"Netrin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A netrin that binds the DCC RECEPTOR or UNC5 receptors, resulting respectively in axon attraction or repulsion. Its interaction with these receptors also prevents APOPTOSIS; it may function as a tumor suppressor protein.
| Descriptor ID |
D000075388
|
| MeSH Number(s) |
D12.644.276.860.494.500 D12.776.467.860.494.500 D12.776.631.600.494.500 D12.776.860.300.731.500 D23.125.842.500 D23.529.850.494.500
|
| Concept/Terms |
Netrin-1- Netrin-1
- Netrin 1
- Netrin-1 Protein
- Netrin 1 Protein
- Protein, Netrin-1
- NTN1 Protein
- Protein, NTN1
|
Below are MeSH descriptors whose meaning is more general than "Netrin-1".
Below are MeSH descriptors whose meaning is more specific than "Netrin-1".
This graph shows the total number of publications written about "Netrin-1" by people in this website by year, and whether "Netrin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
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Below are the most recent publications written about "Netrin-1" by people in Profiles.
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Netrin-1 induces proliferation of Schwann cells through Unc5b receptor. Biochem Biophys Res Commun. 2007 Nov 03; 362(4):1057-62.
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Netrin inhibits regenerative axon growth of adult dorsal root ganglion neurons in vitro. J Korean Med Sci. 2007 Aug; 22(4):641-5.
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Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. J Neurochem. 2005 Oct; 95(1):1-8.
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Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle. 2005 Mar; 4(3):e131-5.
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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003 May 30; 113(5):657-70.
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Function of an axonal chemoattractant modulated by metalloprotease activity. Science. 2000 Aug 25; 289(5483):1365-7.
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Biochemical characterization of netrin-synergizing activity. J Biol Chem. 2000 Mar 17; 275(11):7832-8.
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Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J Neurosci. 1999 Jun 15; 19(12):4938-47.
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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell. 1994 Aug 12; 78(3):409-24.