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AMOS GAIKWAD

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Hematology & Oncology
AddressDEPARTMENT OF PEDIATRICS - HEMATOLOGY/ONCOLOGY
ONE BAYLOR PLAZA
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bonifant CL, Szoor A, Torres D, Joseph N, Velasquez MP, Iwahori K, Gaikwad A, Nguyen P, Arber C, Song XT, Redell M, Gottschalk S. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Mol Ther. 2016 Sep 29; 24(9):1615-26. PMID: 27401038.
      View in: PubMed
    2. Gaikwad A, Bonifant CL, Cubbage M, Goltsova T, Mudannayake M, Ringrose J, Punia J, Lopez-Terrada D, Sheehan AM. Detection of lymphoid and myeloid lineages in infantile B-cell acute lymphoblastic leukemia with mixed-lineage leukemia rearrangement by use of flow cytometry and cytogenetic analysis. Clin Lymphoma Myeloma Leuk. 2014 Sep; 14 Suppl:S2-5. PMID: 25486951.
      View in: PubMed
    3. Gaikwad AS, Donohue RE, Elghetany MT, Sheehan AM, Lu XY, Gramatges MM, McClain KL, Mistretta TA, Punia JN, Moore TJ, Goltsova T, Cubbage M, Curry CV. Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia. Int J Clin Exp Pathol. 2014; 7(9):6225-30. PMID: 25337274; PMCID: PMC4203245.
    4. Quintás-Cardama A, Manshouri T, Estrov Z, Harris D, Zhang Y, Gaikwad A, Kantarjian HM, Verstovsek S. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest New Drugs. 2011 Oct; 29(5):818-26. PMID: 20372971; PMCID: PMC4170651.
    5. Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010 Apr 15; 184(8):4557-67. PMID: 20220088; PMCID: PMC3142675.
    6. Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR. Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. Br J Haematol. 2009 Mar; 144(6):930-2. PMID: 19120350; PMCID: PMC2724897.
    7. Manshouri T, Quintás-Cardama A, Nussenzveig RH, Gaikwad A, Estrov Z, Prchal J, Cortes JE, Kantarjian HM, Verstovsek S. The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation. Cancer Sci. 2008 Jun; 99(6):1265-73. PMID: 18482053; PMCID: PMC4829954.
    8. Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M. Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. J Invest Dermatol. 2008 Nov; 128(11):2728-35. PMID: 18496567.
      View in: PubMed
    9. Agarwal N, Kutlar F, Mojica-Henshaw MP, Ou CN, Gaikwad A, Reading NS, Bailey L, Kutlar A, Prchal JT. Missense mutation of the last nucleotide of exon 1 (G->C) of beta globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele. Haematologica. 2007 Dec; 92(12):1715-6. PMID: 18056002.
      View in: PubMed
    10. Gaikwad A, Prchal JT. Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera. Exp Hematol. 2007 Nov; 35(11):1647-56. PMID: 17976517; PMCID: PMC2206678.
    11. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ. 2007 Nov; 14(11):1948-57. PMID: 17690712.
      View in: PubMed
    12. Gaikwad A, Verstovsek S, Yoon D, Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, Prchal JT. Imatinib effect on growth and signal transduction in polycythemia vera. Exp Hematol. 2007 Jun; 35(6):931-8. PMID: 17533047.
      View in: PubMed
    13. Gaikwad A, Nussenzveig R, Liu E, Gottshalk S, Chang K, Prchal JT. In vitro expansion of erythroid progenitors from polycythemia vera patients leads to decrease in JAK2 V617F allele. Exp Hematol. 2007 Apr; 35(4):587-95. PMID: 17379069; PMCID: PMC1931508.
    14. Nussenzveig RH, Swierczek SI, Jelinek J, Gaikwad A, Liu E, Verstovsek S, Prchal JF, Prchal JT. Polycythemia vera is not initiated by JAK2V617F mutation. Exp Hematol. 2007 Jan; 35(1):32-8. PMID: 17198871.
      View in: PubMed
    15. Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT. A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Haematologica. 2006 Nov; 91(11):1542-5. PMID: 17082011.
      View in: PubMed
    16. Gutterman JU, Lai HT, Yang P, Haridas V, Gaikwad A, Marcus S. Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast. Proc Natl Acad Sci U S A. 2005 Sep 6; 102(36):12771-6. PMID: 16118282; PMCID: PMC1200287.
    17. Iskander K, Gaikwad A, Paquet M, Long DJ, Brayton C, Barrios R, Jaiswal AK. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 2005 Mar 15; 65(6):2054-8. PMID: 15781611.
      View in: PubMed
    18. Gaikwad A, Poblenz A, Haridas V, Zhang C, Duvic M, Gutterman J. Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity. Clin Cancer Res. 2005 Mar 1; 11(5):1953-62. PMID: 15756021.
      View in: PubMed
    19. Stringer JL, Gaikwad A, Gonzales BN, Long DJ, Marks LM, Jaiswal AK. Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. J Comp Neurol. 2004 Apr 5; 471(3):289-97. PMID: 14991562.
      View in: PubMed
    20. Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, Narog M, Spears E, Zoltaszek R, Walaszek Z, Gutterman JU. Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. J Clin Invest. 2004 Jan; 113(1):65-73. PMID: 14702110; PMCID: PMC300766.
    21. Long DJ, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002 Nov 29; 277(48):46131-9. PMID: 12351651.
      View in: PubMed
    22. Long DJ, Gaikwad A, Multani A, Pathak S, Montgomery CA, Gonzalez FJ, Jaiswal AK. Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia. Cancer Res. 2002 Jun 1; 62(11):3030-6. PMID: 12036909.
      View in: PubMed
    23. Gaikwad A, Hop DV, Mukherjee SK. A 70-kDa chloroplast DNA polymerase from pea ( Pisum sativum) that shows high processivity and displays moderate fidelity. Mol Genet Genomics. 2002 Mar; 267(1):45-56. PMID: 11919714.
      View in: PubMed
    24. Gaikwad A, Long DJ, Stringer JL, Jaiswal AK. In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue. J Biol Chem. 2001 Jun 22; 276(25):22559-64. PMID: 11309386.
      View in: PubMed
    25. Gaikwad A, Van Hop D, Mukherjee SK. Carboxy terminal region of a chloroplast DNA polymerase accessory factor stimulates DNA polymerase activity. Indian J Biochem Biophys. 2000 Dec; 37(6):424-32. PMID: 11355629.
      View in: PubMed
    26. Gaikwad A, Babbarwal V, Pant V, Mukherjee SK. Pea chloroplast FtsZ can form multimers and correct the thermosensitive defect of an Escherichia coli ftsZ mutant. Mol Gen Genet. 2000 Mar; 263(2):213-21. PMID: 10778739.
      View in: PubMed
    27. Ehtesham NZ, Phan TN, Gaikwad A, Sopory SK, Tuteja N. Calnexin from Pisum sativum: cloning of the cDNA and characterization of the encoded protein. DNA Cell Biol. 1999 Nov; 18(11):853-62. PMID: 10595399.
      View in: PubMed
    28. Gaikwad A, Tewari KK, Kumar D, Chen W, Mukherjee SK. Isolation and characterisation of the cDNA encoding a glycosylated accessory protein of pea chloroplast DNA polymerase. Nucleic Acids Res. 1999 Aug 1; 27(15):3120-9. PMID: 10454608; PMCID: PMC148538.
    29. Suppression of pea nuclear topoisomerase I enzyme activity by pea PCNA. Plant J. 1999 Jul; 19(2):153-162. PMID: 10476062.
      View in: PubMed
    30. Chen W, Gaikwad A, Mukherjee SK, Choudhary NR, Kumar D, Tewari KK. A 43 kDa DNA binding protein from the pea chloroplast interacts with and stimulates the cognate DNA polymerase. Nucleic Acids Res. 1996 Oct 15; 24(20):3953-61. PMID: 8918797; PMCID: PMC146191.
    31. Gaikwad AS, Cumsky MG. The use of chemical cross-linking to identify proteins that interact with a mitochondrial presequence. J Biol Chem. 1994 Mar 4; 269(9):6437-43. PMID: 8119994.
      View in: PubMed
    32. Omkumar RV, Gaikwad AS, Ramasarma T. Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone. Biochem Biophys Res Commun. 1992 May 15; 184(3):1280-7. PMID: 1590790.
      View in: PubMed
    33. Ramasarma T, Rasheed BK, Vijaya S, Puranam RS, Shivaswamy V, Gaikwad AS, Kurup CK. Functions of cytochrome c in regulation of electron transfer and protein folding. Indian J Biochem Biophys. 1992 Apr; 29(2):173-8. PMID: 1328035.
      View in: PubMed
    34. Gaikwad AS, Ramasarma T, Ramakrishna Kurup CK. Brown adipose tissue mitochondria are cytochrome c-subsaturated. Mol Cell Biochem. 1991 Jul 10; 105(2):119-25. PMID: 1656204.
      View in: PubMed
    35. Gaikwad A, Ramasarma T, Kurup CK. Regulation of respiratory activity of brown adipose tissue mitochondria through changes in cytochromes. Biotechnol Appl Biochem. 1990 Oct; 12(5):562-6. PMID: 2288713.
      View in: PubMed
    36. Gaikwad AS, Ramasarma T, Kurup CK. Decrease of oxidative activities in brown adipose tissue mitochondria of cold acclimated rats on short term exposure to heat stress. Biochim Biophys Acta. 1990 Jun 26; 1017(3):242-50. PMID: 2372558.
      View in: PubMed
    37. Gaikwad AS, Ramasarma T, Kurup CK. Changes in thyroid hormone and insulin status of the brown adipose tissue of cold acclimated rats on short term exposure to heat. Indian J Biochem Biophys. 1990 Jun; 27(3):167-71. PMID: 2201623.
      View in: PubMed
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