Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
| Descriptor ID |
D000072183
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| MeSH Number(s) |
D08.811.277.352.650.624.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
This graph shows the total number of publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in this website by year, and whether "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2012 | 0 | 3 | 3 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in Profiles.
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The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases. Sci Signal. 2018 09 18; 11(548).
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Relation of genomic variants for Alzheimer disease dementia to common neuropathologies. Neurology. 2016 Aug 02; 87(5):489-96.
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s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells. Oncotarget. 2016 May 17; 7(20):29228-44.
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Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction. PLoS One. 2014; 9(11):e112548.
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Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis. Sci Signal. 2012 Sep 11; 5(241):ra66.
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CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol. 2012 Jul 15; 189(2):786-92.
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Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. Oncogene. 2012 Sep 13; 31(37):4085-94.
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Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12. Cancer Res. 2005 Oct 01; 65(19):9099-107.
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Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood. 2005 Apr 15; 105(8):3011-8.
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Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun. 2003 Aug 01; 307(3):719-29.