STAT3 Transcription Factor
"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
| Descriptor ID |
D050796
|
| MeSH Number(s) |
D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
|
| Concept/Terms |
STAT3 Transcription Factor- STAT3 Transcription Factor
- Transcription Factor, STAT3
- LIF-Response Factor
- LIF Response Factor
- Acute-Phase Response Factor
- Acute Phase Response Factor
- Response Factor, Acute-Phase
- APRF Transcription Factor
- Transcription Factor, APRF
- Signal Transducer and Activator of Transcription 3
- IL6-Response Factor
- IL6 Response Factor
- STAT3 Protein
STAT3b Transcription Factor- STAT3b Transcription Factor
- Transcription Factor, STAT3b
- Stat3beta Transcription Factor
- Transcription Factor, Stat3beta
STAT3a Transcription Factor- STAT3a Transcription Factor
- Transcription Factor, STAT3a
- Stat3alpha Transcription Factor
- Transcription Factor, Stat3alpha
|
Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".
This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 3 | 2 | 5 |
| 2008 | 6 | 4 | 10 |
| 2009 | 6 | 6 | 12 |
| 2010 | 1 | 2 | 3 |
| 2011 | 3 | 5 | 8 |
| 2012 | 6 | 3 | 9 |
| 2013 | 5 | 3 | 8 |
| 2014 | 5 | 1 | 6 |
| 2015 | 11 | 3 | 14 |
| 2016 | 6 | 4 | 10 |
| 2017 | 5 | 2 | 7 |
| 2018 | 5 | 2 | 7 |
| 2019 | 5 | 3 | 8 |
| 2020 | 7 | 0 | 7 |
| 2021 | 4 | 1 | 5 |
| 2022 | 0 | 7 | 7 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
| 2025 | 2 | 3 | 5 |
| 2026 | 5 | 1 | 6 |
To return to the timeline,
click here.
Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.
-
Colitis-Associated Colorectal Cancer-STAT3 Inhibition as a Preventive Strategy. Int J Mol Sci. 2026 Sep 20; 27(18).
-
Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 gain of function. JCI Insight. 2026 09 08; 11(17).
-
Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility. Nat Genet. 2026 Sep; 58(9):2177-2191.
-
Enteropathy in STAT3 GOF syndrome: Insights into the role of the JAK-STAT pathway. Autoimmun Rev. 2026 Jul; 25(7):104086.
-
From CVID to PIRD: Genetic Testing Leading to Signal Transducer and Activator of Transcription 3 Gain-of-Function Diagnosis and Directed Therapy. J Allergy Clin Immunol Pract. 2026 07; 14(7):1506-1514.
-
Disease-causing STAT3 variants can be discriminated by a functional flow cytometry test. Pediatr Allergy Immunol. 2026 Feb; 37(2):e70300.
-
STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer. Int J Mol Sci. 2025 Nov 06; 26(21).
-
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity. Nature. 2025 07; 643(8070):219-229.
-
Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity. Front Immunol. 2025; 16:1575181.
-
Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection. Cell Rep. 2025 Apr 22; 44(4):115438.