TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Overview 
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    In the Regulatory Circuits Lab ( we infer pathophysiological consequences of genomic variants and aberrant gene expression through analyses of molecular profiles. Towards this goal we combine computational analyses and biochemical experiments, leveraging regulatory circuits to identify new driver genes and interpret the function of genomic variants that act in cis and in trans.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zheng JJ, Wang PW, Huang TW, Yang YJ, Chiu HS, Sumazin P, Chen TW. MOCHI: a comprehensive cross-platform tool for amplicon-based microbiota analysis. Bioinformatics. 2022 09 15; 38(18):4286-4292. PMID: 35876544; PMCID: PMC9477538.
      Citations:    Fields:    
    2. Woodfield SE, Mistretta BJ, Patel RH, Ibarra AM, Fisher KE, Sarabia SF, Gandhi I, Reuther J, Starosolski Z, Badachhape A, Epps J, Zorman B, Shah AP, Larson SR, Srivastava RK, Shi Y, Espinoza AF, Govindu SR, Whitlock RS, Holloway K, Roy A, Sumazin P, Ghaghada KB, Lopez-Terrada D, Gunaratne PH, Vasudevan SA. HepT1-derived murine models of high-risk hepatoblastoma display vascular invasion, metastasis, and circulating tumor cells. Biol Open. 2022 09 15; 11(9). PMID: 35451474; PMCID: PMC9493725.
      Citations:    Fields:    
    3. Lewis AH, Bridges CS, Moorshead DN, Chen TJ, Du W, Zorman B, Sumazin P, Puppi M, Lacorazza HD. Kr?ppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia. Stem Cells. 2022 08 25; 40(8):736-750. PMID: 35535819; PMCID: PMC9406610.
      Citations:    Fields:    
    4. Tao L, Mohammad MA, Milazzo G, Moreno-Smith M, Patel TD, Zorman B, Badachhape A, Hernandez BE, Wolf AB, Zeng Z, Foster JH, Aloisi S, Sumazin P, Zu Y, Hicks J, Ghaghada KB, Putluri N, Perini G, Coarfa C, Barbieri E. MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma. Nat Commun. 2022 06 28; 13(1):3728. PMID: 35764645; PMCID: PMC9240069.
      Citations:    Fields:    Translation:AnimalsCells
    5. Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Patel KR, Finegold MJ, Pozza A, Alaggio R, L?pez-Terrada DH. Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. J Hepatol. 2022 10; 77(4):1026-1037. PMID: 35577029; PMCID: PMC9524481.
      Citations:    Fields:    
    6. Fu Y, Lorrai I, Zorman B, Mercatelli D, Shankula C, Marquez Gaytan J, Lefebvre C, de Guglielmo G, Kim HR, Sumazin P, Giorgi FM, Repunte-Canonigo V, Sanna PP. Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats. Viruses. 2022 03 24; 14(4). PMID: 35458399; PMCID: PMC9030762.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Junco JJ, Zorman B, Gant VU, Lacorazza HD, Sumazin P, Rabin KR, Mu?oz J. CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome. Exp Hematol. 2022 06; 110:34-38. PMID: 35306048; PMCID: PMC9133228.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Lorenzi L, Chiu HS, Avila Cobos F, Gross S, Volders PJ, Cannoodt R, Nuytens J, Vanderheyden K, Anckaert J, Lefever S, Tay AP, de Bony EJ, Trypsteen W, Gysens F, Vromman M, Goovaerts T, Hansen TB, Kuersten S, Nijs N, Taghon T, Vermaelen K, Bracke KR, Saeys Y, De Meyer T, Deshpande NP, Anande G, Chen TW, Wilkins MR, Unnikrishnan A, De Preter K, Koster J, Schroth GP, Vandesompele J, Sumazin P, Mestdagh P, Kjems J. Publisher Correction: The RNA Atlas expands the catalog of human non-coding RNAs. Nat Biotechnol. 2021 Nov; 39(11):1467. PMID: 34183863.
      Citations:    Fields:    
    9. Woodfield SE, Shi Y, Patel RH, Chen Z, Shah AP, Srivastava RK, Whitlock RS, Ibarra AM, Larson SR, Sarabia SF, Badachhape A, Starosolski Z, Ghaghada KB, Sumazin P, Annis DA, Vasudevan SA, L?pez-Terrada D. Author Correction: MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma. Sci Rep. 2021 Oct 01; 11(1):19916. PMID: 34599198; PMCID: PMC8486835.
      Citations:    Fields:    
    10. Rosa A, Ciaudo C, Sumazin P, Fazi F. Editorial: The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease. Front Cell Dev Biol. 2021; 9:715341. PMID: 34595170; PMCID: PMC8476796.
    11. Tao L, Moreno-Smith M, Milazzo G, Drolet NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P, Perini G, Parchem RJ, Uribe RA, Barbieri E, Ibarra-Garc?a-Padilla R. CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Adv Sci (Weinh). 2021 10; 8(19):e2005047. PMID: 34365742; PMCID: PMC8498874.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Moreno-Smith M, Milazzo G, Tao L, Fekry B, Zhu B, Mohammad MA, Di Giacomo S, Borkar R, Reddy KRK, Vasudevan SA, Sumazin P, Hicks J, Putluri N, Perini G, Eckel-Mahan K, Burris TP, Barbieri E, Capasso M. Restoration of the molecular clock is tumor suppressive in neuroblastoma. Nat Commun. 2021 06 28; 12(1):4006. PMID: 34183658; PMCID: PMC8238982.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    13. Lorenzi L, Chiu HS, Avila Cobos F, Gross S, Volders PJ, Cannoodt R, Nuytens J, Vanderheyden K, Anckaert J, Lefever S, Tay AP, de Bony EJ, Trypsteen W, Gysens F, Vromman M, Goovaerts T, Hansen TB, Kuersten S, Nijs N, Taghon T, Vermaelen K, Bracke KR, Saeys Y, De Meyer T, Deshpande NP, Anande G, Chen TW, Wilkins MR, Unnikrishnan A, De Preter K, Koster J, Schroth GP, Vandesompele J, Sumazin P, Mestdagh P, Kjems J. The RNA Atlas expands the catalog of human non-coding RNAs. Nat Biotechnol. 2021 11; 39(11):1453-1465. PMID: 34140680.
      Citations: 18     Fields:    Translation:HumansCells
    14. Flint DB, Bright SJ, McFadden CH, Konishi T, Ohsawa D, Turner B, Lin SH, Grosshans DR, Chiu HS, Sumazin P, Shaitelman SF, Sawakuchi GO. Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions. Med Phys. 2021 Jun; 48(6):3243-3261. PMID: 33837540.
      Citations:    Fields:    Translation:HumansCells
    15. . A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Reports. 2021; 100281. View Publication.
    16. Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281. PMID: 34036256; PMCID: PMC8138774.
      Citations: 6     
    17. Woodfield SE, Shi Y, Patel RH, Chen Z, Shah AP, Srivastava RK, Whitlock RS, Ibarra AM, Larson SR, Sarabia SF, Badachhape A, Starosolski Z, Ghaghada KB, Sumazin P, Annis DA, Vasudevan SA, L?pez-Terrada D. MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma. Sci Rep. 2021 02 03; 11(1):2967. PMID: 33536467; PMCID: PMC7859402.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    18. Chiu HS, Somvanshi S, Chen TW, Sumazin P. Illuminating lncRNA Function Through Target Prediction. Methods Mol Biol. 2021; 2372:263-295. PMID: 34417758.
      Citations: 1     Fields:    Translation:Humans
    19. Kim HR, Chouvarine P, Rutishauser D, De Vargas Roditi L, Szalai B, Wagner U, Oehl K, Saba K, Pati A, Saez-Rodriguez J, Roy A, Parsons DW, Wild PJ, Sumazin P, Manica M, Mathis R, Mart?nez MR. Inferring clonal composition from multiple tumor biopsies. NPJ Syst Biol Appl. 2020 08 25; 6(1):27. PMID: 32843649; PMCID: PMC7447821.
      Citations: 2     Fields:    Translation:Humans
    20. Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, O'Connell JR, Mitchell BD, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, O'Connor TD, Celed?n JC, Soto-Quiros ME, Avila L, Z?llner S. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2560-2569. PMID: 31964835; PMCID: PMC7007577.
      Citations: 20     Fields:    Translation:Humans
    21. Stevens AM, Xiang M, Heppler LN, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA, To?ic I. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. Blood Adv. 2019 12 23; 3(24):4215-4227. PMID: 31856268; PMCID: PMC6929386.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    22. Lara OD, Wang Y, Asare A, Xu T, Chiu HS, Liu Y, Hu W, Sumazin P, Uppal S, Zhang L, Rauh-Hain JA, Sood AK. Pan-cancer clinical and molecular analysis of racial disparities. Cancer. 2020 02 15; 126(4):800-807. PMID: 31730714; PMCID: PMC6992510.
      Citations: 9     Fields:    Translation:Humans
    23. . The RNA Atlas, a single nucleotide resolution map of the human transcriptome. bioRxiv. 2019; (807529).
    24. de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Sanna PP. Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions. Brain Res. 2020 01 01; 1726:146502. PMID: 31605699; PMCID: PMC7195807.
      Citations: 12     Fields:    Translation:Animals
    25. Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO. Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death. Int J Radiat Oncol Biol Phys. 2019 12 01; 105(5):1119-1125. PMID: 31425731; PMCID: PMC6872929.
      Citations: 9     Fields:    Translation:HumansCells
    26. Rombaut D, Chiu HS, Decaesteker B, Everaert C, Yigit N, Bartenhagen C, Fischer M, Roberts S, De Preter K, Speleman F, Denecker G, Sumazin P, Vandesompele J, Lefever S, Mestdagh P, Peltier A, Janoueix-Lerosey I, D'Haene N. Author Correction: Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes. Sci Rep. 2019 Jul 17; 9(1):10536. PMID: 31311990; PMCID: PMC6635357.
      Citations:    Fields:    
    27. Rombaut D, Chiu HS, Decaesteker B, Everaert C, Yigit N, Bartenhagen C, Fischer M, Roberts S, De Preter K, Speleman F, Denecker G, Sumazin P, Vandesompele J, Lefever S, Mestdagh P, Peltier A, Janoueix-Lerosey I, D'Haene N. Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes. Sci Rep. 2019 04 05; 9(1):5685. PMID: 30952905; PMCID: PMC6451017.
      Citations: 4     Fields:    Translation:HumansCells
    28. Zhang J, Liu P, Tao J, Wang P, Zhang Y, Song X, Che L, Sumazin P, Ribback S, Kiss A, Schaff Z, Cigliano A, Dombrowski F, Cossu C, Pascale RM, Calvisi DF, Monga SP, Chen X. TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma. Am J Pathol. 2019 05; 189(5):1077-1090. PMID: 30794805; PMCID: PMC6526503.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    29. Fu Y, Zorman B, Sumazin P, Sanna PP, Repunte-Canonigo V. Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats. PLoS One. 2019; 14(1):e0203566. PMID: 30653517; PMCID: PMC6336335.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    30. Ustianenko D, Chiu HS, Treiber T, Weyn-Vanhentenryck SM, Treiber N, Meister G, Sumazin P, Zhang C. LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs. Mol Cell. 2018 07 19; 71(2):271-283.e5. PMID: 30029005; PMCID: PMC6238216.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    31. Zhang Y, Paikari A, Sumazin P, Ginter Summarell CC, Crosby JR, Boerwinkle E, Weiss MJ, Sheehan VA. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018 07 19; 132(3):321-333. PMID: 29884740; PMCID: PMC6053951.
      Citations: 20     Fields:    Translation:HumansCells
    32. Chiu HS, Yang X, Sumazin P, Mart?nez MR, Komissarova EV, Llobet-Navas D, Bansal M, Paull EO, Silva J, Califano A. The number of titrated microRNA species dictates ceRNA regulation. Nucleic Acids Res. 2018 05 18; 46(9):4354-4369. PMID: 29684207; PMCID: PMC5961349.
      Citations: 17     Fields:    Translation:Humans
    33. Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS, Cancer Genome Atlas Research Network, Sood AK, Gunaratne PH, Sumazin P. Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context. Cell Rep. 2018 04 03; 23(1):297-312.e12. PMID: 29617668; PMCID: PMC5906131.
      Citations: 102     Fields:    Translation:HumansCells
    34. Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, Gevaert O, Prunello M, Shen H, Anur P, Chen J, Cheng H, Hayes DN, Bullman S, Pedamallu CS, Ojesina AI, Sadeghi S, Mungall KL, Robertson AG, Benz C, Schultz A, Kanchi RS, Gay CM, Hegde A, Diao L, Wang J, Ma W, Sumazin P, Chiu HS, Chen TW, Gunaratne P, Donehower L, Rader JS, Zuna R, Al-Ahmadie H, Lazar AJ, Flores ER, Tsai KY, Zhou JH, Rustgi AK, Drill E, Shen R, Wong CK, Cancer Genome Atlas Research Network, Stuart JM, Laird PW, Hoadley KA, Weinstein JN, Peto M, Pickering CR, Chen Z, Van Waes C. Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. Cell Rep. 2018 04 03; 23(1):194-212.e6. PMID: 29617660; PMCID: PMC6002769.
      Citations: 107     Fields:    Translation:HumansCells
    35. Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, Liu Y, Fan H, Shen H, Ravikumar V, Rao A, Schultz A, Li X, Sumazin P, Mestdagh P, Gunaratne PH, Yau C, Bowlby R, Robertson AG, Wang C, Cherniack AD, Godwin AK, Kuderer NM, Rader JS, Zuna RE, Sood AK, Lazar AJ, Ojesina AI, Adebamowo C, Adebamowo SN, Baggerly KA, Chen TW, Chiu HS, Lefever S, Liu L, MacKenzie K, Orsulic S, Roszik J, Shelley CS, Song Q, Vellano CP, Wentzensen N, Cancer Genome Atlas Research Network, Weinstein JN, Mills GB, Levine DA, Akbani R, Williams C, Tiezzi DG. A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. Cancer Cell. 2018 04 09; 33(4):690-705.e9. PMID: 29622464; PMCID: PMC5959730.
      Citations: 207     Fields:    Translation:Humans
    36. Bielamowicz K, Fousek K, Byrd TT, Samaha H, Mukherjee M, Aware N, Wu MF, Orange JS, Sumazin P, Man TK, Joseph SK, Hegde M, Ahmed N. Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma. Neuro Oncol. 2018 03 27; 20(4):506-518. PMID: 29016929; PMCID: PMC5909636.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    37. Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, Ibarra AM, Bissig KD, Ghaghada KB, Sumazin P, Vasudevan SA, L?pez-Terrada D. A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma. Sci Rep. 2017 12 19; 7(1):17751. PMID: 29259231; PMCID: PMC5736579.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    38. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 10 17; 8(1):984. PMID: 29042563; PMCID: PMC5645338.
      Citations: 1     Fields:    
    39. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39. PMID: 28659616; PMCID: PMC5489481.
      Citations: 14     Fields:    Translation:HumansAnimals
    40. Chiu HS, Bansal M, Subramanian A, Golub TR, Yang X, Sumazin P, Califano A, Mart?nez MR. High-throughput validation of ceRNA regulatory networks. BMC Genomics. 2017 05 30; 18(1):418. PMID: 28558729; PMCID: PMC5450082.
      Citations: 27     Fields:    Translation:HumansCells
    41. Sumazin P, Chen Y, Sarabia SF, Hampton OA, Patel K, Mistretta TA, Zorman B, Thompson P, Heczey A, Comerford S, Wheeler DA, Chintagumpala M, Meyers R, Rakheja D, Finegold MJ, Tomlinson G, Parsons DW, Trevi?o LR, L?pez-Terrada D. Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology. 2017 01; 65(1):104-121. PMID: 27775819.
      Citations: 59     Fields:    Translation:Humans
    42. Pankowicz FP, Barzi M, Legras X, Hubert L, Mi T, Tomolonis JA, Ravishankar M, Sun Q, Yang D, Borowiak M, Sumazin P, Elsea SH, Bissig-Choisat B, Bissig KD. Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. Nat Commun. 2016 08 30; 7:12642. PMID: 27572891; PMCID: PMC5013601.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    43. Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, Bissig KD, L?pez-Terrada D. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. J Hepatol. 2016 08; 65(2):325-33. PMID: 27117591; PMCID: PMC5668139.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    44. Roy A, Kumar V, Zorman B, Fang E, Haines KM, Doddapaneni H, Hampton OA, White S, Bavle AA, Patel NR, Eldin KW, John Hicks M, Rakheja D, Leavey PJ, Skapek SX, Amatruda JF, Nuchtern JG, Chintagumpala MM, Wheeler DA, Plon SE, Sumazin P, Parsons DW. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nat Commun. 2015 Nov 17; 6:8891. PMID: 26573325; PMCID: PMC4660214.
      Citations: 41     Fields:    Translation:HumansCells
    45. Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson GL, Sumazin P, Leabu M, Nikolajczyk BS, Avram D, Kunej T, Calin GA, Godwin AK, Adami HO, Zaphiropoulos PG, Richardson DR, Schmitt-Ulms G, Keniry M, Grau GE, Carbonetto S, Stan RV, Popa-Wagner A, Takhar K, Baron BW, Galardy PJ, Yang F, Data D, Fadare O, Yeo KJ, Gabreanu GR, Soare GR, Nelson MA, Liehn EA, Westerblad H, Andrei S. An updated h-index measures both the primary and total scientific output of a researcher. Discoveries (Craiova). 2015 Jul-Sep; 3(3). PMID: 26504901; PMCID: PMC4617786.
      Citations: 4     
    46. Bansal M, Mendiratta G, Anand S, Kushwaha R, Kim R, Kustagi M, Iyer A, Chaganti RS, Califano A, Sumazin P. Direct ChIP-Seq significance analysis improves target prediction. BMC Genomics. 2015; 16 Suppl 5:S4. PMID: 26040656; PMCID: PMC4460594.
      Citations: 4     Fields:    Translation:HumansCells
    47. Kushwaha R, Jagadish N, Kustagi M, Tomishima MJ, Mendiratta G, Bansal M, Kim HR, Sumazin P, Alvarez MJ, Lefebvre C, Villagrasa-Gonzalez P, Viale A, Korkola JE, Houldsworth J, Feldman DR, Bosl GJ, Califano A, Chaganti RS. Interrogation of a context-specific transcription factor network identifies novel regulators of pluripotency. Stem Cells. 2015 Feb; 33(2):367-77. PMID: 25336442; PMCID: PMC4305010.
      Citations: 20     Fields:    Translation:HumansCells
    48. Chiu HS, Llobet-Navas D, Yang X, Chung WJ, Ambesi-Impiombato A, Iyer A, Kim HR, Seviour EG, Luo Z, Sehgal V, Moss T, Lu Y, Ram P, Mills GB, Califano A, Sumazin P, Silva J. Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks. Genome Res. 2015 Feb; 25(2):257-67. PMID: 25378249; PMCID: PMC4315299.
      Citations: 51     Fields:    Translation:HumansCells
    49. Mukherjee M, Byrd T, Brawley VS, Bielamowicz K, Li XN, Merchant F, Maitra S, Sumazin P, Fuller G, Kew Y, Sun D, Powell SZ, Ahmed N, Zhang N, Pati D. Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. J Neurooncol. 2014 Aug; 119(1):27-35. PMID: 24792645; PMCID: PMC4160150.
      Citations: 15     Fields:    Translation:HumansCells
    50. Llobet-Navas D, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Putcha P, Marshall N, Villagrasa P, Chan J, Pe'er D, Iavarone A, Califano A, Ezhkova E, Silva JM, Rodr?guez-Barrueco R, Castro V, Castillo-Mart?n M, Sanchez-Garcia F, Rabad?n R, Cord?n-Card? C, L?pez-Ot?n C. The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland. Genes Dev. 2014 Apr 01; 28(7):765-82. PMID: 24636986; PMCID: PMC4015488.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    51. Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERa)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-5522. PMID: 24276237; PMCID: PMC4032816.
      Citations: 30     Fields:    Translation:AnimalsCells
    52. Irshad S, Bansal M, Castillo-Martin M, Zheng T, Aytes A, Wenske S, Guarnieri P, Sumazin P, Benson MC, Shen MM, Califano A, Abate-Shen C, Le Magnen C. A molecular signature predictive of indolent prostate cancer. Sci Transl Med. 2013 Sep 11; 5(202):202ra122. PMID: 24027026; PMCID: PMC3943244.
      Citations: 62     Fields:    Translation:HumansAnimals
    53. Maute RL, Schneider C, Sumazin P, Holmes A, Califano A, Basso K, Dalla-Favera R. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1404-9. PMID: 23297232; PMCID: PMC3557069.
      Citations: 268     Fields:    Translation:HumansCells
    54. Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet. 2012 Jun; 5(3):336-43. PMID: 22474227; PMCID: PMC3380156.
      Citations: 170     Fields:    Translation:HumansCells
    55. Sumazin P, Yang X, Chiu HS, Chung WJ, Iyer A, Llobet-Navas D, Rajbhandari P, Bansal M, Guarnieri P, Silva J, Califano A. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell. 2011 Oct 14; 147(2):370-81. PMID: 22000015; PMCID: PMC3214599.
      Citations: 383     Fields:    Translation:Humans
    56. Lefebvre C, Rajbhandari P, Alvarez MJ, Bandaru P, Lim WK, Sato M, Wang K, Sumazin P, Kustagi M, Bisikirska BC, Basso K, Beltrao P, Krogan N, Gautier J, Dalla-Favera R, Califano A. A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol. 2010 Jun 08; 6:377. PMID: 20531406; PMCID: PMC2913282.
      Citations: 196     Fields:    Translation:HumansCells
    57. Zhou X, Sumazin P, Rajbhandari P, Califano A. A systems biology approach to transcription factor binding site prediction. PLoS One. 2010 Mar 26; 5(3):e9878. PMID: 20360861; PMCID: PMC2845628.
      Citations: 4     Fields:    Translation:HumansCells
    58. Alvarez MJ, Sumazin P, Rajbhandari P, Califano A. Correlating measurements across samples improves accuracy of large-scale expression profile experiments. Genome Biol. 2009; 10(12):R143. PMID: 20042104; PMCID: PMC2812950.
      Citations: 6     Fields:    
    59. Basso K, Saito M, Sumazin P, Margolin AA, Wang K, Lim WK, Kitagawa Y, Schneider C, Alvarez MJ, Califano A, Dalla-Favera R. Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood. 2010 Feb 04; 115(5):975-84. PMID: 19965633; PMCID: PMC2817639.
      Citations: 113     Fields:    Translation:HumansCells
    60. Saito M, Novak U, Piovan E, Basso K, Sumazin P, Schneider C, Crespo M, Shen Q, Bhagat G, Califano A, Chadburn A, Pasqualucci L, Dalla-Favera R. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11294-9. PMID: 19549844; PMCID: PMC2708681.
      Citations: 85     Fields:    Translation:HumansCells
    61. Basso K, Sumazin P, Morozov P, Schneider C, Maute RL, Kitagawa Y, Mandelbaum J, Haddad J, Chen CZ, Califano A, Dalla-Favera R. Identification of the human mature B cell miRNome. Immunity. 2009 May; 30(5):744-52. PMID: 19446474; PMCID: PMC2764486.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    62. Margolin AA, Palomero T, Sumazin P, Califano A, Ferrando AA, Stolovitzky G. ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):244-9. PMID: 19118200; PMCID: PMC2613038.
      Citations: 47     Fields:    Translation:HumansCells
    63. Smith AD, Sumazin P, Zhang MQ. Tissue-specific regulatory elements in mammalian promoters. Mol Syst Biol. 2007; 3:73. PMID: 17224917; PMCID: PMC1800356.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    64. Smith AD, Sumazin P, Xuan Z, Zhang MQ. DNA motifs in human and mouse proximal promoters predict tissue-specific expression. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6275-80. PMID: 16606849; PMCID: PMC1458868.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    65. Smith AD, Sumazin P, Das D, Zhang MQ. Mining ChIP-chip data for transcription factor and cofactor binding sites. Bioinformatics. 2005 Jun; 21 Suppl 1:i403-12. PMID: 15961485.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    66. Smith AD, Sumazin P, Zhang MQ. Identifying tissue-selective transcription factor binding sites in vertebrate promoters. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1560-5. PMID: 15668401; PMCID: PMC547828.
      Citations: 73     Fields:    Translation:AnimalsCells
    67. Sumazin P, Chen G, Hata N, Smith AD, Zhang T, Zhang MQ. DWE: discriminating word enumerator. Bioinformatics. 2005 Jan 01; 21(1):31-8. PMID: 15333453.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    68. Schones DE, Sumazin P, Zhang MQ. Similarity of position frequency matrices for transcription factor binding sites. Bioinformatics. 2005 Feb 01; 21(3):307-13. PMID: 15319260.
      Citations: 55     Fields:    Translation:Cells
    69. Long F, Liu H, Hahn C, Sumazin P, Zhang MQ, Zilberstein A. Genome-wide prediction and analysis of function-specific transcription factor binding sites. In Silico Biol. 2004; 4(4):395-410. PMID: 15506990.
      Citations: 22     Fields:    Translation:HumansCells
    70. Wildenberg A, Skiena S, Sumazin P. Deconvolving sequence variation in mixed DNA populations. J Comput Biol. 2003; 10(3-4):635-52. PMID: 12935349.
      Citations: 1     Fields:    
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