"Folic Acid Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Descriptor ID |
D005494
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| MeSH Number(s) |
C18.654.521.500.133.699.308
|
| Concept/Terms |
Folic Acid Deficiency- Folic Acid Deficiency
- Deficiency, Folic Acid
- Acid Deficiencies, Folic
- Acid Deficiency, Folic
- Deficiencies, Folic Acid
- Folic Acid Deficiencies
|
Below are MeSH descriptors whose meaning is more general than "Folic Acid Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Folic Acid Deficiency".
This graph shows the total number of publications written about "Folic Acid Deficiency" by people in this website by year, and whether "Folic Acid Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2001 | 0 | 1 | 1 |
| 2003 | 2 | 0 | 2 |
| 2005 | 2 | 2 | 4 |
| 2006 | 3 | 0 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 2 | 1 | 3 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Folic Acid Deficiency" by people in Profiles.
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Cao X, Wolf A, Kim SE, Cabrera RM, Wlodarczyk BJ, Zhu H, Parker M, Lin Y, Steele JW, Han X, Ramaekers VT, Steinfeld R, Finnell RH, Lei Y. CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. J Med Genet. 2021 07; 58(7):484-494.
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Steele JW, Kim SE, Finnell RH. One-carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects? Biochimie. 2020 Jun; 173:27-32.
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Li H, Wang X, Zhao H, Wang F, Bao Y, Guo J, Chang S, Wu L, Cheng H, Chen S, Zou J, Cui X, Niswander L, Finnell RH, Wang H, Zhang T. Low folate concentration impacts mismatch repair deficiency in neural tube defects. Epigenomics. 2020 01; 12(1):5-18.
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Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw G, Agopian AJ. Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study. J Nutr. 2019 02 01; 149(2):295-303.
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Cappuccio G, Torella A, Mastrangelo M, Carducci C, Nigro V, Brunetti-Pierri N, Leuzzi V. AP1S2-truncating variant in a patient with severe neurodevelopmental disorder and cerebral folate deficiency. Acta Paediatr. 2019 03; 108(3):564-565.
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Rojas-Hernandez CM, Oo TH. The unusual nutritional and toxin-related underproduction anemias: approaching the riddle beyond iron, cobalamin, and folate. Discov Med. 2018 02; 25(136):67-74.
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Mathew SJ, Lijffijt M. Neurometabolic Abnormalities in Treatment-Resistant Depression. Am J Psychiatry. 2017 01 01; 174(1):3-5.
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Denny KJ, Kelly CF, Kumar V, Witham KL, Cabrera RM, Finnell RH, Taylor SM, Jeanes A, Woodruff TM. Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Res A Clin Mol Teratol. 2016 Mar; 106(3):201-7.
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Morrow GP, MacMillan L, Lamarre SG, Young SK, MacFarlane AJ, Brosnan ME, Brosnan JT. In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats. J Biol Chem. 2015 Jan 23; 290(4):2244-50.
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Fathe K, Person MD, Finnell RH. The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects. J Nutr Biochem. 2015 Apr; 26(4):312-8.