STAT3 Transcription Factor
"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
Descriptor ID |
D050796
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MeSH Number(s) |
D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
|
Concept/Terms |
STAT3 Transcription Factor- STAT3 Transcription Factor
- Transcription Factor, STAT3
- LIF-Response Factor
- LIF Response Factor
- Acute-Phase Response Factor
- Acute Phase Response Factor
- Response Factor, Acute-Phase
- APRF Transcription Factor
- Transcription Factor, APRF
- Signal Transducer and Activator of Transcription 3
- IL6-Response Factor
- IL6 Response Factor
- STAT3 Protein
STAT3b Transcription Factor- STAT3b Transcription Factor
- Transcription Factor, STAT3b
- Stat3beta Transcription Factor
- Transcription Factor, Stat3beta
STAT3a Transcription Factor- STAT3a Transcription Factor
- Transcription Factor, STAT3a
- Stat3alpha Transcription Factor
- Transcription Factor, Stat3alpha
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Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".
This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 0 | 11 | 11 |
1999 | 0 | 6 | 6 |
2000 | 0 | 7 | 7 |
2001 | 0 | 3 | 3 |
2002 | 0 | 5 | 5 |
2003 | 0 | 18 | 18 |
2004 | 0 | 21 | 21 |
2005 | 2 | 18 | 20 |
2006 | 20 | 5 | 25 |
2007 | 19 | 11 | 30 |
2008 | 16 | 13 | 29 |
2009 | 22 | 16 | 38 |
2010 | 15 | 7 | 22 |
2011 | 16 | 13 | 29 |
2012 | 22 | 10 | 32 |
2013 | 16 | 12 | 28 |
2014 | 25 | 6 | 31 |
2015 | 24 | 9 | 33 |
2016 | 15 | 15 | 30 |
2017 | 18 | 9 | 27 |
2018 | 9 | 8 | 17 |
2019 | 11 | 6 | 17 |
2020 | 16 | 3 | 19 |
2021 | 11 | 2 | 13 |
2022 | 3 | 8 | 11 |
2023 | 2 | 0 | 2 |
2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.
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The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun. 2024 Feb 14; 15(1):1373.
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Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio. 2024 Feb 14; 15(2):e0299823.
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Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia. Am J Respir Cell Mol Biol. 2023 06; 68(6):679-688.
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Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers. Blood. 2023 03 23; 141(12):1411-1424.
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A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice. JCI Insight. 2022 Nov 08; 7(21).
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Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome. J Allergy Clin Immunol. 2023 04; 151(4):1081-1095.
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STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells. J Immunol. 2022 10 01; 209(7):1286-1299.
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Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression. Commun Biol. 2022 07 14; 5(1):697.
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IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3. FASEB J. 2022 07; 36(7):e22298.
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A Novel STAT3 Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease. Front Immunol. 2022; 13:866638.