Transcription Factor AP-1
"Transcription Factor AP-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
| Descriptor ID |
D018808
|
| MeSH Number(s) |
D12.776.260.108.875 D12.776.930.127.875
|
| Concept/Terms |
Transcription Factor AP-1- Transcription Factor AP-1
- Transcription Factor AP 1
- AP-1 Enhancer-Binding Protein
- Enhancer-Binding Protein, AP-1
- AP-1
- Activator Protein-1
- Activator Protein 1
- AP-1 Enhancer Binding Protein
- AP 1 Enhancer Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor AP-1".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor AP-1".
This graph shows the total number of publications written about "Transcription Factor AP-1" by people in this website by year, and whether "Transcription Factor AP-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 2 | 0 | 2 |
| 2001 | 3 | 2 | 5 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 2 | 4 |
| 2004 | 3 | 3 | 6 |
| 2005 | 1 | 2 | 3 |
| 2006 | 3 | 1 | 4 |
| 2007 | 1 | 1 | 2 |
| 2008 | 3 | 2 | 5 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 4 | 4 |
| 2013 | 1 | 2 | 3 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 2 | 3 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transcription Factor AP-1" by people in Profiles.
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MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK-ERK and AP-1 pathways. Carcinogenesis. 2024 Aug 12; 45(8):582-594.
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Assigning pathogenicity for TAB2 variants using a novel scalable functional assay and expanding TAB2 disease spectrum. Hum Mol Genet. 2023 03 06; 32(6):959-970.
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Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes. Nat Struct Mol Biol. 2023 01; 30(1):10-21.
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Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies. J Leukoc Biol. 2022 11; 112(5):1245-1259.
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Interferon Signaling in Estrogen Receptor-positive Breast Cancer: A Revitalized Topic. Endocrinology. 2022 01 01; 163(1).
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Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance. Nat Cell Biol. 2020 06; 22(6):701-715.
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YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In?Vivo. Dev Cell. 2019 03 25; 48(6):765-779.e7.
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Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res. 2017 Aug 21; 45(14):8596-8608.
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miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. Int J Cancer. 2017 11 15; 141(10):2062-2075.
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Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance. Mol Cancer Res. 2016 05; 14(5):470-81.