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SHUBHAM SINGH

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fong V, Ly M, Erickson AW, Abeysundara N, Hendrikse L, Ommeren RV, Balin P, Mishra J, Livingston B, Skowron P, Sirbu O, Mankahla N, Zhang J, Richman C, Suarez R, Huang N, Wang H, Qin L, Douglas T, Pallotta J, Mak E, Kumar SA, Kaushik AK, Vu H, Zacharias L, Veerasammy K, Chen YX, Ocsenas O, Voisin V, Taj F, Koubourli D, Dzieciol V, Xu L, Harvey M, Fan JJ, Przelicki D, Yeh A, Kharas K, Rasnitsyn A, Wang E, Ong W, Jubenville T, Yang Q, Huang X, Ayrault O, Wechsler-Reya R, Egan SE, Largaespada D, DeBerardinis RJ, Ye H, Abzalimov R, Stein L, Ellison DW, Bader G, Lucas CH, Saulnier O, Shih D, Reimand J, Daniels C, Singh S, Agnihotri S, Rich JN, Ramaswamy V, Taylor MD, Wu X, Reimand J. Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases. bioRxiv. 2026 Aug 09. PMID: 42619780; PMCID: PMC13483896.
      Citations:    
    2. Ambaw YA, Nana AL, Li Z, Singh S, Monetti M, Miller BL, Spina SE, Grinberg LT, Seeley WW, Walther TC, Farese RV. Shared lipidome and proteome signatures of frontotemporal lobar degeneration and Alzheimer's disease. Res Sq. 2026 Jul 23. PMID: 42539062; PMCID: PMC13419613.
      Citations:    
    3. Ambaw Y, Nana A, Zhuoning L, Singh S, Monetti M, Miller BL, Spina S, Grinberg LT, Seeley WW, Walther TC, Farese R. Shared lipidome and proteome signatures of frontotemporal lobar degeneration and Alzheimer's disease. bioRxiv. 2026 Jul 11. PMID: 42465421; PMCID: PMC13370404.
      Citations:    
    4. Wen AX, Bos J, Panda D, Hagstrom KM, Singh S, Mageswaran SK, Wang X, Hu B, Welch KT, Cooke MB, Halliday JA, Deus Ramirez L, Martinez AE, Chang YW, Weitz DA, Herman C. Antibiotics stimulate protein transfer to persister cells. Science. 2026 Jun 25; 392(6805):eadx3972. PMID: 42348700.
      Citations:    Fields:    Translation:Cells
    5. Kim Y, Vaidya B, Kim J, Bitar S, Shajan FJ, Verma AK, Yalamanchili HK, Singh S, Zoghbi HY. Astrocytic ACSBG1 depletion improves lipid-cytokine signaling and attenuates a-Synuclein pathology in a Parkinson's disease mouse model. bioRxiv. 2026 Jun 08. PMID: 42239329; PMCID: PMC13228550.
      Citations:    
    6. Abdi H, Ambaw YA, Lai ZW, Ly R, Chitraju C, Singh S, Farese RV, Walther TC. LipidCruncher: an open-source platform for processing, visualizing, and analyzing lipidomic data. BMC Bioinformatics. 2026 Jun 04; 27(1). PMID: 42243672; PMCID: PMC13466190.
      Citations:    Fields:    
    7. Chander D, Koul D, Singh S, Manhas RS, Kumar D, Shukla S, Mishra RPN, Ahmed Z, Chaubey A. Heterologous expression, purification and functional characterization of recombinant serratiopeptidase from Serratia marcescens AD-W2. World J Microbiol Biotechnol. 2026 Feb 24; 42(3). PMID: 41731164.
      Citations:    Fields:    Translation:AnimalsCells
    8. Singh S, Mehta J, Mishra RPN. Efficient bioprocess for high-density fermentation and rapid purification of soluble tag-free CRM197 protein expressed in Escherichia coli. Int J Biol Macromol. 2026 Jan; 338(Pt 2):149685. PMID: 41397589.
      Citations: 1     Fields:    Translation:Cells
    9. Singh S, Sharma H, Arumugam MK, Gupta G, Panth N, Kulkarni MP, De Rubis G, Oliver BG, Paudel KR, Pandey NK, Hussain MS, Kumbhar PS, Disouza J, Dua K, Singh SK. Box-Behnken-designed nanostructured lipid carriers of xanthohumol for enhanced cellular uptake in human lung cancer cell line A549: formulation, optimization, characterization, and cytotoxicity assessment. Med Oncol. 2025 Oct 22; 42(11):525. PMID: 41123733.
      Citations:    Fields:    Translation:HumansCells
    10. Ambaw YA, Ljubenkov PA, Singh S, Hamed A, Boland S, Boxer AL, Walther TC, Farese RV. Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations. Alzheimers Dement. 2025 09; 21(9):e70631. PMID: 40922380; PMCID: PMC12417310.
      Citations: 2     Fields:    Translation:Humans
    11. Mohanty C, Dubey MR, Panigrahi S, Singh S, Rathi S, Nath J. Acetylcholinesterase Inhibitor-Based Nose-to-Brain Delivery of Donepezil-Loaded Lipid Nanoemulsion for Alzheimer's Therapy. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2025 Aug 18; 41:e20250020. PMID: 40820521.
      Citations:    Fields:    Translation:Animals
    12. Hamed A, Ambaw YA, Chitraju C, Singh S, Lai ZW, Farese RV, Walther TC. LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data. bioRxiv. 2025 May 01. PMID: 40654803; PMCID: PMC12247890.
      Citations:    
    13. Singh S, Sharma H, Kumar V, Gupta G, Patel S, Patel A, Dua K, Kumar Singh S. Method development and validation on RP-HPLC method for estimation of xanthohumol in nanostructured lipid carriers drug delivery systems. J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Feb 01; 1252:124437. PMID: 39753015.
      Citations:    
    14. Singh S, Dransfeld UE, Ambaw YA, Lopez-Scarim J, Farese RV, Walther TC. PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. Cell. 2024 Nov 27; 187(24):6820-6834.e24. PMID: 39423811; PMCID: PMC12055030.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    15. Singh S, Saxena S, Sharma H, Gupta G, Dua K, Singh SK. Opening avenue for the targeted treatment of lung cancer using xanthohumol loaded nanostructured lipid carriers. EXCLI J. 2024; 23:1068-1070. PMID: 39421029; PMCID: PMC11483262.
      Citations:    
    16. Vaghela MC, Rathi S, Shirole RL, Verma J, Panigrahi S, Singh S. Leveraging AI and Machine Learning in Six-Sigma Documentation for Pharmaceutical Quality Assurance. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jul 18; 40:e20240005. PMID: 39019923.
      Citations:    
    17. Ravikkumar VR, Patel BD, Rathi S, Parthiban S, Upadhye MC, Shah AM, Rehan SSA, Samanta S, Singh S. Formulation and Evaluation of Drumstick Leaves Tablet as An Immunomodulator. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jun 21; 40:e20240004. PMID: 38902996.
      Citations:    
    18. Singh S, Dransfeld U, Ambaw Y, Lopez-Scarim J, Farese RV, Walther TC. PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. bioRxiv. 2024 Mar 21. PMID: 38562702; PMCID: PMC10983895.
      Citations:    
    19. Singh S, Saxena S, Sharma H, Paudel KR, Chakraborty A, MacLoughlin R, Oliver BG, Gupta G, Negi P, Singh SK, Dua K. Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer. Pathol Res Pract. 2024 Apr; 256:155222. PMID: 38452582.
      Citations:    
    20. Mehdiratta K, Nain S, Sharma M, Singh S, Srivastava S, Dhamale BD, Mohanty D, Kamat SS, Natarajan VT, Sharma R, Gokhale RS. Respiratory Quinone Switches from Menaquinone to Polyketide Quinone during the Development Cycle in Streptomyces sp. Strain MNU77. Microbiol Spectr. 2023 02 14; 11(1):e0259722. PMID: 36507669; PMCID: PMC9927152.
      Citations: 2     Fields:    Translation:Cells
    21. Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022 10 07; 13(1):5924. PMID: 36207292; PMCID: PMC9546883.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    22. Mondal S, Kinatukara P, Singh S, Shambhavi S, Patil GS, Dubey N, Singh SH, Pal B, Shekar PC, Kamat SS, Sankaranarayanan R. DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes. Elife. 2022 06 29; 11. PMID: 35766356; PMCID: PMC9342972.
      Citations: 7     Fields:    Translation:Animals
    23. Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RS. Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). PMID: 35193957; PMCID: PMC8872721.
      Citations: 23     Fields:    Translation:AnimalsCells
    24. Singh S, Kamat SS. The loss of enzymatic activity of the PHARC-associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation. Eur J Neurosci. 2021 11; 54(10):7442-7457. PMID: 34727579; PMCID: PMC7612011.
      Citations: 4     Fields:    Translation:Animals
    25. Bora P, Manna S, Nair MA, Sathe RRM, Singh S, Sreyas Adury VS, Gupta K, Mukherjee A, Saini DK, Kamat SS, Hazra AB, Chakrapani H. Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation. Chem Sci. 2021 Oct 13; 12(39):12939-12949. PMID: 34745524; PMCID: PMC8513928.
      Citations: 5     
    26. Khandelwal N, Shaikh M, Mhetre A, Singh S, Sajeevan T, Joshi A, Balaji KN, Chakrapani H, Kamat SS. Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs. Cell Chem Biol. 2021 08 19; 28(8):1169-1179.e6. PMID: 33571455; PMCID: PMC7611549.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Kinatukara P, Subramaniyan PS, Patil GS, Shambhavi S, Singh S, Mhetre A, Madduri MK, Soundararajan A, Patel KD, Shekar PC, Kamat SS, Kumar S, Sankaranarayanan R. Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition. Transgenic Res. 2020 12; 29(5-6):553-562. PMID: 33184751.
      Citations: 3     Fields:    Translation:Animals
    28. Singh S, Joshi A, Kamat SS. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC. Biochemistry. 2020 06 23; 59(24):2299-2311. PMID: 32462874; PMCID: PMC7311203.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    29. Singh S, Sangam SR, Senthilkumar R. Regulation of Dietary Amino Acids and Voltage-Gated Calcium Channels in Autism Spectrum Disorder. Adv Neurobiol. 2020; 24:647-660. PMID: 32006378.
      Citations:    
    30. Kelkar DS, Ravikumar G, Mehendale N, Singh S, Joshi A, Sharma AK, Mhetre A, Rajendran A, Chakrapani H, Kamat SS. A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase. Nat Chem Biol. 2019 02; 15(2):169-178. PMID: 30643283; PMCID: PMC6420073.
      Citations:    
    31. Joshi A, Shaikh M, Singh S, Rajendran A, Mhetre A, Kamat SS. Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids. J Biol Chem. 2018 11 02; 293(44):16953-16963. PMID: 30237167; PMCID: PMC6217928.
      Citations:    
    32. Pathak D, Mehendale N, Singh S, Mallik R, Kamat SS. Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis. ACS Chem Biol. 2018 08 17; 13(8):2280-2287. PMID: 29963848; PMCID: PMC6102644.
      Citations:    
    33. Prasad S, Mandal I, Singh S, Paul A, Mandal B, Venkatramani R, Swaminathan R. Near UV-Visible electronic absorption originating from charged amino acids in a monomeric protein. Chem Sci. 2017 Aug 01; 8(8):5416-5433. PMID: 28970921; PMCID: PMC5609530.
      Citations:    
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