"Fumarate Hydratase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the citric acid cycle enzymes. EC 4.2.1.2.
| Descriptor ID |
D005649
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| MeSH Number(s) |
D08.811.520.241.300.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fumarate Hydratase".
Below are MeSH descriptors whose meaning is more specific than "Fumarate Hydratase".
This graph shows the total number of publications written about "Fumarate Hydratase" by people in this website by year, and whether "Fumarate Hydratase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Fumarate Hydratase" by people in Profiles.
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PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood. Clin Cancer Res. 2017 Jun 15; 23(12):e76-e82.
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Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism. Oncol Rep. 2017 Apr; 37(4):1971-1979.
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Joint mouse-human phenome-wide association to test gene function and disease risk. Nat Commun. 2016 Feb 02; 7:10464.
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The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Am J Surg Pathol. 2007 Oct; 31(10):1578-85.
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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 2005 Aug; 8(2):143-53.