"Uncoupling Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial uncoupling protein that is expressed in many tissues and exhibits the greatest expression in SKELETAL MUSCLE. It regulates mitochondrial ATP production and the generation of REACTIVE OXYGEN SPECIES.
| Descriptor ID |
D000071246
|
| MeSH Number(s) |
D12.776.157.530.937.598.750 D12.776.543.585.475.688.750 D12.776.543.585.937.696.750 D12.776.575.750.688.750
|
| Concept/Terms |
Uncoupling Protein 2- Uncoupling Protein 2
- Mitochondrial Uncoupling Protein 2
- SLC25A8 Protein
- UCP2 Protein
- Uncoupling Protein-2
- Solute Carrier Family 25 Member 8
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Protein 2".
This graph shows the total number of publications written about "Uncoupling Protein 2" by people in this website by year, and whether "Uncoupling Protein 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Uncoupling Protein 2" by people in Profiles.
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UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect. Cancer Metastasis Rev. 2024 Jun; 43(2):777-794.
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Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. J Am Soc Nephrol. 2015 Feb; 26(2):364-78.
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Bmal1 and ?-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ?-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38.
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Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet. Nutr Res. 2012 Sep; 32(9):701-8.
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Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice. Kidney Int. 2012 Oct; 82(8):867-77.
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Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in ?-cells. Islets. 2011 Nov-Dec; 3(6):381-8.
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Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J Hepatol. 2010 Dec; 53(6):1108-16.
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Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study. Cancer Epidemiol Biomarkers Prev. 2010 Feb; 19(2):558-65.
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Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest. 2010 Jan; 120(1):142-56.
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Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. J Leukoc Biol. 2009 Oct; 86(4):981-8.