutman GA, Chandy KG. The handbook of peptides, A.J. Kastin, Editor. Targets and therapeutic properties of venom peptides. 2006; ISBN 0123694426 .
    65. Wulff H, BEETON C, Calabresi PA, Gutman GA, Pennington MW, Chandy KG . Voltage-gated ion channels as drug targets, D.J. Triggle, M. Gopalakrishnan, D. Rampe, Editors. The Kv1.3 potassium channel: physiology, pharmacology and therapeutic indications. 2006; ISBN 3-527-31258-7.
    66. Chandy KG, BEETON C, Pennington MW. Analogs of ShK toxin and their uses in selective inhibition of Kv1.3 potassium channels. 2006.
    67. Beeton C, Chandy KG. Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist. 2005 Dec; 11(6):550-62. PMID: 16282596.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    68. Mosbah A, Ferrat G, Beeton C, Andreotti N, Mansuelle P, De Waard M, Sabatier JM, Carrega L, Darbon H. The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily. Proteins. 2005 Dec 01; 61(4):1010-23. PMID: 16247791.
      Citations: 10     Fields:    Translation:AnimalsCells
    69. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9. PMID: 16043714; PMCID: PMC1182417.
      Citations: 92     Fields:    Translation:HumansCells
    70. Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81. PMID: 15665253; PMCID: PMC4275123.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    71. Beeton C, Ferrat G, Andreotti N, De Waard M, Sabatier JM, Regaya I, Darbon H. Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J Biol Chem. 2004 Dec 31; 279(53):55690-6. PMID: 15498765.
      Citations: 16     Fields:    Translation:AnimalsCells
    72. Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Chandy KG, H?nsel W. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74. PMID: 15155830.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    73. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. PMID: 15120495; PMCID: PMC2749963.
      Citations: 191     Fields:    Translation:HumansCells
    74. Beeton C, Crest M, Devaux J, B?raud E. [Ion channels and demyelination: basis of a treatment of experimental autoimmune encephalomyelitis (EAE) by potassium channel blockers]. Rev Neurol (Paris). 2004 May; 160(5 Pt 2):S16-27. PMID: 15269656.
      Citations: 3     Fields:    Translation:AnimalsCells
    75. Wulff H, Beeton C, Chandy KG. Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):640-7. PMID: 14579513.
      Citations: 55     Fields:    Translation:HumansCells
    76. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13. PMID: 12782673; PMCID: PMC156104.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    77. Forni C, Beeton C, Barbaria J, Gola M, Crest M, Devaux J, B?raud E. Myelin basic protein-reactive T cells induce conduction failure in vivo but not in vitro. Neuroreport. 2003 Mar 03; 14(3):317-20. PMID: 12634475.
      Citations: 6     Fields:    Translation:AnimalsCells
    78. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. PMID: 12511563.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    79. Béraud E, Devaux J, BEETON C, Clot-Faybesse O, Barbaria J, Crest M. Ion channels and physiopathologies of nerve conduction and cell proliferation, B. Rouzaire-Dubois, E. Benoit & J.M. Dubois, Editors. Potassium channel blockers modify central nervous conduction, inhibit T-lymphocyte proliferation, and improve experimental autoimmune encephalomyelitis. 2002; ISBN 81-7736-135-X.
    80. Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Beeton C, B?raud E. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. PMID: 11717451; PMCID: PMC61146.
      Citations: 134     Fields:    Translation:AnimalsCells
    81. Barbaria J, Giraud P, Devaux J, Benoliel AM, Gola M, Sabatier JM, Bernard D, Crest M, Beeton C, B?raud E. Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J Immunol. 2001 Jan 15; 166(2):936-44. PMID: 11145670.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    82. BEETON C. Potassium channel blockers: immunosuppressive properties and therapy of experimental autoimmune encephalomyelitis. 2001.
    BEETON's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (368)
    Co-Authors (26)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors