"Synapses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
| Descriptor ID |
D013569
|
| MeSH Number(s) |
A08.850 A11.284.149.165.420.780
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Synapses".
Below are MeSH descriptors whose meaning is more specific than "Synapses".
This graph shows the total number of publications written about "Synapses" by people in this website by year, and whether "Synapses" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 6 | 1 | 7 |
| 1995 | 3 | 2 | 5 |
| 1996 | 2 | 2 | 4 |
| 1997 | 2 | 1 | 3 |
| 1998 | 0 | 2 | 2 |
| 1999 | 3 | 6 | 9 |
| 2000 | 4 | 2 | 6 |
| 2001 | 3 | 7 | 10 |
| 2002 | 4 | 8 | 12 |
| 2003 | 8 | 3 | 11 |
| 2004 | 10 | 8 | 18 |
| 2005 | 8 | 10 | 18 |
| 2006 | 7 | 4 | 11 |
| 2007 | 11 | 4 | 15 |
| 2008 | 9 | 9 | 18 |
| 2009 | 12 | 3 | 15 |
| 2010 | 10 | 4 | 14 |
| 2011 | 11 | 4 | 15 |
| 2012 | 9 | 6 | 15 |
| 2013 | 10 | 7 | 17 |
| 2014 | 13 | 5 | 18 |
| 2015 | 7 | 7 | 14 |
| 2016 | 8 | 5 | 13 |
| 2017 | 8 | 1 | 9 |
| 2018 | 8 | 7 | 15 |
| 2019 | 4 | 5 | 9 |
| 2020 | 11 | 6 | 17 |
| 2021 | 8 | 7 | 15 |
| 2022 | 3 | 10 | 13 |
| 2023 | 4 | 8 | 12 |
| 2024 | 5 | 2 | 7 |
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Below are the most recent publications written about "Synapses" by people in Profiles.
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Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity. Hum Mol Genet. 2024 Oct 07; 33(20):1815-1832.
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Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors? Expert Opin Ther Targets. 2024 Aug; 28(8):651-653.
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Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology. 2024 Nov; 50(1):153-163.
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Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release. Sci Adv. 2024 Jul 12; 10(28):eadk5462.
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Presynaptic nanoscale components of retrograde synaptic signaling. Sci Adv. 2024 May 31; 10(22):eado0077.
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Calcineurin regulates synaptic Ca2+-permeable AMPA receptors in hypothalamic presympathetic neurons via a2d-1-mediated GluA1/GluA2 assembly. J Physiol. 2024 May; 602(10):2179-2197.
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Retrograde endocannabinoid signaling at inhibitory synapses in vivo. Science. 2024 Mar; 383(6686):967-970.
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P2Y6 Receptor-Dependent Microglial Phagocytosis of Synapses during Development Regulates Synapse Density and Memory. J Neurosci. 2023 11 29; 43(48):8090-8103.
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iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2024 02; 72(2):452-469.
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Clinical and functional consequences of GRIA variants in patients with neurological diseases. Cell Mol Life Sci. 2023 Nov 03; 80(11):345.