| Item Type | Name |
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Academic Article
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Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
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Academic Article
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Determination of the membrane contact residues and solution structure of the helix F/G loop of prostaglandin I2 synthase.
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Academic Article
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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators.
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Academic Article
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Substrate access channel topology in membrane-bound prostacyclin synthase.
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Academic Article
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The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase.
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Academic Article
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Prunella stica inhibits the proliferation but not the prostaglandin production of Ishikawa cells.
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Academic Article
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Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin.
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Academic Article
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Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential.
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Academic Article
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A new strategy, SuperEnzyme gene therapy in penile rehabilitation.
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Academic Article
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A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis.
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Academic Article
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NMR structure of the thromboxane A2 receptor ligand recognition pocket.
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Academic Article
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Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique.
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Academic Article
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Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein.
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Academic Article
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A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor.
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Academic Article
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Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs.
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Academic Article
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Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin.
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Academic Article
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A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor.
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Academic Article
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Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket.
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Academic Article
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Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution.
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Academic Article
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Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis.
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Academic Article
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An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector.
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Academic Article
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Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2.
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Academic Article
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Prostacyclin therapy for pulmonary arterial hypertension.
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Academic Article
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Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease.
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Academic Article
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Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity.
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Academic Article
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Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases.
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Academic Article
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Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase.
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Academic Article
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Evidence of the residues involved in ligand recognition in the second extracellular loop of the prostacyclin receptor characterized by high resolution 2D NMR techniques.
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Academic Article
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Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway.
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Academic Article
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From the design to the clinical application of thromboxane modulators.
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Academic Article
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Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells.
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Academic Article
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Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression.
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Academic Article
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An agonist sensitive, quick and simple cell-based signaling assay for determination of ligands mimicking prostaglandin E2 or E1 activity through subtype EP1 receptor: Suitable for high throughput screening.
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Academic Article
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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.
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Academic Article
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COX-2-10aa-PGIS gene therapy improves erectile function in rats after cavernous nerve injury.
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Concept
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Receptors, Prostaglandin
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Concept
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Receptors, Epoprostenol
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Concept
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Prostaglandin-Endoperoxide Synthases
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Concept
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Epoprostenol
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Concept
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Prostaglandin Endoperoxides, Synthetic
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Concept
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Receptors, Prostaglandin E
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Concept
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Prostaglandin H2
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Concept
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Receptors, Thromboxane A2, Prostaglandin H2
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Academic Article
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Resistant to thrombosis, induced stroke and heart arrest by incorporation of a single gene of PGI2-synthesizing COX-1-PGIS in vivo: Implication against human heart disease.
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Academic Article
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Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits.
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Academic Article
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Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior.
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Academic Article
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Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2.
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Academic Article
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Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1.
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Academic Article
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How can we address the controversies surrounding the use of NSAIDS in neurodegeneration?
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Academic Article
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The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells.
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Academic Article
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Advances in extracellular ligand recognition sites on prostanoid receptors.
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Concept
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Prostaglandin-E Synthases
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Concept
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Receptors, Prostaglandin E, EP3 Subtype
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Academic Article
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A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti-bleeding functions.
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Academic Article
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The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus.
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Academic Article
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Redirecting thromboxane A2 and prostacyclin biosyntheses from thrombotic to antithrombotic property by an Enzymelink.
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Academic Article
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Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity.
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Academic Article
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Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E2 synthase-1.
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Academic Article
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Design, synthesis and characterization of lead compounds as anti-inflammatory drugs targeting mPGES-1 via enzymelink screening.
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Academic Article
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Latest advancements in the study of the relationship between NSAIDs and three prostaglandin E2 synthases.
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