bcl-2 Homologous Antagonist-Killer Protein
"bcl-2 Homologous Antagonist-Killer Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
| Descriptor ID |
D050998
|
| MeSH Number(s) |
D12.644.360.075.718.750 D12.776.476.075.718.425
|
| Concept/Terms |
bcl-2 Homologous Antagonist-Killer Protein- bcl-2 Homologous Antagonist-Killer Protein
- bcl 2 Homologous Antagonist Killer Protein
- bcl2 Homologous Antagonist-Killer Protein
- bcl2 Homologous Antagonist Killer Protein
- Bak Protein
|
Below are MeSH descriptors whose meaning is more general than "bcl-2 Homologous Antagonist-Killer Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2 Homologous Antagonist-Killer Protein".
This graph shows the total number of publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in this website by year, and whether "bcl-2 Homologous Antagonist-Killer Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in Profiles.
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Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. Elife. 2017 11 17; 6.
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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20; 24(4):493-506.e5.
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Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS One. 2015; 10(6):e0130520.
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Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circ Res. 2015 May 22; 116(11):1800-9.
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Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife. 2013 Aug 27; 2:e00772.
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A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31.
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Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol. 2011 Dec 01; 187(11):5684-92.
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Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma. Br J Haematol. 2011 Mar; 152(5):579-92.
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Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta. 2011 Jul; 1813(7):1382-94.
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Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor. J Biol Chem. 2010 Nov 19; 285(47):36876-83.