"Thymidine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
| Descriptor ID |
D013937
|
| MeSH Number(s) |
D08.811.913.696.620.750
|
| Concept/Terms |
Thymidine Kinase- Thymidine Kinase
- Kinase, Thymidine
- Deoxypyrimidine Kinase
- Kinase, Deoxypyrimidine
- Deoxythymidine Kinase
- Kinase, Deoxythymidine
|
Below are MeSH descriptors whose meaning is more general than "Thymidine Kinase".
Below are MeSH descriptors whose meaning is more specific than "Thymidine Kinase".
This graph shows the total number of publications written about "Thymidine Kinase" by people in this website by year, and whether "Thymidine Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 1 | 3 |
| 1997 | 2 | 3 | 5 |
| 1998 | 3 | 2 | 5 |
| 1999 | 3 | 1 | 4 |
| 2000 | 2 | 5 | 7 |
| 2001 | 1 | 3 | 4 |
| 2002 | 0 | 3 | 3 |
| 2003 | 1 | 1 | 2 |
| 2004 | 3 | 0 | 3 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 2 | 3 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thymidine Kinase" by people in Profiles.
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Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. Neurosurgery. 2016 Sep; 79(3):481-91.
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Induction of recombination between diverged sequences in a mammalian genome by a double-strand break. Cell Mol Life Sci. 2014 Jun; 71(12):2359-71.
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Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion syndrome caused by mutations in the thymidine kinase (TK2) gene. Mol Genet Metab. 2013 Sep-Oct; 110(1-2):153-61.
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Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-?B signaling improves the efficacy of immunotherapy in a brain cancer model. Neurotherapeutics. 2012 Oct; 9(4):827-43.
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Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One. 2011; 6(9):e22949.
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Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G976-87.
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Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice. Surgery. 2011 Apr; 149(4):484-95.
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High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia. Am J Clin Pathol. 2010 Sep; 134(3):472-7.
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Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma. Mol Ther. 2010 Oct; 18(10):1885-90.
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Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU. Mol Imaging. 2009 Jul-Aug; 8(4):230-7.