"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
|
Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
|
Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 6 | 5 | 11 |
1995 | 6 | 3 | 9 |
1996 | 6 | 2 | 8 |
1997 | 1 | 6 | 7 |
1998 | 4 | 8 | 12 |
1999 | 10 | 8 | 18 |
2000 | 4 | 10 | 14 |
2001 | 8 | 12 | 20 |
2002 | 6 | 9 | 15 |
2003 | 4 | 12 | 16 |
2004 | 11 | 9 | 20 |
2005 | 14 | 16 | 30 |
2006 | 7 | 6 | 13 |
2007 | 9 | 7 | 16 |
2008 | 7 | 9 | 16 |
2009 | 3 | 14 | 17 |
2010 | 7 | 10 | 17 |
2011 | 8 | 4 | 12 |
2012 | 3 | 5 | 8 |
2013 | 6 | 8 | 14 |
2014 | 7 | 6 | 13 |
2015 | 11 | 4 | 15 |
2016 | 9 | 10 | 19 |
2017 | 4 | 2 | 6 |
2018 | 8 | 8 | 16 |
2019 | 3 | 3 | 6 |
2020 | 2 | 11 | 13 |
2021 | 2 | 3 | 5 |
2022 | 2 | 3 | 5 |
2023 | 5 | 4 | 9 |
2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Identification of Nonfunctional Alternatively Spliced Isoforms of STING in Human Acute Myeloid Leukemia. Cancer Res Commun. 2024 Mar 25; 4(3):911-918.
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Combinatorial effects of ion channel mis-splicing as a cause of myopathy in myotonic dystrophy. J Clin Invest. 2024 Jan 02; 134(1).
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RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. Nat Commun. 2023 Dec 19; 14(1):8444.
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Long-Read Sequencing Reveals Alternative Splicing-Driven, Shared Immunogenic Neoepitopes Regardless of SF3B1 Status in Uveal Melanoma. Cancer Immunol Res. 2023 12 01; 11(12):1671-1687.
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Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. Circulation. 2023 10 17; 148(16):1263-1266.
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Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants. Genetics. 2023 08 09; 224(4).
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Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Sci Immunol. 2023 04 28; 8(82):eadg3196.
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The role of Limch1 alternative splicing in skeletal muscle function. Life Sci Alliance. 2023 06; 6(6).
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Bi-allelic SNAPC4 variants dysregulate global alternative splicing and lead to neuroregression and progressive spastic paraparesis. Am J Hum Genet. 2023 04 06; 110(4):663-680.
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Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nucleic Acids Res. 2023 02 22; 51(3):1245-1259.