Regulatory Factor X Transcription Factors
"Regulatory Factor X Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of eukaryotic transcription factors that recognize and bind to a highly-conserved cis-regulatory sequence (X-box) within the promoter region of MHC CLASS II GENES. They contain a conserved winged-helix DNA binding domain and function as homo or heterodimers.
| Descriptor ID |
D000071701
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| MeSH Number(s) |
D12.776.260.950.624 D12.776.930.977.624
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Regulatory Factor X Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "Regulatory Factor X Transcription Factors".
This graph shows the total number of publications written about "Regulatory Factor X Transcription Factors" by people in this website by year, and whether "Regulatory Factor X Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Regulatory Factor X Transcription Factors" by people in Profiles.
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Mitchell-Riley Syndrome: Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations. Front Endocrinol (Lausanne). 2022; 13:802351.
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Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior. Genet Med. 2021 06; 23(6):1028-1040.
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ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).
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Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4a (HNF4?) Is Vital to Beta-cell Function. J Biol Chem. 2016 Mar 18; 291(12):6146-57.
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Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab. 2014 Sep 02; 20(3):471-82.
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XBP1 promotes triple-negative breast cancer by controlling the HIF1a pathway. Nature. 2014 Apr 03; 508(7494):103-107.
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Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clin Cancer Res. 2013 Nov 15; 19(22):6242-51.
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Why proteasome inhibitors cannot ERADicate multiple myeloma. Cancer Cell. 2013 Sep 09; 24(3):275-7.
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Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem. 2012 Jun 01; 287(23):19687-98.
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Activation of unfolded protein response in transgenic mouse lenses. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2100-8.