"Alarmins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
| Descriptor ID |
D000067531
|
| MeSH Number(s) |
D23.035
|
| Concept/Terms |
Alarmins- Alarmins
- Damage-Associated Molecular Pattern Molecules
- Damage Associated Molecular Pattern Molecules
- Danger-Associated Molecular Pattern Molecules
- Danger Associated Molecular Pattern Molecules
- Alarmin Proteins
- Alarmin
|
Below are MeSH descriptors whose meaning is more general than "Alarmins".
Below are MeSH descriptors whose meaning is more specific than "Alarmins".
This graph shows the total number of publications written about "Alarmins" by people in this website by year, and whether "Alarmins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Alarmins" by people in Profiles.
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Impact of Low Humidity on Damage-associated Molecular Patterns at the Ocular Surface during Dry Eye Disease. Optom Vis Sci. 2021 11 01; 98(11):1231-1238.
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Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death. J Immunol. 2021 04 15; 206(8):1878-1889.
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Mechanisms of immunogenic cell death and immune checkpoint blockade therapy. Kaohsiung J Med Sci. 2021 Jun; 37(6):448-458.
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Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death. Nat Commun. 2020 12 07; 11(1):6299.
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Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nat Commun. 2019 02 22; 10(1):899.
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Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018 04; 154(5):1405-1420.e2.