"Uncoupling Protein 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial uncoupling protein that is expressed in heart and skeletal muscle tissues. It functions to regulate tissue respiration, energy balance, and THERMOGENESIS. Mutations in the UCP3 gene are associated with OBESITY.
| Descriptor ID |
D000071247
|
| MeSH Number(s) |
D12.776.157.530.937.598.875 D12.776.543.585.475.688.875 D12.776.543.585.937.696.875 D12.776.575.750.688.875
|
| Concept/Terms |
Uncoupling Protein 3- Uncoupling Protein 3
- Uncoupling Protein-3
- Solute Carrier Family 25 Member 9
- UCP3 Protein
- SLC25A9 Protein
- Mitochondrial Uncoupling Protein 3
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Protein 3".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Protein 3".
This graph shows the total number of publications written about "Uncoupling Protein 3" by people in this website by year, and whether "Uncoupling Protein 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Uncoupling Protein 3" by people in Profiles.
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Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart. J Biol Chem. 2015 Dec 25; 290(52):30947-61.
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Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun. 2015 Aug 27; 6:8137.
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Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Res Cardiol. 2014; 109(6):447.
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Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heart. FASEB J. 2013 Oct; 27(10):3966-78.
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Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012; 7(5):e36994.
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Insulin resistance improves metabolic and contractile efficiency in stressed rat heart. FASEB J. 2012 Aug; 26(8):3118-26.
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Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis. Oncogene. 2012 Nov 01; 31(44):4725-31.
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Metabolic adaptation follows contractile dysfunction in the heart of obese Zucker rats fed a high-fat "Western" diet. Obesity (Silver Spring). 2010 Oct; 18(10):1895-901.
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The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1530-41.
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Hypoxia-induced decrease of UCP3 gene expression in rat heart parallels metabolic gene switching but fails to affect mitochondrial respiratory coupling. Biochem Biophys Res Commun. 2004 Feb 06; 314(2):561-4.