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E. LYNN ZECHIEDRICH

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    Collapse Biography 
    Collapse awards and honors
    1981 - 1982Freshman Academic Tuition Scholarship, University of Arkansas
    1989Vanderbilt University Travel Awards (three), Vanderbilt University School of Medicine
    1989First Place, Graduate Student Oral Presentation, The Eastern Student Research Forum, University of Miami School of Medicine
    1989Outstanding (First Place) Graduate Student Presentation, Student Research Day, Vanderbilt University
    1990Travel Award to attend Mathematical Approaches to DNA, Santa Fe, NM
    1991 - 1994National Institutes of Health Postdoctoral Fellowship
    1994National Institutes of Environmental Health Sciences Center Pilot Study Grant , University of California, Berkeley
    1994 - 1997Leukemia Society of America (Leukemia and Lymphoma Society) Special (Senior) Postdoctoral Fellowship
    1997Fellowship from Juan March Institute, Madrid, to speak at International workshop
    1998 - 1999Curtis Hankamer Research Award , Baylor College of Medicine
    1998 - 2002Burroughs Wellcome Fund New Investigator Award in the Toxicological Sciences
    2004Burroughs Wellcome Fund Award
    2007Finalist, NIH Director's Pioneer Award
    2009Applied Biosystems SOLiDTM 3 System $10K Genome Award
    2010 - 2013Human Frontier Science Program Research Grant
    2011 - 2013John S. Dunn Foundation Collaborative Research Award
    2013Baylor Research Advocates for Student Scientists (BRASS) mentor of the year award, Baylor College of Medicine

    Collapse Overview 
    Collapse keywords
    DNA structure/function
    DNA topology
    DNA supercoiling
    DNA topoisomerases
    DNA vectors
    MiniVector DNA
    Minicircle DNA
    Antibiotic resistance
    Fluoroquinolone resistance
    Gram-negative bacterial infections
    Multidrug resistance
    Escherichia coli
    Gene therapy


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Carlson-Banning, Kimberly M. Zechiedrich, Lynn. Encyclopedia of Metagenomics (Karen E. Nelson, editor). Antibiotic Classes and Mechanisms of Resistance. 2014; (303370).
    2. Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One. 2013; 8(7):e69646. PMID: 23936064; PMCID: PMC3720592.
    3. Swick MC, Evangelista MA, Bodine TJ, Easton-Marks JR, Barth P, Shah MJ, Bormann Chung CA, Stanley S, McLaughlin SF, Lee CC, Sheth V, Doan Q, Hamill RJ, Steffen D, Becnel LB, Sucgang R, Zechiedrich L. Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates. PLoS One. 2013; 8(6):e65961. PMID: 23824211; PMCID: PMC3688849.
    4. Fogg JM, Randall GL, Pettitt BM, Sumners de WL, Harris SA, Zechiedrich L. Bullied no more: when and how DNA shoves proteins around. Q Rev Biophys. 2012 Aug; 45(3):257-99. PMID: 22850561; PMCID: PMC4866820.
    5. Zechiedrich L. Editorial comment to genome-wide transcriptome analysis of fluoroquinolone resistance in clinical isolates of Escherichia coli. Int J Urol. 2012 Apr; 19(4):368-9. PMID: 22394085.
      View in: PubMed
    6. Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH. Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother. 2012 Apr; 56(4):1680-5. PMID: 22232279; PMCID: PMC3318314.
    7. Catanese DJ, Fogg JM, Schrock DE, Gilbert BE, Zechiedrich L. Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery. Gene Ther. 2012 Jan; 19(1):94-100. PMID: 21633394; PMCID: PMC3252587.
    8. Swick MC, Morgan-Linnell SK, Carlson KM, Zechiedrich L. Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrob Agents Chemother. 2011 Feb; 55(2):921-4. PMID: 21098250; PMCID: PMC3028778.
    9. Zhao N, Fogg JM, Zechiedrich L, Zu Y. Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells. Gene Ther. 2011 Mar; 18(3):220-4. PMID: 20962872; PMCID: PMC3154479.
    10. Zechiedrich L, Osheroff N. Topoisomerase IB-DNA interactions: X marks the spot. Structure. 2010 Jun 9; 18(6):661-3. PMID: 20541502; PMCID: PMC2891060.
    11. Liu Z, Zechiedrich L, Chan HS. Action at hooked or twisted-hooked DNA juxtapositions rationalizes unlinking preference of type-2 topoisomerases. J Mol Biol. 2010 Jul 30; 400(5):963-82. PMID: 20460130.
      View in: PubMed
    12. Liu Z, Zechiedrich L, Chan HS. Local site preference rationalizes disentangling by DNA topoisomerases. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Mar; 81(3 Pt 1):031902. PMID: 20365765; PMCID: PMC3645352.
    13. Randall GL, Zechiedrich L, Pettitt BM. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form. Nucleic Acids Res. 2009 Sep; 37(16):5568-77. PMID: 19586933; PMCID: PMC2760789.
    14. Liu Z, Deibler RW, Chan HS, Zechiedrich L. The why and how of DNA unlinking. Nucleic Acids Res. 2009 Feb; 37(3):661-71. PMID: 19240147; PMCID: PMC2647305.
    15. Becnel Boyd L, Maynard MJ, Morgan-Linnell SK, Horton LB, Sucgang R, Hamill RJ, Jimenez JR, Versalovic J, Steffen D, Zechiedrich L. Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):229-34. PMID: 18838594; PMCID: PMC2612140.
    16. Morgan-Linnell SK, Becnel Boyd L, Steffen D, Zechiedrich L. Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):235-41. PMID: 18838592; PMCID: PMC2612180.
    17. Boyd LB, Atmar RL, Randall GL, Hamill RJ, Steffen D, Zechiedrich L. Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location. BMC Infect Dis. 2008; 8:4. PMID: 18197977; PMCID: PMC2258293.
    18. Morgan-Linnell SK, Hiasa H, Zechiedrich L, Nitiss JL. Assessing sensitivity to antibacterial topoisomerase II inhibitors. Curr Protoc Pharmacol. 2007 Dec; Chapter 3:Unit3.13. PMID: 21948169; PMCID: PMC2850120.
    19. Morgan-Linnell SK, Zechiedrich L. Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother. 2007 Nov; 51(11):4205-8. PMID: 17682104; PMCID: PMC2151436.
    20. Deibler RW, Mann JK, Sumners de WL, Zechiedrich L. Hin-mediated DNA knotting and recombining promote replicon dysfunction and mutation. BMC Mol Biol. 2007; 8:44. PMID: 17531098; PMCID: PMC1904230.
    21. Liu Z, Mann JK, Zechiedrich EL, Chan HS. Topological information embodied in local juxtaposition geometry provides a statistical mechanical basis for unknotting by type-2 DNA topoisomerases. J Mol Biol. 2006 Aug 11; 361(2):268-85. PMID: 16842819.
      View in: PubMed
    22. Randall GL, Pettitt BM, Buck GR, Zechiedrich EL. Electrostatics of DNA-DNA juxtapositions: consequences for type II topoisomerase function. J Phys Condens Matter. 2006 Apr 12; 18(14):S173-S185. PMID: 19088861.
      View in: PubMed
    23. Fogg JM, Kolmakova N, Rees I, Magonov S, Hansma H, Perona JJ, Zechiedrich EL. Exploring writhe in supercoiled minicircle DNA. J Phys Condens Matter. 2006 Apr 12; 18(14):S145-S159. PMID: 19337583.
      View in: PubMed
    24. Liu Z, Zechiedrich EL, Chan HS. Inferring global topology from local juxtaposition geometry: interlinking polymer rings and ramifications for topoisomerase action. Biophys J. 2006 Apr 1; 90(7):2344-55. PMID: 16537549; PMCID: PMC1403174.
    25. Yang S, Lopez CR, Zechiedrich EL. Quorum sensing and multidrug transporters in Escherichia coli. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2386-91. PMID: 16467145; PMCID: PMC1413681.
    26. Lopez CR, Yang S, Deibler RW, Ray SA, Pennington JM, Digate RJ, Hastings PJ, Rosenberg SM, Zechiedrich EL. A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol Microbiol. 2005 Oct; 58(1):80-101. PMID: 16164551.
      View in: PubMed
    27. Gruger T, Nitiss JL, Maxwell A, Zechiedrich EL, Heisig P, Seeber S, Pommier Y, Strumberg D. A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II. Antimicrob Agents Chemother. 2004 Dec; 48(12):4495-504. PMID: 15561817; PMCID: PMC529191.
    28. Buck GR, Zechiedrich EL. DNA disentangling by type-2 topoisomerases. J Mol Biol. 2004 Jul 23; 340(5):933-9. PMID: 15236957.
      View in: PubMed
    29. Yang S, Clayton SR, Zechiedrich EL. Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli. J Antimicrob Chemother. 2003 Mar; 51(3):545-56. PMID: 12615854.
      View in: PubMed
    30. Rahmati S, Yang S, Davidson AL, Zechiedrich EL. Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. Mol Microbiol. 2002 Feb; 43(3):677-85. PMID: 11929524.
      View in: PubMed
    31. Deibler RW, Rahmati S, Zechiedrich EL. Topoisomerase IV, alone, unknots DNA in E. coli. Genes Dev. 2001 Mar 15; 15(6):748-61. PMID: 11274059; PMCID: PMC312656.
    32. Zechiedrich EL, Khodursky AB, Bachellier S, Schneider R, Chen D, Lilley DM, Cozzarelli NR. Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J Biol Chem. 2000 Mar 17; 275(11):8103-13. PMID: 10713132.
      View in: PubMed
    33. Zechiedrich EL, Crisona NJ. Coating DNA with RecA protein to distinguish DNA path by electron microscopy. Methods Mol Biol. 1999; 94:99-107. PMID: 12844866.
      View in: PubMed
    34. Zechiedrich EL, Khodursky AB, Cozzarelli NR. Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. Genes Dev. 1997 Oct 1; 11(19):2580-92. PMID: 9334322; PMCID: PMC316566.
    35. Khodursky AB, Zechiedrich EL, Cozzarelli NR. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc Natl Acad Sci U S A. 1995 Dec 5; 92(25):11801-5. PMID: 8524852; PMCID: PMC40490.
    36. Zechiedrich EL, Cozzarelli NR. Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 1995 Nov 15; 9(22):2859-69. PMID: 7590259.
      View in: PubMed
    37. Crisona NJ, Kanaar R, Gonzalez TN, Zechiedrich EL, Klippel A, Cozzarelli NR. Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange. J Mol Biol. 1994 Oct 28; 243(3):437-57. PMID: 7966272.
      View in: PubMed
    38. Adams DE, Shekhtman EM, Zechiedrich EL, Schmid MB, Cozzarelli NR. The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication. Cell. 1992 Oct 16; 71(2):277-88. PMID: 1330320.
      View in: PubMed
    39. Corbett AH, Zechiedrich EL, Osheroff N. A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavage. J Biol Chem. 1992 Jan 15; 267(2):683-6. PMID: 1309770.
      View in: PubMed
    40. Corbett AH, Zechiedrich EL, Lloyd RS, Osheroff N. Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers. J Biol Chem. 1991 Oct 15; 266(29):19666-71. PMID: 1655791.
      View in: PubMed
    41. Osheroff N, Zechiedrich EL, Gale KC. Catalytic function of DNA topoisomerase II. Bioessays. 1991 Jun; 13(6):269-73. PMID: 1654050.
      View in: PubMed
    42. Zechiedrich EL, Osheroff N. Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers. EMBO J. 1990 Dec; 9(13):4555-62. PMID: 2176156; PMCID: PMC552253.
    43. Andersen AH, Christiansen K, Zechiedrich EL, Jensen PS, Osheroff N, Westergaard O. Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction. Biochemistry. 1989 Jul 25; 28(15):6237-44. PMID: 2551368.
      View in: PubMed
    44. Zechiedrich EL, Christiansen K, Andersen AH, Westergaard O, Osheroff N. Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. Biochemistry. 1989 Jul 25; 28(15):6229-36. PMID: 2551367.
      View in: PubMed
    45. Osheroff N, Zechiedrich EL. Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form. Biochemistry. 1987 Jul 14; 26(14):4303-9. PMID: 2822084.
      View in: PubMed
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