Cystathionine beta-Synthase
"Cystathionine beta-Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
| Descriptor ID |
D003541
|
| MeSH Number(s) |
D08.811.520.241.300.200
|
| Concept/Terms |
Cystathionine beta-Synthase- Cystathionine beta-Synthase
- Cystathionine beta Synthase
- beta-Synthase, Cystathionine
- Serine Sulfhydrase
- Sulfhydrase, Serine
- Cystathionine Synthetase
- Synthetase, Cystathionine
- beta-Thionase
- beta Thionase
|
Below are MeSH descriptors whose meaning is more general than "Cystathionine beta-Synthase".
Below are MeSH descriptors whose meaning is more specific than "Cystathionine beta-Synthase".
This graph shows the total number of publications written about "Cystathionine beta-Synthase" by people in this website by year, and whether "Cystathionine beta-Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cystathionine beta-Synthase" by people in Profiles.
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H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response. Sci Adv. 2024 Nov 15; 10(46):eadp1152.
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Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival. Commun Biol. 2024 01 03; 7(1):9.
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Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants. Hum Mutat. 2019 09; 40(9):1530-1545.
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Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS One. 2013; 8(11):e79167.
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Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-?-synthase. PLoS One. 2012; 7(9):e45020.
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Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J. 2009 Jun; 23(6):1721-7.
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Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3408-13.
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Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res. 2006 Jan; 69(1):253-62.
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Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2515-21.
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Hyperhomocysteinemia and atherosclerosis. Sheng Li Xue Bao. 2005 Apr 25; 57(2):103-14.