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RUSSELL SCOTT RAY

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
DivisionNeuroscience
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


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    The overarching goal of our laboratory is to understand how the myriad of neurons and glia in our brain are organized into circuits that keep us alive and enable complex behaviors that may be disrupted in diseases ranging from sudden infant death syndrome (SIDS), the leading cause of neonate death in the United States, to panic disorder, the most common mental illness in the United States. On the surface, SIDS and panic disorder may have little in common. However, there is indeed a likely nexus in the neural control of breathing. In SIDS, defined as the death of an infant for which no cause of death can be determined, the current thinking is that in many cases there are small-unseen abnormalities in brain regions that regulate breathing, leaving the infant vulnerable. Conversely, a connection between breathing and anxiety has long been appreciated, such that breathing challenges are used in clinical diagnostic tests for panic disorder and this relationship is best appreciated in our common perception of a panic attack where a person breaths too much and risks passing out. Unfortunately, little is known about these critical breathing circuits that are also important in spinal cord injuries where the number one desire for quadriplegic patients is to breath on their own, or in neuro-degenerative disorders such as Alzheimer’s, Parkinson’s and ALS, where the ultimate cause of death is typically respiratory arrest. Thus, we aim to define the neural pathways important in breathing to understand how they may be targeted for therapeutic interventions and predicative diagnostic tests.

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    Brainstem
    Breathing
    Genetic engineering
    Neural circuit mapping
    Noradrenergic System
    Fear
    Anxiety
    Neurodegeneration


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sun JJ, Ray RS. Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes. Biol Open. 2017 Jul 06. PMID: 28684394.
      View in: PubMed
    2. Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY. Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 04. PMID: 28392070.
      View in: PubMed
    3. Sun JJ, Nanu R, Ray RS. A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements. J Pharmacol Toxicol Methods. 2017 Feb 15; 86:1-11. PMID: 28213294.
      View in: PubMed
    4. Dharmadhikari AV, Sun JJ, Gogolewski K, Carofino BL, Ustiyan V, Hill M, Majewski T, Szafranski P, Justice MJ, Ray RS, Dickinson ME, Kalinichenko VV, Gambin A, Stankiewicz P. Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression. Biol Open. 2016 Nov 15; 5(11):1595-1606. PMID: 27638768.
      View in: PubMed
    5. Sun JJ, Ray R. Generation of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells. PLoS One. 2016; 11(7):e0159474. PMID: 27441631; PMCID: PMC4956144.
    6. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevi? K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2?. Elife. 2016; 5. PMID: 26928076; PMCID: PMC4786418.
    7. Teissier A, Chemiakine A, Inbar B, Bagchi S, Ray RS, Palmiter RD, Dymecki SM, Moore H, Ansorge MS. Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors. Cell Rep. 2015 Dec 1; 13(9):1965-76. PMID: 26655908.
      View in: PubMed
    8. Landstrom AP, Sun JJ, Ray RS, Wehrens XH. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5. PMID: 26164374.
      View in: PubMed
    9. Ray RS, Corcoran AE, Brust RD, Soriano LP, Nattie EE, Dymecki SM. Egr2-neurons control the adult respiratory response to hypercapnia. Brain Res. 2013 May 20; 1511:115-25. PMID: 23261662; PMCID: PMC3947592.
    10. Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012 Oct 26; 151(3):645-57. PMID: 23101631; PMCID: PMC3500616.
    11. Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science. 2011 Jul 29; 333(6042):637-42. PMID: 21798952; PMCID: PMC3729433.
    12. Dymecki SM, Ray RS, Kim JC. Mapping cell fate and function using recombinase-based intersectional strategies. Methods Enzymol. 2010; 477:183-213. PMID: 20699143.
      View in: PubMed
    13. Ray RS, Dymecki SM. Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip. Curr Opin Cell Biol. 2009 Dec; 21(6):741-7. PMID: 19883998; PMCID: PMC3729404.
    14. Ray R, Capecchi M. An examination of the Chiropteran HoxD locus from an evolutionary perspective. Evol Dev. 2008 Nov-Dec; 10(6):657-70. PMID: 19021736.
      View in: PubMed
    15. Geisler R, Rauch GJ, Geiger-Rudolph S, Albrecht A, van Bebber F, Berger A, Busch-Nentwich E, Dahm R, Dekens MP, Dooley C, Elli AF, Gehring I, Geiger H, Geisler M, Glaser S, Holley S, Huber M, Kerr A, Kirn A, Knirsch M, Konantz M, Küchler AM, Maderspacher F, Neuhauss SC, Nicolson T, Ober EA, Praeg E, Ray R, Rentzsch B, Rick JM, Rief E, Schauerte HE, Schepp CP, Schönberger U, Schonthaler HB, Seiler C, Sidi S, Söllner C, Wehner A, Weiler C, Nüsslein-Volhard C. Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 2007 Jan 09; 8:11. PMID: 17212827; PMCID: PMC1781435.
    16. Lee JS, Ray R, Chien CB. Cloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration. Dev Dyn. 2001 Jun; 221(2):216-30. PMID: 11376489.
      View in: PubMed
    17. Geisler R, Rauch GJ, Baier H, van Bebber F, Bross L, Dekens MP, Finger K, Fricke C, Gates MA, Geiger H, Geiger-Rudolph S, Gilmour D, Glaser S, Gnügge L, Habeck H, Hingst K, Holley S, Keenan J, Kirn A, Knaut H, Lashkari D, Maderspacher F, Martyn U, Neuhauss S, Neumann C, Nicolson T, Pelegri F, Ray R, Rick JM, Roehl H, Roeser T, Schauerte HE, Schier AF, Schönberger U, Schönthaler HB, Schulte-Merker S, Seydler C, Talbot WS, Weiler C, Nüsslein-Volhard C, Haffter P. A radiation hybrid map of the zebrafish genome. Nat Genet. 1999 Sep; 23(1):86-9. PMID: 10471505.
      View in: PubMed
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