"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
| Descriptor ID |
D019943
|
| MeSH Number(s) |
E05.393.420.601.035 G05.558.109
|
| Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
|
Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 5 | 5 |
| 1999 | 1 | 5 | 6 |
| 2000 | 0 | 7 | 7 |
| 2001 | 0 | 9 | 9 |
| 2002 | 0 | 12 | 12 |
| 2003 | 0 | 11 | 11 |
| 2004 | 1 | 19 | 20 |
| 2005 | 1 | 7 | 8 |
| 2006 | 1 | 8 | 9 |
| 2007 | 1 | 5 | 6 |
| 2008 | 1 | 14 | 15 |
| 2009 | 4 | 17 | 21 |
| 2010 | 1 | 7 | 8 |
| 2011 | 1 | 13 | 14 |
| 2012 | 0 | 10 | 10 |
| 2013 | 1 | 20 | 21 |
| 2014 | 1 | 9 | 10 |
| 2015 | 0 | 11 | 11 |
| 2016 | 0 | 17 | 17 |
| 2017 | 0 | 8 | 8 |
| 2018 | 2 | 7 | 9 |
| 2019 | 3 | 14 | 17 |
| 2020 | 0 | 11 | 11 |
| 2021 | 0 | 6 | 6 |
| 2024 | 2 | 1 | 3 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
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Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges. Hum Genet. 2025 Mar; 144(2-3):265-280.
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Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges. Hum Genet. 2025 Mar; 144(2-3):113-125.
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Synergistic effects of novel penicillin-binding protein 1A amino acid substitutions contribute to high-level amoxicillin resistance of Helicobacter pylori. mSphere. 2024 Aug 28; 9(8):e0008924.
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Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12):e2313513121.
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Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape. Sci Rep. 2021 09 22; 11(1):18827.
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep. 2021 07 13; 36(2):109364.
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Langerhans cell histiocytosis: Version 2021. Hematol Oncol. 2021 Jun; 39 Suppl 1:15-23.
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Crystallographic modeling of the PNPT1:c.1453A>G variant as a cause of mitochondrial dysfunction and autosomal recessive deafness; expanding the neuroimaging and clinical features. Mitochondrion. 2021 07; 59:1-7.
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Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).
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Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention. JCI Insight. 2021 02 08; 6(3).