Solute Carrier Family 12, Member 2
"Solute Carrier Family 12, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Na-K-Cl transporter ubiquitously expressed. It plays a key role in salt secretion in epithelial cells and cell volume regulation in nonepithelial cells.
| Descriptor ID |
D064506
|
| MeSH Number(s) |
D12.776.157.530.450.625.750.625 D12.776.157.530.937.750.625 D12.776.543.585.450.625.750.625 D12.776.543.585.937.875.625
|
| Concept/Terms |
Solute Carrier Family 12, Member 2- Solute Carrier Family 12, Member 2
- Bumetanide-Sensitive Sodium Potassium Chloride Cotransporter 2
- Bumetanide Sensitive Sodium Potassium Chloride Cotransporter 2
- Sodium-Potassium-Chloride Cotransporter 1 Protein
- Sodium Potassium Chloride Cotransporter 1 Protein
- BSC2 Protein
- Protein, BSC2
- BSC2 Transport Protein
- Protein, BSC2 Transport
- Transport Protein, BSC2
- Bumetanide-Sensitive Cotransporter 2
- Bumetanide Sensitive Cotransporter 2
- Cotransporter 2, Bumetanide-Sensitive
- NKCC1 Protein
- Protein, NKCC1
- SLC12A2 Cotransporter
- Cotransporter, SLC12A2
- Solute Carrier Family 12 (Sodium Potassium Chloride Transporters), Member 2
- SLC12A2 Protein
- Protein, SLC12A2
- SLC12A2 Transporter
- Transporter, SLC12A2
- NKCC1 Cotransporter
- Cotransporter, NKCC1
- NKCC1 Transport Protein
- Protein, NKCC1 Transport
- Transport Protein, NKCC1
|
Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 12, Member 2".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 12, Member 2".
This graph shows the total number of publications written about "Solute Carrier Family 12, Member 2" by people in this website by year, and whether "Solute Carrier Family 12, Member 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Solute Carrier Family 12, Member 2" by people in Profiles.
-
DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development. J Biol Chem. 2024 02; 300(2):105597.
-
Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. Sci Rep. 2016 10 26; 6:35986.
-
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. Brain Struct Funct. 2017 04; 222(3):1543-1556.
-
Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation. Neuroendocrinology. 2017; 104(2):194-208.
-
Increased spinal cord Na?-K?-2Cl? cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain. J Biol Chem. 2014 Nov 07; 289(45):31111-20.
-
NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension. J Neurosci. 2012 Jun 20; 32(25):8560-8.
-
With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume. Am J Physiol Cell Physiol. 2011 Nov; 301(5):C1150-60.
-
Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol. 2001 Nov 12; 155(4):531-42.