STAT3 Transcription Factor
"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
| Descriptor ID |
D050796
|
| MeSH Number(s) |
D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
|
| Concept/Terms |
STAT3 Transcription Factor- STAT3 Transcription Factor
- Transcription Factor, STAT3
- LIF-Response Factor
- LIF Response Factor
- Acute-Phase Response Factor
- Acute Phase Response Factor
- Response Factor, Acute-Phase
- APRF Transcription Factor
- Transcription Factor, APRF
- Signal Transducer and Activator of Transcription 3
- IL6-Response Factor
- IL6 Response Factor
- STAT3 Protein
STAT3b Transcription Factor- STAT3b Transcription Factor
- Transcription Factor, STAT3b
- Stat3beta Transcription Factor
- Transcription Factor, Stat3beta
STAT3a Transcription Factor- STAT3a Transcription Factor
- Transcription Factor, STAT3a
- Stat3alpha Transcription Factor
- Transcription Factor, Stat3alpha
|
Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".
This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1998 | 0 | 10 | 10 |
| 1999 | 0 | 6 | 6 |
| 2000 | 0 | 9 | 9 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 9 | 9 |
| 2003 | 0 | 18 | 18 |
| 2004 | 0 | 19 | 19 |
| 2005 | 2 | 18 | 20 |
| 2006 | 21 | 5 | 26 |
| 2007 | 18 | 11 | 29 |
| 2008 | 16 | 13 | 29 |
| 2009 | 23 | 16 | 39 |
| 2010 | 15 | 7 | 22 |
| 2011 | 16 | 13 | 29 |
| 2012 | 22 | 10 | 32 |
| 2013 | 16 | 13 | 29 |
| 2014 | 26 | 6 | 32 |
| 2015 | 25 | 10 | 35 |
| 2016 | 17 | 16 | 33 |
| 2017 | 18 | 8 | 26 |
| 2018 | 9 | 8 | 17 |
| 2019 | 11 | 6 | 17 |
| 2020 | 16 | 4 | 20 |
| 2021 | 12 | 2 | 14 |
| 2022 | 3 | 9 | 12 |
| 2023 | 2 | 0 | 2 |
| 2024 | 4 | 3 | 7 |
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Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.
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Integrated Clinical Genotype-Phenotype Characteristics of STAT3-Mutated Myeloid Neoplasms. Clin Cancer Res. 2024 Oct 15; 30(20):4681-4689.
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LIFR regulates cholesterol-driven bidirectional hepatocyte-neutrophil cross-talk to promote liver regeneration. Nat Metab. 2024 Sep; 6(9):1756-1774.
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Allergic fungal rhinosinusitis linked to other hyper-IgE syndromes through defective TH17 responses. J Allergy Clin Immunol. 2024 Nov; 154(5):1169-1179.
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STAT3 Contributes a Favorable Response to Pembrolizumab Through IFN-?-induced Apoptosis in Urothelial Cancer. Anticancer Res. 2024 May; 44(5):1925-1930.
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STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response. Leukemia. 2024 May; 38(5):1143-1155.
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The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun. 2024 Feb 14; 15(1):1373.
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Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio. 2024 Feb 14; 15(2):e0299823.
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Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia. Am J Respir Cell Mol Biol. 2023 06; 68(6):679-688.
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Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers. Blood. 2023 03 23; 141(12):1411-1424.
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STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+?T?cell dysregulation and accumulation. Immunity. 2022 12 13; 55(12):2386-2404.e8.