Tissue Inhibitor of Metalloproteinase-2
"Tissue Inhibitor of Metalloproteinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
| Descriptor ID |
D019716
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| MeSH Number(s) |
D12.776.645.875.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tissue Inhibitor of Metalloproteinase-2".
Below are MeSH descriptors whose meaning is more specific than "Tissue Inhibitor of Metalloproteinase-2".
This graph shows the total number of publications written about "Tissue Inhibitor of Metalloproteinase-2" by people in this website by year, and whether "Tissue Inhibitor of Metalloproteinase-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2008 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Inhibitor of Metalloproteinase-2" by people in Profiles.
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APOL1 Kidney Risk Variants and Proteomics. Clin J Am Soc Nephrol. 2022 05; 17(5):684-692.
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Mechanical pressure unloading therapy reverses thoracic aortic structural and functional changes in a hypertensive rat model. J Hypertens. 2018 12; 36(12):2350-2361.
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Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats. Oxid Med Cell Longev. 2018; 2018:6709742.
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Biomarkers and mortality in severe Chagas cardiomyopathy. Glob Heart. 2015 Sep; 10(3):173-80.
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Absence of nicotinic acetylcholine receptor a7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model. FASEB J. 2015 Aug; 29(8):3558-70.
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Biomarkers in Trypanosoma cruzi-infected and uninfected individuals with varying severity of cardiomyopathy in Santa Cruz, Bolivia. PLoS Negl Trop Dis. 2014 Oct; 8(10):e3227.
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Impact of percutaneous coronary intervention on biomarker levels in patients in the subacute phase following myocardial infarction: the Occluded Artery Trial (OAT) biomarker ancillary study. BMC Cardiovasc Disord. 2013 Oct 24; 13:91.
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Fibroblast-conditioned media promote human sarcoma cell invasion. Surgery. 2009 Jan; 145(1):42-7.
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CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov; 378(5):541-52.
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Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol. 2006 Oct 09; 175(1):179-91.