"Prostaglandin H2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins.
| Descriptor ID |
D044262
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| MeSH Number(s) |
D01.248.497.158.685.750.744.650.500 D01.339.431.374.744.650.500 D01.650.550.750.700.650.500 D02.389.338.638.650.500 D10.251.355.255.550.025.650.500 D23.469.050.175.725.025.650.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Prostaglandin H2".
Below are MeSH descriptors whose meaning is more specific than "Prostaglandin H2".
This graph shows the total number of publications written about "Prostaglandin H2" by people in this website by year, and whether "Prostaglandin H2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 2 | 0 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prostaglandin H2" by people in Profiles.
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A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti-bleeding functions. J Cell Mol Med. 2019 12; 23(12):8343-8354.
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Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1. Arch Biochem Biophys. 2016 08 01; 603:29-37.
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Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2. Biochemistry. 2015 Jun 16; 54(23):3707-15.
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Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution. Arch Biochem Biophys. 2008 Sep 15; 477(2):396-403.
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Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. Biochemistry. 2008 Jan 15; 47(2):680-8.
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Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique. Arch Biochem Biophys. 2005 Dec 15; 444(2):165-73.
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Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases. J Biol Chem. 2005 Jul 15; 280(28):26371-82.
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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators. Curr Med Chem. 2004 May; 11(10):1223-41.
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Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle. Hum Reprod. 2002 Dec; 17(12):3053-9.
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Topology of catalytic portion of prostaglandin I(2) synthase: identification by molecular modeling-guided site-specific antibodies. Arch Biochem Biophys. 2000 Jul 15; 379(2):188-97.