"RNA Polymerase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. The enzyme functions in the nucleolar structure and transcribes DNA into RNA. It has different requirements for cations and salts than RNA polymerase II and III and is not inhibited by alpha-amanitin.
| Descriptor ID |
D012318
|
| MeSH Number(s) |
D08.811.913.696.445.735.270.750
|
| Concept/Terms |
RNA Polymerase I- RNA Polymerase I
- Polymerase I, RNA
- DNA-Dependent RNA Polymerase I
- DNA Dependent RNA Polymerase I
- RNA Polymerase A
- Polymerase A, RNA
|
Below are MeSH descriptors whose meaning is more general than "RNA Polymerase I".
Below are MeSH descriptors whose meaning is more specific than "RNA Polymerase I".
This graph shows the total number of publications written about "RNA Polymerase I" by people in this website by year, and whether "RNA Polymerase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA Polymerase I" by people in Profiles.
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Control of ribosomal RNA synthesis by hematopoietic transcription factors. Mol Cell. 2022 10 20; 82(20):3826-3839.e9.
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Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. J Clin Invest. 2021 01 04; 131(1).
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RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma. Br J Haematol. 2017 04; 177(1):80-94.
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The Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157276.
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Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions. J Biol Chem. 2016 08 19; 291(34):17919-28.
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New Face for Chromatin-Related Mesenchymal Modulator: n-CHD9 Localizes to Nucleoli and Interacts With Ribosomal Genes. J Cell Physiol. 2015 Sep; 230(9):2270-80.
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Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014 Dec 24; 9(6):2180-91.
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Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions. Nat Commun. 2014 Aug 13; 5:4599.
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Divergent contributions of conserved active site residues to transcription by eukaryotic RNA polymerases I and II. Cell Rep. 2013 Sep 12; 4(5):974-84.
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Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res. 2011 Jun 15; 71(12):4269-79.