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ROBERTO ADACHI

TitleAssociate Professor
InstitutionMD Anderson
DepartmentPulmonary Medicine
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Noh S, Bertini C, Mira-Avendano I, Kaous M, Patel B, Faiz SA, Shannon VR, Balachandran DD, Bashoura L, Adachi R, Evans SE, Dickey B, Wu C, Shroff GS, Manzano JG, Granwehr B, Holloway S, Dickson K, Mohammed A, Muthu M, Song H, D3CODE Team, Chung C, Wu J, Lee L, Jiang Y, Khawaja F, Sheshadri A. Interstitial lung abnormalities after hospitalization for COVID-19 in patients with cancer: A prospective cohort study. Cancer Med. 2023 09; 12(17):17753-17765. PMID: 37592894; PMCID: PMC10524033.
      Citations: 2     Fields:    Translation:HumansCells
    2. Hoang ON, Ermund A, Jaramillo AM, Fakih D, French CB, Flores JR, Karmouty-Quintana H, Magnusson JM, Fois G, Fauler M, Frick M, Braubach P, Hales JB, Kurten RC, Panettieri R, Vergara L, Ehre C, Adachi R, Tuvim MJ, Hansson GC, Dickey BF. Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am J Respir Crit Care Med. 2022 11 01; 206(9):1081-1095. PMID: 35776514; PMCID: PMC9704839.
      Citations:    Fields:    
    3. Molina S, Martinez-Zayas G, Sainz PV, Leung CH, Li L, Grosu HB, Adachi R, Ost DE. Breast and Lung Effusion Survival Score Models: Improving Survival Prediction in Patients With Malignant Pleural Effusion and Metastasis. Chest. 2021 09; 160(3):1075-1094. PMID: 33852918; PMCID: PMC8449006.
      Citations: 1     Fields:    Translation:HumansCells
    4. Janecke AR, Liu X, Punuru S, Viestenz A, Laass M, Sanchez E, Adachi R, Schatz MP, Saboo US, Mittal N, Escher J, Ganesh A, Al Zuhaibi S, Al Murshedi F, AlSaleem B, Alfadhel M, Al Sinani S, Alkuraya FS, Huber LA, Heidelberger R, Janz R, Adam R, Strau? V, Rohrschneider K, M?ller T. Pathogenic STX3 variants affecting the retinal and intestinal transcripts cause an early-onset severe retinal dystrophy in microvillus inclusion disease subjects. Hum Genet. 2021 Aug; 140(8):1143-1156. PMID: 33974130; PMCID: PMC8263458.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Sanchez E, Ramos MA, Burns AR, Heidelberger R, Adachi R, Cardenas RA, Gonzalez R, Cardenas EI, Rodarte AI, Alcazar-Felix RJ, Isaza A. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis. J Biol Chem. 2021 Jan-Jun; 296:100268. PMID: 33837726; PMCID: PMC7948755.
      Citations:    Fields:    Translation:AnimalsCells
    6. Jaramillo AM, Piccotti L, Velasco WV, Delgado ASH, Azzegagh Z, Chung F, Nazeer U, Farooq J, Brenner J, Parker-Thornburg J, Scott BL, Evans CM, Adachi R, Burns AR, Kreda SM, Tuvim MJ, Dickey BF. Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 03 21; 4(6). PMID: 30721150; PMCID: PMC6483006.
      Citations: 6     Fields:    Translation:AnimalsCells
    7. Debiane L, Reitzel R, Rosenblatt J, Gagea M, Chavez MA, Adachi R, Grosu HB, Sheshadri A, Hill LR, Raad I, Ost DE. A Design-Based Stereologic Method to Quantify the Tissue Changes Associated with a Novel Drug-Eluting Tracheobronchial Stent. Respiration. 2019; 98(1):60-69. PMID: 30799409.
      Citations: 3     Fields:    Translation:HumansAnimals
    8. Cardenas EI, Gonzalez R, Breaux K, Da Q, Gutierrez BA, Ramos MA, Cardenas RA, Burns AR, Rumbaut RE, Adachi R. Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis. J Biol Chem. 2019 03 29; 294(13):4784-4792. PMID: 30696774; PMCID: PMC6442067.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Sanchez E, Gonzalez EA, Moreno DS, Cardenas RA, Ramos MA, Davalos AJ, Manllo J, Rodarte AI, Petrova Y, Moreira DC, Chavez MA, Tortoriello A, Lara A, Gutierrez BA, Burns AR, Heidelberger R, Adachi R. Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis. J Biol Chem. 2019 03 01; 294(9):3012-3023. PMID: 30563839; PMCID: PMC6398129.
      Citations: 10     Fields:    Translation:AnimalsCells
    10. Casal RF, Walsh G, McArthur M, Hill LR, Landaeta MF, Armas Villalba AJ, Ong P, Debiane L, Vakil E, Grosu HB, Jimenez CA, Ost D, Adachi R, Eapen GA. Bronchoscopic Laser Interstitial Thermal Therapy: An Experimental Study in Normal Porcine Lung Parenchyma. J Bronchology Interv Pulmonol. 2018 Oct; 25(4):322-329. PMID: 29771774.
      Citations: 5     Fields:    Translation:Animals
    11. Cardenas EI, Breaux K, Da Q, Flores JR, Ramos MA, Tuvim MJ, Burns AR, Rumbaut RE, Adachi R. Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation. Haematologica. 2018 07; 103(7):1235-1244. PMID: 29674495; PMCID: PMC6029531.
      Citations: 9     Fields:    Translation:AnimalsCells
    12. Ramos MA, Petrova Y, Davalos AJ, Costa RM, Tuvim MJ, Dickey BF, Burns AR, Heidelberger R, Adachi R, Gutierrez BA, Chavez MA, Rodarte AI, Dominguez A, Elizondo R. Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells. J Biol Chem. 2018 05 11; 293(19):7148-7159. PMID: 29599294; PMCID: PMC5950006.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Ramos MA, Petrova Y, Rendon LE, Sanchez E, Breaux K, Manllo J, Tuvim MJ, Dickey BF, Burns AR, Heidelberger R, Adachi R, Rodarte EM, Davalos AJ, Moreira DC, Moreno DS, Cardenas EI, Rodarte AI, Molina S, Tortoriello A, Gonzalez EA. Munc13 proteins control regulated exocytosis in mast cells. J Biol Chem. 2018 01 05; 293(1):345-358. PMID: 29141910; PMCID: PMC5766930.
      Citations: 18     Fields:    Translation:AnimalsCells
    14. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM, Romo I. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696; PMCID: PMC4001806.
      Citations: 296     Fields:    Translation:AnimalsCells
    15. Johnson SL, Wedemeyer C, Vetter DE, Adachi R, Holley MC, Marcotti W, Elgoyhen AB. Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. Open Biol. 2013 Nov; 3(11):130163. PMID: 24350389; PMCID: PMC3843824.
      Citations: 36     Fields:    Translation:AnimalsCells
    16. Magarinos NJ, Bryant KJ, Fosang AJ, Adachi R, Stevens RL, McNeil HP. Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens. J Immunol. 2013 Aug 01; 191(3):1404-12. PMID: 23797671; PMCID: PMC3727140.
      Citations: 14     Fields:    Translation:AnimalsCells
    17. Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin Immunol. 2013 Mar; 131(3):752-62. PMID: 23380220; PMCID: PMC4060894.
      Citations: 89     Fields:    Translation:AnimalsCells
    18. Zhou Z, Gushiken FC, Bolgiano D, Salsbery BJ, Aghakasiri N, Jing N, Wu X, Vijayan KV, Rumbaut RE, Adachi R, Lopez JA, Dong JF. Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity. Circulation. 2013 Jan 29; 127(4):476-485. PMID: 23266857; PMCID: PMC4472638.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    19. Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen VM, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim MJ, Dickey BF. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15; 446(3):383-94. PMID: 22694344; PMCID: PMC3430001.
      Citations: 20     Fields:    Translation:AnimalsCells
    20. Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 08; 287(24):20047-55. PMID: 22511759; PMCID: PMC3370188.
      Citations: 13     Fields:    Translation:AnimalsCells
    21. Zheng D, Adachi R, Xing W, Lane WS, Chung K, Anderson P, Hansbro PM, Castells M, Stevens RL, Prieto-Garc?a A. Mast cell restricted mouse and human tryptase?heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J Biol Chem. 2012 Mar 09; 287(11):7834-44. PMID: 22235124; PMCID: PMC3318743.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    22. Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP, Zhang J. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res. 2011 May 27; 108(11):1316-27. PMID: 21493897; PMCID: PMC3108141.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    23. Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL. Essential role for mast cell tryptase in acute experimental colitis. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):290-5. PMID: 21173247; PMCID: PMC3017166.
      Citations: 53     Fields:    Translation:AnimalsCells
    24. Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD, Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15; 185(12):7681-90. PMID: 21076070; PMCID: PMC3058366.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    25. Casal RF, Adachi R, Jimenez CA, Sarkiss M, Morice RC, Eapen GA. Diagnosis of invasive aspergillus tracheobronchitis facilitated by endobronchial ultrasound-guided transbronchial needle aspiration: a case report. J Med Case Rep. 2009 Nov 23; 3:9290. PMID: 19946509; PMCID: PMC2783092.
      Citations: 8     Fields:    
    26. Wu XS, McNeil BD, Xu J, Fan J, Xue L, Melicoff E, Adachi R, Bai L, Wu LG. Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. Nat Neurosci. 2009 Aug; 12(8):1003-1010. PMID: 19633667; PMCID: PMC4887276.
      Citations: 121     Fields:    Translation:AnimalsCells
    27. Melicoff E, Sansores-Garcia L, Gomez A, Moreira DC, Datta P, Thakur P, Petrova Y, Siddiqi T, Murthy JN, Dickey BF, Heidelberger R, Adachi R. Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem. 2009 Jul 17; 284(29):19445-51. PMID: 19473977; PMCID: PMC2740570.
      Citations: 25     Fields:    Translation:AnimalsCells
    28. He L, Xue L, Xu J, McNeil BD, Bai L, Melicoff E, Adachi R, Wu LG. Compound vesicle fusion increases quantal size and potentiates synaptic transmission. Nature. 2009 May 07; 459(7243):93-7. PMID: 19279571; PMCID: PMC2768540.
      Citations: 63     Fields:    Translation:AnimalsCells
    29. Tuvim MJ, Mospan AR, Burns KA, Chua M, Mohler PJ, Melicoff E, Adachi R, Ammar-Aouchiche Z, Davis CW, Dickey BF. Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum. J Biol Chem. 2009 Apr 10; 284(15):9781-7. PMID: 19208631; PMCID: PMC2665099.
      Citations: 30     Fields:    Translation:AnimalsCells
    30. Shin K, Nigrovic PA, Crish J, Boilard E, McNeil HP, Larabee KS, Adachi R, Gurish MF, Gobezie R, Stevens RL, Lee DM. Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes. J Immunol. 2009 Jan 01; 182(1):647-56. PMID: 19109198; PMCID: PMC2610352.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    31. McNeil HP, Shin K, Campbell IK, Wicks IP, Adachi R, Lee DM, Stevens RL. The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis. Arthritis Rheum. 2008 Aug; 58(8):2338-46. PMID: 18668540.
      Citations: 43     Fields:    Translation:AnimalsCells
    32. Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 2008 Jun 15; 177(12):1322-30. PMID: 18388354; PMCID: PMC2427056.
      Citations: 64     Fields:    Translation:AnimalsCells
    33. Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, S?dhof TC. A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature. 2007 Nov 29; 450(7170):676-82. PMID: 18046404; PMCID: PMC3536472.
      Citations: 198     Fields:    Translation:AnimalsCells
    34. Katsoulotos GP, Qi M, Qi JC, Tanaka K, Hughes WE, Molloy TJ, Adachi R, Stevens RL, Krilis SA. The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2. J Biol Chem. 2008 Jan 18; 283(3):1610-1621. PMID: 18024961.
      Citations: 8     Fields:    Translation:HumansCells
    35. Stevens RL, Adachi R. Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity. Immunol Rev. 2007 Jun; 217:155-67. PMID: 17498058.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    36. McNeil HP, Adachi R, Stevens RL. Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense. J Biol Chem. 2007 Jul 20; 282(29):20785-9. PMID: 17504754.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    37. Young HW, Williams OW, Chandra D, Bellinghausen LK, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM, P?rez G, Su?rez A. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol. 2007 Sep; 37(3):273-90. PMID: 17463395; PMCID: PMC1994232.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    38. Thakurdas SM, Melicoff E, Sansores-Garcia L, Moreira DC, Petrova Y, Stevens RL, Adachi R. The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem. 2007 Jul 20; 282(29):20809-15. PMID: 17456473.
      Citations: 84     Fields:    Translation:AnimalsCells
    39. Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, S?dhof TC. Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci. 2006 Dec 27; 26(52):13493-504. PMID: 17192432; PMCID: PMC6674714.
      Citations: 106     Fields:    Translation:AnimalsCells
    40. Nigam R, Sepulveda J, Tuvim M, Petrova Y, Adachi R, Dickey BF, Agrawal A. Expression and transcriptional regulation of Munc18 isoforms in mast cells. Biochim Biophys Acta. 2005 Apr 05; 1728(1-2):77-83. PMID: 15777698.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Blood. 2005 May 15; 105(10):3893-901. PMID: 15701722; PMCID: PMC1895090.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    42. Dhillon SS, Adachi R. A 62-year-old man with shoulder pain. Chest. 2004 Aug; 126(2):614-6. PMID: 15302751.
      Citations:    Fields:    Translation:Humans
    43. Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R. Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. J Exp Med. 1999 May 17; 189(10):1649-58. PMID: 10330444; PMCID: PMC2193646.
      Citations: 32     Fields:    Translation:AnimalsCells
    44. Dickey BF, Adachi R. Exercise-induced asthma. N Engl J Med. 1998 Dec 10; 339(24):1783-4; author reply 1785. PMID: 9867554.
      Citations:    Fields:    Translation:Humans
    45. Panchenko MP, Joyce-Brady M, Starikova MG, Oakes SM, Adachi R, Brody JS, Dickey BF. Atrial natriuretic peptide modulates alveolar type 2 cell adenylyl and guanylyl cyclases and inhibits surfactant secretion. Biochim Biophys Acta. 1998 May 27; 1403(1):115-25. PMID: 9622608.
      Citations: 4     Fields:    Translation:AnimalsCells
    46. Erratum. Nature Neuroscience. 13:649.
    47. Invited commentary. Radiographics. 26:39-40.
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